Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Internal virion protein gp15

Gene

15

Organism
Enterobacteria phage T7 (Bacteriophage T7)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the cylindrical core that assembles on the inner surface of the capsid during capsid formation and plays a role in viral DNA ejection into the host cell. The inner core is composed of stacked rings of gp14, gp15 and gp16 proteins. Following binding to the host cell surface, the internal core is disassembled and gp15 is ejected along with gp14 and gp16 into the infected cell. Gp15 probably remains associated with gp16. The gp15-gp16 complex binds to both the viral DNA and the host inner membrane, probably escorting the leading end of the genome through the periplasm and controlling the extend of DNA translocated into the host cell.UniRule annotation2 Publications

GO - Biological processi

Keywordsi

Molecular functionViral short tail ejection system
Biological processViral genome ejection through host cell envelope, Viral penetration into host cytoplasm, Virus entry into host cell

Protein family/group databases

TCDBi3.A.17.1.1 the phage t7 injectisome (t7 injectisome) family

Names & Taxonomyi

Protein namesi
Recommended name:
Internal virion protein gp15UniRule annotation
Alternative name(s):
Gene product 15
Short name:
Gp15
Gene namesi
Ordered Locus Names:15
OrganismiEnterobacteria phage T7 (Bacteriophage T7)
Taxonomic identifieri10760 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeAutographivirinaeT7virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000000840 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host periplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001065291 – 747Internal virion protein gp15Add BLAST747

Interactioni

Subunit structurei

Homooctamer (PubMed:12614603). Interacts with gp16; after ejection the gp15-gp16 complex composed of a gp15 octamer and a gp16 tetramer probably binds both the viral DNA and the host inner membrane (PubMed:26476287). Interacts with gp14.UniRule annotation3 Publications

Protein-protein interaction databases

IntActiP03725, 1 interactor
MINTiP03725

Family & Domainsi

Sequence similaritiesi

Belongs to the T7virus internal virion protein gp15 family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900003N

Family and domain databases

HAMAPiMF_04122 GP15_T7, 1 hit

Sequencei

Sequence statusi: Complete.

P03725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIESALQA AQPGLSRLRG GAGGMGYRAA TTQAEQPRSS LLDTIGRFAK
60 70 80 90 100
AGADMYTAKE QRARDLADER SNEIIRKLTP EQRREALNNG TLLYQDDPYA
110 120 130 140 150
MEALRVKTGR NAAYLVDDDV MQKIKEGVFR TREEMEEYRH SRLQEGAKVY
160 170 180 190 200
AEQFGIDPED VDYQRGFNGD ITERNISLYG AHDNFLSQQA QKGAIMNSRV
210 220 230 240 250
ELNGVLQDPD MLRRPDSADF FEKYIDNGLV TGAIPSDAQA TQLISQAFSD
260 270 280 290 300
ASSRAGGADF LMRVGDKKVT LNGATTTYRE LIGEEQWNAL MVTAQRSQFE
310 320 330 340 350
TDAKLNEQYR LKINSALNQE DPRTAWEMLQ GIKAELDKVQ PDEQMTPQRE
360 370 380 390 400
WLISAQEQVQ NQMNAWTKAQ AKALDDSMKS MNKLDVIDKQ FQKRINGEWV
410 420 430 440 450
STDFKDMPVN ENTGEFKHSD MVNYANKKLA EIDSMDIPDG AKDAMKLKYL
460 470 480 490 500
QADSKDGAFR TAIGTMVTDA GQEWSAAVIN GKLPERTPAM DALRRIRNAD
510 520 530 540 550
PQLIAALYPD QAELFLTMDM MDKQGIDPQV ILDADRLTVK RSKEQRFEDD
560 570 580 590 600
KAFESALNAS KAPEIARMPA SLRESARKIY DSVKYRSGNE SMAMEQMTKF
610 620 630 640 650
LKESTYTFTG DDVDGDTVGV IPKNMMQVNS DPKSWEQGRD ILEEARKGII
660 670 680 690 700
ASNPWITNKQ LTMYSQGDSI YLMDTTGQVR VRYDKELLSK VWSENQKKLE
710 720 730 740
EKAREKALAD VNKRAPIVAA TKAREAAAKR VREKRKQTPK FIYGRKE
Length:747
Mass (Da):84,341
Last modified:July 21, 1986 - v1
Checksum:i959C572B7B42C2B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01146 Genomic DNA Translation: CAA24433.1
PIRiA04351 HIBPC7
RefSeqiNP_042003.1, NC_001604.1

Genome annotation databases

GeneIDi1261034
KEGGivg:1261034

Similar proteinsi

Entry informationi

Entry nameiGP15_BPT7
AccessioniPrimary (citable) accession number: P03725
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health