P03875 (AI1M_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative COX1/OXI3 intron 1 protein

Gene names

Name:	aI1
Ordered Locus Names:	Q0050

Encoded on

Mitochondrion

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	834 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion Potential.
Miscellaneous	This protein is coded in group-II intron 1 of OXI3 (COX1).
Sequence similarities	Contains 1 reverse transcriptase domain.
Sequence caution	The sequence CAA24071.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Mitochondrion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro aerobic respiration Inferred from electronic annotation. Source: InterPro homing of group II introns Inferred from direct assay. Source: SGD mRNA processing Inferred from direct assay. Source: SGD
Cellular component	chloroplast Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: InterPro mitochondrion Traceable author statement. Source: SGD
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro endonuclease activity Traceable author statement. Source: SGD heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 834	834	Putative COX1/OXI3 intron 1 protein		PRO_0000196880
Regions
	Domain	296 – 577	282	Reverse transcriptase
Experimental info
	Sequence conflict	118	1	F → N Ref.1
	Sequence conflict	118	1	F → N Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P03875 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: BFB64B6F36416A5A	FASTA	834	96,079
	10 20 30 40 50 60 MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG NSQLFNGAPT 70 80 90 100 110 120 SAYISLMRTA LVLWIINRYL KHMTNSVGAN FTGTMACHKT PMISVGGVKC YMVRLTNFLQ 130 140 150 160 170 180 VFIRITISSY HLDMVKQVWL FYVEVIRLWF IVLDSTGSVK KMKDTNNTKG NTKSEGSTER 190 200 210 220 230 240 GNSGVDRGMV VPNTQMKMRF LNQVRYYSVN NNLKMGKDTN IELSKDTSTS DLLEFEKLVM 250 260 270 280 290 300 DNMNEENMNN NLLSIMKNVD MLMLAYNRIK SKPGNMTPGT TLETLDGMNM MYLNKLSNEL 310 320 330 340 350 360 GTGKFKFKPM RMVNIPKPKG GMRPLSVGNP RDKIVQEVMR MILDTIFDKK MSTHSHGFRK 370 380 390 400 410 420 NMSCQTAIWE VRNMFGGSNW FIEVDLKKCF DTISHDLIIK ELKRYISDKG FIDLVYKLLR 430 440 450 460 470 480 AGYIDEKGTY HKPMLGLPQG SLISPILCNI VMTLVDNWLE DYINLYNKGK VKKQHPTYKK 490 500 510 520 530 540 LSRMIAKAKM FSTRLKLHKE RAKGPTFIYN DPNFKRMKYV RYADDILIGV LGSKNDCKMI 550 560 570 580 590 600 KRDLNNFLNS LGLTMNEEKT LITCATETPA RFLGYNISIT PLKRMPTVTK TIRGKTIRSR 610 620 630 640 650 660 NTTRPIINAP IRDIINKLAT NGYCKHNKNG RMGVPTRVGR WTYEEPRTII NNYKALGRGI 670 680 690 700 710 720 LNYYKLATNY KRLRERIYYV LYYSCVLTLA SKYRLKTMSK TIKKFGYNLN IIENDKLIAN 730 740 750 760 770 780 FPRNTFDNIK KIENHGMFMY MSEAKVTDPF EYIDSIKYML PTAKANFNKP CSICNSTIDV 790 800 810 820 830 EMHHVKQLHR GMLKATKDYI TGRMITMNRK QIPLCKQCHI KTHKNKFKNM GPGM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Assembly of the mitochondrial membrane system. Structure and nucleotide sequence of the gene coding for subunit 1 of yeast cytochrome oxidase." Bonitz S.G., Coruzzi G., Thalenfeld B.E., Tzagoloff A., Macino G. J. Biol. Chem. 255:11927-11941(1980) [PubMed: 6254986] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 24657 / D273-10B.
[2]	"The primary structure of the mitochondrial genome of Saccharomyces cerevisiae -- a review." de Zamaroczy M., Bernardi G. Gene 47:155-177(1986) [PubMed: 3549452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae." Foury F., Roganti T., Lecrenier N., Purnelle B. FEBS Lett. 440:325-331(1998) [PubMed: 9872396] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V00694 Genomic DNA. Translation: CAA24071.1. Different initiation. L36897 Genomic DNA. Translation: AAA67532.1. AJ011856 Genomic DNA. Translation: CAA09825.1.
PIR	QXBY31. A04508. S78642.
RefSeq	NP_009310.1. NM_001184353.1.
3D structure databases
ProteinModelPortal	P03875.
SMR	P03875. Positions 2-68.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-8242N.
IntAct	P03875. 1 interaction.
MINT	MINT-690265.
STRING	P03875.
Protein family/group databases
REBASE	2622. I-SceIII.
Proteomic databases
PeptideAtlas	P03875.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	Q0050; Q0050; Q0050.
GeneID	854593.
KEGG	sce:Q0050.
NMPDR	fig|4932.3.peg.1861.
Organism-specific databases
CYGD	Q0050.
SGD	S000007261. AI1.
Phylogenomic databases
eggNOG	fuNOG14462.
GeneTree	EFGT00050000008548.
HOGENOM	HBG203563.
OrthoDB	EOG4HX8BM.
Gene expression databases
ArrayExpress	P03875.
Genevestigator	P03875.
GermOnline	Q0050. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000883. Cyt_c_Oxase_su1. IPR023616. Cyt_c_Oxase_su1_dom. IPR003615. HNH_nuc. IPR000477. RVT. [Graphical view]
Gene3D	G3DSA:1.20.210.10. COX1. 1 hit.
PANTHER	PTHR10422. COX1. 1 hit.
Pfam	PF00078. RVT_1. 1 hit. [Graphical view]
SMART	SM00507. HNHc. 1 hit. [Graphical view]
SUPFAM	SSF81442. COX1. 1 hit.
PROSITE	PS50878. RT_POL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	977065.

Entry information

Entry name

AI1M_YEAST

Accession

Primary (citable) accession number: P03875
Secondary accession number(s): Q9ZZX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	December 20, 2005
Last modified:	January 25, 2012
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program