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P03888 (NU1M_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 1

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 1
Gene names
Name:Mtnd1
Synonyms:mt-Nd1, Nd1
Encoded onMitochondrion
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. HAMAP-Rule MF_01350

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01350

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01350.

Sequence similarities

Belongs to the complex I subunit 1 family.

Sequence caution

The sequence AAB48644.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA24080.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318NADH-ubiquinone oxidoreductase chain 1 HAMAP-Rule MF_01350
PRO_0000117431

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane136 – 15621Helical; Potential
Transmembrane171 – 19121Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane253 – 27321Helical; Potential
Transmembrane293 – 31321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P03888 [UniParc].

Last modified January 4, 2005. Version 3.
Checksum: ECFAB96696610024

FASTA31836,059
        10         20         30         40         50         60 
MFFINILTLL VPILIAMAFL TLVERKILGY MQLRKGPNIV GPYGILQPFA DAMKLFMKEP 

        70         80         90        100        110        120 
MRPLTTSMSL FIIAPTLSLT LALSLWVPLP MPHPLINLNL GILFILATSS LSVYSILWSG 

       130        140        150        160        170        180 
WASNSKYSLF GALRAVAQTI SYEVTMAIIL LSVLLMNGSY SLQTLITTQE HMWLLLPAWP 

       190        200        210        220        230        240 
MAMMWFISTL AETNRAPFDL TEGESELVSG FNVEYAAGPF ALFFMAEYTN IILMNALTTI 

       250        260        270        280        290        300 
IFLGPLYYIN LPELYSTNFM MEALLLSSTF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL 

       310 
CMWHISLPIF TAGVPPYM 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and gene organization of mouse mitochondrial DNA."
Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains."
Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.
J. Hered. 92:352-355(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C3H/He, SAMP1, SAMP8 and SAMR1.
Tissue: Liver.
[3]"The ALR/Lt mouse: contribution of the mitochondrial genome in resistance against both chemically-induced and autoimmune diabetes."
Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., Fischel-Ghodsian N.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ALR/Lt, ALS/Lt, NOD/LtJ and NON/Lt.
[4]"Revisiting the mouse mitochondrial DNA sequence."
Bayona-Bafaluy M.P., Acin-Perez R., Mullikin J.C., Park J.S., Moreno-Loshuertos R., Hu P., Perez-Martos A., Fernandez-Silva P., Bai Y., Enriquez J.A.
Nucleic Acids Res. 31:5349-5355(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BALB/cJ, C3H/An and C57BL/6J.
Tissue: Fibroblast and Platelet.
[5]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 27-54 AND 127-134, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00711 Genomic DNA. Translation: CAA24080.1. Different initiation.
J01420 Genomic DNA. Translation: AAB48644.1. Different initiation.
AB042523 Genomic DNA. Translation: BAA95653.2.
AB042524 Genomic DNA. Translation: BAA95640.2.
AB042809 Genomic DNA. Translation: BAA95795.2.
AB049357 Genomic DNA. Translation: BAB13801.2.
AJ512208 Genomic DNA. Translation: CAD54432.1.
AY172335 Genomic DNA. Translation: AAN85122.1.
AY339599 Genomic DNA. Translation: AAP89023.2.
AJ489607 Genomic DNA. Translation: CAD33907.1.
AY533105 Genomic DNA. Translation: AAS01439.1.
AY533106 Genomic DNA. Translation: AAS01452.1.
AY533107 Genomic DNA. Translation: AAS01465.1.
AY533108 Genomic DNA. Translation: AAS01478.1.
PIRQXMS1M. A00409.
RefSeqNP_904328.1. NC_005089.1.
YP_220550.1. NC_006914.1.

3D structure databases

ProteinModelPortalP03888.
SMRP03888. Positions 1-298.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201547. 1 interaction.
IntActP03888. 1 interaction.

Proteomic databases

MaxQBP03888.
PaxDbP03888.
PRIDEP03888.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082392; ENSMUSP00000080991; ENSMUSG00000064341.
GeneID17716.
3338902.
KEGGmmu:17716.

Organism-specific databases

CTD4535.
MGIMGI:101787. mt-Nd1.

Phylogenomic databases

eggNOGCOG1005.
HOGENOMHOG000228276.
HOVERGENHBG016682.
InParanoidP03888.
KOK03878.
OMAAMWYIST.
OrthoDBEOG77WWCV.
PhylomeDBP03888.

Gene expression databases

GenevestigatorP03888.

Family and domain databases

HAMAPMF_01350. NDH1_NuoH.
InterProIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERPTHR11432. PTHR11432. 1 hit.
PfamPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio292332.
SOURCESearch...

Entry information

Entry nameNU1M_MOUSE
AccessionPrimary (citable) accession number: P03888
Secondary accession number(s): Q9G0S6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot