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P03903 (NU4LM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4L

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene names
Name:Mtnd4l
Synonyms:mt-Nd4l, Nd4l
Encoded onMitochondrion
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4L family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9797NADH-ubiquinone oxidoreductase chain 4L
PRO_0000118448

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane26 – 4621Helical; Potential
Transmembrane58 – 7821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P03903 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: FFA1596E86F91D34

FASTA9710,494
        10         20         30         40         50         60 
MPSTFFNLTM AFSLSLLGTL MFRSHLMSTL LCLEGMVLSL FIMTSVTSLN SNSMSSMPIP 

        70         80         90 
ITLVFAACEA AVGLALLVKV SNTYGTDYVQ NLNLLQC 

« Hide

References

[1]"Sequence and gene organization of mouse mitochondrial DNA."
Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01420 Genomic DNA. Translation: AAB48652.1.
V00711 Genomic DNA. Translation: CAA24087.1.
PIRQXMS4L. A00430.

3D structure databases

ProteinModelPortalP03903.
SMRP03903. Positions 8-96.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP03903.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:102497. mt-Nd4l.

Phylogenomic databases

eggNOGNOG260597.
HOVERGENHBG071122.

Gene expression databases

BgeeP03903.
GenevestigatorP03903.

Family and domain databases

InterProIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PANTHERPTHR11434. PTHR11434. 1 hit.
PfamPF00420. Oxidored_q2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35563512.
SOURCESearch...

Entry information

Entry nameNU4LM_MOUSE
AccessionPrimary (citable) accession number: P03903
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 19, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot