Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH-ubiquinone oxidoreductase chain 3

Gene

MT-ND3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 3 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 3
Gene namesi
Name:MT-ND3
Synonyms:MTND3, NADH3, ND3
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence analysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4498.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 115115NADH-ubiquinone oxidoreductase chain 3PRO_0000117716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-formylmethionine1 Publication

Keywords - PTMi

Formylation

Proteomic databases

PaxDbiP03898.

Expressioni

Gene expression databases

BgeeiENSBTAG00000043568.
ExpressionAtlasiP03898. baseline.

Interactioni

Protein-protein interaction databases

IntActiP03898. 2 interactions.
MINTiMINT-8414445.
STRINGi9913.ENSBTAP00000053159.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4662. Eukaryota.
COG0838. LUCA.
HOVERGENiHBG017392.
InParanoidiP03898.
KOiK03880.
OMAiAYEWLQK.
OrthoDBiEOG091G14Y7.
TreeFamiTF343336.

Family and domain databases

InterProiIPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
PANTHERiPTHR11058. PTHR11058. 1 hit.
PfamiPF00507. Oxidored_q4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLMLALLTN FTLATLLVII AFWLPQLNVY SEKTSPYECG FDPMGSARLP
60 70 80 90 100
FSMKFFLVAI TFLLFDLEIA LLLPLPWASQ TANLNTMLTM ALFLIILLAV
110
SLAYEWTQKG LEWTE
Length:115
Mass (Da):13,055
Last modified:July 21, 1986 - v1
Checksum:iA55C1B856B1C3515
GO

Mass spectrometryi

Molecular mass is 13082.4 Da from positions 1 - 115. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA24008.1. Sequence problems.
AF490528 Genomic DNA. Translation: AAM08324.1. Sequence problems.
AF490529 Genomic DNA. Translation: AAM08337.1. Sequence problems.
AF493541 Genomic DNA. Translation: AAM12796.1. Sequence problems.
AF493542 Genomic DNA. Translation: AAM12809.1. Sequence problems.
PIRiA00423. QXBO3M.
RefSeqiYP_209212.2. NC_006853.1.

Genome annotation databases

EnsembliENSBTAT00000060547; ENSBTAP00000053159; ENSBTAG00000043568.
GeneIDi3283884.
KEGGibta:3283884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA24008.1. Sequence problems.
AF490528 Genomic DNA. Translation: AAM08324.1. Sequence problems.
AF490529 Genomic DNA. Translation: AAM08337.1. Sequence problems.
AF493541 Genomic DNA. Translation: AAM12796.1. Sequence problems.
AF493542 Genomic DNA. Translation: AAM12809.1. Sequence problems.
PIRiA00423. QXBO3M.
RefSeqiYP_209212.2. NC_006853.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03898. 2 interactions.
MINTiMINT-8414445.
STRINGi9913.ENSBTAP00000053159.

Chemistry

ChEMBLiCHEMBL4498.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP03898.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000060547; ENSBTAP00000053159; ENSBTAG00000043568.
GeneIDi3283884.
KEGGibta:3283884.

Organism-specific databases

CTDi4537.

Phylogenomic databases

eggNOGiKOG4662. Eukaryota.
COG0838. LUCA.
HOVERGENiHBG017392.
InParanoidiP03898.
KOiK03880.
OMAiAYEWLQK.
OrthoDBiEOG091G14Y7.
TreeFamiTF343336.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000043568.
ExpressionAtlasiP03898. baseline.

Family and domain databases

InterProiIPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
PANTHERiPTHR11058. PTHR11058. 1 hit.
PfamiPF00507. Oxidored_q4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU3M_BOVIN
AccessioniPrimary (citable) accession number: P03898
Secondary accession number(s): Q8SEI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.