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Protein

Excisionase

Gene

xis

Organism
Escherichia phage lambda (Bacteriophage lambda)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the excision complex necessary for the excision of prophage from the host genome by site-specific recombination at the att site.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA recombination, Viral genome excision

Names & Taxonomyi

Protein namesi
Recommended name:
Excisionase
Gene namesi
Name:xis
OrganismiEscherichia phage lambda (Bacteriophage lambda)
Taxonomic identifieri10710 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdavirus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000001711 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000777141 – 72ExcisionaseAdd BLAST72

Interactioni

Subunit structurei

Interacts (via C-terminus) with the integrase (via N-terminus) (PubMed:12832614). Part of the excision complex made of the integrase tetramer, IHF, Fis and Xis (PubMed:25114241).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-4479236,EBI-4479236

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-60872N
IntActiP03699 3 interactors.

Structurei

Secondary structure

172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Helixi5 – 10Combined sources6
Beta strandi12 – 14Combined sources3
Helixi18 – 26Combined sources9
Beta strandi30 – 32Combined sources3
Beta strandi35 – 37Combined sources3
Beta strandi40 – 44Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LX8NMR-A1-55[»]
1RH6X-ray1.70A/B1-55[»]
2IEFX-ray2.60A/B/C1-55[»]
2OG0X-ray1.90A/B1-52[»]
5J0Nelectron microscopy11.00M/N/O1-55[»]
ProteinModelPortaliP03699
SMRiP03699
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03699

Family & Domainsi

Phylogenomic databases

OrthoDBiVOG090001OE

Family and domain databases

Gene3Di1.10.1660.201 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR012884 Excisionase-like
IPR038137 Excisionase-like_sf
PfamiView protein in Pfam
PF07825 Exc, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit

Sequencei

Sequence statusi: Complete.

P03699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLTLQEWNA RQRRPRSLET VRRWVRECRI FPPPVKDGRE YLFHESAVKV
60 70
DLNRPVTGGL LKRIRNGKKA KS
Length:72
Mass (Da):8,605
Last modified:July 21, 1986 - v1
Checksum:i0E6A4843502200AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA Translation: AAA96563.1
PIRiC94164 RSBPXL
RefSeqiNP_040610.1, NC_001416.1

Genome annotation databases

GeneIDi2703504
KEGGivg:2703504

Similar proteinsi

Entry informationi

Entry nameiVXIS_LAMBD
AccessioniPrimary (citable) accession number: P03699
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome