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P03899

- NU3M_MOUSE

UniProt

P03899 - NU3M_MOUSE

Protein

NADH-ubiquinone oxidoreductase chain 3

Gene

Mtnd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 3 (EC:1.6.5.3)
    Alternative name(s):
    NADH dehydrogenase subunit 3
    Gene namesi
    Name:Mtnd3
    Synonyms:mt-Nd3, Nd3
    Encoded oniMitochondrion
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:102499. mt-Nd3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex I Source: Ensembl
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 115115NADH-ubiquinone oxidoreductase chain 3PRO_0000117765Add
    BLAST

    Proteomic databases

    PaxDbiP03899.
    PRIDEiP03899.

    PTM databases

    PhosphoSiteiP03899.

    Expressioni

    Gene expression databases

    GenevestigatoriP03899.

    Structurei

    3D structure databases

    ProteinModelPortaliP03899.
    SMRiP03899. Positions 3-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 3 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0838.
    HOGENOMiHOG000100119.
    HOVERGENiHBG017392.
    InParanoidiP03899.
    KOiK03880.
    OMAiFENAHIP.
    OrthoDBiEOG7RV9K7.
    PhylomeDBiP03899.

    Family and domain databases

    InterProiIPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
    [Graphical view]
    PANTHERiPTHR11058. PTHR11058. 1 hit.
    PfamiPF00507. Oxidored_q4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P03899-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLYTVIFIN ILLSLTLILV AFWLPQMNLY SEKANPYECG FDPTSSARLP    50
    FSMKFFLVAI TFLLFDLEIA LLLPLPWAIQ TIKTSTMMIM AFILVTILSL 100
    GLAYEWTQKG LEWTE 115
    Length:115
    Mass (Da):13,219
    Last modified:November 16, 2001 - v3
    Checksum:i6925F293601CB391
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161T → A in AAA19255. (PubMed:8022788)Curated
    Sequence conflicti33 – 331Missing in AAB48651. (PubMed:7332926)Curated
    Sequence conflicti33 – 331Missing in CAA24086. (PubMed:7332926)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48651.1.
    V00711 Genomic DNA. Translation: CAA24086.1.
    U09637 Genomic DNA. Translation: AAA19254.2.
    U09638 Genomic DNA. Translation: AAA19255.2.
    AB042432 Genomic DNA. Translation: BAA95623.1.
    AB042523 Genomic DNA. Translation: BAA95660.1.
    AB042524 Genomic DNA. Translation: BAA95647.1.
    AB042809 Genomic DNA. Translation: BAA95802.1.
    AB049357 Genomic DNA. Translation: BAB13808.1.
    PIRiA55746.
    B55746. QXMS3M.
    RefSeqiNP_904335.1. NC_005089.1.
    YP_220557.1. NC_006914.1.

    Genome annotation databases

    EnsembliENSMUST00000082411; ENSMUSP00000080998; ENSMUSG00000064360.
    GeneIDi17718.
    3338896.
    KEGGimmu:17718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48651.1 .
    V00711 Genomic DNA. Translation: CAA24086.1 .
    U09637 Genomic DNA. Translation: AAA19254.2 .
    U09638 Genomic DNA. Translation: AAA19255.2 .
    AB042432 Genomic DNA. Translation: BAA95623.1 .
    AB042523 Genomic DNA. Translation: BAA95660.1 .
    AB042524 Genomic DNA. Translation: BAA95647.1 .
    AB042809 Genomic DNA. Translation: BAA95802.1 .
    AB049357 Genomic DNA. Translation: BAB13808.1 .
    PIRi A55746.
    B55746. QXMS3M.
    RefSeqi NP_904335.1. NC_005089.1.
    YP_220557.1. NC_006914.1.

    3D structure databases

    ProteinModelPortali P03899.
    SMRi P03899. Positions 3-112.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P03899.

    Proteomic databases

    PaxDbi P03899.
    PRIDEi P03899.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082411 ; ENSMUSP00000080998 ; ENSMUSG00000064360 .
    GeneIDi 17718.
    3338896.
    KEGGi mmu:17718.

    Organism-specific databases

    CTDi 4537.
    MGIi MGI:102499. mt-Nd3.

    Phylogenomic databases

    eggNOGi COG0838.
    HOGENOMi HOG000100119.
    HOVERGENi HBG017392.
    InParanoidi P03899.
    KOi K03880.
    OMAi FENAHIP.
    OrthoDBi EOG7RV9K7.
    PhylomeDBi P03899.

    Miscellaneous databases

    NextBioi 292338.
    PROi P03899.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P03899.

    Family and domain databases

    InterProi IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
    [Graphical view ]
    PANTHERi PTHR11058. PTHR11058. 1 hit.
    Pfami PF00507. Oxidored_q4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and gene organization of mouse mitochondrial DNA."
      Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
      Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nonneutral evolution at the mitochondrial NADH dehydrogenase subunit 3 gene in mice."
      Nachman M.W., Boyer S.N., Aquadro C.F.
      Proc. Natl. Acad. Sci. U.S.A. 91:6364-6368(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains."
      Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.
      J. Hered. 92:352-355(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AKR/J, C3H/He, SAMP1, SAMP8 and SAMR1.
      Tissue: Liver.

    Entry informationi

    Entry nameiNU3M_MOUSE
    AccessioniPrimary (citable) accession number: P03899
    Secondary accession number(s): Q35039, Q35040, Q9MD73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3