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Protein

Protein MioC

Gene

mioC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable electron transporter required for biotin synthase activity.

Cofactori

GO - Molecular functioni

  • FMN binding Source: EcoCyc

GO - Biological processi

  • biotin biosynthetic process Source: EcoCyc
  • oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciEcoCyc:EG11199-MONOMER.
ECOL316407:JW3720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MioC
Gene namesi
Name:mioC
Synonyms:yieB
Ordered Locus Names:b3742, JW3720
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11199. mioC.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001965722 – 147Protein MioCAdd BLAST146

Proteomic databases

EPDiP03817.
PaxDbiP03817.
PRIDEiP03817.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

BioGridi4263259. 223 interactors.
IntActiP03817. 4 interactors.
STRINGi511145.b3742.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Beta strandi11 – 13Combined sources3
Helixi16 – 28Combined sources13
Beta strandi33 – 36Combined sources4
Helixi41 – 43Combined sources3
Beta strandi46 – 53Combined sources8
Turni56 – 59Combined sources4
Helixi67 – 76Combined sources10
Beta strandi82 – 89Combined sources8
Helixi92 – 95Combined sources4
Beta strandi98 – 100Combined sources3
Helixi104 – 112Combined sources9
Beta strandi121 – 124Combined sources4
Beta strandi126 – 130Combined sources5
Helixi136 – 146Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HNANMR-A1-147[»]
2HNBNMR-A1-147[»]
ProteinModelPortaliP03817.
SMRiP03817.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03817.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 143Flavodoxin-likePROSITE-ProRule annotationAdd BLAST140

Sequence similaritiesi

Belongs to the flavodoxin family. MioC subfamily.Curated
Contains 1 flavodoxin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105QTB. Bacteria.
COG0716. LUCA.
HOGENOMiHOG000030545.
InParanoidiP03817.
KOiK06205.
OMAiIDVTQHE.
PhylomeDBiP03817.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
[Graphical view]
PfamiPF00258. Flavodoxin_1. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADITLISGS TLGGAEYVAE HLAEKLEEAG FTTETLHGPL LEDLPASGIW
60 70 80 90 100
LVISSTHGAG DIPDNLSPFY EALQEQKPDL SAVRFGAIGI GSREYDTFCG
110 120 130 140
AIDKLEAELK NSGAKQTGET LKINILDHDI PEDPAEEWLG SWVNLLK
Length:147
Mass (Da):15,808
Last modified:January 23, 2007 - v4
Checksum:i48D984FFFB348730
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56 – 99THGAG…YDTFC → PTVPEIFRTTFLLSMKHCRN RSPIFLQSALAQSVLAVVNM TPFV in AAA24247 (PubMed:6169112).CuratedAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00826 Genomic DNA. Translation: AAA24251.1.
V00308 Genomic DNA. No translation available.
J01657 Genomic DNA. Translation: AAA24247.1. Sequence problems.
L10328 Genomic DNA. Translation: AAA62094.1.
U00096 Genomic DNA. Translation: AAC76765.1.
AP009048 Genomic DNA. Translation: BAE77546.1.
X01631 Genomic DNA. Translation: CAA25772.1.
PIRiG65177. QQEC16.
RefSeqiNP_418198.1. NC_000913.3.
WP_000763724.1. NZ_LN832404.1.
YP_006952151.1. NC_019049.1.

Genome annotation databases

EnsemblBacteriaiAAC76765; AAC76765; b3742.
BAE77546; BAE77546; BAE77546.
GeneIDi13909069.
948249.
KEGGiecj:JW3720.
eco:b3742.
PATRICi32122983. VBIEscCol129921_3867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00826 Genomic DNA. Translation: AAA24251.1.
V00308 Genomic DNA. No translation available.
J01657 Genomic DNA. Translation: AAA24247.1. Sequence problems.
L10328 Genomic DNA. Translation: AAA62094.1.
U00096 Genomic DNA. Translation: AAC76765.1.
AP009048 Genomic DNA. Translation: BAE77546.1.
X01631 Genomic DNA. Translation: CAA25772.1.
PIRiG65177. QQEC16.
RefSeqiNP_418198.1. NC_000913.3.
WP_000763724.1. NZ_LN832404.1.
YP_006952151.1. NC_019049.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HNANMR-A1-147[»]
2HNBNMR-A1-147[»]
ProteinModelPortaliP03817.
SMRiP03817.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263259. 223 interactors.
IntActiP03817. 4 interactors.
STRINGi511145.b3742.

Proteomic databases

EPDiP03817.
PaxDbiP03817.
PRIDEiP03817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76765; AAC76765; b3742.
BAE77546; BAE77546; BAE77546.
GeneIDi13909069.
948249.
KEGGiecj:JW3720.
eco:b3742.
PATRICi32122983. VBIEscCol129921_3867.

Organism-specific databases

EchoBASEiEB1185.
EcoGeneiEG11199. mioC.

Phylogenomic databases

eggNOGiENOG4105QTB. Bacteria.
COG0716. LUCA.
HOGENOMiHOG000030545.
InParanoidiP03817.
KOiK06205.
OMAiIDVTQHE.
PhylomeDBiP03817.

Enzyme and pathway databases

BioCyciEcoCyc:EG11199-MONOMER.
ECOL316407:JW3720-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP03817.
PROiP03817.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
[Graphical view]
PfamiPF00258. Flavodoxin_1. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIOC_ECOLI
AccessioniPrimary (citable) accession number: P03817
Secondary accession number(s): Q2M860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 146 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.