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P03899 (NU3M_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 3

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 3
Gene names
Name:Mtnd3
Synonyms:mt-Nd3, Nd3
Encoded onMitochondrion
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 115115NADH-ubiquinone oxidoreductase chain 3
PRO_0000117765

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane55 – 7521Helical; Potential
Transmembrane86 – 10621Helical; Potential

Experimental info

Sequence conflict161T → A in AAA19255. Ref.2
Sequence conflict331Missing in AAB48651. Ref.1
Sequence conflict331Missing in CAA24086. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P03899 [UniParc].

Last modified November 16, 2001. Version 3.
Checksum: 6925F293601CB391

FASTA11513,219
        10         20         30         40         50         60 
MNLYTVIFIN ILLSLTLILV AFWLPQMNLY SEKANPYECG FDPTSSARLP FSMKFFLVAI 

        70         80         90        100        110 
TFLLFDLEIA LLLPLPWAIQ TIKTSTMMIM AFILVTILSL GLAYEWTQKG LEWTE 

« Hide

References

[1]"Sequence and gene organization of mouse mitochondrial DNA."
Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nonneutral evolution at the mitochondrial NADH dehydrogenase subunit 3 gene in mice."
Nachman M.W., Boyer S.N., Aquadro C.F.
Proc. Natl. Acad. Sci. U.S.A. 91:6364-6368(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains."
Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.
J. Hered. 92:352-355(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AKR/J, C3H/He, SAMP1, SAMP8 and SAMR1.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01420 Genomic DNA. Translation: AAB48651.1.
V00711 Genomic DNA. Translation: CAA24086.1.
U09637 Genomic DNA. Translation: AAA19254.2.
U09638 Genomic DNA. Translation: AAA19255.2.
AB042432 Genomic DNA. Translation: BAA95623.1.
AB042523 Genomic DNA. Translation: BAA95660.1.
AB042524 Genomic DNA. Translation: BAA95647.1.
AB042809 Genomic DNA. Translation: BAA95802.1.
AB049357 Genomic DNA. Translation: BAB13808.1.
PIRA55746.
QXMS3M. B55746.
RefSeqNP_904335.1. NC_005089.1.
YP_220557.1. NC_006914.1.

3D structure databases

ProteinModelPortalP03899.
SMRP03899. Positions 3-112.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP03899.

Proteomic databases

PaxDbP03899.
PRIDEP03899.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082411; ENSMUSP00000080998; ENSMUSG00000064360.
GeneID17718.
3338896.
KEGGmmu:17718.

Organism-specific databases

CTD4537.
MGIMGI:102499. mt-Nd3.

Phylogenomic databases

eggNOGCOG0838.
HOGENOMHOG000100119.
HOVERGENHBG017392.
InParanoidP03899.
KOK03880.
OMAFENAHIP.
OrthoDBEOG7RV9K7.
PhylomeDBP03899.

Gene expression databases

GenevestigatorP03899.

Family and domain databases

InterProIPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
PANTHERPTHR11058. PTHR11058. 1 hit.
PfamPF00507. Oxidored_q4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio292338.
PROP03899.
SOURCESearch...

Entry information

Entry nameNU3M_MOUSE
AccessionPrimary (citable) accession number: P03899
Secondary accession number(s): Q35039, Q35040, Q9MD73
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 16, 2001
Last modified: May 14, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot