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Protein

Protein MioC

Gene

mioC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable electron transporter required for biotin synthase activity.

Cofactori

GO - Molecular functioni

  • FMN binding Source: EcoCyc

GO - Biological processi

  • biotin biosynthetic process Source: EcoCyc
  • oxidation-reduction process Source: UniProtKB-KW

Keywordsi

Biological processElectron transport, Transport
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciEcoCyc:EG11199-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MioC
Gene namesi
Name:mioC
Synonyms:yieB
Ordered Locus Names:b3742, JW3720
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11199. mioC.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001965722 – 147Protein MioCAdd BLAST146

Proteomic databases

PaxDbiP03817.
PRIDEiP03817.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

BioGridi4263259. 223 interactors.
IntActiP03817. 4 interactors.
STRINGi316385.ECDH10B_3930.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Beta strandi11 – 13Combined sources3
Helixi16 – 28Combined sources13
Beta strandi33 – 36Combined sources4
Helixi41 – 43Combined sources3
Beta strandi46 – 53Combined sources8
Turni56 – 59Combined sources4
Helixi67 – 76Combined sources10
Beta strandi82 – 89Combined sources8
Helixi92 – 95Combined sources4
Beta strandi98 – 100Combined sources3
Helixi104 – 112Combined sources9
Beta strandi121 – 124Combined sources4
Beta strandi126 – 130Combined sources5
Helixi136 – 146Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HNANMR-A1-147[»]
2HNBNMR-A1-147[»]
ProteinModelPortaliP03817.
SMRiP03817.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03817.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 143Flavodoxin-likePROSITE-ProRule annotationAdd BLAST140

Sequence similaritiesi

Belongs to the flavodoxin family. MioC subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105QTB. Bacteria.
COG0716. LUCA.
HOGENOMiHOG000030545.
InParanoidiP03817.
KOiK06205.
PhylomeDBiP03817.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiView protein in InterPro
IPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
PfamiView protein in Pfam
PF00258. Flavodoxin_1. 1 hit.
SUPFAMiSSF52218. SSF52218. 1 hit.
PROSITEiView protein in PROSITE
PS50902. FLAVODOXIN_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADITLISGS TLGGAEYVAE HLAEKLEEAG FTTETLHGPL LEDLPASGIW
60 70 80 90 100
LVISSTHGAG DIPDNLSPFY EALQEQKPDL SAVRFGAIGI GSREYDTFCG
110 120 130 140
AIDKLEAELK NSGAKQTGET LKINILDHDI PEDPAEEWLG SWVNLLK
Length:147
Mass (Da):15,808
Last modified:January 23, 2007 - v4
Checksum:i48D984FFFB348730
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56 – 99THGAG…YDTFC → PTVPEIFRTTFLLSMKHCRN RSPIFLQSALAQSVLAVVNM TPFV in AAA24247 (PubMed:6169112).CuratedAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00826 Genomic DNA. Translation: AAA24251.1.
V00308 Genomic DNA. No translation available.
J01657 Genomic DNA. Translation: AAA24247.1. Sequence problems.
L10328 Genomic DNA. Translation: AAA62094.1.
U00096 Genomic DNA. Translation: AAC76765.1.
AP009048 Genomic DNA. Translation: BAE77546.1.
X01631 Genomic DNA. Translation: CAA25772.1.
PIRiG65177. QQEC16.
RefSeqiNP_418198.1. NC_000913.3.
WP_000763724.1. NZ_LN832404.1.
YP_006952151.1. NC_019049.1.

Genome annotation databases

EnsemblBacteriaiAAC76765; AAC76765; b3742.
BAE77546; BAE77546; BAE77546.
GeneIDi13909069.
948249.
KEGGiecj:JW3720.
eco:b3742.
PATRICifig|1411691.4.peg.2958.

Similar proteinsi

Entry informationi

Entry nameiMIOC_ECOLI
AccessioniPrimary (citable) accession number: P03817
Secondary accession number(s): Q2M860
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 150 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families