ID NU4LM_HUMAN Reviewed; 98 AA. AC P03901; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 24-JAN-2024, entry version 190. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L; DE EC=7.1.1.2 {ECO:0000305|PubMed:28844695}; DE AltName: Full=NADH dehydrogenase subunit 4L {ECO:0000303|PubMed:3921850}; DE Short=ND4L {ECO:0000303|PubMed:3921850}; GN Name=MT-ND4L {ECO:0000312|HGNC:HGNC:7460}; GN Synonyms=MTND4L, NADH4L, ND4L; OS Homo sapiens (Human). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=7219534; DOI=10.1038/290457a0; RA Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R., RA Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H., RA Smith A.J.H., Staden R., Young I.G.; RT "Sequence and organization of the human mitochondrial genome."; RL Nature 290:457-465(1981). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Placenta; RX PubMed=7530363; DOI=10.1073/pnas.92.2.532; RA Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.; RT "Recent African origin of modern humans revealed by complete sequences of RT hominoid mitochondrial DNAs."; RL Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8919866; DOI=10.1007/bf02198840; RA Arnason U., Xu X., Gullberg A.; RT "Comparison between the complete mitochondrial DNA sequences of Homo and RT the common chimpanzee based on nonchimeric sequences."; RL J. Mol. Evol. 42:145-152(1996). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12949126; DOI=10.1093/molbev/msg230; RA Moilanen J.S., Finnila S., Majamaa K.; RT "Lineage-specific selection in human mtDNA: lack of polymorphisms in a RT segment of MTND5 gene in haplogroup J."; RL Mol. Biol. Evol. 20:2132-2142(2003). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=11130070; DOI=10.1038/35047064; RA Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.; RT "Mitochondrial genome variation and the origin of modern humans."; RL Nature 408:708-713(2000). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12840039; DOI=10.1101/gr.686603; RA Ingman M., Gyllensten U.; RT "Mitochondrial genome variation and evolutionary history of Australian and RT New Guinean aborigines."; RL Genome Res. 13:1600-1606(2003). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=14760490; DOI=10.1007/s00414-004-0427-6; RA Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T., RA Irwin J.A., Parsons T.J.; RT "Single nucleotide polymorphisms over the entire mtDNA genome that increase RT the power of forensic testing in Caucasians."; RL Int. J. Legal Med. 118:137-146(2004). RN [8] RP IDENTIFICATION OF PROTEIN. RX PubMed=3921850; DOI=10.1038/314592a0; RA Chomyn A., Mariottini P., Cleeter M.W.J., Ragan C.I., Matsuno-Yagi A., RA Hatefi Y., Doolittle R.F., Attardi G.; RT "Six unidentified reading frames of human mitochondrial DNA encode RT components of the respiratory-chain NADH dehydrogenase."; RL Nature 314:592-597(1985). RN [9] {ECO:0000312|PDB:5XTC, ECO:0000312|PDB:5XTD} RP STRUCTURE BY ELECTRON MICROSCOPY (3.70 ANGSTROMS) OF 1-97, FUNCTION, RP CATALYTIC ACTIVITY, AND SUBUNIT. RX PubMed=28844695; DOI=10.1016/j.cell.2017.07.050; RA Guo R., Zong S., Wu M., Gu J., Yang M.; RT "Architecture of human mitochondrial respiratory megacomplex I2III2IV2."; RL Cell 170:1247-1257(2017). RN [10] RP VARIANTS ILE-36; SER-57 AND THR-61. RX PubMed=1757091; DOI=10.1007/bf00206061; RA Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R., RA Utthanaphol P., Byrne E.; RT "Normal variants of human mitochondrial DNA and translation products: the RT building of a reference data base."; RL Hum. Genet. 88:139-145(1991). RN [11] RP VARIANT LHON ALA-65. RX PubMed=8680405; DOI=10.1002/humu.1380060405; RA Brown M.D., Torroni A., Reckord C.L., Wallace D.C.; RT "Phylogenetic analysis of Leber's hereditary optic neuropathy mitochondrial RT DNA's indicates multiple independent occurrences of the common mutations."; RL Hum. Mutat. 6:311-325(1995). RN [12] RP VARIANT COLORECTAL CANCER ARG-32. RX PubMed=9806551; DOI=10.1038/3108; RA Polyak K., Li Y., Zhu H., Lengauer C., Willson J.K.V., Markowitz S.D., RA Trush M.A., Kinzler K.W., Vogelstein B.; RT "Somatic mutations of the mitochondrial genome in human colorectal RT tumours."; RL Nat. Genet. 20:291-293(1998). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor (PubMed:28844695). Part of the enzyme membrane arm which is CC embedded in the lipid bilayer and involved in proton translocation CC (PubMed:28844695). {ECO:0000269|PubMed:28844695}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000305|PubMed:28844695}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29092; CC Evidence={ECO:0000305|PubMed:28844695}; CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex CC I) which is composed of 45 different subunits. CC {ECO:0000269|PubMed:28844695}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein CC {ECO:0000255}. CC -!- DISEASE: Leber hereditary optic neuropathy (LHON) [MIM:535000]: A CC maternally inherited form of Leber hereditary optic neuropathy, a CC mitochondrial disease resulting in bilateral painless loss of central CC vision due to selective degeneration of the retinal ganglion cells and CC their axons. The disorder shows incomplete penetrance and male CC predominance. Cardiac conduction defects and neurological defects have CC also been described in some LHON patients. LHON results from primary CC mitochondrial DNA mutations affecting the respiratory chain complexes. CC {ECO:0000269|PubMed:8680405}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J01415; AAB58951.1; -; Genomic_DNA. DR EMBL; V00662; CAA24034.1; -; Genomic_DNA. DR EMBL; X62996; CAA44730.1; -; Genomic_DNA. DR EMBL; D38112; BAA07296.1; -; Genomic_DNA. DR EMBL; X93334; CAA63721.1; -; Genomic_DNA. DR EMBL; AY339402; AAP89044.1; -; Genomic_DNA. DR EMBL; AY339403; AAP89057.1; -; Genomic_DNA. DR EMBL; AY339404; AAP89070.1; -; Genomic_DNA. DR EMBL; AY339405; AAP89083.1; -; Genomic_DNA. DR EMBL; AY339406; AAP89096.1; -; Genomic_DNA. DR EMBL; AY339407; AAP89109.1; -; Genomic_DNA. DR EMBL; AY339408; AAP89122.1; -; Genomic_DNA. DR EMBL; AY339409; AAP89135.1; -; Genomic_DNA. DR EMBL; AY339410; AAP89148.1; -; Genomic_DNA. DR EMBL; AY339411; AAP89161.1; -; Genomic_DNA. DR EMBL; AY339412; AAP89174.1; -; Genomic_DNA. DR EMBL; AY339413; AAP89187.1; -; Genomic_DNA. DR EMBL; AY339414; AAP89200.1; -; Genomic_DNA. DR EMBL; AY339415; AAP89213.1; -; Genomic_DNA. DR EMBL; AY339416; AAP89226.1; -; Genomic_DNA. DR EMBL; AY339417; AAP89239.1; -; Genomic_DNA. DR EMBL; AY339418; AAP89252.1; -; Genomic_DNA. DR EMBL; AY339419; AAP89265.1; -; Genomic_DNA. DR EMBL; AY339420; AAP89278.1; -; Genomic_DNA. DR EMBL; AY339421; AAP89291.1; -; Genomic_DNA. DR EMBL; AY339422; AAP89304.1; -; Genomic_DNA. DR EMBL; AY339423; AAP89317.1; -; Genomic_DNA. DR EMBL; AY339424; AAP89330.1; -; Genomic_DNA. DR EMBL; AY339425; AAP89343.1; -; Genomic_DNA. DR EMBL; AY339426; AAP89356.1; -; Genomic_DNA. DR EMBL; AY339427; AAP89369.1; -; Genomic_DNA. DR EMBL; AY339428; AAP89382.1; -; Genomic_DNA. DR EMBL; AY339429; AAP89395.1; -; Genomic_DNA. DR EMBL; AY339430; AAP89408.1; -; Genomic_DNA. DR EMBL; AY339431; AAP89421.1; -; Genomic_DNA. DR EMBL; AY339432; AAP89434.1; -; Genomic_DNA. DR EMBL; AY339433; AAP89447.1; -; Genomic_DNA. DR EMBL; AY339434; AAP89460.1; -; Genomic_DNA. DR EMBL; AY339435; AAP89473.1; -; Genomic_DNA. DR EMBL; AY339436; AAP89486.1; -; Genomic_DNA. DR EMBL; AY339437; AAP89499.1; -; Genomic_DNA. DR EMBL; AY339438; AAP89512.1; -; Genomic_DNA. DR EMBL; AY339439; AAP89525.1; -; Genomic_DNA. DR EMBL; AY339440; AAP89538.1; -; Genomic_DNA. DR EMBL; AY339441; AAP89551.1; -; Genomic_DNA. DR EMBL; AY339442; AAP89564.1; -; Genomic_DNA. DR EMBL; AY339443; AAP89577.1; -; Genomic_DNA. DR EMBL; AY339444; AAP89590.1; -; Genomic_DNA. DR EMBL; AY339445; AAP89603.1; -; Genomic_DNA. DR EMBL; AY339446; AAP89616.1; -; Genomic_DNA. DR EMBL; AY339447; AAP89629.1; -; Genomic_DNA. DR EMBL; AY339448; AAP89642.1; -; Genomic_DNA. DR EMBL; AY339449; AAP89655.1; -; Genomic_DNA. DR EMBL; AY339450; AAP89668.1; -; Genomic_DNA. DR EMBL; AY339451; AAP89681.1; -; Genomic_DNA. DR EMBL; AY339452; AAP89694.1; -; Genomic_DNA. DR EMBL; AY339453; AAP89707.1; -; Genomic_DNA. DR EMBL; AY339454; AAP89720.1; -; Genomic_DNA. DR EMBL; AY339455; AAP89733.1; -; Genomic_DNA. DR EMBL; AY339456; AAP89746.1; -; Genomic_DNA. DR EMBL; AY339457; AAP89759.1; -; Genomic_DNA. DR EMBL; AY339458; AAP89772.1; -; Genomic_DNA. DR EMBL; AY339459; AAP89785.1; -; Genomic_DNA. DR EMBL; AY339460; AAP89798.1; -; Genomic_DNA. DR EMBL; AY339461; AAP89811.1; -; Genomic_DNA. DR EMBL; AY339462; AAP89824.1; -; Genomic_DNA. DR EMBL; AY339463; AAP89837.1; -; Genomic_DNA. DR EMBL; AY339464; AAP89850.1; -; Genomic_DNA. DR EMBL; AY339465; AAP89863.1; -; Genomic_DNA. DR EMBL; AY339466; AAP89876.1; -; Genomic_DNA. DR EMBL; AY339467; AAP89889.1; -; Genomic_DNA. DR EMBL; AY339468; AAP89902.1; -; Genomic_DNA. DR EMBL; AY339469; AAP89915.1; -; Genomic_DNA. DR EMBL; AY339470; AAP89928.1; -; Genomic_DNA. DR EMBL; AY339471; AAP89941.1; -; Genomic_DNA. DR EMBL; AY339472; AAP89954.1; -; Genomic_DNA. DR EMBL; AY339473; AAP89967.1; -; Genomic_DNA. DR EMBL; AY339474; AAP89980.1; -; Genomic_DNA. DR EMBL; AY339475; AAP89993.1; -; Genomic_DNA. DR EMBL; AY339476; AAP90006.1; -; Genomic_DNA. DR EMBL; AY339477; AAP90019.1; -; Genomic_DNA. DR EMBL; AY339478; AAP90032.1; -; Genomic_DNA. DR EMBL; AY339479; AAP90045.1; -; Genomic_DNA. DR EMBL; AY339480; AAP90058.1; -; Genomic_DNA. DR EMBL; AY339481; AAP90071.1; -; Genomic_DNA. DR EMBL; AY339482; AAP90084.1; -; Genomic_DNA. DR EMBL; AY339483; AAP90097.1; -; Genomic_DNA. DR EMBL; AY339484; AAP90110.1; -; Genomic_DNA. DR EMBL; AY339485; AAP90123.1; -; Genomic_DNA. DR EMBL; AY339486; AAP90136.1; -; Genomic_DNA. DR EMBL; AY339487; AAP90149.1; -; Genomic_DNA. DR EMBL; AY339488; AAP90162.1; -; Genomic_DNA. DR EMBL; AY339489; AAP90175.1; -; Genomic_DNA. DR EMBL; AY339490; AAP90188.1; -; Genomic_DNA. DR EMBL; AY339491; AAP90201.1; -; Genomic_DNA. DR EMBL; AY339492; AAP90214.1; -; Genomic_DNA. DR EMBL; AY339493; AAP90227.1; -; Genomic_DNA. DR EMBL; AY339494; AAP90240.1; -; Genomic_DNA. DR EMBL; AY339495; AAP90253.1; -; Genomic_DNA. DR EMBL; AY339496; AAP90266.1; -; Genomic_DNA. DR EMBL; AY339497; AAP90279.1; -; Genomic_DNA. DR EMBL; AY339498; AAP90292.1; -; Genomic_DNA. DR EMBL; AY339499; AAP90305.1; -; Genomic_DNA. DR EMBL; AY339500; AAP90318.1; -; Genomic_DNA. DR EMBL; AY339501; AAP90331.1; -; Genomic_DNA. DR EMBL; AY339502; AAP90344.1; -; Genomic_DNA. DR EMBL; AY339503; AAP90357.1; -; Genomic_DNA. DR EMBL; AY339504; AAP90370.1; -; Genomic_DNA. DR EMBL; AY339505; AAP90383.1; -; Genomic_DNA. DR EMBL; AY339506; AAP90396.1; -; Genomic_DNA. DR EMBL; AY339507; AAP90409.1; -; Genomic_DNA. DR EMBL; AY339508; AAP90422.1; -; Genomic_DNA. DR EMBL; AY339509; AAP90435.1; -; Genomic_DNA. DR EMBL; AY339510; AAP90448.1; -; Genomic_DNA. DR EMBL; AY339511; AAP90461.1; -; Genomic_DNA. DR EMBL; AY339512; AAP90474.1; -; Genomic_DNA. DR EMBL; AY339513; AAP90487.1; -; Genomic_DNA. DR EMBL; AY339514; AAP90500.1; -; Genomic_DNA. DR EMBL; AY339515; AAP90513.1; -; Genomic_DNA. DR EMBL; AY339516; AAP90526.1; -; Genomic_DNA. DR EMBL; AY339517; AAP90539.1; -; Genomic_DNA. DR EMBL; AY339518; AAP90552.1; -; Genomic_DNA. DR EMBL; AY339519; AAP90565.1; -; Genomic_DNA. DR EMBL; AY339520; AAP90578.1; -; Genomic_DNA. DR EMBL; AY339521; AAP90591.1; -; Genomic_DNA. DR EMBL; AY339522; AAP90604.1; -; Genomic_DNA. DR EMBL; AY339523; AAP90617.1; -; Genomic_DNA. DR EMBL; AY339524; AAP90630.1; -; Genomic_DNA. DR EMBL; AY339525; AAP90643.1; -; Genomic_DNA. DR EMBL; AY339526; AAP90656.1; -; Genomic_DNA. DR EMBL; AY339527; AAP90669.1; -; Genomic_DNA. DR EMBL; AY339528; AAP90682.1; -; Genomic_DNA. DR EMBL; AY339529; AAP90695.1; -; Genomic_DNA. DR EMBL; AY339530; AAP90708.1; -; Genomic_DNA. DR EMBL; AY339531; AAP90721.1; -; Genomic_DNA. DR EMBL; AY339532; AAP90734.1; -; Genomic_DNA. DR EMBL; AY339533; AAP90747.1; -; Genomic_DNA. DR EMBL; AY339534; AAP90760.1; -; Genomic_DNA. DR EMBL; AY339535; AAP90773.1; -; Genomic_DNA. DR EMBL; AY339536; AAP90786.1; -; Genomic_DNA. DR EMBL; AY339537; AAP90799.1; -; Genomic_DNA. DR EMBL; AY339538; AAP90812.1; -; Genomic_DNA. DR EMBL; AY339539; AAP90825.1; -; Genomic_DNA. DR EMBL; AY339540; AAP90838.1; -; Genomic_DNA. DR EMBL; AY339541; AAP90851.1; -; Genomic_DNA. DR EMBL; AY339542; AAP90864.1; -; Genomic_DNA. DR EMBL; AY339543; AAP90877.1; -; Genomic_DNA. DR EMBL; AY339544; AAP90890.1; -; Genomic_DNA. DR EMBL; AY339545; AAP90903.1; -; Genomic_DNA. DR EMBL; AY339546; AAP90916.1; -; Genomic_DNA. DR EMBL; AY339547; AAP90929.1; -; Genomic_DNA. DR EMBL; AY339548; AAP90942.1; -; Genomic_DNA. DR EMBL; AY339549; AAP90955.1; -; Genomic_DNA. DR EMBL; AY339550; AAP90968.1; -; Genomic_DNA. DR EMBL; AY339551; AAP90981.1; -; Genomic_DNA. DR EMBL; AY339552; AAP90994.1; -; Genomic_DNA. DR EMBL; AY339553; AAP91007.1; -; Genomic_DNA. DR EMBL; AY339554; AAP91020.1; -; Genomic_DNA. DR EMBL; AY339555; AAP91033.1; -; Genomic_DNA. DR EMBL; AY339556; AAP91046.1; -; Genomic_DNA. DR EMBL; AY339557; AAP91059.1; -; Genomic_DNA. DR EMBL; AY339558; AAP91072.1; -; Genomic_DNA. DR EMBL; AY339559; AAP91085.1; -; Genomic_DNA. DR EMBL; AY339560; AAP91098.1; -; Genomic_DNA. DR EMBL; AY339561; AAP91111.1; -; Genomic_DNA. DR EMBL; AY339562; AAP91124.1; -; Genomic_DNA. DR EMBL; AY339563; AAP91137.1; -; Genomic_DNA. DR EMBL; AY339564; AAP91150.1; -; Genomic_DNA. DR EMBL; AY339565; AAP91163.1; -; Genomic_DNA. DR EMBL; AY339566; AAP91176.1; -; Genomic_DNA. DR EMBL; AY339568; AAP91202.1; -; Genomic_DNA. DR EMBL; AY339569; AAP91215.1; -; Genomic_DNA. DR EMBL; AY339570; AAP91228.1; -; Genomic_DNA. DR EMBL; AY339571; AAP91241.1; -; Genomic_DNA. DR EMBL; AY339572; AAP91254.1; -; Genomic_DNA. DR EMBL; AY339573; AAP91267.1; -; Genomic_DNA. DR EMBL; AY339574; AAP91280.1; -; Genomic_DNA. DR EMBL; AY339575; AAP91293.1; -; Genomic_DNA. DR EMBL; AY339576; AAP91306.1; -; Genomic_DNA. DR EMBL; AY339577; AAP91319.1; -; Genomic_DNA. DR EMBL; AY339578; AAP91332.1; -; Genomic_DNA. DR EMBL; AY339579; AAP91345.1; -; Genomic_DNA. DR EMBL; AY339580; AAP91358.1; -; Genomic_DNA. DR EMBL; AY339581; AAP91371.1; -; Genomic_DNA. DR EMBL; AY339582; AAP91384.1; -; Genomic_DNA. DR EMBL; AY339583; AAP91397.1; -; Genomic_DNA. DR EMBL; AY339584; AAP91410.1; -; Genomic_DNA. DR EMBL; AY339585; AAP91423.1; -; Genomic_DNA. DR EMBL; AY339586; AAP91436.1; -; Genomic_DNA. DR EMBL; AY339587; AAP91449.1; -; Genomic_DNA. DR EMBL; AY339588; AAP91462.1; -; Genomic_DNA. DR EMBL; AY339589; AAP91475.1; -; Genomic_DNA. DR EMBL; AY339590; AAP91488.1; -; Genomic_DNA. DR EMBL; AY339591; AAP91501.1; -; Genomic_DNA. DR EMBL; AY339592; AAP91514.1; -; Genomic_DNA. DR EMBL; AY339593; AAP91527.1; -; Genomic_DNA. DR EMBL; AF346963; AAK17215.1; -; Genomic_DNA. DR EMBL; AF346964; AAK17228.1; -; Genomic_DNA. DR EMBL; AF346965; AAK17241.1; -; Genomic_DNA. DR EMBL; AF346966; AAK17254.1; -; Genomic_DNA. DR EMBL; AF346967; AAK17267.1; -; Genomic_DNA. DR EMBL; AF346968; AAK17280.1; -; Genomic_DNA. DR EMBL; AF346969; AAK17293.1; -; Genomic_DNA. DR EMBL; AF346970; AAK17306.1; -; Genomic_DNA. DR EMBL; AF346972; AAK17332.1; -; Genomic_DNA. DR EMBL; AF346973; AAK17345.1; -; Genomic_DNA. DR EMBL; AF346974; AAK17358.1; -; Genomic_DNA. DR EMBL; AF346975; AAK17371.1; -; Genomic_DNA. DR EMBL; AF346976; AAK17384.1; -; Genomic_DNA. DR EMBL; AF346977; AAK17397.1; -; Genomic_DNA. DR EMBL; AF346978; AAK17410.1; -; Genomic_DNA. DR EMBL; AF346979; AAK17423.1; -; Genomic_DNA. DR EMBL; AF346980; AAK17436.1; -; Genomic_DNA. DR EMBL; AF346981; AAK17449.1; -; Genomic_DNA. DR EMBL; AF346982; AAK17462.1; -; Genomic_DNA. DR EMBL; AF346983; AAK17475.1; -; Genomic_DNA. DR EMBL; AF346984; AAK17488.1; -; Genomic_DNA. DR EMBL; AF346985; AAK17501.1; -; Genomic_DNA. DR EMBL; AF346986; AAK17514.1; -; Genomic_DNA. DR EMBL; AF346987; AAK17527.1; -; Genomic_DNA. DR EMBL; AF346988; AAK17540.1; -; Genomic_DNA. DR EMBL; AF346989; AAK17553.1; -; Genomic_DNA. DR EMBL; AF346990; AAK17566.1; -; Genomic_DNA. DR EMBL; AF346991; AAK17579.1; -; Genomic_DNA. DR EMBL; AF346992; AAK17592.1; -; Genomic_DNA. DR EMBL; AF346993; AAK17605.1; -; Genomic_DNA. DR EMBL; AF346994; AAK17618.1; -; Genomic_DNA. DR EMBL; AF346995; AAK17631.1; -; Genomic_DNA. DR EMBL; AF346996; AAK17644.1; -; Genomic_DNA. DR EMBL; AF346997; AAK17657.1; -; Genomic_DNA. DR EMBL; AF346998; AAK17670.1; -; Genomic_DNA. DR EMBL; AF346999; AAK17683.1; -; Genomic_DNA. DR EMBL; AF347000; AAK17696.1; -; Genomic_DNA. DR EMBL; AF347001; AAK17709.1; -; Genomic_DNA. DR EMBL; AF347002; AAK17722.1; -; Genomic_DNA. DR EMBL; AF347003; AAK17735.1; -; Genomic_DNA. DR EMBL; AF347004; AAK17748.1; -; Genomic_DNA. DR EMBL; AF347005; AAK17761.1; -; Genomic_DNA. DR EMBL; AF347006; AAK17774.1; -; Genomic_DNA. DR EMBL; AF347007; AAK17787.1; -; Genomic_DNA. DR EMBL; AF347008; AAK17800.1; -; Genomic_DNA. DR EMBL; AF347009; AAK17813.1; -; Genomic_DNA. DR EMBL; AF347010; AAK17826.1; -; Genomic_DNA. DR EMBL; AF347011; AAK17839.1; -; Genomic_DNA. DR EMBL; AF347012; AAK17852.1; -; Genomic_DNA. DR EMBL; AF347013; AAK17865.1; -; Genomic_DNA. DR EMBL; AF347014; AAK17878.1; -; Genomic_DNA. DR EMBL; AF347015; AAK17891.1; -; Genomic_DNA. DR EMBL; AY289051; AAP47888.1; -; Genomic_DNA. DR EMBL; AY289052; AAP47901.1; -; Genomic_DNA. DR EMBL; AY289053; AAP47914.1; -; Genomic_DNA. DR EMBL; AY289054; AAP47927.1; -; Genomic_DNA. DR EMBL; AY289055; AAP47940.1; -; Genomic_DNA. DR EMBL; AY289056; AAP47953.1; -; Genomic_DNA. DR EMBL; AY289057; AAP47966.1; -; Genomic_DNA. DR EMBL; AY289058; AAP47979.1; -; Genomic_DNA. DR EMBL; AY289059; AAP47992.1; -; Genomic_DNA. DR EMBL; AY289060; AAP48005.1; -; Genomic_DNA. DR EMBL; AY289061; AAP48018.1; -; Genomic_DNA. DR EMBL; AY289062; AAP48031.1; -; Genomic_DNA. DR EMBL; AY289063; AAP48044.1; -; Genomic_DNA. DR EMBL; AY289064; AAP48057.1; -; Genomic_DNA. DR EMBL; AY289065; AAP48070.1; -; Genomic_DNA. DR EMBL; AY289066; AAP48083.1; -; Genomic_DNA. DR EMBL; AY289067; AAP48096.1; -; Genomic_DNA. DR EMBL; AY289068; AAP48109.1; -; Genomic_DNA. DR EMBL; AY289069; AAP48122.1; -; Genomic_DNA. DR EMBL; AY289070; AAP48135.1; -; Genomic_DNA. DR EMBL; AY289071; AAP48148.1; -; Genomic_DNA. DR EMBL; AY289072; AAP48161.1; -; Genomic_DNA. DR EMBL; AY289073; AAP48174.1; -; Genomic_DNA. DR EMBL; AY289074; AAP48187.1; -; Genomic_DNA. DR EMBL; AY289075; AAP48200.1; -; Genomic_DNA. DR EMBL; AY289076; AAP48213.1; -; Genomic_DNA. DR EMBL; AY289077; AAP48226.1; -; Genomic_DNA. DR EMBL; AY289078; AAP48239.1; -; Genomic_DNA. DR EMBL; AY289079; AAP48252.1; -; Genomic_DNA. DR EMBL; AY289080; AAP48265.1; -; Genomic_DNA. DR EMBL; AY289081; AAP48278.1; -; Genomic_DNA. DR EMBL; AY289082; AAP48291.1; -; Genomic_DNA. DR EMBL; AY289083; AAP48304.1; -; Genomic_DNA. DR EMBL; AY289084; AAP48317.1; -; Genomic_DNA. DR EMBL; AY289085; AAP48330.1; -; Genomic_DNA. DR EMBL; AY289086; AAP48343.1; -; Genomic_DNA. DR EMBL; AY289087; AAP48356.1; -; Genomic_DNA. DR EMBL; AY289088; AAP48369.1; -; Genomic_DNA. DR EMBL; AY289089; AAP48382.1; -; Genomic_DNA. DR EMBL; AY289090; AAP48395.1; -; Genomic_DNA. DR EMBL; AY289091; AAP48408.1; -; Genomic_DNA. DR EMBL; AY289092; AAP48421.1; -; Genomic_DNA. DR EMBL; AY289093; AAP48433.1; -; Genomic_DNA. DR EMBL; AY289094; AAP48446.1; -; Genomic_DNA. DR EMBL; AY289095; AAP48459.1; -; Genomic_DNA. DR EMBL; AY289096; AAP48472.1; -; Genomic_DNA. DR EMBL; AY289097; AAP48485.1; -; Genomic_DNA. DR EMBL; AY289098; AAP48498.1; -; Genomic_DNA. DR EMBL; AY289100; AAP48524.1; -; Genomic_DNA. DR EMBL; AY289101; AAP48537.1; -; Genomic_DNA. DR EMBL; AY289102; AAP48550.1; -; Genomic_DNA. DR EMBL; AY495090; AAR92504.1; -; Genomic_DNA. DR EMBL; AY495091; AAR92517.1; -; Genomic_DNA. DR EMBL; AY495092; AAR92530.1; -; Genomic_DNA. DR EMBL; AY495093; AAR92543.1; -; Genomic_DNA. DR EMBL; AY495094; AAR92556.1; -; Genomic_DNA. DR EMBL; AY495095; AAR92569.1; -; Genomic_DNA. DR EMBL; AY495096; AAR92582.1; -; Genomic_DNA. DR EMBL; AY495097; AAR92595.1; -; Genomic_DNA. DR EMBL; AY495098; AAR92608.1; -; Genomic_DNA. DR EMBL; AY495099; AAR92621.1; -; Genomic_DNA. DR EMBL; AY495100; AAR92634.1; -; Genomic_DNA. DR EMBL; AY495101; AAR92647.1; -; Genomic_DNA. DR EMBL; AY495102; AAR92660.1; -; Genomic_DNA. DR EMBL; AY495103; AAR92673.1; -; Genomic_DNA. DR EMBL; AY495104; AAR92686.1; -; Genomic_DNA. DR EMBL; AY495105; AAR92699.1; -; Genomic_DNA. DR EMBL; AY495106; AAR92712.1; -; Genomic_DNA. DR EMBL; AY495107; AAR92725.1; -; Genomic_DNA. DR EMBL; AY495108; AAR92738.1; -; Genomic_DNA. DR EMBL; AY495109; AAR92751.1; -; Genomic_DNA. DR EMBL; AY495110; AAR92764.1; -; Genomic_DNA. DR EMBL; AY495111; AAR92777.1; -; Genomic_DNA. DR EMBL; AY495112; AAR92790.1; -; Genomic_DNA. DR EMBL; AY495113; AAR92803.1; -; Genomic_DNA. DR EMBL; AY495114; AAR92816.1; -; Genomic_DNA. DR EMBL; AY495115; AAR92829.1; -; Genomic_DNA. DR EMBL; AY495116; AAR92842.1; -; Genomic_DNA. DR EMBL; AY495117; AAR92855.1; -; Genomic_DNA. DR EMBL; AY495118; AAR92868.1; -; Genomic_DNA. DR EMBL; AY495119; AAR92881.1; -; Genomic_DNA. DR EMBL; AY495120; AAR92894.1; -; Genomic_DNA. DR EMBL; AY495121; AAR92907.1; -; Genomic_DNA. DR EMBL; AY495122; AAR92920.1; -; Genomic_DNA. DR EMBL; AY495123; AAR92933.1; -; Genomic_DNA. DR EMBL; AY495124; AAR92946.1; -; Genomic_DNA. DR EMBL; AY495125; AAR92959.1; -; Genomic_DNA. DR EMBL; AY495126; AAR92972.1; -; Genomic_DNA. DR EMBL; AY495127; AAR92985.1; -; Genomic_DNA. DR EMBL; AY495128; AAR92998.1; -; Genomic_DNA. DR EMBL; AY495129; AAR93011.1; -; Genomic_DNA. DR EMBL; AY495130; AAR93024.1; -; Genomic_DNA. DR EMBL; AY495131; AAR93037.1; -; Genomic_DNA. DR EMBL; AY495132; AAR93050.1; -; Genomic_DNA. DR EMBL; AY495133; AAR93063.1; -; Genomic_DNA. DR EMBL; AY495134; AAR93076.1; -; Genomic_DNA. DR EMBL; AY495135; AAR93089.1; -; Genomic_DNA. DR EMBL; AY495136; AAR93102.1; -; Genomic_DNA. DR EMBL; AY495137; AAR93115.1; -; Genomic_DNA. DR EMBL; AY495138; AAR93128.1; -; Genomic_DNA. DR EMBL; AY495139; AAR93141.1; -; Genomic_DNA. DR EMBL; AY495140; AAR93154.1; -; Genomic_DNA. DR EMBL; AY495141; AAR93167.1; -; Genomic_DNA. DR EMBL; AY495142; AAR93180.1; -; Genomic_DNA. DR EMBL; AY495143; AAR93193.1; -; Genomic_DNA. DR EMBL; AY495144; AAR93206.1; -; Genomic_DNA. DR EMBL; AY495145; AAR93219.1; -; Genomic_DNA. DR EMBL; AY495146; AAR93232.1; -; Genomic_DNA. DR EMBL; AY495147; AAR93245.1; -; Genomic_DNA. DR EMBL; AY495148; AAR93258.1; -; Genomic_DNA. DR EMBL; AY495149; AAR93271.1; -; Genomic_DNA. DR EMBL; AY495150; AAR93284.1; -; Genomic_DNA. DR EMBL; AY495151; AAR93297.1; -; Genomic_DNA. DR EMBL; AY495152; AAR93310.1; -; Genomic_DNA. DR EMBL; AY495153; AAR93323.1; -; Genomic_DNA. DR EMBL; AY495154; AAR93336.1; -; Genomic_DNA. DR EMBL; AY495155; AAR93349.1; -; Genomic_DNA. DR EMBL; AY495156; AAR93362.1; -; Genomic_DNA. DR EMBL; AY495157; AAR93375.1; -; Genomic_DNA. DR EMBL; AY495158; AAR93388.1; -; Genomic_DNA. DR EMBL; AY495159; AAR93401.1; -; Genomic_DNA. DR EMBL; AY495160; AAR93414.1; -; Genomic_DNA. DR EMBL; AY495161; AAR93427.1; -; Genomic_DNA. DR EMBL; AY495162; AAR93440.1; -; Genomic_DNA. DR EMBL; AY495163; AAR93453.1; -; Genomic_DNA. DR EMBL; AY495164; AAR93466.1; -; Genomic_DNA. DR EMBL; AY495165; AAR93479.1; -; Genomic_DNA. DR EMBL; AY495166; AAR93492.1; -; Genomic_DNA. DR EMBL; AY495167; AAR93505.1; -; Genomic_DNA. DR EMBL; AY495168; AAR93518.1; -; Genomic_DNA. DR EMBL; AY495169; AAR93531.1; -; Genomic_DNA. DR EMBL; AY495170; AAR93544.1; -; Genomic_DNA. DR EMBL; AY495171; AAR93557.1; -; Genomic_DNA. DR EMBL; AY495172; AAR93570.1; -; Genomic_DNA. DR EMBL; AY495173; AAR93583.1; -; Genomic_DNA. DR EMBL; AY495174; AAR93596.1; -; Genomic_DNA. DR EMBL; AY495175; AAR93609.1; -; Genomic_DNA. DR EMBL; AY495176; AAR93622.1; -; Genomic_DNA. DR EMBL; AY495177; AAR93635.1; -; Genomic_DNA. DR EMBL; AY495178; AAR93648.1; -; Genomic_DNA. DR EMBL; AY495179; AAR93661.1; -; Genomic_DNA. DR EMBL; AY495180; AAR93674.1; -; Genomic_DNA. DR EMBL; AY495181; AAR93687.1; -; Genomic_DNA. DR EMBL; AY495182; AAR93700.1; -; Genomic_DNA. DR EMBL; AY495183; AAR93713.1; -; Genomic_DNA. DR EMBL; AY495184; AAR93726.1; -; Genomic_DNA. DR EMBL; AY495185; AAR93739.1; -; Genomic_DNA. DR EMBL; AY495186; AAR93752.1; -; Genomic_DNA. DR EMBL; AY495187; AAR93765.1; -; Genomic_DNA. DR EMBL; AY495188; AAR93778.1; -; Genomic_DNA. DR EMBL; AY495189; AAR93791.1; -; Genomic_DNA. DR EMBL; AY495190; AAR93804.1; -; Genomic_DNA. DR EMBL; AY495191; AAR93817.1; -; Genomic_DNA. DR EMBL; AY495192; AAR93830.1; -; Genomic_DNA. DR EMBL; AY495193; AAR93843.1; -; Genomic_DNA. DR EMBL; AY495194; AAR93856.1; -; Genomic_DNA. DR EMBL; AY495195; AAR93869.1; -; Genomic_DNA. DR EMBL; AY495196; AAR93882.1; -; Genomic_DNA. DR EMBL; AY495197; AAR93895.1; -; Genomic_DNA. DR EMBL; AY495198; AAR93908.1; -; Genomic_DNA. DR EMBL; AY495199; AAR93921.1; -; Genomic_DNA. DR EMBL; AY495200; AAR93934.1; -; Genomic_DNA. DR EMBL; AY495201; AAR93947.1; -; Genomic_DNA. DR EMBL; AY495202; AAR93960.1; -; Genomic_DNA. DR EMBL; AY495203; AAR93973.1; -; Genomic_DNA. DR EMBL; AY495204; AAR93986.1; -; Genomic_DNA. DR EMBL; AY495205; AAR93999.1; -; Genomic_DNA. DR EMBL; AY495206; AAR94012.1; -; Genomic_DNA. DR EMBL; AY495207; AAR94025.1; -; Genomic_DNA. DR EMBL; AY495208; AAR94038.1; -; Genomic_DNA. DR EMBL; AY495209; AAR94051.1; -; Genomic_DNA. DR EMBL; AY495210; AAR94064.1; -; Genomic_DNA. DR EMBL; AY495211; AAR94077.1; -; Genomic_DNA. DR EMBL; AY495212; AAR94090.1; -; Genomic_DNA. DR EMBL; AY495213; AAR94103.1; -; Genomic_DNA. DR EMBL; AY495214; AAR94116.1; -; Genomic_DNA. DR EMBL; AY495215; AAR94129.1; -; Genomic_DNA. DR EMBL; AY495216; AAR94142.1; -; Genomic_DNA. DR EMBL; AY495217; AAR94155.1; -; Genomic_DNA. DR EMBL; AY495218; AAR94168.1; -; Genomic_DNA. DR EMBL; AY495219; AAR94181.1; -; Genomic_DNA. DR EMBL; AY495220; AAR94194.1; -; Genomic_DNA. DR EMBL; AY495221; AAR94207.1; -; Genomic_DNA. DR EMBL; AY495222; AAR94220.1; -; Genomic_DNA. DR EMBL; AY495223; AAR94233.1; -; Genomic_DNA. DR EMBL; AY495224; AAR94246.1; -; Genomic_DNA. DR EMBL; AY495225; AAR94259.1; -; Genomic_DNA. DR EMBL; AY495226; AAR94272.1; -; Genomic_DNA. DR EMBL; AY495227; AAR94285.1; -; Genomic_DNA. DR EMBL; AY495228; AAR94298.1; -; Genomic_DNA. DR EMBL; AY495229; AAR94311.1; -; Genomic_DNA. DR EMBL; AY495230; AAR94324.1; -; Genomic_DNA. DR EMBL; AY495231; AAR94337.1; -; Genomic_DNA. DR EMBL; AY495232; AAR94350.1; -; Genomic_DNA. DR EMBL; AY495233; AAR94363.1; -; Genomic_DNA. DR EMBL; AY495234; AAR94376.1; -; Genomic_DNA. DR EMBL; AY495235; AAR94389.1; -; Genomic_DNA. DR EMBL; AY495236; AAR94402.1; -; Genomic_DNA. DR EMBL; AY495237; AAR94415.1; -; Genomic_DNA. DR EMBL; AY495238; AAR94428.1; -; Genomic_DNA. DR EMBL; AY495239; AAR94441.1; -; Genomic_DNA. DR EMBL; AY495240; AAR94454.1; -; Genomic_DNA. DR EMBL; AY495241; AAR94467.1; -; Genomic_DNA. DR EMBL; AY495242; AAR94480.1; -; Genomic_DNA. DR EMBL; AY495243; AAR94493.1; -; Genomic_DNA. DR EMBL; AY495244; AAR94506.1; -; Genomic_DNA. DR EMBL; AY495245; AAR94519.1; -; Genomic_DNA. DR EMBL; AY495246; AAR94532.1; -; Genomic_DNA. DR EMBL; AY495247; AAR94545.1; -; Genomic_DNA. DR EMBL; AY495248; AAR94558.1; -; Genomic_DNA. DR EMBL; AY495249; AAR94571.1; -; Genomic_DNA. DR EMBL; AY495250; AAR94584.1; -; Genomic_DNA. DR EMBL; AY495251; AAR94597.1; -; Genomic_DNA. DR EMBL; AY495252; AAR94610.1; -; Genomic_DNA. DR EMBL; AY495253; AAR94623.1; -; Genomic_DNA. DR EMBL; AY495254; AAR94636.1; -; Genomic_DNA. DR EMBL; AY495255; AAR94649.1; -; Genomic_DNA. DR EMBL; AY495256; AAR94662.1; -; Genomic_DNA. DR EMBL; AY495257; AAR94675.1; -; Genomic_DNA. DR EMBL; AY495258; AAR94688.1; -; Genomic_DNA. DR EMBL; AY495259; AAR94701.1; -; Genomic_DNA. DR EMBL; AY495260; AAR94714.1; -; Genomic_DNA. DR EMBL; AY495261; AAR94727.1; -; Genomic_DNA. DR EMBL; AY495262; AAR94740.1; -; Genomic_DNA. DR EMBL; AY495263; AAR94753.1; -; Genomic_DNA. DR EMBL; AY495264; AAR94766.1; -; Genomic_DNA. DR EMBL; AY495265; AAR94779.1; -; Genomic_DNA. DR EMBL; AY495266; AAR94792.1; -; Genomic_DNA. DR EMBL; AY495267; AAR94805.1; -; Genomic_DNA. DR EMBL; AY495268; AAR94818.1; -; Genomic_DNA. DR EMBL; AY495269; AAR94831.1; -; Genomic_DNA. DR EMBL; AY495270; AAR94844.1; -; Genomic_DNA. DR EMBL; AY495271; AAR94857.1; -; Genomic_DNA. DR EMBL; AY495272; AAR94870.1; -; Genomic_DNA. DR EMBL; AY495273; AAR94883.1; -; Genomic_DNA. DR EMBL; AY495274; AAR94896.1; -; Genomic_DNA. DR EMBL; AY495276; AAR94922.1; -; Genomic_DNA. DR EMBL; AY495277; AAR94935.1; -; Genomic_DNA. DR EMBL; AY495278; AAR94948.1; -; Genomic_DNA. DR EMBL; AY495279; AAR94961.1; -; Genomic_DNA. DR EMBL; AY495280; AAR94974.1; -; Genomic_DNA. DR EMBL; AY495281; AAR94987.1; -; Genomic_DNA. DR EMBL; AY495282; AAR95000.1; -; Genomic_DNA. DR EMBL; AY495283; AAR95013.1; -; Genomic_DNA. DR EMBL; AY495284; AAR95026.1; -; Genomic_DNA. DR EMBL; AY495285; AAR95039.1; -; Genomic_DNA. DR EMBL; AY495286; AAR95052.1; -; Genomic_DNA. DR EMBL; AY495287; AAR95065.1; -; Genomic_DNA. DR EMBL; AY495288; AAR95078.1; -; Genomic_DNA. DR EMBL; AY495289; AAR95091.1; -; Genomic_DNA. DR EMBL; AY495290; AAR95104.1; -; Genomic_DNA. DR EMBL; AY495291; AAR95117.1; -; Genomic_DNA. DR EMBL; AY495292; AAR95130.1; -; Genomic_DNA. DR EMBL; AY495293; AAR95143.1; -; Genomic_DNA. DR EMBL; AY495294; AAR95156.1; -; Genomic_DNA. DR EMBL; AY495295; AAR95169.1; -; Genomic_DNA. DR EMBL; AY495296; AAR95182.1; -; Genomic_DNA. DR EMBL; AY495297; AAR95195.1; -; Genomic_DNA. DR EMBL; AY495298; AAR95208.1; -; Genomic_DNA. DR EMBL; AY495299; AAR95221.1; -; Genomic_DNA. DR EMBL; AY495300; AAR95234.1; -; Genomic_DNA. DR EMBL; AY495301; AAR95247.1; -; Genomic_DNA. DR EMBL; AY495302; AAR95260.1; -; Genomic_DNA. DR EMBL; AY495303; AAR95273.1; -; Genomic_DNA. DR EMBL; AY495304; AAR95286.1; -; Genomic_DNA. DR EMBL; AY495305; AAR95299.1; -; Genomic_DNA. DR EMBL; AY495306; AAR95312.1; -; Genomic_DNA. DR EMBL; AY495307; AAR95325.1; -; Genomic_DNA. DR EMBL; AY495308; AAR95338.1; -; Genomic_DNA. DR EMBL; AY495309; AAR95351.1; -; Genomic_DNA. DR EMBL; AY495310; AAR95364.1; -; Genomic_DNA. DR EMBL; AY495311; AAR95377.1; -; Genomic_DNA. DR EMBL; AY495312; AAR95390.1; -; Genomic_DNA. DR EMBL; AY495313; AAR95403.1; -; Genomic_DNA. DR EMBL; AY495314; AAR95416.1; -; Genomic_DNA. DR EMBL; AY495315; AAR95429.1; -; Genomic_DNA. DR EMBL; AY495316; AAR95442.1; -; Genomic_DNA. DR EMBL; AY495317; AAR95455.1; -; Genomic_DNA. DR EMBL; AY495318; AAR95468.1; -; Genomic_DNA. DR EMBL; AY495319; AAR95481.1; -; Genomic_DNA. DR EMBL; AY495320; AAR95494.1; -; Genomic_DNA. DR EMBL; AY495321; AAR95507.1; -; Genomic_DNA. DR EMBL; AY495322; AAR95520.1; -; Genomic_DNA. DR EMBL; AY495323; AAR95533.1; -; Genomic_DNA. DR EMBL; AY495324; AAR95546.1; -; Genomic_DNA. DR EMBL; AY495325; AAR95559.1; -; Genomic_DNA. DR EMBL; AY495326; AAR95572.1; -; Genomic_DNA. DR EMBL; AY495327; AAR95585.1; -; Genomic_DNA. DR EMBL; AY495328; AAR95598.1; -; Genomic_DNA. DR EMBL; AY495329; AAR95611.1; -; Genomic_DNA. DR EMBL; AY495330; AAR95624.1; -; Genomic_DNA. DR PIR; A00428; DNHUNL. DR RefSeq; YP_003024034.1; NC_012920.1. DR PDB; 5XTC; EM; 3.70 A; k=1-97. DR PDB; 5XTD; EM; 3.70 A; k=1-97. DR PDBsum; 5XTC; -. DR PDBsum; 5XTD; -. DR AlphaFoldDB; P03901; -. DR SMR; P03901; -. DR BioGRID; 110635; 5. DR ComplexPortal; CPX-577; Mitochondrial respiratory chain complex I. DR CORUM; P03901; -. DR IntAct; P03901; 3. DR STRING; 9606.ENSP00000354728; -. DR BindingDB; P03901; -. DR ChEMBL; CHEMBL2363065; -. DR DrugBank; DB00157; NADH. DR DrugCentral; P03901; -. DR BioMuta; MT-ND4L; -. DR DMDM; 128888; -. DR PaxDb; 9606-ENSP00000354728; -. DR PeptideAtlas; P03901; -. DR Antibodypedia; 68604; 91 antibodies from 19 providers. DR DNASU; 4539; -. DR Ensembl; ENST00000361335.1; ENSP00000354728.1; ENSG00000212907.2. DR GeneID; 4539; -. DR KEGG; hsa:4539; -. DR AGR; HGNC:7460; -. DR CTD; 4539; -. DR DisGeNET; 4539; -. DR GeneCards; MT-ND4L; -. DR GeneReviews; MT-ND4L; -. DR HGNC; HGNC:7460; MT-ND4L. DR HPA; ENSG00000212907; Tissue enhanced (heart muscle, tongue). DR MalaCards; MT-ND4L; -. DR MIM; 516004; gene. DR MIM; 535000; phenotype. DR neXtProt; NX_P03901; -. DR OpenTargets; ENSG00000212907; -. DR Orphanet; 104; Leber hereditary optic neuropathy. DR PharmGKB; PA31264; -. DR VEuPathDB; HostDB:ENSG00000212907; -. DR eggNOG; KOG4669; Eukaryota. DR GeneTree; ENSGT00390000004755; -. DR HOGENOM; CLU_182394_0_0_1; -. DR InParanoid; P03901; -. DR OMA; MYRSHLM; -. DR PhylomeDB; P03901; -. DR TreeFam; TF338190; -. DR BioCyc; MetaCyc:HS00034-MONOMER; -. DR PathwayCommons; P03901; -. DR SignaLink; P03901; -. DR SIGNOR; P03901; -. DR BioGRID-ORCS; 4539; 0 hits in 3 CRISPR screens. DR ChiTaRS; MT-ND4L; human. DR GeneWiki; MT-ND4L; -. DR GenomeRNAi; 4539; -. DR Pharos; P03901; Tclin. DR PRO; PR:P03901; -. DR Proteomes; UP000005640; Mitochondrion. DR RNAct; P03901; Protein. DR Bgee; ENSG00000212907; Expressed in primary visual cortex and 99 other cell types or tissues. DR ExpressionAtlas; P03901; baseline and differential. DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:ComplexPortal. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IDA:UniProtKB. DR GO; GO:0009060; P:aerobic respiration; NAS:ComplexPortal. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB. DR GO; GO:0042776; P:proton motive force-driven mitochondrial ATP synthesis; NAS:ComplexPortal. DR Gene3D; 1.10.287.3510; -; 1. DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K. DR InterPro; IPR039428; NUOK/Mnh_C1-like. DR PANTHER; PTHR11434:SF0; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L; 1. DR PANTHER; PTHR11434; NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L; 1. DR Pfam; PF00420; Oxidored_q2; 1. DR Genevisible; P03901; HS. PE 1: Evidence at protein level; KW 3D-structure; Disease variant; Electron transport; KW Leber hereditary optic neuropathy; Membrane; Mitochondrion; KW Mitochondrion inner membrane; NAD; Primary mitochondrial disease; KW Reference proteome; Respiratory chain; Translocase; Transmembrane; KW Transmembrane helix; Transport; Ubiquinone. FT CHAIN 1..98 FT /note="NADH-ubiquinone oxidoreductase chain 4L" FT /id="PRO_0000118431" FT TRANSMEM 1..21 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 29..49 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 58..78 FT /note="Helical" FT /evidence="ECO:0000255" FT VARIANT 32 FT /note="C -> R (in colorectal cancer; dbSNP:rs267606892)" FT /evidence="ECO:0000269|PubMed:9806551" FT /id="VAR_008496" FT VARIANT 36 FT /note="M -> I" FT /evidence="ECO:0000269|PubMed:1757091" FT /id="VAR_008605" FT VARIANT 57 FT /note="N -> S (in dbSNP:rs1603222927)" FT /evidence="ECO:0000269|PubMed:1757091" FT /id="VAR_008606" FT VARIANT 61 FT /note="I -> T" FT /evidence="ECO:0000269|PubMed:1757091" FT /id="VAR_008607" FT VARIANT 65 FT /note="V -> A (in LHON; possible rare primary mutation; FT dbSNP:rs1556423844)" FT /evidence="ECO:0000269|PubMed:8680405" FT /id="VAR_008397" SQ SEQUENCE 98 AA; 10741 MW; 24B91F1DCDB0BE22 CRC64; MPLIYMNIML AFTISLLGML VYRSHLMSSL LCLEGMMLSL FIMATLMTLN THSLLANIVP IAMLVFAACE AAVGLALLVS ISNTYGLDYV HNLNLLQC //