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Protein

Serine/threonine-protein phosphatase

Gene
N/A
Organism
Enterobacteria phage lambda (Bacteriophage lambda)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+1 PublicationNote: Binds 2 manganese ions per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi20Manganese 11
Metal bindingi22Manganese 11
Metal bindingi49Manganese 11
Metal bindingi49Manganese 21
Metal bindingi75Manganese 21
Active sitei76Proton donorBy similarity1
Metal bindingi186Manganese 21

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase (EC:3.1.3.16)
OrganismiEnterobacteria phage lambda (Bacteriophage lambda)
Taxonomic identifieri10710 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000001711 Componenti: Genome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3695.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000589121 – 221Serine/threonine-protein phosphataseAdd BLAST221

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Plk4Q647022EBI-4478820,EBI-2552433From a different organism.

Protein-protein interaction databases

DIPiDIP-44028N.
IntActiP03772. 3 interactors.
MINTiMINT-4053809.

Chemistry databases

BindingDBiP03772.

Structurei

Secondary structure

1221
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi9 – 11Combined sources3
Beta strandi15 – 18Combined sources4
Helixi25 – 35Combined sources11
Turni39 – 41Combined sources3
Beta strandi43 – 46Combined sources4
Beta strandi51 – 55Combined sources5
Helixi57 – 61Combined sources5
Helixi62 – 65Combined sources4
Beta strandi69 – 71Combined sources3
Helixi75 – 84Combined sources10
Helixi91 – 94Combined sources4
Turni95 – 97Combined sources3
Helixi98 – 103Combined sources6
Helixi106 – 119Combined sources14
Beta strandi124 – 130Combined sources7
Beta strandi133 – 137Combined sources5
Beta strandi144 – 146Combined sources3
Helixi155 – 160Combined sources6
Helixi163 – 169Combined sources7
Beta strandi179 – 184Combined sources6
Beta strandi193 – 195Combined sources3
Beta strandi198 – 200Combined sources3
Helixi205 – 208Combined sources4
Beta strandi213 – 217Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G5BX-ray2.15A/B/C1-221[»]
ProteinModelPortaliP03772.
SMRiP03772.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03772.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family.Curated

Phylogenomic databases

KOiK07313.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYYEKIDGS KYRNIWVVGD LHGCYTNLMN KLDTIGFDNK KDLLISVGDL
60 70 80 90 100
VDRGAENVEC LELITFPWFR AVRGNHEQMM IDGLSERGNV NHWLLNGGGW
110 120 130 140 150
FFNLDYDKEI LAKALAHKAD ELPLIIELVS KDKKYVICHA DYPFDEYEFG
160 170 180 190 200
KPVDHQQVIW NRERISNSQN GIVKEIKGAD TFIFGHTPAV KPLKFANQMY
210 220
IDTGAVFCGN LTLIQVQGEG A
Length:221
Mass (Da):25,219
Last modified:July 21, 1986 - v1
Checksum:i5CE0E1A0F3BC5CB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96594.1.
PIRiG43011. Q1BP1L.
RefSeqiNP_040641.1. NC_001416.1.

Genome annotation databases

GeneIDi2703476.
KEGGivg:2703476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96594.1.
PIRiG43011. Q1BP1L.
RefSeqiNP_040641.1. NC_001416.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G5BX-ray2.15A/B/C1-221[»]
ProteinModelPortaliP03772.
SMRiP03772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-44028N.
IntActiP03772. 3 interactors.
MINTiMINT-4053809.

Chemistry databases

BindingDBiP03772.
ChEMBLiCHEMBL3695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703476.
KEGGivg:2703476.

Phylogenomic databases

KOiK07313.

Miscellaneous databases

EvolutionaryTraceiP03772.
PROiP03772.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP_LAMBD
AccessioniPrimary (citable) accession number: P03772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.