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Protein

NADH-ubiquinone oxidoreductase chain 1

Gene

MT-ND1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 1 (EC:1.6.5.31 Publication)
Alternative name(s):
NADH dehydrogenase subunit 1
Gene namesi
Name:MT-ND1
Synonyms:MTND1, NADH1, ND1
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001173541 – 318NADH-ubiquinone oxidoreductase chain 1Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-formylmethionine2 Publications1

Keywords - PTMi

Formylation

Proteomic databases

PaxDbiP03887.
PRIDEiP03887.

Interactioni

Protein-protein interaction databases

IntActiP03887. 1 interactor.
STRINGi9913.ENSBTAP00000053145.

Chemistry databases

BindingDBiP03887.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35H3-315[»]
5LDWelectron microscopy4.27H1-318[»]
5LDXelectron microscopy5.60H1-318[»]
ProteinModelPortaliP03887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4770. Eukaryota.
COG1005. LUCA.
HOGENOMiHOG000228276.
HOVERGENiHBG016682.
InParanoidiP03887.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH. 1 hit.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFMINILMLI IPILLAVAFL TLVERKVLGY MQLRKGPNVV GPYGLLQPIA
60 70 80 90 100
DAIKLFIKEP LRPATSSASM FILAPIMALG LALTMWIPLP MPYPLINMNL
110 120 130 140 150
GVLFMLAMSS LAVYSILWSG WASNSKYALI GALRAVAQTI SYEVTLAIIL
160 170 180 190 200
LSVLLMSGSF TLSTLITTQE QMWLILPAWP LAMMWFISTL AETNRAPFDL
210 220 230 240 250
TEGESELVSG FNVEYAAGPF ALFFMAEYAN IIMMNIFTAI LFLGTSHNPH
260 270 280 290 300
MPELYTINFT IKSLLLTMSF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL
310
CMWHVSLPIL TSGIPPQT
Length:318
Mass (Da):35,670
Last modified:July 21, 1986 - v1
Checksum:i638727DBA839B1C3
GO

Mass spectrometryi

Molecular mass is 35699.1 Da from positions 1 - 318. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA23997.1.
AF490528 Genomic DNA. Translation: AAM08322.1.
AF490529 Genomic DNA. Translation: AAM08335.1.
AF493541 Genomic DNA. Translation: AAM12789.1.
AF493542 Genomic DNA. Translation: AAM12802.1.
PIRiA00408. QXBO1M.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA23997.1.
AF490528 Genomic DNA. Translation: AAM08322.1.
AF490529 Genomic DNA. Translation: AAM08335.1.
AF493541 Genomic DNA. Translation: AAM12789.1.
AF493542 Genomic DNA. Translation: AAM12802.1.
PIRiA00408. QXBO1M.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35H3-315[»]
5LDWelectron microscopy4.27H1-318[»]
5LDXelectron microscopy5.60H1-318[»]
ProteinModelPortaliP03887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03887. 1 interactor.
STRINGi9913.ENSBTAP00000053145.

Chemistry databases

BindingDBiP03887.
ChEMBLiCHEMBL4497.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP03887.
PRIDEiP03887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4770. Eukaryota.
COG1005. LUCA.
HOGENOMiHOG000228276.
HOVERGENiHBG016682.
InParanoidiP03887.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH. 1 hit.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU1M_BOVIN
AccessioniPrimary (citable) accession number: P03887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.