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Protein

NADH-ubiquinone oxidoreductase chain 1

Gene

Mtnd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 1 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 1
Gene namesi
Name:Mtnd1
Synonyms:mt-Nd1, Nd1
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:101787 mt-Nd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001174311 – 318NADH-ubiquinone oxidoreductase chain 1Add BLAST318

Proteomic databases

EPDiP03888
PaxDbiP03888
PRIDEiP03888

Expressioni

Gene expression databases

BgeeiENSMUSG00000064341
ExpressionAtlasiP03888 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi201547, 2 interactors
CORUMiP03888
DIPiDIP-61655N
IntActiP03888, 2 interactors
STRINGi10090.ENSMUSP00000080991

Structurei

3D structure databases

ProteinModelPortaliP03888
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4770 Eukaryota
COG1005 LUCA
GeneTreeiENSGT00390000006621
HOGENOMiHOG000228276
HOVERGENiHBG016682
InParanoidiP03888
KOiK03878
OMAiWNIWRQP
OrthoDBiEOG091G0F0D
PhylomeDBiP03888

Family and domain databases

HAMAPiMF_01350 NDH1_NuoH, 1 hit
InterProiView protein in InterPro
IPR001694 NADH_UbQ_OxRdtase_su1/FPO
IPR018086 NADH_UbQ_OxRdtase_su1_CS
PANTHERiPTHR11432 PTHR11432, 1 hit
PfamiView protein in Pfam
PF00146 NADHdh, 1 hit
PROSITEiView protein in PROSITE
PS00667 COMPLEX1_ND1_1, 1 hit
PS00668 COMPLEX1_ND1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P03888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFINILTLL VPILIAMAFL TLVERKILGY MQLRKGPNIV GPYGILQPFA
60 70 80 90 100
DAMKLFMKEP MRPLTTSMSL FIIAPTLSLT LALSLWVPLP MPHPLINLNL
110 120 130 140 150
GILFILATSS LSVYSILWSG WASNSKYSLF GALRAVAQTI SYEVTMAIIL
160 170 180 190 200
LSVLLMNGSY SLQTLITTQE HMWLLLPAWP MAMMWFISTL AETNRAPFDL
210 220 230 240 250
TEGESELVSG FNVEYAAGPF ALFFMAEYTN IILMNALTTI IFLGPLYYIN
260 270 280 290 300
LPELYSTNFM MEALLLSSTF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL
310
CMWHISLPIF TAGVPPYM
Length:318
Mass (Da):36,059
Last modified:January 4, 2005 - v3
Checksum:iECFAB96696610024
GO

Sequence cautioni

The sequence AAB48644 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA24080 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00711 Genomic DNA Translation: CAA24080.1 Different initiation.
J01420 Genomic DNA Translation: AAB48644.1 Different initiation.
AB042523 Genomic DNA Translation: BAA95653.2
AB042524 Genomic DNA Translation: BAA95640.2
AB042809 Genomic DNA Translation: BAA95795.2
AB049357 Genomic DNA Translation: BAB13801.2
AJ512208 Genomic DNA Translation: CAD54432.1
AY172335 Genomic DNA Translation: AAN85122.1
AY339599 Genomic DNA Translation: AAP89023.2
AJ489607 Genomic DNA Translation: CAD33907.1
AY533105 Genomic DNA Translation: AAS01439.1
AY533106 Genomic DNA Translation: AAS01452.1
AY533107 Genomic DNA Translation: AAS01465.1
AY533108 Genomic DNA Translation: AAS01478.1
PIRiA00409 QXMS1M
RefSeqiNP_904328.1, NC_005089.1
YP_220550.1, NC_006914.1

Genome annotation databases

EnsembliENSMUST00000082392; ENSMUSP00000080991; ENSMUSG00000064341
GeneIDi17716
3338902
KEGGimmu:17716

Similar proteinsi

Entry informationi

Entry nameiNU1M_MOUSE
AccessioniPrimary (citable) accession number: P03888
Secondary accession number(s): Q9G0S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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