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P03891

- NU2M_HUMAN

UniProt

P03891 - NU2M_HUMAN

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Protein

NADH-ubiquinone oxidoreductase chain 2

Gene

MT-ND2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  3. reactive oxygen species metabolic process Source: Ensembl
  4. respiratory electron transport chain Source: Reactome
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 2 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 2
Gene namesi
Name:MT-ND2
Synonyms:MTND2, NADH2, ND2
Encoded oniMitochondrion
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Mitochondrion

Organism-specific databases

HGNCiHGNC:7456. MT-ND2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501N → D in LHON; secondary mutation; does not seem to directly cause the disease. 2 Publications
VAR_004755
Natural varianti259 – 2591G → S in LHON; rare primary mutation. 1 Publication
VAR_004756
Alzheimer disease mitochondrial (AD-MT) [MIM:502500]: Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti331 – 3311A → S in AD-MT. 1 Publication
VAR_004758

Keywords - Diseasei

Alzheimer disease, Amyloidosis, Disease mutation, Leber hereditary optic neuropathy

Organism-specific databases

MIMi502500. phenotype.
535000. phenotype.
Orphaneti2609. Isolated NADH-CoQ reductase deficiency.
104. Leber hereditary optic neuropathy.
255210. Maternally-inherited Leigh syndrome.
PharmGKBiPA31260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347NADH-ubiquinone oxidoreductase chain 2PRO_0000117595Add
BLAST

Proteomic databases

MaxQBiP03891.
PaxDbiP03891.
PRIDEiP03891.

PTM databases

PhosphoSiteiP03891.

Expressioni

Gene expression databases

ExpressionAtlasiP03891. baseline.
GenevestigatoriP03891.

Interactioni

Protein-protein interaction databases

BioGridi110632. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP03891.
SMRiP03891. Positions 8-338.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4668.
HOGENOMiHOG000113879.
HOVERGENiHBG016692.
InParanoidiP03891.
KOiK03879.
OMAiKLGMAPF.
OrthoDBiEOG78D7MF.
PhylomeDBiP03891.

Family and domain databases

InterProiIPR010933. NADH_DH_su2_C.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003917. NADH_UbQ_OxRdtase_chain2.
[Graphical view]
PfamiPF06444. NADH_dehy_S2_C. 1 hit.
PF00361. Oxidored_q1. 1 hit.
[Graphical view]
PRINTSiPR01436. NADHDHGNASE2.

Sequencei

Sequence statusi: Complete.

P03891-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPLAQPVIY STIFAGTLIT ALSSHWFFTW VGLEMNMLAF IPVLTKKMNP
60 70 80 90 100
RSTEAAIKYF LTQATASMIL LMAILFNNML SGQWTMTNTT NQYSSLMIMM
110 120 130 140 150
AMAMKLGMAP FHFWVPEVTQ GTPLTSGLLL LTWQKLAPIS IMYQISPSLN
160 170 180 190 200
VSLLLTLSIL SIMAGSWGGL NQTQLRKILA YSSITHMGWM MAVLPYNPNM
210 220 230 240 250
TILNLTIYII LTTTAFLLLN LNSSTTTLLL SRTWNKLTWL TPLIPSTLLS
260 270 280 290 300
LGGLPPLTGF LPKWAIIEEF TKNNSLIIPT IMATITLLNL YFYLRLIYST
310 320 330 340
SITLLPMSNN VKMKWQFEHT KPTPFLPTLI ALTTLLLPIS PFMLMIL
Length:347
Mass (Da):38,961
Last modified:December 1, 1992 - v2
Checksum:iC06FD982317C3F2D
GO

Sequence cautioni

The sequence AAA65502.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421P → L.1 Publication
VAR_008590
Natural varianti43 – 431V → I.1 Publication
VAR_011348
Natural varianti57 – 571I → T.1 Publication
VAR_008591
Natural varianti63 – 631Q → R.1 Publication
VAR_008592
Natural varianti69 – 691I → V.1 Publication
VAR_011349
Natural varianti88 – 881N → S.1 Publication
VAR_011350
Natural varianti119 – 1191T → A.1 Publication
VAR_008593
Natural varianti148 – 1481S → P.1 Publication
VAR_008594
Natural varianti150 – 1501N → D in LHON; secondary mutation; does not seem to directly cause the disease. 2 Publications
VAR_004755
Natural varianti150 – 1501N → S.1 Publication
VAR_008595
Natural varianti159 – 1591I → T.1 Publication
VAR_008596
Natural varianti185 – 1851T → A.1 Publication
VAR_008597
Natural varianti237 – 2371L → M.1 Publication
VAR_011351
Natural varianti259 – 2591G → S in LHON; rare primary mutation. 1 Publication
VAR_004756
Natural varianti265 – 2651A → T.1 Publication
VAR_011352
Natural varianti265 – 2651A → V.1 Publication
VAR_011353
Natural varianti278 – 2781I → T.1 Publication
VAR_011354
Natural varianti325 – 3251F → L.1 Publication
VAR_011355
Natural varianti331 – 3311A → S in AD-MT. 1 Publication
VAR_004758
Natural varianti331 – 3311A → T.1 Publication
VAR_004757
Natural varianti333 – 3331T → A.1 Publication
VAR_011356

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01415 Genomic DNA. Translation: AAB58944.1.
V00662 Genomic DNA. Translation: CAA24027.1.
M10546 Genomic DNA. Translation: AAA65502.1. Different initiation.
D38112 Genomic DNA. Translation: BAA07291.1.
AF014882 Genomic DNA. Translation: AAC25441.1.
AF014884 Genomic DNA. Translation: AAC25443.1.
AF014885 Genomic DNA. Translation: AAC25444.1.
AF014887 Genomic DNA. Translation: AAC25446.1.
AF014889 Genomic DNA. Translation: AAC25448.1.
AF014890 Genomic DNA. Translation: AAC25449.1.
AF014891 Genomic DNA. Translation: AAC25450.1.
AF014892 Genomic DNA. Translation: AAC25451.1.
AF014895 Genomic DNA. Translation: AAC25454.1.
AF014896 Genomic DNA. Translation: AAC25455.2.
AF014897 Genomic DNA. Translation: AAC25456.1.
AF014898 Genomic DNA. Translation: AAC25457.1.
AF014899 Genomic DNA. Translation: AAC25458.2.
AF014900 Genomic DNA. Translation: AAC25459.1.
AF014901 Genomic DNA. Translation: AAC25460.1.
AY339402 Genomic DNA. Translation: AAP89037.1.
AY339403 Genomic DNA. Translation: AAP89050.1.
AY339404 Genomic DNA. Translation: AAP89063.1.
AY339405 Genomic DNA. Translation: AAP89076.1.
AY339406 Genomic DNA. Translation: AAP89089.1.
AY339407 Genomic DNA. Translation: AAP89102.1.
AY339408 Genomic DNA. Translation: AAP89115.1.
AY339409 Genomic DNA. Translation: AAP89128.1.
AY339410 Genomic DNA. Translation: AAP89141.1.
AY339411 Genomic DNA. Translation: AAP89154.1.
AY339412 Genomic DNA. Translation: AAP89167.1.
AY339413 Genomic DNA. Translation: AAP89180.1.
AY339414 Genomic DNA. Translation: AAP89193.1.
AY339415 Genomic DNA. Translation: AAP89206.1.
AY339416 Genomic DNA. Translation: AAP89219.1.
AY339417 Genomic DNA. Translation: AAP89232.1.
AY339418 Genomic DNA. Translation: AAP89245.1.
AY339419 Genomic DNA. Translation: AAP89258.1.
AY339420 Genomic DNA. Translation: AAP89271.1.
AY339421 Genomic DNA. Translation: AAP89284.1.
AY339422 Genomic DNA. Translation: AAP89297.1.
AY339423 Genomic DNA. Translation: AAP89310.1.
AY339424 Genomic DNA. Translation: AAP89323.1.
AY339425 Genomic DNA. Translation: AAP89336.1.
AY339426 Genomic DNA. Translation: AAP89349.1.
AY339427 Genomic DNA. Translation: AAP89362.1.
AY339428 Genomic DNA. Translation: AAP89375.1.
AY339429 Genomic DNA. Translation: AAP89388.1.
AY339430 Genomic DNA. Translation: AAP89401.1.
AY339431 Genomic DNA. Translation: AAP89414.1.
AY339432 Genomic DNA. Translation: AAP89427.1.
AY339433 Genomic DNA. Translation: AAP89440.1.
AY339446 Genomic DNA. Translation: AAP89609.1.
AY339447 Genomic DNA. Translation: AAP89622.1.
AY339448 Genomic DNA. Translation: AAP89635.1.
AY339449 Genomic DNA. Translation: AAP89648.1.
AY339450 Genomic DNA. Translation: AAP89661.1.
AY339451 Genomic DNA. Translation: AAP89674.1.
AY339452 Genomic DNA. Translation: AAP89687.1.
AY339453 Genomic DNA. Translation: AAP89700.1.
AY339454 Genomic DNA. Translation: AAP89713.1.
AY339455 Genomic DNA. Translation: AAP89726.1.
AY339456 Genomic DNA. Translation: AAP89739.1.
AY339457 Genomic DNA. Translation: AAP89752.1.
AY339458 Genomic DNA. Translation: AAP89765.1.
AY339459 Genomic DNA. Translation: AAP89778.1.
AY339497 Genomic DNA. Translation: AAP90272.1.
AY339498 Genomic DNA. Translation: AAP90285.1.
AY339499 Genomic DNA. Translation: AAP90298.1.
AY339500 Genomic DNA. Translation: AAP90311.1.
AY339501 Genomic DNA. Translation: AAP90324.1.
AY339502 Genomic DNA. Translation: AAP90337.1.
AY339503 Genomic DNA. Translation: AAP90350.1.
AY339504 Genomic DNA. Translation: AAP90363.1.
AY339505 Genomic DNA. Translation: AAP90376.1.
AY339506 Genomic DNA. Translation: AAP90389.1.
AY339507 Genomic DNA. Translation: AAP90402.1.
AY339508 Genomic DNA. Translation: AAP90415.1.
AY339509 Genomic DNA. Translation: AAP90428.1.
AY339510 Genomic DNA. Translation: AAP90441.1.
AY339511 Genomic DNA. Translation: AAP90454.1.
AY339512 Genomic DNA. Translation: AAP90467.1.
AY339513 Genomic DNA. Translation: AAP90480.1.
AY339514 Genomic DNA. Translation: AAP90493.1.
AY339515 Genomic DNA. Translation: AAP90506.1.
AY339516 Genomic DNA. Translation: AAP90519.1.
AY339517 Genomic DNA. Translation: AAP90532.1.
AY339518 Genomic DNA. Translation: AAP90545.1.
AY339519 Genomic DNA. Translation: AAP90558.1.
AY339520 Genomic DNA. Translation: AAP90571.1.
AY339521 Genomic DNA. Translation: AAP90584.1.
AY339522 Genomic DNA. Translation: AAP90597.1.
AY339523 Genomic DNA. Translation: AAP90610.1.
AY339524 Genomic DNA. Translation: AAP90623.1.
AY339525 Genomic DNA. Translation: AAP90636.1.
AY339526 Genomic DNA. Translation: AAP90649.1.
AY339527 Genomic DNA. Translation: AAP90662.1.
AY339528 Genomic DNA. Translation: AAP90675.1.
AY339529 Genomic DNA. Translation: AAP90688.1.
AY339530 Genomic DNA. Translation: AAP90701.1.
AY339531 Genomic DNA. Translation: AAP90714.1.
AY339532 Genomic DNA. Translation: AAP90727.1.
AY339533 Genomic DNA. Translation: AAP90740.1.
AY339534 Genomic DNA. Translation: AAP90753.1.
AY339535 Genomic DNA. Translation: AAP90766.1.
AY339536 Genomic DNA. Translation: AAP90779.1.
AY339537 Genomic DNA. Translation: AAP90792.1.
AY339538 Genomic DNA. Translation: AAP90805.1.
AY339539 Genomic DNA. Translation: AAP90818.1.
AY339540 Genomic DNA. Translation: AAP90831.1.
AY339541 Genomic DNA. Translation: AAP90844.1.
AY339542 Genomic DNA. Translation: AAP90857.1.
AY339543 Genomic DNA. Translation: AAP90870.1.
AY339545 Genomic DNA. Translation: AAP90896.1.
AY339546 Genomic DNA. Translation: AAP90909.1.
AY339547 Genomic DNA. Translation: AAP90922.1.
AY339548 Genomic DNA. Translation: AAP90935.1.
AY339549 Genomic DNA. Translation: AAP90948.1.
AY339550 Genomic DNA. Translation: AAP90961.1.
AY339551 Genomic DNA. Translation: AAP90974.1.
AY339552 Genomic DNA. Translation: AAP90987.1.
AY339553 Genomic DNA. Translation: AAP91000.1.
AY339554 Genomic DNA. Translation: AAP91013.1.
AY339555 Genomic DNA. Translation: AAP91026.1.
AY339556 Genomic DNA. Translation: AAP91039.1.
AY339557 Genomic DNA. Translation: AAP91052.1.
AY339558 Genomic DNA. Translation: AAP91065.1.
AY339559 Genomic DNA. Translation: AAP91078.1.
AY339560 Genomic DNA. Translation: AAP91091.1.
AY339561 Genomic DNA. Translation: AAP91104.1.
AY339562 Genomic DNA. Translation: AAP91117.1.
AY339563 Genomic DNA. Translation: AAP91130.1.
AY339564 Genomic DNA. Translation: AAP91143.1.
AY339565 Genomic DNA. Translation: AAP91156.1.
AY339577 Genomic DNA. Translation: AAP91312.1.
AY339578 Genomic DNA. Translation: AAP91325.1.
AY339579 Genomic DNA. Translation: AAP91338.1.
AY339580 Genomic DNA. Translation: AAP91351.1.
AY339583 Genomic DNA. Translation: AAP91390.1.
AY339584 Genomic DNA. Translation: AAP91403.1.
AY339585 Genomic DNA. Translation: AAP91416.1.
AY339586 Genomic DNA. Translation: AAP91429.1.
AY339587 Genomic DNA. Translation: AAP91442.1.
AY339588 Genomic DNA. Translation: AAP91455.1.
AY339589 Genomic DNA. Translation: AAP91468.1.
AY339590 Genomic DNA. Translation: AAP91481.1.
AY339591 Genomic DNA. Translation: AAP91494.1.
AY339592 Genomic DNA. Translation: AAP91507.1.
AY339593 Genomic DNA. Translation: AAP91520.1.
AF346963 Genomic DNA. Translation: AAK17208.1.
AF346964 Genomic DNA. Translation: AAK17221.1.
AF346965 Genomic DNA. Translation: AAK17234.1.
AF346968 Genomic DNA. Translation: AAK17273.1.
AF346970 Genomic DNA. Translation: AAK17299.1.
AF346974 Genomic DNA. Translation: AAK17351.1.
AF346975 Genomic DNA. Translation: AAK17364.1.
AF346976 Genomic DNA. Translation: AAK17377.1.
AF346977 Genomic DNA. Translation: AAK17390.1.
AF346978 Genomic DNA. Translation: AAK17403.1.
AF346979 Genomic DNA. Translation: AAK17416.1.
AF346980 Genomic DNA. Translation: AAK17429.1.
AF346981 Genomic DNA. Translation: AAK17442.1.
AF346983 Genomic DNA. Translation: AAK17468.1.
AF346988 Genomic DNA. Translation: AAK17533.1.
AF346991 Genomic DNA. Translation: AAK17572.1.
AF346992 Genomic DNA. Translation: AAK17585.1.
AF346994 Genomic DNA. Translation: AAK17611.1.
AF346995 Genomic DNA. Translation: AAK17624.1.
AF346997 Genomic DNA. Translation: AAK17650.1.
AF347000 Genomic DNA. Translation: AAK17689.1.
AF347001 Genomic DNA. Translation: AAK17702.1.
AF347002 Genomic DNA. Translation: AAK17715.1.
AF347004 Genomic DNA. Translation: AAK17741.1.
AF347005 Genomic DNA. Translation: AAK17754.1.
AF347006 Genomic DNA. Translation: AAK17767.1.
AF347007 Genomic DNA. Translation: AAK17780.1.
AF347011 Genomic DNA. Translation: AAK17832.1.
AF347012 Genomic DNA. Translation: AAK17845.1.
AF347013 Genomic DNA. Translation: AAK17858.1.
AF347014 Genomic DNA. Translation: AAK17871.1.
AF347015 Genomic DNA. Translation: AAK17884.1.
AY289051 Genomic DNA. Translation: AAP47881.1.
AY289053 Genomic DNA. Translation: AAP47907.1.
AY289054 Genomic DNA. Translation: AAP47920.1.
AY289055 Genomic DNA. Translation: AAP47933.1.
AY289057 Genomic DNA. Translation: AAP47959.1.
AY289061 Genomic DNA. Translation: AAP48011.1.
AY289062 Genomic DNA. Translation: AAP48024.1.
AY289063 Genomic DNA. Translation: AAP48037.1.
AY289065 Genomic DNA. Translation: AAP48063.1.
AY289068 Genomic DNA. Translation: AAP48102.1.
AY289069 Genomic DNA. Translation: AAP48115.1.
AY289071 Genomic DNA. Translation: AAP48141.1.
AY289072 Genomic DNA. Translation: AAP48154.1.
AY289073 Genomic DNA. Translation: AAP48167.1.
AY289074 Genomic DNA. Translation: AAP48180.1.
AY289076 Genomic DNA. Translation: AAP48206.1.
AY289077 Genomic DNA. Translation: AAP48219.1.
AY289079 Genomic DNA. Translation: AAP48245.1.
AY289083 Genomic DNA. Translation: AAP48297.1.
AY289084 Genomic DNA. Translation: AAP48310.1.
AY289086 Genomic DNA. Translation: AAP48336.1.
AY289087 Genomic DNA. Translation: AAP48349.1.
AY289088 Genomic DNA. Translation: AAP48362.1.
AY289089 Genomic DNA. Translation: AAP48375.1.
AY289091 Genomic DNA. Translation: AAP48401.1.
AY289092 Genomic DNA. Translation: AAP48414.1.
AY289094 Genomic DNA. Translation: AAP48439.1.
AY289099 Genomic DNA. Translation: AAP48504.1.
AY289100 Genomic DNA. Translation: AAP48517.1.
AY289101 Genomic DNA. Translation: AAP48530.1.
AY289102 Genomic DNA. Translation: AAP48543.1.
AY495090 Genomic DNA. Translation: AAR92497.1.
AY495091 Genomic DNA. Translation: AAR92510.1.
AY495092 Genomic DNA. Translation: AAR92523.1.
AY495093 Genomic DNA. Translation: AAR92536.1.
AY495095 Genomic DNA. Translation: AAR92562.1.
AY495096 Genomic DNA. Translation: AAR92575.1.
AY495097 Genomic DNA. Translation: AAR92588.1.
AY495098 Genomic DNA. Translation: AAR92601.1.
AY495099 Genomic DNA. Translation: AAR92614.1.
AY495100 Genomic DNA. Translation: AAR92627.1.
AY495101 Genomic DNA. Translation: AAR92640.1.
AY495102 Genomic DNA. Translation: AAR92653.1.
AY495103 Genomic DNA. Translation: AAR92666.1.
AY495104 Genomic DNA. Translation: AAR92679.1.
AY495105 Genomic DNA. Translation: AAR92692.1.
AY495106 Genomic DNA. Translation: AAR92705.1.
AY495107 Genomic DNA. Translation: AAR92718.1.
AY495108 Genomic DNA. Translation: AAR92731.1.
AY495109 Genomic DNA. Translation: AAR92744.1.
AY495110 Genomic DNA. Translation: AAR92757.1.
AY495111 Genomic DNA. Translation: AAR92770.1.
AY495113 Genomic DNA. Translation: AAR92796.1.
AY495114 Genomic DNA. Translation: AAR92809.1.
AY495115 Genomic DNA. Translation: AAR92822.1.
AY495116 Genomic DNA. Translation: AAR92835.1.
AY495117 Genomic DNA. Translation: AAR92848.1.
AY495118 Genomic DNA. Translation: AAR92861.1.
AY495119 Genomic DNA. Translation: AAR92874.1.
AY495120 Genomic DNA. Translation: AAR92887.1.
AY495121 Genomic DNA. Translation: AAR92900.1.
AY495122 Genomic DNA. Translation: AAR92913.1.
AY495123 Genomic DNA. Translation: AAR92926.1.
AY495124 Genomic DNA. Translation: AAR92939.1.
AY495125 Genomic DNA. Translation: AAR92952.1.
AY495126 Genomic DNA. Translation: AAR92965.1.
AY495127 Genomic DNA. Translation: AAR92978.1.
AY495128 Genomic DNA. Translation: AAR92991.1.
AY495129 Genomic DNA. Translation: AAR93004.1.
AY495130 Genomic DNA. Translation: AAR93017.1.
AY495131 Genomic DNA. Translation: AAR93030.1.
AY495132 Genomic DNA. Translation: AAR93043.1.
AY495133 Genomic DNA. Translation: AAR93056.1.
AY495135 Genomic DNA. Translation: AAR93082.1.
AY495136 Genomic DNA. Translation: AAR93095.1.
AY495137 Genomic DNA. Translation: AAR93108.1.
AY495138 Genomic DNA. Translation: AAR93121.1.
AY495139 Genomic DNA. Translation: AAR93134.1.
AY495140 Genomic DNA. Translation: AAR93147.1.
AY495141 Genomic DNA. Translation: AAR93160.1.
AY495142 Genomic DNA. Translation: AAR93173.1.
AY495143 Genomic DNA. Translation: AAR93186.1.
AY495144 Genomic DNA. Translation: AAR93199.1.
AY495145 Genomic DNA. Translation: AAR93212.1.
AY495146 Genomic DNA. Translation: AAR93225.1.
AY495147 Genomic DNA. Translation: AAR93238.1.
AY495148 Genomic DNA. Translation: AAR93251.1.
AY495149 Genomic DNA. Translation: AAR93264.1.
AY495150 Genomic DNA. Translation: AAR93277.1.
AY495151 Genomic DNA. Translation: AAR93290.1.
AY495152 Genomic DNA. Translation: AAR93303.1.
AY495153 Genomic DNA. Translation: AAR93316.1.
AY495154 Genomic DNA. Translation: AAR93329.1.
AY495155 Genomic DNA. Translation: AAR93342.1.
AY495156 Genomic DNA. Translation: AAR93355.1.
AY495157 Genomic DNA. Translation: AAR93368.1.
AY495158 Genomic DNA. Translation: AAR93381.1.
AY495159 Genomic DNA. Translation: AAR93394.1.
AY495160 Genomic DNA. Translation: AAR93407.1.
AY495161 Genomic DNA. Translation: AAR93420.1.
AY495162 Genomic DNA. Translation: AAR93433.1.
AY495163 Genomic DNA. Translation: AAR93446.1.
AY495164 Genomic DNA. Translation: AAR93459.1.
AY495165 Genomic DNA. Translation: AAR93472.1.
AY495166 Genomic DNA. Translation: AAR93485.1.
AY495167 Genomic DNA. Translation: AAR93498.1.
AY495168 Genomic DNA. Translation: AAR93511.1.
AY495169 Genomic DNA. Translation: AAR93524.1.
AY495170 Genomic DNA. Translation: AAR93537.1.
AY495171 Genomic DNA. Translation: AAR93550.1.
AY495172 Genomic DNA. Translation: AAR93563.1.
AY495173 Genomic DNA. Translation: AAR93576.1.
AY495174 Genomic DNA. Translation: AAR93589.1.
AY495175 Genomic DNA. Translation: AAR93602.1.
AY495176 Genomic DNA. Translation: AAR93615.1.
AY495177 Genomic DNA. Translation: AAR93628.1.
AY495178 Genomic DNA. Translation: AAR93641.1.
AY495179 Genomic DNA. Translation: AAR93654.1.
AY495180 Genomic DNA. Translation: AAR93667.1.
AY495181 Genomic DNA. Translation: AAR93680.1.
AY495182 Genomic DNA. Translation: AAR93693.1.
AY495183 Genomic DNA. Translation: AAR93706.1.
AY495184 Genomic DNA. Translation: AAR93719.1.
AY495185 Genomic DNA. Translation: AAR93732.1.
AY495186 Genomic DNA. Translation: AAR93745.1.
AY495187 Genomic DNA. Translation: AAR93758.1.
AY495188 Genomic DNA. Translation: AAR93771.1.
AY495190 Genomic DNA. Translation: AAR93797.1.
AY495191 Genomic DNA. Translation: AAR93810.1.
AY495192 Genomic DNA. Translation: AAR93823.1.
AY495194 Genomic DNA. Translation: AAR93849.1.
AY495195 Genomic DNA. Translation: AAR93862.1.
AY495196 Genomic DNA. Translation: AAR93875.1.
AY495197 Genomic DNA. Translation: AAR93888.1.
AY495198 Genomic DNA. Translation: AAR93901.1.
AY495199 Genomic DNA. Translation: AAR93914.1.
AY495200 Genomic DNA. Translation: AAR93927.1.
AY495201 Genomic DNA. Translation: AAR93940.1.
AY495202 Genomic DNA. Translation: AAR93953.1.
AY495203 Genomic DNA. Translation: AAR93966.1.
AY495204 Genomic DNA. Translation: AAR93979.1.
AY495205 Genomic DNA. Translation: AAR93992.1.
AY495206 Genomic DNA. Translation: AAR94005.1.
AY495207 Genomic DNA. Translation: AAR94018.1.
AY495208 Genomic DNA. Translation: AAR94031.1.
AY495209 Genomic DNA. Translation: AAR94044.1.
AY495210 Genomic DNA. Translation: AAR94057.1.
AY495211 Genomic DNA. Translation: AAR94070.1.
AY495212 Genomic DNA. Translation: AAR94083.1.
AY495213 Genomic DNA. Translation: AAR94096.1.
AY495215 Genomic DNA. Translation: AAR94122.1.
AY495216 Genomic DNA. Translation: AAR94135.1.
AY495217 Genomic DNA. Translation: AAR94148.1.
AY495218 Genomic DNA. Translation: AAR94161.1.
AY495219 Genomic DNA. Translation: AAR94174.1.
AY495220 Genomic DNA. Translation: AAR94187.1.
AY495221 Genomic DNA. Translation: AAR94200.1.
AY495222 Genomic DNA. Translation: AAR94213.1.
AY495223 Genomic DNA. Translation: AAR94226.1.
AY495224 Genomic DNA. Translation: AAR94239.1.
AY495225 Genomic DNA. Translation: AAR94252.1.
AY495226 Genomic DNA. Translation: AAR94265.1.
AY495227 Genomic DNA. Translation: AAR94278.1.
AY495228 Genomic DNA. Translation: AAR94291.1.
AY495229 Genomic DNA. Translation: AAR94304.1.
AY495230 Genomic DNA. Translation: AAR94317.1.
AY495243 Genomic DNA. Translation: AAR94486.1.
AY495245 Genomic DNA. Translation: AAR94512.1.
AY495250 Genomic DNA. Translation: AAR94577.1.
AY495251 Genomic DNA. Translation: AAR94590.1.
AY495253 Genomic DNA. Translation: AAR94616.1.
AY495254 Genomic DNA. Translation: AAR94629.1.
AY495255 Genomic DNA. Translation: AAR94642.1.
AY495256 Genomic DNA. Translation: AAR94655.1.
AY495258 Genomic DNA. Translation: AAR94681.1.
AY495259 Genomic DNA. Translation: AAR94694.1.
AY495260 Genomic DNA. Translation: AAR94707.1.
AY495261 Genomic DNA. Translation: AAR94720.1.
AY495262 Genomic DNA. Translation: AAR94733.1.
AY495263 Genomic DNA. Translation: AAR94746.1.
AY495264 Genomic DNA. Translation: AAR94759.1.
AY495265 Genomic DNA. Translation: AAR94772.1.
AY495266 Genomic DNA. Translation: AAR94785.1.
AY495306 Genomic DNA. Translation: AAR95305.1.
AY495307 Genomic DNA. Translation: AAR95318.1.
AY495308 Genomic DNA. Translation: AAR95331.1.
AY495309 Genomic DNA. Translation: AAR95344.1.
AY495310 Genomic DNA. Translation: AAR95357.1.
AY495311 Genomic DNA. Translation: AAR95370.1.
AY495312 Genomic DNA. Translation: AAR95383.1.
AY495313 Genomic DNA. Translation: AAR95396.1.
AY495314 Genomic DNA. Translation: AAR95409.1.
AY495315 Genomic DNA. Translation: AAR95422.1.
AY495316 Genomic DNA. Translation: AAR95435.1.
AY495317 Genomic DNA. Translation: AAR95448.1.
AY495318 Genomic DNA. Translation: AAR95461.1.
AY495319 Genomic DNA. Translation: AAR95474.1.
AY495320 Genomic DNA. Translation: AAR95487.1.
AY495321 Genomic DNA. Translation: AAR95500.1.
AY495322 Genomic DNA. Translation: AAR95513.1.
AY495323 Genomic DNA. Translation: AAR95526.1.
AY495326 Genomic DNA. Translation: AAR95565.1.
AY495327 Genomic DNA. Translation: AAR95578.1.
AY495328 Genomic DNA. Translation: AAR95591.1.
AY495329 Genomic DNA. Translation: AAR95604.1.
AY495330 Genomic DNA. Translation: AAR95617.1.
AY495302 Genomic DNA. Translation: AAR95253.1.
PIRiA00414. DNHUN2.
RefSeqiYP_003024027.1. NC_012920.1.

Genome annotation databases

EnsembliENST00000361453; ENSP00000355046; ENSG00000198763.
GeneIDi4536.
KEGGihsa:4536.

Polymorphism databases

DMDMi128676.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01415 Genomic DNA. Translation: AAB58944.1 .
V00662 Genomic DNA. Translation: CAA24027.1 .
M10546 Genomic DNA. Translation: AAA65502.1 . Different initiation.
D38112 Genomic DNA. Translation: BAA07291.1 .
AF014882 Genomic DNA. Translation: AAC25441.1 .
AF014884 Genomic DNA. Translation: AAC25443.1 .
AF014885 Genomic DNA. Translation: AAC25444.1 .
AF014887 Genomic DNA. Translation: AAC25446.1 .
AF014889 Genomic DNA. Translation: AAC25448.1 .
AF014890 Genomic DNA. Translation: AAC25449.1 .
AF014891 Genomic DNA. Translation: AAC25450.1 .
AF014892 Genomic DNA. Translation: AAC25451.1 .
AF014895 Genomic DNA. Translation: AAC25454.1 .
AF014896 Genomic DNA. Translation: AAC25455.2 .
AF014897 Genomic DNA. Translation: AAC25456.1 .
AF014898 Genomic DNA. Translation: AAC25457.1 .
AF014899 Genomic DNA. Translation: AAC25458.2 .
AF014900 Genomic DNA. Translation: AAC25459.1 .
AF014901 Genomic DNA. Translation: AAC25460.1 .
AY339402 Genomic DNA. Translation: AAP89037.1 .
AY339403 Genomic DNA. Translation: AAP89050.1 .
AY339404 Genomic DNA. Translation: AAP89063.1 .
AY339405 Genomic DNA. Translation: AAP89076.1 .
AY339406 Genomic DNA. Translation: AAP89089.1 .
AY339407 Genomic DNA. Translation: AAP89102.1 .
AY339408 Genomic DNA. Translation: AAP89115.1 .
AY339409 Genomic DNA. Translation: AAP89128.1 .
AY339410 Genomic DNA. Translation: AAP89141.1 .
AY339411 Genomic DNA. Translation: AAP89154.1 .
AY339412 Genomic DNA. Translation: AAP89167.1 .
AY339413 Genomic DNA. Translation: AAP89180.1 .
AY339414 Genomic DNA. Translation: AAP89193.1 .
AY339415 Genomic DNA. Translation: AAP89206.1 .
AY339416 Genomic DNA. Translation: AAP89219.1 .
AY339417 Genomic DNA. Translation: AAP89232.1 .
AY339418 Genomic DNA. Translation: AAP89245.1 .
AY339419 Genomic DNA. Translation: AAP89258.1 .
AY339420 Genomic DNA. Translation: AAP89271.1 .
AY339421 Genomic DNA. Translation: AAP89284.1 .
AY339422 Genomic DNA. Translation: AAP89297.1 .
AY339423 Genomic DNA. Translation: AAP89310.1 .
AY339424 Genomic DNA. Translation: AAP89323.1 .
AY339425 Genomic DNA. Translation: AAP89336.1 .
AY339426 Genomic DNA. Translation: AAP89349.1 .
AY339427 Genomic DNA. Translation: AAP89362.1 .
AY339428 Genomic DNA. Translation: AAP89375.1 .
AY339429 Genomic DNA. Translation: AAP89388.1 .
AY339430 Genomic DNA. Translation: AAP89401.1 .
AY339431 Genomic DNA. Translation: AAP89414.1 .
AY339432 Genomic DNA. Translation: AAP89427.1 .
AY339433 Genomic DNA. Translation: AAP89440.1 .
AY339446 Genomic DNA. Translation: AAP89609.1 .
AY339447 Genomic DNA. Translation: AAP89622.1 .
AY339448 Genomic DNA. Translation: AAP89635.1 .
AY339449 Genomic DNA. Translation: AAP89648.1 .
AY339450 Genomic DNA. Translation: AAP89661.1 .
AY339451 Genomic DNA. Translation: AAP89674.1 .
AY339452 Genomic DNA. Translation: AAP89687.1 .
AY339453 Genomic DNA. Translation: AAP89700.1 .
AY339454 Genomic DNA. Translation: AAP89713.1 .
AY339455 Genomic DNA. Translation: AAP89726.1 .
AY339456 Genomic DNA. Translation: AAP89739.1 .
AY339457 Genomic DNA. Translation: AAP89752.1 .
AY339458 Genomic DNA. Translation: AAP89765.1 .
AY339459 Genomic DNA. Translation: AAP89778.1 .
AY339497 Genomic DNA. Translation: AAP90272.1 .
AY339498 Genomic DNA. Translation: AAP90285.1 .
AY339499 Genomic DNA. Translation: AAP90298.1 .
AY339500 Genomic DNA. Translation: AAP90311.1 .
AY339501 Genomic DNA. Translation: AAP90324.1 .
AY339502 Genomic DNA. Translation: AAP90337.1 .
AY339503 Genomic DNA. Translation: AAP90350.1 .
AY339504 Genomic DNA. Translation: AAP90363.1 .
AY339505 Genomic DNA. Translation: AAP90376.1 .
AY339506 Genomic DNA. Translation: AAP90389.1 .
AY339507 Genomic DNA. Translation: AAP90402.1 .
AY339508 Genomic DNA. Translation: AAP90415.1 .
AY339509 Genomic DNA. Translation: AAP90428.1 .
AY339510 Genomic DNA. Translation: AAP90441.1 .
AY339511 Genomic DNA. Translation: AAP90454.1 .
AY339512 Genomic DNA. Translation: AAP90467.1 .
AY339513 Genomic DNA. Translation: AAP90480.1 .
AY339514 Genomic DNA. Translation: AAP90493.1 .
AY339515 Genomic DNA. Translation: AAP90506.1 .
AY339516 Genomic DNA. Translation: AAP90519.1 .
AY339517 Genomic DNA. Translation: AAP90532.1 .
AY339518 Genomic DNA. Translation: AAP90545.1 .
AY339519 Genomic DNA. Translation: AAP90558.1 .
AY339520 Genomic DNA. Translation: AAP90571.1 .
AY339521 Genomic DNA. Translation: AAP90584.1 .
AY339522 Genomic DNA. Translation: AAP90597.1 .
AY339523 Genomic DNA. Translation: AAP90610.1 .
AY339524 Genomic DNA. Translation: AAP90623.1 .
AY339525 Genomic DNA. Translation: AAP90636.1 .
AY339526 Genomic DNA. Translation: AAP90649.1 .
AY339527 Genomic DNA. Translation: AAP90662.1 .
AY339528 Genomic DNA. Translation: AAP90675.1 .
AY339529 Genomic DNA. Translation: AAP90688.1 .
AY339530 Genomic DNA. Translation: AAP90701.1 .
AY339531 Genomic DNA. Translation: AAP90714.1 .
AY339532 Genomic DNA. Translation: AAP90727.1 .
AY339533 Genomic DNA. Translation: AAP90740.1 .
AY339534 Genomic DNA. Translation: AAP90753.1 .
AY339535 Genomic DNA. Translation: AAP90766.1 .
AY339536 Genomic DNA. Translation: AAP90779.1 .
AY339537 Genomic DNA. Translation: AAP90792.1 .
AY339538 Genomic DNA. Translation: AAP90805.1 .
AY339539 Genomic DNA. Translation: AAP90818.1 .
AY339540 Genomic DNA. Translation: AAP90831.1 .
AY339541 Genomic DNA. Translation: AAP90844.1 .
AY339542 Genomic DNA. Translation: AAP90857.1 .
AY339543 Genomic DNA. Translation: AAP90870.1 .
AY339545 Genomic DNA. Translation: AAP90896.1 .
AY339546 Genomic DNA. Translation: AAP90909.1 .
AY339547 Genomic DNA. Translation: AAP90922.1 .
AY339548 Genomic DNA. Translation: AAP90935.1 .
AY339549 Genomic DNA. Translation: AAP90948.1 .
AY339550 Genomic DNA. Translation: AAP90961.1 .
AY339551 Genomic DNA. Translation: AAP90974.1 .
AY339552 Genomic DNA. Translation: AAP90987.1 .
AY339553 Genomic DNA. Translation: AAP91000.1 .
AY339554 Genomic DNA. Translation: AAP91013.1 .
AY339555 Genomic DNA. Translation: AAP91026.1 .
AY339556 Genomic DNA. Translation: AAP91039.1 .
AY339557 Genomic DNA. Translation: AAP91052.1 .
AY339558 Genomic DNA. Translation: AAP91065.1 .
AY339559 Genomic DNA. Translation: AAP91078.1 .
AY339560 Genomic DNA. Translation: AAP91091.1 .
AY339561 Genomic DNA. Translation: AAP91104.1 .
AY339562 Genomic DNA. Translation: AAP91117.1 .
AY339563 Genomic DNA. Translation: AAP91130.1 .
AY339564 Genomic DNA. Translation: AAP91143.1 .
AY339565 Genomic DNA. Translation: AAP91156.1 .
AY339577 Genomic DNA. Translation: AAP91312.1 .
AY339578 Genomic DNA. Translation: AAP91325.1 .
AY339579 Genomic DNA. Translation: AAP91338.1 .
AY339580 Genomic DNA. Translation: AAP91351.1 .
AY339583 Genomic DNA. Translation: AAP91390.1 .
AY339584 Genomic DNA. Translation: AAP91403.1 .
AY339585 Genomic DNA. Translation: AAP91416.1 .
AY339586 Genomic DNA. Translation: AAP91429.1 .
AY339587 Genomic DNA. Translation: AAP91442.1 .
AY339588 Genomic DNA. Translation: AAP91455.1 .
AY339589 Genomic DNA. Translation: AAP91468.1 .
AY339590 Genomic DNA. Translation: AAP91481.1 .
AY339591 Genomic DNA. Translation: AAP91494.1 .
AY339592 Genomic DNA. Translation: AAP91507.1 .
AY339593 Genomic DNA. Translation: AAP91520.1 .
AF346963 Genomic DNA. Translation: AAK17208.1 .
AF346964 Genomic DNA. Translation: AAK17221.1 .
AF346965 Genomic DNA. Translation: AAK17234.1 .
AF346968 Genomic DNA. Translation: AAK17273.1 .
AF346970 Genomic DNA. Translation: AAK17299.1 .
AF346974 Genomic DNA. Translation: AAK17351.1 .
AF346975 Genomic DNA. Translation: AAK17364.1 .
AF346976 Genomic DNA. Translation: AAK17377.1 .
AF346977 Genomic DNA. Translation: AAK17390.1 .
AF346978 Genomic DNA. Translation: AAK17403.1 .
AF346979 Genomic DNA. Translation: AAK17416.1 .
AF346980 Genomic DNA. Translation: AAK17429.1 .
AF346981 Genomic DNA. Translation: AAK17442.1 .
AF346983 Genomic DNA. Translation: AAK17468.1 .
AF346988 Genomic DNA. Translation: AAK17533.1 .
AF346991 Genomic DNA. Translation: AAK17572.1 .
AF346992 Genomic DNA. Translation: AAK17585.1 .
AF346994 Genomic DNA. Translation: AAK17611.1 .
AF346995 Genomic DNA. Translation: AAK17624.1 .
AF346997 Genomic DNA. Translation: AAK17650.1 .
AF347000 Genomic DNA. Translation: AAK17689.1 .
AF347001 Genomic DNA. Translation: AAK17702.1 .
AF347002 Genomic DNA. Translation: AAK17715.1 .
AF347004 Genomic DNA. Translation: AAK17741.1 .
AF347005 Genomic DNA. Translation: AAK17754.1 .
AF347006 Genomic DNA. Translation: AAK17767.1 .
AF347007 Genomic DNA. Translation: AAK17780.1 .
AF347011 Genomic DNA. Translation: AAK17832.1 .
AF347012 Genomic DNA. Translation: AAK17845.1 .
AF347013 Genomic DNA. Translation: AAK17858.1 .
AF347014 Genomic DNA. Translation: AAK17871.1 .
AF347015 Genomic DNA. Translation: AAK17884.1 .
AY289051 Genomic DNA. Translation: AAP47881.1 .
AY289053 Genomic DNA. Translation: AAP47907.1 .
AY289054 Genomic DNA. Translation: AAP47920.1 .
AY289055 Genomic DNA. Translation: AAP47933.1 .
AY289057 Genomic DNA. Translation: AAP47959.1 .
AY289061 Genomic DNA. Translation: AAP48011.1 .
AY289062 Genomic DNA. Translation: AAP48024.1 .
AY289063 Genomic DNA. Translation: AAP48037.1 .
AY289065 Genomic DNA. Translation: AAP48063.1 .
AY289068 Genomic DNA. Translation: AAP48102.1 .
AY289069 Genomic DNA. Translation: AAP48115.1 .
AY289071 Genomic DNA. Translation: AAP48141.1 .
AY289072 Genomic DNA. Translation: AAP48154.1 .
AY289073 Genomic DNA. Translation: AAP48167.1 .
AY289074 Genomic DNA. Translation: AAP48180.1 .
AY289076 Genomic DNA. Translation: AAP48206.1 .
AY289077 Genomic DNA. Translation: AAP48219.1 .
AY289079 Genomic DNA. Translation: AAP48245.1 .
AY289083 Genomic DNA. Translation: AAP48297.1 .
AY289084 Genomic DNA. Translation: AAP48310.1 .
AY289086 Genomic DNA. Translation: AAP48336.1 .
AY289087 Genomic DNA. Translation: AAP48349.1 .
AY289088 Genomic DNA. Translation: AAP48362.1 .
AY289089 Genomic DNA. Translation: AAP48375.1 .
AY289091 Genomic DNA. Translation: AAP48401.1 .
AY289092 Genomic DNA. Translation: AAP48414.1 .
AY289094 Genomic DNA. Translation: AAP48439.1 .
AY289099 Genomic DNA. Translation: AAP48504.1 .
AY289100 Genomic DNA. Translation: AAP48517.1 .
AY289101 Genomic DNA. Translation: AAP48530.1 .
AY289102 Genomic DNA. Translation: AAP48543.1 .
AY495090 Genomic DNA. Translation: AAR92497.1 .
AY495091 Genomic DNA. Translation: AAR92510.1 .
AY495092 Genomic DNA. Translation: AAR92523.1 .
AY495093 Genomic DNA. Translation: AAR92536.1 .
AY495095 Genomic DNA. Translation: AAR92562.1 .
AY495096 Genomic DNA. Translation: AAR92575.1 .
AY495097 Genomic DNA. Translation: AAR92588.1 .
AY495098 Genomic DNA. Translation: AAR92601.1 .
AY495099 Genomic DNA. Translation: AAR92614.1 .
AY495100 Genomic DNA. Translation: AAR92627.1 .
AY495101 Genomic DNA. Translation: AAR92640.1 .
AY495102 Genomic DNA. Translation: AAR92653.1 .
AY495103 Genomic DNA. Translation: AAR92666.1 .
AY495104 Genomic DNA. Translation: AAR92679.1 .
AY495105 Genomic DNA. Translation: AAR92692.1 .
AY495106 Genomic DNA. Translation: AAR92705.1 .
AY495107 Genomic DNA. Translation: AAR92718.1 .
AY495108 Genomic DNA. Translation: AAR92731.1 .
AY495109 Genomic DNA. Translation: AAR92744.1 .
AY495110 Genomic DNA. Translation: AAR92757.1 .
AY495111 Genomic DNA. Translation: AAR92770.1 .
AY495113 Genomic DNA. Translation: AAR92796.1 .
AY495114 Genomic DNA. Translation: AAR92809.1 .
AY495115 Genomic DNA. Translation: AAR92822.1 .
AY495116 Genomic DNA. Translation: AAR92835.1 .
AY495117 Genomic DNA. Translation: AAR92848.1 .
AY495118 Genomic DNA. Translation: AAR92861.1 .
AY495119 Genomic DNA. Translation: AAR92874.1 .
AY495120 Genomic DNA. Translation: AAR92887.1 .
AY495121 Genomic DNA. Translation: AAR92900.1 .
AY495122 Genomic DNA. Translation: AAR92913.1 .
AY495123 Genomic DNA. Translation: AAR92926.1 .
AY495124 Genomic DNA. Translation: AAR92939.1 .
AY495125 Genomic DNA. Translation: AAR92952.1 .
AY495126 Genomic DNA. Translation: AAR92965.1 .
AY495127 Genomic DNA. Translation: AAR92978.1 .
AY495128 Genomic DNA. Translation: AAR92991.1 .
AY495129 Genomic DNA. Translation: AAR93004.1 .
AY495130 Genomic DNA. Translation: AAR93017.1 .
AY495131 Genomic DNA. Translation: AAR93030.1 .
AY495132 Genomic DNA. Translation: AAR93043.1 .
AY495133 Genomic DNA. Translation: AAR93056.1 .
AY495135 Genomic DNA. Translation: AAR93082.1 .
AY495136 Genomic DNA. Translation: AAR93095.1 .
AY495137 Genomic DNA. Translation: AAR93108.1 .
AY495138 Genomic DNA. Translation: AAR93121.1 .
AY495139 Genomic DNA. Translation: AAR93134.1 .
AY495140 Genomic DNA. Translation: AAR93147.1 .
AY495141 Genomic DNA. Translation: AAR93160.1 .
AY495142 Genomic DNA. Translation: AAR93173.1 .
AY495143 Genomic DNA. Translation: AAR93186.1 .
AY495144 Genomic DNA. Translation: AAR93199.1 .
AY495145 Genomic DNA. Translation: AAR93212.1 .
AY495146 Genomic DNA. Translation: AAR93225.1 .
AY495147 Genomic DNA. Translation: AAR93238.1 .
AY495148 Genomic DNA. Translation: AAR93251.1 .
AY495149 Genomic DNA. Translation: AAR93264.1 .
AY495150 Genomic DNA. Translation: AAR93277.1 .
AY495151 Genomic DNA. Translation: AAR93290.1 .
AY495152 Genomic DNA. Translation: AAR93303.1 .
AY495153 Genomic DNA. Translation: AAR93316.1 .
AY495154 Genomic DNA. Translation: AAR93329.1 .
AY495155 Genomic DNA. Translation: AAR93342.1 .
AY495156 Genomic DNA. Translation: AAR93355.1 .
AY495157 Genomic DNA. Translation: AAR93368.1 .
AY495158 Genomic DNA. Translation: AAR93381.1 .
AY495159 Genomic DNA. Translation: AAR93394.1 .
AY495160 Genomic DNA. Translation: AAR93407.1 .
AY495161 Genomic DNA. Translation: AAR93420.1 .
AY495162 Genomic DNA. Translation: AAR93433.1 .
AY495163 Genomic DNA. Translation: AAR93446.1 .
AY495164 Genomic DNA. Translation: AAR93459.1 .
AY495165 Genomic DNA. Translation: AAR93472.1 .
AY495166 Genomic DNA. Translation: AAR93485.1 .
AY495167 Genomic DNA. Translation: AAR93498.1 .
AY495168 Genomic DNA. Translation: AAR93511.1 .
AY495169 Genomic DNA. Translation: AAR93524.1 .
AY495170 Genomic DNA. Translation: AAR93537.1 .
AY495171 Genomic DNA. Translation: AAR93550.1 .
AY495172 Genomic DNA. Translation: AAR93563.1 .
AY495173 Genomic DNA. Translation: AAR93576.1 .
AY495174 Genomic DNA. Translation: AAR93589.1 .
AY495175 Genomic DNA. Translation: AAR93602.1 .
AY495176 Genomic DNA. Translation: AAR93615.1 .
AY495177 Genomic DNA. Translation: AAR93628.1 .
AY495178 Genomic DNA. Translation: AAR93641.1 .
AY495179 Genomic DNA. Translation: AAR93654.1 .
AY495180 Genomic DNA. Translation: AAR93667.1 .
AY495181 Genomic DNA. Translation: AAR93680.1 .
AY495182 Genomic DNA. Translation: AAR93693.1 .
AY495183 Genomic DNA. Translation: AAR93706.1 .
AY495184 Genomic DNA. Translation: AAR93719.1 .
AY495185 Genomic DNA. Translation: AAR93732.1 .
AY495186 Genomic DNA. Translation: AAR93745.1 .
AY495187 Genomic DNA. Translation: AAR93758.1 .
AY495188 Genomic DNA. Translation: AAR93771.1 .
AY495190 Genomic DNA. Translation: AAR93797.1 .
AY495191 Genomic DNA. Translation: AAR93810.1 .
AY495192 Genomic DNA. Translation: AAR93823.1 .
AY495194 Genomic DNA. Translation: AAR93849.1 .
AY495195 Genomic DNA. Translation: AAR93862.1 .
AY495196 Genomic DNA. Translation: AAR93875.1 .
AY495197 Genomic DNA. Translation: AAR93888.1 .
AY495198 Genomic DNA. Translation: AAR93901.1 .
AY495199 Genomic DNA. Translation: AAR93914.1 .
AY495200 Genomic DNA. Translation: AAR93927.1 .
AY495201 Genomic DNA. Translation: AAR93940.1 .
AY495202 Genomic DNA. Translation: AAR93953.1 .
AY495203 Genomic DNA. Translation: AAR93966.1 .
AY495204 Genomic DNA. Translation: AAR93979.1 .
AY495205 Genomic DNA. Translation: AAR93992.1 .
AY495206 Genomic DNA. Translation: AAR94005.1 .
AY495207 Genomic DNA. Translation: AAR94018.1 .
AY495208 Genomic DNA. Translation: AAR94031.1 .
AY495209 Genomic DNA. Translation: AAR94044.1 .
AY495210 Genomic DNA. Translation: AAR94057.1 .
AY495211 Genomic DNA. Translation: AAR94070.1 .
AY495212 Genomic DNA. Translation: AAR94083.1 .
AY495213 Genomic DNA. Translation: AAR94096.1 .
AY495215 Genomic DNA. Translation: AAR94122.1 .
AY495216 Genomic DNA. Translation: AAR94135.1 .
AY495217 Genomic DNA. Translation: AAR94148.1 .
AY495218 Genomic DNA. Translation: AAR94161.1 .
AY495219 Genomic DNA. Translation: AAR94174.1 .
AY495220 Genomic DNA. Translation: AAR94187.1 .
AY495221 Genomic DNA. Translation: AAR94200.1 .
AY495222 Genomic DNA. Translation: AAR94213.1 .
AY495223 Genomic DNA. Translation: AAR94226.1 .
AY495224 Genomic DNA. Translation: AAR94239.1 .
AY495225 Genomic DNA. Translation: AAR94252.1 .
AY495226 Genomic DNA. Translation: AAR94265.1 .
AY495227 Genomic DNA. Translation: AAR94278.1 .
AY495228 Genomic DNA. Translation: AAR94291.1 .
AY495229 Genomic DNA. Translation: AAR94304.1 .
AY495230 Genomic DNA. Translation: AAR94317.1 .
AY495243 Genomic DNA. Translation: AAR94486.1 .
AY495245 Genomic DNA. Translation: AAR94512.1 .
AY495250 Genomic DNA. Translation: AAR94577.1 .
AY495251 Genomic DNA. Translation: AAR94590.1 .
AY495253 Genomic DNA. Translation: AAR94616.1 .
AY495254 Genomic DNA. Translation: AAR94629.1 .
AY495255 Genomic DNA. Translation: AAR94642.1 .
AY495256 Genomic DNA. Translation: AAR94655.1 .
AY495258 Genomic DNA. Translation: AAR94681.1 .
AY495259 Genomic DNA. Translation: AAR94694.1 .
AY495260 Genomic DNA. Translation: AAR94707.1 .
AY495261 Genomic DNA. Translation: AAR94720.1 .
AY495262 Genomic DNA. Translation: AAR94733.1 .
AY495263 Genomic DNA. Translation: AAR94746.1 .
AY495264 Genomic DNA. Translation: AAR94759.1 .
AY495265 Genomic DNA. Translation: AAR94772.1 .
AY495266 Genomic DNA. Translation: AAR94785.1 .
AY495306 Genomic DNA. Translation: AAR95305.1 .
AY495307 Genomic DNA. Translation: AAR95318.1 .
AY495308 Genomic DNA. Translation: AAR95331.1 .
AY495309 Genomic DNA. Translation: AAR95344.1 .
AY495310 Genomic DNA. Translation: AAR95357.1 .
AY495311 Genomic DNA. Translation: AAR95370.1 .
AY495312 Genomic DNA. Translation: AAR95383.1 .
AY495313 Genomic DNA. Translation: AAR95396.1 .
AY495314 Genomic DNA. Translation: AAR95409.1 .
AY495315 Genomic DNA. Translation: AAR95422.1 .
AY495316 Genomic DNA. Translation: AAR95435.1 .
AY495317 Genomic DNA. Translation: AAR95448.1 .
AY495318 Genomic DNA. Translation: AAR95461.1 .
AY495319 Genomic DNA. Translation: AAR95474.1 .
AY495320 Genomic DNA. Translation: AAR95487.1 .
AY495321 Genomic DNA. Translation: AAR95500.1 .
AY495322 Genomic DNA. Translation: AAR95513.1 .
AY495323 Genomic DNA. Translation: AAR95526.1 .
AY495326 Genomic DNA. Translation: AAR95565.1 .
AY495327 Genomic DNA. Translation: AAR95578.1 .
AY495328 Genomic DNA. Translation: AAR95591.1 .
AY495329 Genomic DNA. Translation: AAR95604.1 .
AY495330 Genomic DNA. Translation: AAR95617.1 .
AY495302 Genomic DNA. Translation: AAR95253.1 .
PIRi A00414. DNHUN2.
RefSeqi YP_003024027.1. NC_012920.1.

3D structure databases

ProteinModelPortali P03891.
SMRi P03891. Positions 8-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110632. 4 interactions.

Chemistry

BindingDBi P03891.
ChEMBLi CHEMBL2363065.

PTM databases

PhosphoSitei P03891.

Polymorphism databases

DMDMi 128676.

Proteomic databases

MaxQBi P03891.
PaxDbi P03891.
PRIDEi P03891.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361453 ; ENSP00000355046 ; ENSG00000198763 .
GeneIDi 4536.
KEGGi hsa:4536.

Organism-specific databases

CTDi 4536.
GeneCardsi GCMTP004472.
GeneReviewsi MT-ND2.
HGNCi HGNC:7456. MT-ND2.
MIMi 502500. phenotype.
516001. gene.
535000. phenotype.
neXtProti NX_P03891.
Orphaneti 2609. Isolated NADH-CoQ reductase deficiency.
104. Leber hereditary optic neuropathy.
255210. Maternally-inherited Leigh syndrome.
PharmGKBi PA31260.
GenAtlasi Search...

Phylogenomic databases

eggNOGi KOG4668.
HOGENOMi HOG000113879.
HOVERGENi HBG016692.
InParanoidi P03891.
KOi K03879.
OMAi KLGMAPF.
OrthoDBi EOG78D7MF.
PhylomeDBi P03891.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

GeneWikii MT-ND2.
GenomeRNAii 4536.
NextBioi 17499.
PROi P03891.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi P03891. baseline.
Genevestigatori P03891.

Family and domain databases

InterProi IPR010933. NADH_DH_su2_C.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003917. NADH_UbQ_OxRdtase_chain2.
[Graphical view ]
Pfami PF06444. NADH_dehy_S2_C. 1 hit.
PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
PRINTSi PR01436. NADHDHGNASE2.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing."
    Sanger F., Coulson A.R., Barrell B.G., Smith A.J.H., Roe B.A.
    J. Mol. Biol. 143:161-178(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Departure from neutrality at the mitochondrial NADH dehydrogenase subunit 2 gene in humans, but not in chimpanzees."
    Wise C.A., Sraml M., Easteal S.
    Genetics 148:409-421(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-69; SER-88; ASP-150; MET-237; THR-265; VAL-265; THR-278 AND ALA-333.
  4. "Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs."
    Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.
    Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-43; LEU-325 AND THR-331.
    Tissue: Placenta.
  5. "Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J."
    Moilanen J.S., Finnila S., Majamaa K.
    Mol. Biol. Evol. 20:2132-2142(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Mitochondrial genome variation and the origin of modern humans."
    Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.
    Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines."
    Ingman M., Gyllensten U.
    Genome Res. 13:1600-1606(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. "Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians."
    Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T., Irwin J.A., Parsons T.J.
    Int. J. Legal Med. 118:137-146(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  9. "Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase."
    Chomyn A., Mariottini P., Cleeter M.W.J., Ragan C.I., Matsuno-Yagi A., Hatefi Y., Doolittle R.F., Attardi G.
    Nature 314:592-597(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROTEIN.
  10. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
    Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
    J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  11. "Alternative, simultaneous complex I mitochondrial DNA mutations in Leber's hereditary optic neuropathy."
    Johns D.R., Berman J.
    Biochem. Biophys. Res. Commun. 174:1324-1330(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LHON ASP-150.
  12. "Normal variants of human mitochondrial DNA and translation products: the building of a reference data base."
    Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R., Utthanaphol P., Byrne E.
    Hum. Genet. 88:139-145(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LEU-42; ARG-63; ALA-119; PRO-148; SER-150; THR-159 AND ALA-185.
  13. "Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy."
    Brown M.D., Voljavec A.S., Lott M.T., Torroni A., Yang C.C., Wallace D.C.
    Genetics 130:163-173(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LHON SER-259.
  14. "Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains."
    Lin F.-H., Lin R., Wisniewski H.M., Hwang Y.-W., Grundke-Iqbal I., Healy-Louie G., Iqbal K.
    Biochem. Biophys. Res. Commun. 182:238-246(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AD-MT SER-331.
  15. "Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome."
    Rieder M.J., Taylor S.L., Tobe V.O., Nickerson D.A.
    Nucleic Acids Res. 26:967-973(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT THR-57.

Entry informationi

Entry nameiNU2M_HUMAN
AccessioniPrimary (citable) accession number: P03891
Secondary accession number(s): Q34769
, Q9TGI0, Q9TGI1, Q9TGI2, Q9TGI3, Q9TGI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 1, 1992
Last modified: October 29, 2014
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3