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Protein

NADH-ubiquinone oxidoreductase chain 1

Gene

MT-ND1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 1 (EC:1.6.5.31 Publication)
Alternative name(s):
NADH dehydrogenase subunit 1
Gene namesi
Name:MT-ND1
Synonyms:MTND1, NADH1, ND1
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence analysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318NADH-ubiquinone oxidoreductase chain 1PRO_0000117354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-formylmethionine2 Publications

Keywords - PTMi

Formylation

Proteomic databases

PaxDbiP03887.
PRIDEiP03887.

Interactioni

Protein-protein interaction databases

IntActiP03887. 1 interaction.
STRINGi9913.ENSBTAP00000053145.

Chemistry

BindingDBiP03887.

Structurei

3D structure databases

ProteinModelPortaliP03887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4770. Eukaryota.
COG1005. LUCA.
HOGENOMiHOG000228276.
HOVERGENiHBG016682.
InParanoidiP03887.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH. 1 hit.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFMINILMLI IPILLAVAFL TLVERKVLGY MQLRKGPNVV GPYGLLQPIA
60 70 80 90 100
DAIKLFIKEP LRPATSSASM FILAPIMALG LALTMWIPLP MPYPLINMNL
110 120 130 140 150
GVLFMLAMSS LAVYSILWSG WASNSKYALI GALRAVAQTI SYEVTLAIIL
160 170 180 190 200
LSVLLMSGSF TLSTLITTQE QMWLILPAWP LAMMWFISTL AETNRAPFDL
210 220 230 240 250
TEGESELVSG FNVEYAAGPF ALFFMAEYAN IIMMNIFTAI LFLGTSHNPH
260 270 280 290 300
MPELYTINFT IKSLLLTMSF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL
310
CMWHVSLPIL TSGIPPQT
Length:318
Mass (Da):35,670
Last modified:July 21, 1986 - v1
Checksum:i638727DBA839B1C3
GO

Mass spectrometryi

Molecular mass is 35699.1 Da from positions 1 - 318. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA23997.1.
AF490528 Genomic DNA. Translation: AAM08322.1.
AF490529 Genomic DNA. Translation: AAM08335.1.
AF493541 Genomic DNA. Translation: AAM12789.1.
AF493542 Genomic DNA. Translation: AAM12802.1.
PIRiA00408. QXBO1M.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA23997.1.
AF490528 Genomic DNA. Translation: AAM08322.1.
AF490529 Genomic DNA. Translation: AAM08335.1.
AF493541 Genomic DNA. Translation: AAM12789.1.
AF493542 Genomic DNA. Translation: AAM12802.1.
PIRiA00408. QXBO1M.

3D structure databases

ProteinModelPortaliP03887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03887. 1 interaction.
STRINGi9913.ENSBTAP00000053145.

Chemistry

BindingDBiP03887.
ChEMBLiCHEMBL4497.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP03887.
PRIDEiP03887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4770. Eukaryota.
COG1005. LUCA.
HOGENOMiHOG000228276.
HOVERGENiHBG016682.
InParanoidiP03887.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH. 1 hit.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU1M_BOVIN
AccessioniPrimary (citable) accession number: P03887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.