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Protein

Host-nuclease inhibitor protein gam

Gene

gam

Organism
Enterobacteria phage lambda (Bacteriophage lambda)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to host RecBCD nuclease and inhibits it thereby protecting the viral DNA against recBCD mediated degradation.1 Publication

GO - Molecular functioni

  • deoxyribonuclease inhibitor activity Source: CACAO

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA end degradation evasion by virus, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Host-nuclease inhibitor protein gam
Gene namesi
Name:gam
Synonyms:gamma
OrganismiEnterobacteria phage lambda (Bacteriophage lambda)
Taxonomic identifieri10710 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000001711 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Host-nuclease inhibitor protein gamPRO_0000077641Add
BLAST

Interactioni

Subunit structurei

Interacts with host RecBCD; this interaction prevents RecBCD from binding to DNA.1 Publication

Protein-protein interaction databases

DIPiDIP-572N.

Structurei

Secondary structure

1
138
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi50 – 7627Combined sources
Helixi81 – 9212Combined sources
Helixi93 – 953Combined sources
Helixi99 – 1079Combined sources
Helixi110 – 13526Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2UUZX-ray2.30A/B40-138[»]
2UV1X-ray2.60A/B40-138[»]
ProteinModelPortaliP03702.
SMRiP03702. Positions 49-137.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03702.

Family & Domainsi

Family and domain databases

InterProiIPR009274. Gam.
[Graphical view]
PfamiPF06064. Gam. 1 hit.
[Graphical view]
ProDomiPD084412. Gam. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P03702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDINTETEIK QKHSLTPFPV FLISPAFRGR YFHSYFRSSA MNAYYIQDRL
60 70 80 90 100
EAQSWARHYQ QLAREEKEAE LADDMEKGLP QHLFESLCID HLQRHGASKK
110 120 130
SITRAFDDDV EFQERMAEHI RYMVETIAHH QVDIDSEV
Length:138
Mass (Da):16,346
Last modified:July 21, 1986 - v1
Checksum:i19479118D37F576C
GO

Sequence cautioni

The sequence CAA23977 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791L → I in AAB23852 (PubMed:1327972).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00638 Genomic DNA. Translation: CAA23978.1.
V00638 Genomic DNA. Translation: CAA23977.1. Different initiation.
J02459 Genomic DNA. Translation: AAA96571.1.
S46756 Genomic DNA. Translation: AAB23852.2.
PIRiD93737. QGBPL.
RefSeqiNP_040618.1. NC_001416.1.

Genome annotation databases

GeneIDi2703509.
KEGGivg:2703509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00638 Genomic DNA. Translation: CAA23978.1.
V00638 Genomic DNA. Translation: CAA23977.1. Different initiation.
J02459 Genomic DNA. Translation: AAA96571.1.
S46756 Genomic DNA. Translation: AAB23852.2.
PIRiD93737. QGBPL.
RefSeqiNP_040618.1. NC_001416.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2UUZX-ray2.30A/B40-138[»]
2UV1X-ray2.60A/B40-138[»]
ProteinModelPortaliP03702.
SMRiP03702. Positions 49-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-572N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703509.
KEGGivg:2703509.

Miscellaneous databases

EvolutionaryTraceiP03702.

Family and domain databases

InterProiIPR009274. Gam.
[Graphical view]
PfamiPF06064. Gam. 1 hit.
[Graphical view]
ProDomiPD084412. Gam. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiGAM_LAMBD
AccessioniPrimary (citable) accession number: P03702
Secondary accession number(s): Q53285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 6, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Originally (PubMed:6458018) the gam gene product was assigned to the sequence shown and it was suggested that the gene kil protein is encoded from within this gene and corresponds to residues 41-138. For an alternative assignment of this gene see the entry for the kil gene protein of lambda.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.