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Protein

Excisionase

Gene

xis

Organism
Enterobacteria phage lambda (Bacteriophage lambda)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Excisionase and integrase are necessary for the excision of prophage from the host genome by site-specific recombination at the att site.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA recombination

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Excisionase
Gene namesi
Name:xis
OrganismiEnterobacteria phage lambda (Bacteriophage lambda)
Taxonomic identifieri10710 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirus
Virus hostiEscherichia coli [TaxID: 562]
ProteomesiUP000001711 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272ExcisionasePRO_0000077714Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-60872N.
IntActiP03699. 2 interactions.

Structurei

Secondary structure

1
72
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 43Combined sources
Helixi5 – 106Combined sources
Beta strandi12 – 143Combined sources
Helixi18 – 269Combined sources
Beta strandi30 – 323Combined sources
Beta strandi35 – 373Combined sources
Beta strandi40 – 445Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LX8NMR-A1-55[»]
1RH6X-ray1.70A/B1-55[»]
2IEFX-ray2.60A/B/C1-55[»]
2OG0X-ray1.90A/B1-52[»]
ProteinModelPortaliP03699.
SMRiP03699. Positions 1-72.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03699.

Family & Domainsi

Family and domain databases

Gene3Di1.10.1660.20. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR012884. Excisionase-like.
[Graphical view]
PfamiPF07825. Exc. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.

Sequencei

Sequence statusi: Complete.

P03699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLTLQEWNA RQRRPRSLET VRRWVRECRI FPPPVKDGRE YLFHESAVKV
60 70
DLNRPVTGGL LKRIRNGKKA KS
Length:72
Mass (Da):8,605
Last modified:July 21, 1986 - v1
Checksum:i0E6A4843502200AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96563.1.
PIRiC94164. RSBPXL.
RefSeqiNP_040610.1. NC_001416.1.

Genome annotation databases

GeneIDi2703504.
KEGGivg:2703504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96563.1.
PIRiC94164. RSBPXL.
RefSeqiNP_040610.1. NC_001416.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LX8NMR-A1-55[»]
1RH6X-ray1.70A/B1-55[»]
2IEFX-ray2.60A/B/C1-55[»]
2OG0X-ray1.90A/B1-52[»]
ProteinModelPortaliP03699.
SMRiP03699. Positions 1-72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60872N.
IntActiP03699. 2 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703504.
KEGGivg:2703504.

Miscellaneous databases

EvolutionaryTraceiP03699.

Family and domain databases

Gene3Di1.10.1660.20. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR012884. Excisionase-like.
[Graphical view]
PfamiPF07825. Exc. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "DNA sequence of the int-xis-Pi region of the bacteriophage lambda; overlap of the int and xis genes."
    Davies R.W.
    Nucleic Acids Res. 8:1765-1782(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Site-specific recombination functions of bacteriophage lambda: DNA sequence of regulatory regions and overlapping structural genes for Int and Xis."
    Hoess R.H., Foeller C., Bidwell K., Landy A.
    Proc. Natl. Acad. Sci. U.S.A. 77:2482-2486(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiVXIS_LAMBD
AccessioniPrimary (citable) accession number: P03699
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 1, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.