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Protein

Tail tube terminator protein

Gene

U

Organism
Enterobacteria phage lambda (Bacteriophage lambda)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in tail assembly by capping the rapidly polymerizing tail once it has reached its requisite length and serving as the interaction surface for the completion protein.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Viral tail assembly, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Tail tube terminator proteinCurated
Short name:
TrP
Alternative name(s):
Gene product U
Short name:
gpU
Minor tail protein U
Tail sheath-stabilizing proteinCurated
Tail-to-head joining protein
Short name:
THJP
Gene namesi
Name:U
Ordered Locus Names:lambdap12
OrganismiEnterobacteria phage lambda (Bacteriophage lambda)
Taxonomic identifieri10710 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000001711 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • host cell cytoplasm Source: UniProtKB-SubCell
  • virus tail Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Viral tail protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Tail tube terminator proteinPRO_0000077670Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Homohexamer. May bind to major tail protein V, and /or tape measure protein.2 Publications

Protein-protein interaction databases

IntActiP03732. 7 interactions.

Structurei

Secondary structure

1
131
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1716Combined sources
Beta strandi20 – 267Combined sources
Beta strandi29 – 313Combined sources
Turni33 – 353Combined sources
Beta strandi37 – 5014Combined sources
Beta strandi52 – 543Combined sources
Beta strandi57 – 6913Combined sources
Helixi74 – 8411Combined sources
Helixi86 – 894Combined sources
Helixi93 – 986Combined sources
Beta strandi100 – 11112Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi118 – 13013Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z1ZNMR-A1-131[»]
3FZ2X-ray2.70A/B/C/D/E/F/G/H/I/J/K/L1-131[»]
3FZBX-ray2.80A/B/C/D/E/F/G/H/I/J1-131[»]
ProteinModelPortaliP03732.
SMRiP03732. Positions 2-130.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03732.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR009312. Phage_lambda_GpU-like.
[Graphical view]
PfamiPF06141. Phage_tail_U. 1 hit.
[Graphical view]
SUPFAMiSSF143749. SSF143749. 1 hit.

Sequencei

Sequence statusi: Complete.

P03732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHTELRAAV LDALEKHDTG ATFFDGRPAV FDEADFPAVA VYLTGAEYTG
60 70 80 90 100
EELDSDTWQA ELHIEVFLPA QVPDSELDAW MESRIYPVMS DIPALSDLIT
110 120 130
SMVASGYDYR RDDDAGLWSS ADLTYVITYE M
Length:131
Mass (Da):14,649
Last modified:July 21, 1986 - v1
Checksum:i9E3BBE413C2D8E50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96544.1.
PIRiC43008. TLBPUL.
RefSeqiNP_040591.1. NC_001416.1.

Genome annotation databases

GeneIDi2703486.
KEGGivg:2703486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96544.1.
PIRiC43008. TLBPUL.
RefSeqiNP_040591.1. NC_001416.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z1ZNMR-A1-131[»]
3FZ2X-ray2.70A/B/C/D/E/F/G/H/I/J/K/L1-131[»]
3FZBX-ray2.80A/B/C/D/E/F/G/H/I/J1-131[»]
ProteinModelPortaliP03732.
SMRiP03732. Positions 2-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03732. 7 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703486.
KEGGivg:2703486.

Miscellaneous databases

EvolutionaryTraceiP03732.

Family and domain databases

InterProiIPR009312. Phage_lambda_GpU-like.
[Graphical view]
PfamiPF06141. Phage_tail_U. 1 hit.
[Graphical view]
SUPFAMiSSF143749. SSF143749. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Purification and characterization of the major protein and the terminator protein of the bacteriophage lambda tail."
    Katsura I., Tsugita A.
    Virology 76:129-145(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, SUBUNIT, SUBCELLULAR LOCATION.
  3. "Mechanism of length determination in bacteriophage lambda tails."
    Katsura I.
    Adv. Biophys. 26:1-18(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "The NMR structure of the gpU tail-terminator protein from bacteriophage lambda: identification of sites contributing to Mg(II)-mediated oligomerization and biological function."
    Edmonds L., Liu A., Kwan J.J., Avanessy A., Caracoglia M., Yang I., Maxwell K.L., Rubenstein J., Davidson A.R., Donaldson L.W.
    J. Mol. Biol. 365:175-186(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  5. "The X-ray crystal structure of the phage lambda tail terminator protein reveals the biologically relevant hexameric ring structure and demonstrates a conserved mechanism of tail termination among diverse long-tailed phages."
    Pell L.G., Liu A., Edmonds L., Donaldson L.W., Howell P.L., Davidson A.R.
    J. Mol. Biol. 389:938-951(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiTTTP_LAMBD
AccessioniPrimary (citable) accession number: P03732
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.