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Protein

NADH-ubiquinone oxidoreductase chain 3

Gene

Mtnd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 3 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 3
Gene namesi
Name:Mtnd3
Synonyms:mt-Nd3, Nd3
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102499. mt-Nd3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 115115NADH-ubiquinone oxidoreductase chain 3PRO_0000117765Add
BLAST

Proteomic databases

PaxDbiP03899.
PRIDEiP03899.

PTM databases

PhosphoSiteiP03899.

Expressioni

Gene expression databases

ExpressionAtlasiP03899. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080998.

Structurei

3D structure databases

ProteinModelPortaliP03899.
SMRiP03899. Positions 3-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4662. Eukaryota.
COG0838. LUCA.
HOGENOMiHOG000100119.
HOVERGENiHBG017392.
InParanoidiP03899.
KOiK03880.
OMAiAYEWLQK.
OrthoDBiEOG7RV9K7.
PhylomeDBiP03899.

Family and domain databases

InterProiIPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
PANTHERiPTHR11058. PTHR11058. 1 hit.
PfamiPF00507. Oxidored_q4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLYTVIFIN ILLSLTLILV AFWLPQMNLY SEKANPYECG FDPTSSARLP
60 70 80 90 100
FSMKFFLVAI TFLLFDLEIA LLLPLPWAIQ TIKTSTMMIM AFILVTILSL
110
GLAYEWTQKG LEWTE
Length:115
Mass (Da):13,219
Last modified:November 16, 2001 - v3
Checksum:i6925F293601CB391
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161T → A in AAA19255 (PubMed:8022788).Curated
Sequence conflicti33 – 331Missing in AAB48651 (PubMed:7332926).Curated
Sequence conflicti33 – 331Missing in CAA24086 (PubMed:7332926).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48651.1.
V00711 Genomic DNA. Translation: CAA24086.1.
U09637 Genomic DNA. Translation: AAA19254.2.
U09638 Genomic DNA. Translation: AAA19255.2.
AB042432 Genomic DNA. Translation: BAA95623.1.
AB042523 Genomic DNA. Translation: BAA95660.1.
AB042524 Genomic DNA. Translation: BAA95647.1.
AB042809 Genomic DNA. Translation: BAA95802.1.
AB049357 Genomic DNA. Translation: BAB13808.1.
AY172335 Genomic DNA. Translation: AAN85129.1.
PIRiA55746.
B55746. QXMS3M.
RefSeqiNP_904335.1. NC_005089.1.
YP_220557.1. NC_006914.1.

Genome annotation databases

EnsembliENSMUST00000082411; ENSMUSP00000080998; ENSMUSG00000064360.
GeneIDi17718.
3338896.
KEGGimmu:17718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48651.1.
V00711 Genomic DNA. Translation: CAA24086.1.
U09637 Genomic DNA. Translation: AAA19254.2.
U09638 Genomic DNA. Translation: AAA19255.2.
AB042432 Genomic DNA. Translation: BAA95623.1.
AB042523 Genomic DNA. Translation: BAA95660.1.
AB042524 Genomic DNA. Translation: BAA95647.1.
AB042809 Genomic DNA. Translation: BAA95802.1.
AB049357 Genomic DNA. Translation: BAB13808.1.
AY172335 Genomic DNA. Translation: AAN85129.1.
PIRiA55746.
B55746. QXMS3M.
RefSeqiNP_904335.1. NC_005089.1.
YP_220557.1. NC_006914.1.

3D structure databases

ProteinModelPortaliP03899.
SMRiP03899. Positions 3-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080998.

PTM databases

PhosphoSiteiP03899.

Proteomic databases

PaxDbiP03899.
PRIDEiP03899.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082411; ENSMUSP00000080998; ENSMUSG00000064360.
GeneIDi17718.
3338896.
KEGGimmu:17718.

Organism-specific databases

CTDi4537.
MGIiMGI:102499. mt-Nd3.

Phylogenomic databases

eggNOGiKOG4662. Eukaryota.
COG0838. LUCA.
HOGENOMiHOG000100119.
HOVERGENiHBG017392.
InParanoidiP03899.
KOiK03880.
OMAiAYEWLQK.
OrthoDBiEOG7RV9K7.
PhylomeDBiP03899.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.

Miscellaneous databases

NextBioi292338.
PROiP03899.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP03899. baseline and differential.

Family and domain databases

InterProiIPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
PANTHERiPTHR11058. PTHR11058. 1 hit.
PfamiPF00507. Oxidored_q4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nonneutral evolution at the mitochondrial NADH dehydrogenase subunit 3 gene in mice."
    Nachman M.W., Boyer S.N., Aquadro C.F.
    Proc. Natl. Acad. Sci. U.S.A. 91:6364-6368(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains."
    Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.
    J. Hered. 92:352-355(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AKR/J, C3H/He, SAMP1, SAMP8 and SAMR1.
    Tissue: Liver.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNU3M_MOUSE
AccessioniPrimary (citable) accession number: P03899
Secondary accession number(s): Q35039, Q35040, Q9MD73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 16, 2001
Last modified: January 20, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.