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P03772 (PP_LAMBD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase

EC=3.1.3.16
OrganismEnterobacteria phage lambda (Bacteriophage lambda) [Reference proteome]
Taxonomic identifier10710 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirus
Virus hostEscherichia coli [TaxID: 562]

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Plk4Q647022EBI-4478820,EBI-2552433From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221Serine/threonine-protein phosphatase
PRO_0000058912

Sites

Active site761Proton donor By similarity
Metal binding201Iron By similarity
Metal binding221Iron By similarity
Metal binding491Iron By similarity
Metal binding491Manganese By similarity
Metal binding751Manganese By similarity
Metal binding1861Manganese By similarity

Secondary structure

............................................... 221
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P03772 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 5CE0E1A0F3BC5CB5

FASTA22125,219
        10         20         30         40         50         60 
MRYYEKIDGS KYRNIWVVGD LHGCYTNLMN KLDTIGFDNK KDLLISVGDL VDRGAENVEC 

        70         80         90        100        110        120 
LELITFPWFR AVRGNHEQMM IDGLSERGNV NHWLLNGGGW FFNLDYDKEI LAKALAHKAD 

       130        140        150        160        170        180 
ELPLIIELVS KDKKYVICHA DYPFDEYEFG KPVDHQQVIW NRERISNSQN GIVKEIKGAD 

       190        200        210        220 
TFIFGHTPAV KPLKFANQMY IDTGAVFCGN LTLIQVQGEG A 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of bacteriophage lambda DNA."
Sanger F., Coulson A.R., Hong G.F., Hill D.F., Petersen G.B.
J. Mol. Biol. 162:729-773(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Discovery of a protein phosphatase activity encoded in the genome of bacteriophage lambda. Probable identity with open reading frame 221."
Cohen P.T.W., Cohen P.
Biochem. J. 260:931-934(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02459 Genomic DNA. Translation: AAA96594.1.
PIRQ1BP1L. G43011.
RefSeqNP_040641.1. NC_001416.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1G5BX-ray2.15A/B/C1-221[»]
ProteinModelPortalP03772.
SMRP03772. Positions 1-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-44028N.
IntActP03772. 3 interactions.
MINTMINT-4053809.

Chemistry

BindingDBP03772.
ChEMBLCHEMBL3695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703476.

Phylogenomic databases

ProtClustDBCLSP2343890.

Family and domain databases

InterProIPR004843. PEstase_dom.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP03772.

Entry information

Entry namePP_LAMBD
AccessionPrimary (citable) accession number: P03772
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 19, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references