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P03903

- NU4LM_MOUSE

UniProt

P03903 - NU4LM_MOUSE

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Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

Mtnd4l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4L (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene namesi
Name:Mtnd4l
Synonyms:mt-Nd4l, Nd4l
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102497. mt-Nd4l.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797NADH-ubiquinone oxidoreductase chain 4LPRO_0000118448Add
BLAST

Proteomic databases

MaxQBiP03903.
PaxDbiP03903.

Expressioni

Gene expression databases

BgeeiP03903.
ExpressionAtlasiP03903. differential.
GenevestigatoriP03903.

Structurei

3D structure databases

ProteinModelPortaliP03903.
SMRiP03903. Positions 8-96.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence AnalysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4L family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260597.
HOVERGENiHBG071122.
InParanoidiP03903.

Family and domain databases

InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PANTHERiPTHR11434. PTHR11434. 1 hit.
PfamiPF00420. Oxidored_q2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03903-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSTFFNLTM AFSLSLLGTL MFRSHLMSTL LCLEGMVLSL FIMTSVTSLN
60 70 80 90
SNSMSSMPIP ITLVFAACEA AVGLALLVKV SNTYGTDYVQ NLNLLQC
Length:97
Mass (Da):10,494
Last modified:July 21, 1986 - v1
Checksum:iFFA1596E86F91D34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01420 Genomic DNA. Translation: AAB48652.1.
V00711 Genomic DNA. Translation: CAA24087.1.
PIRiA00430. QXMS4L.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01420 Genomic DNA. Translation: AAB48652.1 .
V00711 Genomic DNA. Translation: CAA24087.1 .
PIRi A00430. QXMS4L.

3D structure databases

ProteinModelPortali P03903.
SMRi P03903. Positions 8-96.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi P03903.
PaxDbi P03903.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:102497. mt-Nd4l.

Phylogenomic databases

eggNOGi NOG260597.
HOVERGENi HBG071122.
InParanoidi P03903.

Miscellaneous databases

NextBioi 35563512.
SOURCEi Search...

Gene expression databases

Bgeei P03903.
ExpressionAtlasi P03903. differential.
Genevestigatori P03903.

Family and domain databases

InterProi IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view ]
PANTHERi PTHR11434. PTHR11434. 1 hit.
Pfami PF00420. Oxidored_q2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNU4LM_MOUSE
AccessioniPrimary (citable) accession number: P03903
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3