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P03903

- NU4LM_MOUSE

UniProt

P03903 - NU4LM_MOUSE

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Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

Mtnd4l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiREACT_262523. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4L (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene namesi
Name:Mtnd4l
Synonyms:mt-Nd4l, Nd4l
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102497. mt-Nd4l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence AnalysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797NADH-ubiquinone oxidoreductase chain 4LPRO_0000118448Add
BLAST

Proteomic databases

MaxQBiP03903.
PaxDbiP03903.

Expressioni

Gene expression databases

BgeeiP03903.
ExpressionAtlasiP03903. differential.
GenevestigatoriP03903.

Structurei

3D structure databases

ProteinModelPortaliP03903.
SMRiP03903. Positions 8-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4L family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260597.
HOVERGENiHBG071122.
InParanoidiP03903.

Family and domain databases

InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PANTHERiPTHR11434. PTHR11434. 1 hit.
PfamiPF00420. Oxidored_q2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03903-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSTFFNLTM AFSLSLLGTL MFRSHLMSTL LCLEGMVLSL FIMTSVTSLN
60 70 80 90
SNSMSSMPIP ITLVFAACEA AVGLALLVKV SNTYGTDYVQ NLNLLQC
Length:97
Mass (Da):10,494
Last modified:July 21, 1986 - v1
Checksum:iFFA1596E86F91D34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48652.1.
V00711 Genomic DNA. Translation: CAA24087.1.
PIRiA00430. QXMS4L.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48652.1 .
V00711 Genomic DNA. Translation: CAA24087.1 .
PIRi A00430. QXMS4L.

3D structure databases

ProteinModelPortali P03903.
SMRi P03903. Positions 8-96.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi P03903.
PaxDbi P03903.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:102497. mt-Nd4l.

Phylogenomic databases

eggNOGi NOG260597.
HOVERGENi HBG071122.
InParanoidi P03903.

Enzyme and pathway databases

Reactomei REACT_262523. Respiratory electron transport.

Miscellaneous databases

NextBioi 35563512.
SOURCEi Search...

Gene expression databases

Bgeei P03903.
ExpressionAtlasi P03903. differential.
Genevestigatori P03903.

Family and domain databases

InterProi IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view ]
PANTHERi PTHR11434. PTHR11434. 1 hit.
Pfami PF00420. Oxidored_q2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNU4LM_MOUSE
AccessioniPrimary (citable) accession number: P03903
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3