##gff-version 3
P03891	UniProtKB	Chain	1	347	.	.	.	ID=PRO_0000117595;Note=NADH-ubiquinone oxidoreductase chain 2	
P03891	UniProtKB	Transmembrane	13	33	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P03891	UniProtKB	Transmembrane	56	76	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P03891	UniProtKB	Transmembrane	96	116	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P03891	UniProtKB	Transmembrane	123	143	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P03891	UniProtKB	Transmembrane	149	169	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P03891	UniProtKB	Transmembrane	178	198	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P03891	UniProtKB	Transmembrane	201	221	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P03891	UniProtKB	Transmembrane	247	267	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P03891	UniProtKB	Transmembrane	274	294	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P03891	UniProtKB	Transmembrane	326	346	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P03891	UniProtKB	Natural variant	42	42	.	.	.	ID=VAR_008590;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1757091;Dbxref=PMID:1757091	
P03891	UniProtKB	Natural variant	43	43	.	.	.	ID=VAR_011348;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7530363;Dbxref=dbSNP:rs1117207,PMID:7530363	
P03891	UniProtKB	Natural variant	57	57	.	.	.	ID=VAR_008591;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9461455;Dbxref=dbSNP:rs41510547,PMID:9461455	
P03891	UniProtKB	Natural variant	63	63	.	.	.	ID=VAR_008592;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1757091;Dbxref=PMID:1757091	
P03891	UniProtKB	Natural variant	69	69	.	.	.	ID=VAR_011349;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9475751;Dbxref=dbSNP:rs1556422884,PMID:9475751	
P03891	UniProtKB	Natural variant	71	71	.	.	.	ID=VAR_084383;Note=In LS%3B uncertain significance%3B decrease in enzyme activity and impaired assembly of complex I. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16996290;Dbxref=dbSNP:rs267606889,PMID:16996290	
P03891	UniProtKB	Natural variant	88	88	.	.	.	ID=VAR_011350;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9475751;Dbxref=dbSNP:rs201854167,PMID:9475751	
P03891	UniProtKB	Natural variant	119	119	.	.	.	ID=VAR_008593;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1757091;Dbxref=dbSNP:rs1556422903,PMID:1757091	
P03891	UniProtKB	Natural variant	148	148	.	.	.	ID=VAR_008594;Note=S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1757091;Dbxref=PMID:1757091	
P03891	UniProtKB	Natural variant	150	150	.	.	.	ID=VAR_004755;Note=In LHON%3B secondary mutation%3B does not seem to directly cause the disease. N->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1900003,ECO:0000269|PubMed:9475751;Dbxref=dbSNP:rs28357980,PMID:1900003,PMID:9475751	
P03891	UniProtKB	Natural variant	150	150	.	.	.	ID=VAR_008595;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1757091;Dbxref=dbSNP:rs879058895,PMID:1757091	
P03891	UniProtKB	Natural variant	159	159	.	.	.	ID=VAR_008596;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1757091;Dbxref=PMID:1757091	
P03891	UniProtKB	Natural variant	185	185	.	.	.	ID=VAR_008597;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1757091;Dbxref=PMID:1757091	
P03891	UniProtKB	Natural variant	237	237	.	.	.	ID=VAR_011351;Note=L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9475751;Dbxref=dbSNP:rs28357984,PMID:9475751	
P03891	UniProtKB	Natural variant	259	259	.	.	.	ID=VAR_004756;Note=In LHON%3B rare primary mutation. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1732158;Dbxref=dbSNP:rs199476115,PMID:1732158	
P03891	UniProtKB	Natural variant	265	265	.	.	.	ID=VAR_011352;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9475751;Dbxref=dbSNP:rs1603219855,PMID:9475751	
P03891	UniProtKB	Natural variant	265	265	.	.	.	ID=VAR_011353;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9475751;Dbxref=dbSNP:rs41320049,PMID:9475751	
P03891	UniProtKB	Natural variant	278	278	.	.	.	ID=VAR_011354;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9475751;Dbxref=dbSNP:rs878853115,PMID:9475751	
P03891	UniProtKB	Natural variant	325	325	.	.	.	ID=VAR_011355;Note=F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7530363;Dbxref=dbSNP:rs3020601,PMID:7530363	
P03891	UniProtKB	Natural variant	331	331	.	.	.	ID=VAR_004758;Note=In AD-MT. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1370613;Dbxref=PMID:1370613	
P03891	UniProtKB	Natural variant	331	331	.	.	.	ID=VAR_004757;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7530363;Dbxref=dbSNP:rs3021088,PMID:7530363	
P03891	UniProtKB	Natural variant	333	333	.	.	.	ID=VAR_011356;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9475751;Dbxref=dbSNP:rs1603219973,PMID:9475751