P03888 (NU1M_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-ubiquinone oxidoreductase chain 1
EC=1.6.5.3

Alternative name(s):
NADH dehydrogenase subunit 1

Gene names

Name:	Mtnd1
Synonyms:	mt-Nd1, Nd1

Encoded on

Mitochondrion

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 1 family.
Sequence caution	The sequence AAB48644.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA24080.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain complex I Inferred from electronic annotation. Source: Compara mitochondrion Inferred from direct assay PubMed 18614015. Source: MGI
Molecular_function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	NADH-ubiquinone oxidoreductase chain 1		PRO_0000117431
Regions
	Transmembrane	2 – 22	21	Helical; Potential
	Transmembrane	70 – 90	21	Helical; Potential
	Transmembrane	100 – 120	21	Helical; Potential
	Transmembrane	136 – 156	21	Helical; Potential
	Transmembrane	171 – 191	21	Helical; Potential
	Transmembrane	231 – 251	21	Helical; Potential
	Transmembrane	253 – 273	21	Helical; Potential
	Transmembrane	293 – 313	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P03888 [UniParc]. Last modified January 4, 2005. Version 3. Checksum: ECFAB96696610024	FASTA	318	36,059
	10 20 30 40 50 60 MFFINILTLL VPILIAMAFL TLVERKILGY MQLRKGPNIV GPYGILQPFA DAMKLFMKEP 70 80 90 100 110 120 MRPLTTSMSL FIIAPTLSLT LALSLWVPLP MPHPLINLNL GILFILATSS LSVYSILWSG 130 140 150 160 170 180 WASNSKYSLF GALRAVAQTI SYEVTMAIIL LSVLLMNGSY SLQTLITTQE HMWLLLPAWP 190 200 210 220 230 240 MAMMWFISTL AETNRAPFDL TEGESELVSG FNVEYAAGPF ALFFMAEYTN IILMNALTTI 250 260 270 280 290 300 IFLGPLYYIN LPELYSTNFM MEALLLSSTF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL 310 CMWHISLPIF TAGVPPYM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and gene organization of mouse mitochondrial DNA." Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A. Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains." Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M. J. Hered. 92:352-355(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C3H/He, SAMP1, SAMP8 and SAMR1. Tissue: Liver.
[3]	"The ALR/Lt mouse: contribution of the mitochondrial genome in resistance against both chemically-induced and autoimmune diabetes." Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., Fischel-Ghodsian N. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ALR/Lt, ALS/Lt, NOD/LtJ and NON/Lt.
[4]	"Revisiting the mouse mitochondrial DNA sequence." Bayona-Bafaluy M.P., Acin-Perez R., Mullikin J.C., Park J.S., Moreno-Loshuertos R., Hu P., Perez-Martos A., Fernandez-Silva P., Bai Y., Enriquez J.A. Nucleic Acids Res. 31:5349-5355(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BALB/cJ, C3H/An and C57BL/6J. Tissue: Fibroblast and Platelet.
[5]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 27-54 AND 127-134, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V00711 Genomic DNA. Translation: CAA24080.1. Different initiation. J01420 Genomic DNA. Translation: AAB48644.1. Different initiation. AB042523 Genomic DNA. Translation: BAA95653.2. AB042524 Genomic DNA. Translation: BAA95640.2. AB042809 Genomic DNA. Translation: BAA95795.2. AB049357 Genomic DNA. Translation: BAB13801.2. AJ512208 Genomic DNA. Translation: CAD54432.1. AY172335 Genomic DNA. Translation: AAN85122.1. AY339599 Genomic DNA. Translation: AAP89023.2. AJ489607 Genomic DNA. Translation: CAD33907.1. AY533105 Genomic DNA. Translation: AAS01439.1. AY533106 Genomic DNA. Translation: AAS01452.1. AY533107 Genomic DNA. Translation: AAS01465.1. AY533108 Genomic DNA. Translation: AAS01478.1.
IPI	IPI00341550.
PIR	QXMS1M. A00409.
RefSeq	NP_904328.1. NC_005089.1.
3D structure databases
ProteinModelPortal	P03888.
ModBase	Search...
Protein-protein interaction databases
IntAct	P03888. 1 interaction.
Proteomic databases
PaxDb	P03888.
PRIDE	P03888.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000082392; ENSMUSP00000080991; ENSMUSG00000064341.
GeneID	17716.
KEGG	mmu:17716.
Organism-specific databases
CTD	4535.
MGI	MGI:101787. mt-Nd1.
Phylogenomic databases
eggNOG	COG1005.
HOGENOM	HOG000228276.
HOVERGEN	HBG016682.
InParanoid	P03888.
KO	K03878.
OrthoDB	EOG40VVQB.
ProtClustDB	MTH00104.
Gene expression databases
Genevestigator	P03888.
Family and domain databases
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1/FPO. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. PTHR11432. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	292332.
SOURCE	Search...

Entry information

Entry name

NU1M_MOUSE

Accession

Primary (citable) accession number: P03888
Secondary accession number(s): Q9G0S6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 4, 2005
Last modified:	April 3, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program