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P03888

- NU1M_MOUSE

UniProt

P03888 - NU1M_MOUSE

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Protein

NADH-ubiquinone oxidoreductase chain 1

Gene

Mtnd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiREACT_262523. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 1 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 1
Gene namesi
Name:Mtnd1
Synonyms:mt-Nd1, Nd1
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Mitochondrion

Organism-specific databases

MGIiMGI:101787. mt-Nd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence AnalysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence AnalysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex I Source: Ensembl
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318NADH-ubiquinone oxidoreductase chain 1PRO_0000117431Add
BLAST

Proteomic databases

MaxQBiP03888.
PaxDbiP03888.
PRIDEiP03888.

Expressioni

Gene expression databases

ExpressionAtlasiP03888. baseline and differential.
GenevestigatoriP03888.

Interactioni

Protein-protein interaction databases

BioGridi201547. 1 interaction.
IntActiP03888. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP03888.
SMRiP03888. Positions 1-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1005.
HOGENOMiHOG000228276.
HOVERGENiHBG016682.
InParanoidiP03888.
KOiK03878.
OMAiAMWYIST.
OrthoDBiEOG77WWCV.
PhylomeDBiP03888.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03888-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFFINILTLL VPILIAMAFL TLVERKILGY MQLRKGPNIV GPYGILQPFA
60 70 80 90 100
DAMKLFMKEP MRPLTTSMSL FIIAPTLSLT LALSLWVPLP MPHPLINLNL
110 120 130 140 150
GILFILATSS LSVYSILWSG WASNSKYSLF GALRAVAQTI SYEVTMAIIL
160 170 180 190 200
LSVLLMNGSY SLQTLITTQE HMWLLLPAWP MAMMWFISTL AETNRAPFDL
210 220 230 240 250
TEGESELVSG FNVEYAAGPF ALFFMAEYTN IILMNALTTI IFLGPLYYIN
260 270 280 290 300
LPELYSTNFM MEALLLSSTF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL
310
CMWHISLPIF TAGVPPYM
Length:318
Mass (Da):36,059
Last modified:January 4, 2005 - v3
Checksum:iECFAB96696610024
GO

Sequence cautioni

The sequence AAB48644.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA24080.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00711 Genomic DNA. Translation: CAA24080.1. Different initiation.
J01420 Genomic DNA. Translation: AAB48644.1. Different initiation.
AB042523 Genomic DNA. Translation: BAA95653.2.
AB042524 Genomic DNA. Translation: BAA95640.2.
AB042809 Genomic DNA. Translation: BAA95795.2.
AB049357 Genomic DNA. Translation: BAB13801.2.
AJ512208 Genomic DNA. Translation: CAD54432.1.
AY172335 Genomic DNA. Translation: AAN85122.1.
AY339599 Genomic DNA. Translation: AAP89023.2.
AJ489607 Genomic DNA. Translation: CAD33907.1.
AY533105 Genomic DNA. Translation: AAS01439.1.
AY533106 Genomic DNA. Translation: AAS01452.1.
AY533107 Genomic DNA. Translation: AAS01465.1.
AY533108 Genomic DNA. Translation: AAS01478.1.
PIRiA00409. QXMS1M.
RefSeqiNP_904328.1. NC_005089.1.
YP_220550.1. NC_006914.1.

Genome annotation databases

EnsembliENSMUST00000082392; ENSMUSP00000080991; ENSMUSG00000064341.
GeneIDi17716.
3338902.
KEGGimmu:17716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00711 Genomic DNA. Translation: CAA24080.1 . Different initiation.
J01420 Genomic DNA. Translation: AAB48644.1 . Different initiation.
AB042523 Genomic DNA. Translation: BAA95653.2 .
AB042524 Genomic DNA. Translation: BAA95640.2 .
AB042809 Genomic DNA. Translation: BAA95795.2 .
AB049357 Genomic DNA. Translation: BAB13801.2 .
AJ512208 Genomic DNA. Translation: CAD54432.1 .
AY172335 Genomic DNA. Translation: AAN85122.1 .
AY339599 Genomic DNA. Translation: AAP89023.2 .
AJ489607 Genomic DNA. Translation: CAD33907.1 .
AY533105 Genomic DNA. Translation: AAS01439.1 .
AY533106 Genomic DNA. Translation: AAS01452.1 .
AY533107 Genomic DNA. Translation: AAS01465.1 .
AY533108 Genomic DNA. Translation: AAS01478.1 .
PIRi A00409. QXMS1M.
RefSeqi NP_904328.1. NC_005089.1.
YP_220550.1. NC_006914.1.

3D structure databases

ProteinModelPortali P03888.
SMRi P03888. Positions 1-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201547. 1 interaction.
IntActi P03888. 1 interaction.

Proteomic databases

MaxQBi P03888.
PaxDbi P03888.
PRIDEi P03888.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082392 ; ENSMUSP00000080991 ; ENSMUSG00000064341 .
GeneIDi 17716.
3338902.
KEGGi mmu:17716.

Organism-specific databases

CTDi 4535.
MGIi MGI:101787. mt-Nd1.

Phylogenomic databases

eggNOGi COG1005.
HOGENOMi HOG000228276.
HOVERGENi HBG016682.
InParanoidi P03888.
KOi K03878.
OMAi AMWYIST.
OrthoDBi EOG77WWCV.
PhylomeDBi P03888.

Enzyme and pathway databases

Reactomei REACT_262523. Respiratory electron transport.

Miscellaneous databases

NextBioi 292332.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi P03888. baseline and differential.
Genevestigatori P03888.

Family and domain databases

HAMAPi MF_01350. NDH1_NuoH.
InterProi IPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view ]
PANTHERi PTHR11432. PTHR11432. 1 hit.
Pfami PF00146. NADHdh. 1 hit.
[Graphical view ]
PROSITEi PS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains."
    Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.
    J. Hered. 92:352-355(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C3H/He, SAMP1, SAMP8 and SAMR1.
    Tissue: Liver.
  3. "The ALR/Lt mouse: contribution of the mitochondrial genome in resistance against both chemically-induced and autoimmune diabetes."
    Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., Fischel-Ghodsian N.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ALR/Lt, ALS/Lt, NOD/LtJ and NON/Lt.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BALB/cJ, C3H/An and C57BL/6J.
    Tissue: Fibroblast and Platelet.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 27-54 AND 127-134, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiNU1M_MOUSE
AccessioniPrimary (citable) accession number: P03888
Secondary accession number(s): Q9G0S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 4, 2005
Last modified: November 26, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3