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Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

MT-ND4L

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4L (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene namesi
Name:MT-ND4L
Synonyms:MTND4L, NADH4L, ND4L
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001183961 – 98NADH-ubiquinone oxidoreductase chain 4LAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-formylmethionine1 Publication1

Keywords - PTMi

Formylation

Proteomic databases

PaxDbiP03902.

Expressioni

Gene expression databases

BgeeiENSBTAG00000043559.
ExpressionAtlasiP03902. baseline.

Interactioni

Protein-protein interaction databases

CORUMiP03902.
DIPiDIP-62099N.
STRINGi9913.ENSBTAP00000053153.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35K2-96[»]
5LDWelectron microscopy4.27K1-98[»]
5LDXelectron microscopy5.60K1-98[»]
SMRiP03902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4L family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4669. Eukaryota.
COG0713. LUCA.
GeneTreeiENSGT00390000004755.
HOGENOMiHOG000113880.
HOVERGENiHBG071122.
InParanoidiP03902.
KOiK03882.
OMAiLCLEGMM.
OrthoDBiEOG091G0ZRL.
TreeFamiTF338190.

Family and domain databases

InterProiView protein in InterPro
IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
PANTHERiPTHR11434. PTHR11434. 1 hit.

Sequencei

Sequence statusi: Complete.

P03902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMVYMNIMM AFTVSLVGLL MYRSHLMSSL LCLEGMMLSL FVMAALTILN
60 70 80 90
SHFTLASMMP IILLVFAACE AALGLSLLVM VSNTYGTDYV QNLNLLQC
Length:98
Mass (Da):10,797
Last modified:July 21, 1986 - v1
Checksum:i4DB48B7DA59C1881
GO

Mass spectrometryi

Molecular mass is 10825.4 Da from positions 1 - 98. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti65V → A in strain: 66. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA24004.1.
AF490528 Genomic DNA. Translation: AAM08325.1.
AF490529 Genomic DNA. Translation: AAM08338.1.
AF493541 Genomic DNA. Translation: AAM12797.1.
AF493542 Genomic DNA. Translation: AAM12810.1.
PIRiA00429. QXBO4L.
RefSeqiYP_209213.1. NC_006853.1.

Genome annotation databases

EnsembliENSBTAT00000060543; ENSBTAP00000053153; ENSBTAG00000043559.
GeneIDi3283885.
KEGGibta:3283885.

Similar proteinsi

Entry informationi

Entry nameiNU4LM_BOVIN
AccessioniPrimary (citable) accession number: P03902
Secondary accession number(s): Q8SFX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 27, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families