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P03899

- NU3M_MOUSE

UniProt

P03899 - NU3M_MOUSE

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Protein

NADH-ubiquinone oxidoreductase chain 3

Gene

Mtnd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiREACT_262523. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 3 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 3
Gene namesi
Name:Mtnd3
Synonyms:mt-Nd3, Nd3
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102499. mt-Nd3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex I Source: Ensembl
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 115115NADH-ubiquinone oxidoreductase chain 3PRO_0000117765Add
BLAST

Proteomic databases

MaxQBiP03899.
PaxDbiP03899.
PRIDEiP03899.

PTM databases

PhosphoSiteiP03899.

Expressioni

Gene expression databases

ExpressionAtlasiP03899. baseline and differential.
GenevestigatoriP03899.

Structurei

3D structure databases

ProteinModelPortaliP03899.
SMRiP03899. Positions 3-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0838.
HOGENOMiHOG000100119.
HOVERGENiHBG017392.
InParanoidiP03899.
KOiK03880.
OMAiFENAHIP.
OrthoDBiEOG7RV9K7.
PhylomeDBiP03899.

Family and domain databases

InterProiIPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
PANTHERiPTHR11058. PTHR11058. 1 hit.
PfamiPF00507. Oxidored_q4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03899-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLYTVIFIN ILLSLTLILV AFWLPQMNLY SEKANPYECG FDPTSSARLP
60 70 80 90 100
FSMKFFLVAI TFLLFDLEIA LLLPLPWAIQ TIKTSTMMIM AFILVTILSL
110
GLAYEWTQKG LEWTE
Length:115
Mass (Da):13,219
Last modified:November 16, 2001 - v3
Checksum:i6925F293601CB391
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161T → A in AAA19255. (PubMed:8022788)Curated
Sequence conflicti33 – 331Missing in AAB48651. (PubMed:7332926)Curated
Sequence conflicti33 – 331Missing in CAA24086. (PubMed:7332926)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48651.1.
V00711 Genomic DNA. Translation: CAA24086.1.
U09637 Genomic DNA. Translation: AAA19254.2.
U09638 Genomic DNA. Translation: AAA19255.2.
AB042432 Genomic DNA. Translation: BAA95623.1.
AB042523 Genomic DNA. Translation: BAA95660.1.
AB042524 Genomic DNA. Translation: BAA95647.1.
AB042809 Genomic DNA. Translation: BAA95802.1.
AB049357 Genomic DNA. Translation: BAB13808.1.
PIRiA55746.
B55746. QXMS3M.
RefSeqiNP_904335.1. NC_005089.1.
YP_220557.1. NC_006914.1.

Genome annotation databases

EnsembliENSMUST00000082411; ENSMUSP00000080998; ENSMUSG00000064360.
GeneIDi17718.
3338896.
KEGGimmu:17718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48651.1 .
V00711 Genomic DNA. Translation: CAA24086.1 .
U09637 Genomic DNA. Translation: AAA19254.2 .
U09638 Genomic DNA. Translation: AAA19255.2 .
AB042432 Genomic DNA. Translation: BAA95623.1 .
AB042523 Genomic DNA. Translation: BAA95660.1 .
AB042524 Genomic DNA. Translation: BAA95647.1 .
AB042809 Genomic DNA. Translation: BAA95802.1 .
AB049357 Genomic DNA. Translation: BAB13808.1 .
PIRi A55746.
B55746. QXMS3M.
RefSeqi NP_904335.1. NC_005089.1.
YP_220557.1. NC_006914.1.

3D structure databases

ProteinModelPortali P03899.
SMRi P03899. Positions 3-112.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P03899.

Proteomic databases

MaxQBi P03899.
PaxDbi P03899.
PRIDEi P03899.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082411 ; ENSMUSP00000080998 ; ENSMUSG00000064360 .
GeneIDi 17718.
3338896.
KEGGi mmu:17718.

Organism-specific databases

CTDi 4537.
MGIi MGI:102499. mt-Nd3.

Phylogenomic databases

eggNOGi COG0838.
HOGENOMi HOG000100119.
HOVERGENi HBG017392.
InParanoidi P03899.
KOi K03880.
OMAi FENAHIP.
OrthoDBi EOG7RV9K7.
PhylomeDBi P03899.

Enzyme and pathway databases

Reactomei REACT_262523. Respiratory electron transport.

Miscellaneous databases

NextBioi 292338.
PROi P03899.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi P03899. baseline and differential.
Genevestigatori P03899.

Family and domain databases

InterProi IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view ]
PANTHERi PTHR11058. PTHR11058. 1 hit.
Pfami PF00507. Oxidored_q4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nonneutral evolution at the mitochondrial NADH dehydrogenase subunit 3 gene in mice."
    Nachman M.W., Boyer S.N., Aquadro C.F.
    Proc. Natl. Acad. Sci. U.S.A. 91:6364-6368(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains."
    Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.
    J. Hered. 92:352-355(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AKR/J, C3H/He, SAMP1, SAMP8 and SAMR1.
    Tissue: Liver.

Entry informationi

Entry nameiNU3M_MOUSE
AccessioniPrimary (citable) accession number: P03899
Secondary accession number(s): Q35039, Q35040, Q9MD73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 16, 2001
Last modified: November 26, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3