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Protein

Overcome classical restriction gp0.3

Gene

0.3

Organism
Enterobacteria phage T7 (Bacteriophage T7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Prevents both degradation and modification of T7 DNA by the host restriction-modification complex. Structural mimic of the phosphate backbone of B-form DNA that binds to and completely occupies the DNA-binding site of all guO21970. Thereby, inhibits the restriction endonuclease activity and protects the phage genome as it penetrates into host cytoplasm.2 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Restriction-modification system evasion by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Overcome classical restriction gp0.3
Alternative name(s):
Gene product 0.3
Short name:
Gp0.3
OCR
Gene namesi
Ordered Locus Names:0.3
OrganismiEnterobacteria phage T7 (Bacteriophage T7)
Taxonomic identifieri10760 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeAutographivirinaeT7virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000000840 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001064621 – 117Overcome classical restriction gp0.3Add BLAST117

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer. Interacts with host type I restriction enzyme EcoKI M protein/HsdM.2 Publications

Protein-protein interaction databases

IntActiP03775. 1 interactor.
MINTiMINT-1513795.

Structurei

Secondary structure

1117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 25Combined sources18
Helixi31 – 33Combined sources3
Helixi35 – 45Combined sources11
Helixi50 – 57Combined sources8
Helixi69 – 71Combined sources3
Helixi78 – 96Combined sources19
Helixi98 – 106Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S7ZX-ray1.83A1-117[»]
2Y7Celectron microscopy18.00D/E1-116[»]
ProteinModelPortaliP03775.
SMRiP03775.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03775.

Family & Domainsi

Phylogenomic databases

OrthoDBiVOG090001NG.

Family and domain databases

InterProiView protein in InterPro
IPR014798. Ocr.
PfamiView protein in Pfam
PF08684. ocr. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD069042. Ocr. 1 hit.
SUPFAMiSSF101059. SSF101059. 1 hit.

Sequencei

Sequence statusi: Complete.

P03775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSNMTYNN VFDHAYEMLK ENIRYDDIRD TDDLHDAIHM AADNAVPHYY
60 70 80 90 100
ADIFSVMASE GIDLEFEDSG LMPDTKDVIR ILQARIYEQL TIDLWEDAED
110
LLNEYLEEVE EYEEDEE
Length:117
Mass (Da):13,809
Last modified:July 21, 1986 - v1
Checksum:iBB7D3D45068EB17D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43D → S in AAA32564 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38334 Genomic DNA. Translation: AAA32564.1.
V01146 Genomic DNA. Translation: CAA24384.1.
V01127 Genomic DNA. Translation: CAA24327.1.
PIRiA43002. W0BP37.
RefSeqiNP_041954.1. NC_001604.1.

Genome annotation databases

GeneIDi1261063.
KEGGivg:1261063.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38334 Genomic DNA. Translation: AAA32564.1.
V01146 Genomic DNA. Translation: CAA24384.1.
V01127 Genomic DNA. Translation: CAA24327.1.
PIRiA43002. W0BP37.
RefSeqiNP_041954.1. NC_001604.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S7ZX-ray1.83A1-117[»]
2Y7Celectron microscopy18.00D/E1-116[»]
ProteinModelPortaliP03775.
SMRiP03775.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03775. 1 interactor.
MINTiMINT-1513795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1261063.
KEGGivg:1261063.

Phylogenomic databases

OrthoDBiVOG090001NG.

Miscellaneous databases

EvolutionaryTraceiP03775.

Family and domain databases

InterProiView protein in InterPro
IPR014798. Ocr.
PfamiView protein in Pfam
PF08684. ocr. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD069042. Ocr. 1 hit.
SUPFAMiSSF101059. SSF101059. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOCR_BPT7
AccessioniPrimary (citable) accession number: P03775
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 10, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.