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Protein

Spanin, outer lipoprotein subunit

Gene

18.7

Organism
Enterobacteria phage T7 (Bacteriophage T7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of the spanin complex that disrupts the host outer membrane and participates in cell lysis during virus exit. The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans. Host outer membrane disruption is possibly due to local fusion between the inner and outer membrane performed by the spanin complex.1 Publication

GO - Biological processi

Keywordsi

Biological processCytolysis, Host cell lysis by virus, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Spanin, outer lipoprotein subunit1 Publication
Short name:
o-spanin
Alternative name(s):
Gene product 18.7
Short name:
Gp18.7
Protein 18.7
Gene namesi
Ordered Locus Names:18.7
OrganismiEnterobacteria phage T7 (Bacteriophage T7)
Taxonomic identifieri10760 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeAutographivirinaeT7virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000000840 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell outer membrane, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 50Sequence analysisAdd BLAST50
ChainiPRO_000010653951 – 83Spanin, outer lipoprotein subunitAdd BLAST33

Keywords - PTMi

Lipoprotein

Interactioni

Subunit structurei

Homodimer. Interacts (via C-terminus) with the spanin inner membrane subunit (via C-terminus). Part of the spanin complex which spans the entire periplasmic space. The spanin complex is composed of spanin inner membrane subunit and spanin outer membrane subunit.1 Publication

Protein-protein interaction databases

IntActiP03788. 1 interactor.
MINTiMINT-1513622.

Family & Domainsi

Sequence similaritiesi

Belongs to the T7likevirus o-spanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiVOG090001UI.

Family and domain databases

InterProiView protein in InterPro
IPR020130. O-spanin_T7likevirus.
PfamiView protein in Pfam
PF17531. O_Spanin_T7. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028580. Phage_T7-like_18.7. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03788-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLRELRLR RALKEQSMRY LLSIKKTLPR WKGALIGLFL ICVATISGCA
60 70 80
SESKLPEPPM VSVDSSLMVE PNLTTEMLNV FSQ
Length:83
Mass (Da):9,326
Last modified:July 21, 1986 - v1
Checksum:iB3DB055DE79A53C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01146 Genomic DNA. Translation: CAA24439.1.
PIRiA04413. W8BPG7.
RefSeqiNP_042009.1. NC_001604.1.

Genome annotation databases

GeneIDi1261057.
KEGGivg:1261057.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSPAN2_BPT7
AccessioniPrimary (citable) accession number: P03788
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 5, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families