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P03888

- NU1M_MOUSE

UniProt

P03888 - NU1M_MOUSE

Protein

NADH-ubiquinone oxidoreductase chain 1

Gene

Mtnd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 1 (EC:1.6.5.3)
    Alternative name(s):
    NADH dehydrogenase subunit 1
    Gene namesi
    Name:Mtnd1
    Synonyms:mt-Nd1, Nd1
    Encoded oniMitochondrion
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Mitochondrion

    Organism-specific databases

    MGIiMGI:101787. mt-Nd1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex I Source: Ensembl
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318NADH-ubiquinone oxidoreductase chain 1PRO_0000117431Add
    BLAST

    Proteomic databases

    MaxQBiP03888.
    PaxDbiP03888.
    PRIDEiP03888.

    Expressioni

    Gene expression databases

    GenevestigatoriP03888.

    Interactioni

    Protein-protein interaction databases

    BioGridi201547. 1 interaction.
    IntActiP03888. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP03888.
    SMRiP03888. Positions 1-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1005.
    HOGENOMiHOG000228276.
    HOVERGENiHBG016682.
    InParanoidiP03888.
    KOiK03878.
    OMAiAMWYIST.
    OrthoDBiEOG77WWCV.
    PhylomeDBiP03888.

    Family and domain databases

    HAMAPiMF_01350. NDH1_NuoH.
    InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view]
    PANTHERiPTHR11432. PTHR11432. 1 hit.
    PfamiPF00146. NADHdh. 1 hit.
    [Graphical view]
    PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
    PS00668. COMPLEX1_ND1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P03888-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFFINILTLL VPILIAMAFL TLVERKILGY MQLRKGPNIV GPYGILQPFA    50
    DAMKLFMKEP MRPLTTSMSL FIIAPTLSLT LALSLWVPLP MPHPLINLNL 100
    GILFILATSS LSVYSILWSG WASNSKYSLF GALRAVAQTI SYEVTMAIIL 150
    LSVLLMNGSY SLQTLITTQE HMWLLLPAWP MAMMWFISTL AETNRAPFDL 200
    TEGESELVSG FNVEYAAGPF ALFFMAEYTN IILMNALTTI IFLGPLYYIN 250
    LPELYSTNFM MEALLLSSTF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL 300
    CMWHISLPIF TAGVPPYM 318
    Length:318
    Mass (Da):36,059
    Last modified:January 4, 2005 - v3
    Checksum:iECFAB96696610024
    GO

    Sequence cautioni

    The sequence AAB48644.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA24080.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00711 Genomic DNA. Translation: CAA24080.1. Different initiation.
    J01420 Genomic DNA. Translation: AAB48644.1. Different initiation.
    AB042523 Genomic DNA. Translation: BAA95653.2.
    AB042524 Genomic DNA. Translation: BAA95640.2.
    AB042809 Genomic DNA. Translation: BAA95795.2.
    AB049357 Genomic DNA. Translation: BAB13801.2.
    AJ512208 Genomic DNA. Translation: CAD54432.1.
    AY172335 Genomic DNA. Translation: AAN85122.1.
    AY339599 Genomic DNA. Translation: AAP89023.2.
    AJ489607 Genomic DNA. Translation: CAD33907.1.
    AY533105 Genomic DNA. Translation: AAS01439.1.
    AY533106 Genomic DNA. Translation: AAS01452.1.
    AY533107 Genomic DNA. Translation: AAS01465.1.
    AY533108 Genomic DNA. Translation: AAS01478.1.
    PIRiA00409. QXMS1M.
    RefSeqiNP_904328.1. NC_005089.1.
    YP_220550.1. NC_006914.1.

    Genome annotation databases

    EnsembliENSMUST00000082392; ENSMUSP00000080991; ENSMUSG00000064341.
    GeneIDi17716.
    3338902.
    KEGGimmu:17716.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00711 Genomic DNA. Translation: CAA24080.1 . Different initiation.
    J01420 Genomic DNA. Translation: AAB48644.1 . Different initiation.
    AB042523 Genomic DNA. Translation: BAA95653.2 .
    AB042524 Genomic DNA. Translation: BAA95640.2 .
    AB042809 Genomic DNA. Translation: BAA95795.2 .
    AB049357 Genomic DNA. Translation: BAB13801.2 .
    AJ512208 Genomic DNA. Translation: CAD54432.1 .
    AY172335 Genomic DNA. Translation: AAN85122.1 .
    AY339599 Genomic DNA. Translation: AAP89023.2 .
    AJ489607 Genomic DNA. Translation: CAD33907.1 .
    AY533105 Genomic DNA. Translation: AAS01439.1 .
    AY533106 Genomic DNA. Translation: AAS01452.1 .
    AY533107 Genomic DNA. Translation: AAS01465.1 .
    AY533108 Genomic DNA. Translation: AAS01478.1 .
    PIRi A00409. QXMS1M.
    RefSeqi NP_904328.1. NC_005089.1.
    YP_220550.1. NC_006914.1.

    3D structure databases

    ProteinModelPortali P03888.
    SMRi P03888. Positions 1-298.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201547. 1 interaction.
    IntActi P03888. 1 interaction.

    Proteomic databases

    MaxQBi P03888.
    PaxDbi P03888.
    PRIDEi P03888.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082392 ; ENSMUSP00000080991 ; ENSMUSG00000064341 .
    GeneIDi 17716.
    3338902.
    KEGGi mmu:17716.

    Organism-specific databases

    CTDi 4535.
    MGIi MGI:101787. mt-Nd1.

    Phylogenomic databases

    eggNOGi COG1005.
    HOGENOMi HOG000228276.
    HOVERGENi HBG016682.
    InParanoidi P03888.
    KOi K03878.
    OMAi AMWYIST.
    OrthoDBi EOG77WWCV.
    PhylomeDBi P03888.

    Miscellaneous databases

    NextBioi 292332.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P03888.

    Family and domain databases

    HAMAPi MF_01350. NDH1_NuoH.
    InterProi IPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view ]
    PANTHERi PTHR11432. PTHR11432. 1 hit.
    Pfami PF00146. NADHdh. 1 hit.
    [Graphical view ]
    PROSITEi PS00667. COMPLEX1_ND1_1. 1 hit.
    PS00668. COMPLEX1_ND1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and gene organization of mouse mitochondrial DNA."
      Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
      Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains."
      Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.
      J. Hered. 92:352-355(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C3H/He, SAMP1, SAMP8 and SAMR1.
      Tissue: Liver.
    3. "The ALR/Lt mouse: contribution of the mitochondrial genome in resistance against both chemically-induced and autoimmune diabetes."
      Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., Fischel-Ghodsian N.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ALR/Lt, ALS/Lt, NOD/LtJ and NON/Lt.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BALB/cJ, C3H/An and C57BL/6J.
      Tissue: Fibroblast and Platelet.
    5. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 27-54 AND 127-134, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiNU1M_MOUSE
    AccessioniPrimary (citable) accession number: P03888
    Secondary accession number(s): Q9G0S6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3