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P03899

- NU3M_MOUSE

UniProt

P03899 - NU3M_MOUSE

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Protein
NADH-ubiquinone oxidoreductase chain 3
Gene
Mtnd3, mt-Nd3, Nd3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 3 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 3
Gene namesi
Name:Mtnd3
Synonyms:mt-Nd3, Nd3
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced, UP000000589: Mitochondrion

Organism-specific databases

MGIiMGI:102499. mt-Nd3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Reviewed prediction
Add
BLAST
Transmembranei55 – 7521Helical; Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex I Source: Ensembl
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 115115NADH-ubiquinone oxidoreductase chain 3
PRO_0000117765Add
BLAST

Proteomic databases

PaxDbiP03899.
PRIDEiP03899.

PTM databases

PhosphoSiteiP03899.

Expressioni

Gene expression databases

GenevestigatoriP03899.

Structurei

3D structure databases

ProteinModelPortaliP03899.
SMRiP03899. Positions 3-112.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0838.
HOGENOMiHOG000100119.
HOVERGENiHBG017392.
InParanoidiP03899.
KOiK03880.
OMAiFENAHIP.
OrthoDBiEOG7RV9K7.
PhylomeDBiP03899.

Family and domain databases

InterProiIPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
PANTHERiPTHR11058. PTHR11058. 1 hit.
PfamiPF00507. Oxidored_q4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03899-1 [UniParc]FASTAAdd to Basket

« Hide

MNLYTVIFIN ILLSLTLILV AFWLPQMNLY SEKANPYECG FDPTSSARLP    50
FSMKFFLVAI TFLLFDLEIA LLLPLPWAIQ TIKTSTMMIM AFILVTILSL 100
GLAYEWTQKG LEWTE 115
Length:115
Mass (Da):13,219
Last modified:November 16, 2001 - v3
Checksum:i6925F293601CB391
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161T → A in AAA19255. 1 Publication
Sequence conflicti33 – 331Missing in AAB48651. 1 Publication
Sequence conflicti33 – 331Missing in CAA24086. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01420 Genomic DNA. Translation: AAB48651.1.
V00711 Genomic DNA. Translation: CAA24086.1.
U09637 Genomic DNA. Translation: AAA19254.2.
U09638 Genomic DNA. Translation: AAA19255.2.
AB042432 Genomic DNA. Translation: BAA95623.1.
AB042523 Genomic DNA. Translation: BAA95660.1.
AB042524 Genomic DNA. Translation: BAA95647.1.
AB042809 Genomic DNA. Translation: BAA95802.1.
AB049357 Genomic DNA. Translation: BAB13808.1.
PIRiA55746.
B55746. QXMS3M.
RefSeqiNP_904335.1. NC_005089.1.
YP_220557.1. NC_006914.1.

Genome annotation databases

EnsembliENSMUST00000082411; ENSMUSP00000080998; ENSMUSG00000064360.
GeneIDi17718.
3338896.
KEGGimmu:17718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01420 Genomic DNA. Translation: AAB48651.1 .
V00711 Genomic DNA. Translation: CAA24086.1 .
U09637 Genomic DNA. Translation: AAA19254.2 .
U09638 Genomic DNA. Translation: AAA19255.2 .
AB042432 Genomic DNA. Translation: BAA95623.1 .
AB042523 Genomic DNA. Translation: BAA95660.1 .
AB042524 Genomic DNA. Translation: BAA95647.1 .
AB042809 Genomic DNA. Translation: BAA95802.1 .
AB049357 Genomic DNA. Translation: BAB13808.1 .
PIRi A55746.
B55746. QXMS3M.
RefSeqi NP_904335.1. NC_005089.1.
YP_220557.1. NC_006914.1.

3D structure databases

ProteinModelPortali P03899.
SMRi P03899. Positions 3-112.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P03899.

Proteomic databases

PaxDbi P03899.
PRIDEi P03899.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082411 ; ENSMUSP00000080998 ; ENSMUSG00000064360 .
GeneIDi 17718.
3338896.
KEGGi mmu:17718.

Organism-specific databases

CTDi 4537.
MGIi MGI:102499. mt-Nd3.

Phylogenomic databases

eggNOGi COG0838.
HOGENOMi HOG000100119.
HOVERGENi HBG017392.
InParanoidi P03899.
KOi K03880.
OMAi FENAHIP.
OrthoDBi EOG7RV9K7.
PhylomeDBi P03899.

Miscellaneous databases

NextBioi 292338.
PROi P03899.
SOURCEi Search...

Gene expression databases

Genevestigatori P03899.

Family and domain databases

InterProi IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view ]
PANTHERi PTHR11058. PTHR11058. 1 hit.
Pfami PF00507. Oxidored_q4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nonneutral evolution at the mitochondrial NADH dehydrogenase subunit 3 gene in mice."
    Nachman M.W., Boyer S.N., Aquadro C.F.
    Proc. Natl. Acad. Sci. U.S.A. 91:6364-6368(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains."
    Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.
    J. Hered. 92:352-355(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AKR/J, C3H/He, SAMP1, SAMP8 and SAMR1.
    Tissue: Liver.

Entry informationi

Entry nameiNU3M_MOUSE
AccessioniPrimary (citable) accession number: P03899
Secondary accession number(s): Q35039, Q35040, Q9MD73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 16, 2001
Last modified: May 14, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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