Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH-ubiquinone oxidoreductase chain 3

Gene

MT-ND3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport
R-BTA-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 3 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 3
Gene namesi
Name:MT-ND3
Synonyms:MTND3, NADH3, ND3
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4498

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001177161 – 115NADH-ubiquinone oxidoreductase chain 3Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-formylmethionine1 Publication1

Keywords - PTMi

Formylation

Proteomic databases

PaxDbiP03898

Expressioni

Gene expression databases

BgeeiENSBTAG00000043568
ExpressionAtlasiP03898 baseline

Interactioni

Protein-protein interaction databases

CORUMiP03898
DIPiDIP-38829N
IntActiP03898, 2 interactors
MINTiP03898
STRINGi9913.ENSBTAP00000053159

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35A2-112[»]
5LDWelectron microscopy4.27A1-115[»]
5LDXelectron microscopy5.60A1-115[»]
5O31electron microscopy4.13A1-115[»]
SMRiP03898
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4662 Eukaryota
COG0838 LUCA
GeneTreeiENSGT00390000011605
HOVERGENiHBG017392
InParanoidiP03898
KOiK03880
OMAiAYEWRRG
OrthoDBiEOG091G14Y7
TreeFamiTF343336

Family and domain databases

Gene3Di1.20.58.1610, 1 hit
InterProiView protein in InterPro
IPR000440 NADH_UbQ/plastoQ_OxRdtase_su3
IPR038430 NDAH_ubi_oxred_su3_sf
PANTHERiPTHR11058 PTHR11058, 1 hit
PfamiView protein in Pfam
PF00507 Oxidored_q4, 1 hit

Sequencei

Sequence statusi: Complete.

P03898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLMLALLTN FTLATLLVII AFWLPQLNVY SEKTSPYECG FDPMGSARLP
60 70 80 90 100
FSMKFFLVAI TFLLFDLEIA LLLPLPWASQ TANLNTMLTM ALFLIILLAV
110
SLAYEWTQKG LEWTE
Length:115
Mass (Da):13,055
Last modified:July 21, 1986 - v1
Checksum:iA55C1B856B1C3515
GO

Mass spectrometryi

Molecular mass is 13082.4 Da from positions 1 - 115. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA Translation: CAA24008.1 Sequence problems.
AF490528 Genomic DNA Translation: AAM08324.1 Sequence problems.
AF490529 Genomic DNA Translation: AAM08337.1 Sequence problems.
AF493541 Genomic DNA Translation: AAM12796.1 Sequence problems.
AF493542 Genomic DNA Translation: AAM12809.1 Sequence problems.
PIRiA00423 QXBO3M
RefSeqiYP_209212.2, NC_006853.1

Genome annotation databases

EnsembliENSBTAT00000060547; ENSBTAP00000053159; ENSBTAG00000043568
GeneIDi3283884
KEGGibta:3283884

Similar proteinsi

Entry informationi

Entry nameiNU3M_BOVIN
AccessioniPrimary (citable) accession number: P03898
Secondary accession number(s): Q8SEI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health