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Protein

Inhibitor of toxin/antitoxin system

Gene

4.5

Organism
Enterobacteria phage T7 (Bacteriophage T7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the inhibition of the host toxin-antitoxin (TA) system. These modules made by the host and composed of a toxic gene and a neutralizing gene play role in stress response and programmed cell death. Gp4.5 interacts with the host protease lon to neutralize the degradation of the antitoxin that would result in the activation of the toxin and the destruction of the bacteria.1 Publication

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of toxin/antitoxin system
Alternative name(s):
Gene product 4.5
Short name:
Gp4.5
Gene namesi
Ordered Locus Names:4.5
OrganismiEnterobacteria phage T7 (Bacteriophage T7)
Taxonomic identifieri10760 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeAutographivirinaeT7virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000000840 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001064951 – 89Inhibitor of toxin/antitoxin systemAdd BLAST89

Proteomic databases

PRIDEiP03785.

Interactioni

Subunit structurei

Interacts with host lon protease; this interaction prevents the degradation of antitoxin by lon and thus the toxin activation.1 Publication

Protein-protein interaction databases

IntActiP03785. 2 interactors.
MINTiMINT-1513790.

Family & Domainsi

Phylogenomic databases

OrthoDBiVOG090002ZC.

Sequencei

Sequence statusi: Complete.

P03785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVAETIRL SDTADQWNRR VHINVRNGKA TMVYRWKDSK SSKNHTQRMT
60 70 80
LTDEQALRLV NALTKAAVTA IHEAGRVNEA MAILDKIDN
Length:89
Mass (Da):10,091
Last modified:July 21, 1986 - v1
Checksum:i6BE245F92EBB3DAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01146 Genomic DNA. Translation: CAA24410.1.
PIRiA04410. W4BP57.
RefSeqiNP_041980.1. NC_001604.1.

Genome annotation databases

GeneIDi1261059.
KEGGivg:1261059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01146 Genomic DNA. Translation: CAA24410.1.
PIRiA04410. W4BP57.
RefSeqiNP_041980.1. NC_001604.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03785. 2 interactors.
MINTiMINT-1513790.

Proteomic databases

PRIDEiP03785.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1261059.
KEGGivg:1261059.

Phylogenomic databases

OrthoDBiVOG090002ZC.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiITAS_BPT7
AccessioniPrimary (citable) accession number: P03785
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 15, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.