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Protein

NADH-ubiquinone oxidoreductase chain 1

Gene

Mtnd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 1 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 1
Gene namesi
Name:Mtnd1
Synonyms:mt-Nd1, Nd1
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:101787. mt-Nd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001174311 – 318NADH-ubiquinone oxidoreductase chain 1Add BLAST318

Proteomic databases

EPDiP03888.
PaxDbiP03888.
PRIDEiP03888.

Expressioni

Gene expression databases

BgeeiENSMUSG00000064341.
ExpressionAtlasiP03888. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi201547. 1 interactor.
DIPiDIP-61655N.
IntActiP03888. 1 interactor.
STRINGi10090.ENSMUSP00000080991.

Structurei

3D structure databases

ProteinModelPortaliP03888.
SMRiP03888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4770. Eukaryota.
COG1005. LUCA.
GeneTreeiENSGT00390000006621.
HOGENOMiHOG000228276.
HOVERGENiHBG016682.
InParanoidiP03888.
KOiK03878.
OMAiLDLGWKF.
OrthoDBiEOG091G0F0D.
PhylomeDBiP03888.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH. 1 hit.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFINILTLL VPILIAMAFL TLVERKILGY MQLRKGPNIV GPYGILQPFA
60 70 80 90 100
DAMKLFMKEP MRPLTTSMSL FIIAPTLSLT LALSLWVPLP MPHPLINLNL
110 120 130 140 150
GILFILATSS LSVYSILWSG WASNSKYSLF GALRAVAQTI SYEVTMAIIL
160 170 180 190 200
LSVLLMNGSY SLQTLITTQE HMWLLLPAWP MAMMWFISTL AETNRAPFDL
210 220 230 240 250
TEGESELVSG FNVEYAAGPF ALFFMAEYTN IILMNALTTI IFLGPLYYIN
260 270 280 290 300
LPELYSTNFM MEALLLSSTF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL
310
CMWHISLPIF TAGVPPYM
Length:318
Mass (Da):36,059
Last modified:January 4, 2005 - v3
Checksum:iECFAB96696610024
GO

Sequence cautioni

The sequence AAB48644 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA24080 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00711 Genomic DNA. Translation: CAA24080.1. Different initiation.
J01420 Genomic DNA. Translation: AAB48644.1. Different initiation.
AB042523 Genomic DNA. Translation: BAA95653.2.
AB042524 Genomic DNA. Translation: BAA95640.2.
AB042809 Genomic DNA. Translation: BAA95795.2.
AB049357 Genomic DNA. Translation: BAB13801.2.
AJ512208 Genomic DNA. Translation: CAD54432.1.
AY172335 Genomic DNA. Translation: AAN85122.1.
AY339599 Genomic DNA. Translation: AAP89023.2.
AJ489607 Genomic DNA. Translation: CAD33907.1.
AY533105 Genomic DNA. Translation: AAS01439.1.
AY533106 Genomic DNA. Translation: AAS01452.1.
AY533107 Genomic DNA. Translation: AAS01465.1.
AY533108 Genomic DNA. Translation: AAS01478.1.
PIRiA00409. QXMS1M.
RefSeqiNP_904328.1. NC_005089.1.
YP_220550.1. NC_006914.1.

Genome annotation databases

EnsembliENSMUST00000082392; ENSMUSP00000080991; ENSMUSG00000064341.
GeneIDi17716.
3338902.
KEGGimmu:17716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00711 Genomic DNA. Translation: CAA24080.1. Different initiation.
J01420 Genomic DNA. Translation: AAB48644.1. Different initiation.
AB042523 Genomic DNA. Translation: BAA95653.2.
AB042524 Genomic DNA. Translation: BAA95640.2.
AB042809 Genomic DNA. Translation: BAA95795.2.
AB049357 Genomic DNA. Translation: BAB13801.2.
AJ512208 Genomic DNA. Translation: CAD54432.1.
AY172335 Genomic DNA. Translation: AAN85122.1.
AY339599 Genomic DNA. Translation: AAP89023.2.
AJ489607 Genomic DNA. Translation: CAD33907.1.
AY533105 Genomic DNA. Translation: AAS01439.1.
AY533106 Genomic DNA. Translation: AAS01452.1.
AY533107 Genomic DNA. Translation: AAS01465.1.
AY533108 Genomic DNA. Translation: AAS01478.1.
PIRiA00409. QXMS1M.
RefSeqiNP_904328.1. NC_005089.1.
YP_220550.1. NC_006914.1.

3D structure databases

ProteinModelPortaliP03888.
SMRiP03888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201547. 1 interactor.
DIPiDIP-61655N.
IntActiP03888. 1 interactor.
STRINGi10090.ENSMUSP00000080991.

Proteomic databases

EPDiP03888.
PaxDbiP03888.
PRIDEiP03888.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082392; ENSMUSP00000080991; ENSMUSG00000064341.
GeneIDi17716.
3338902.
KEGGimmu:17716.

Organism-specific databases

CTDi4535.
MGIiMGI:101787. mt-Nd1.

Phylogenomic databases

eggNOGiKOG4770. Eukaryota.
COG1005. LUCA.
GeneTreeiENSGT00390000006621.
HOGENOMiHOG000228276.
HOVERGENiHBG016682.
InParanoidiP03888.
KOiK03878.
OMAiLDLGWKF.
OrthoDBiEOG091G0F0D.
PhylomeDBiP03888.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiP03888.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064341.
ExpressionAtlasiP03888. baseline and differential.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH. 1 hit.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU1M_MOUSE
AccessioniPrimary (citable) accession number: P03888
Secondary accession number(s): Q9G0S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 4, 2005
Last modified: November 30, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.