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P03697

- EXO_LAMBD

UniProt

P03697 - EXO_LAMBD

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Protein

Exonuclease

Gene

exo

Organism
Enterobacteria phage lambda (Bacteriophage lambda)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Facilitates phage DNA recombination through the double-strand break repair (DSBR) and single-strand annealing pathways. Also important for the late, rolling-circle mode of lambda DNA replication.

Catalytic activityi

Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi119 – 1191Magnesium
Metal bindingi129 – 1291Magnesium

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. exonuclease activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.11.3. 717.

Names & Taxonomyi

Protein namesi
Recommended name:
Exonuclease (EC:3.1.11.3)
Gene namesi
Name:exo
Synonyms:red-alpha, redX
OrganismiEnterobacteria phage lambda (Bacteriophage lambda)
Taxonomic identifieri10710 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirus
Virus hostiEscherichia coli [TaxID: 562]
ProteomesiUP000001711: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226ExonucleasePRO_0000077574Add
BLAST

Interactioni

Subunit structurei

Trimer of three subunits that form a toroid, with a tapered channel passing through the middle.

Protein-protein interaction databases

DIPiDIP-59695N.

Structurei

Secondary structure

1
226
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 108Combined sources
Helixi14 – 163Combined sources
Beta strandi19 – 213Combined sources
Helixi22 – 276Combined sources
Turni28 – 303Combined sources
Helixi34 – 374Combined sources
Helixi38 – 414Combined sources
Beta strandi45 – 484Combined sources
Helixi52 – 6716Combined sources
Helixi75 – 9622Combined sources
Beta strandi106 – 1094Combined sources
Beta strandi114 – 1163Combined sources
Beta strandi119 – 1224Combined sources
Beta strandi127 – 1315Combined sources
Helixi136 – 14510Combined sources
Helixi146 – 1494Combined sources
Helixi151 – 16515Combined sources
Beta strandi168 – 1758Combined sources
Beta strandi179 – 1813Combined sources
Beta strandi184 – 1907Combined sources
Helixi193 – 21624Combined sources
Helixi223 – 2253Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AVQX-ray2.40A/B/C1-226[»]
3SLPX-ray2.30A/B/C1-226[»]
3SM4X-ray1.88A/B/C1-226[»]
ProteinModelPortaliP03697.
SMRiP03697. Positions 1-226.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03697.

Family & Domainsi

Family and domain databases

Gene3Di3.90.320.10. 1 hit.
InterProiIPR011604. Exonuc_phg/RecB_C.
IPR011335. Restrct_endonuc-II-like.
IPR019080. YqaJ_viral_recombinase.
[Graphical view]
PfamiPF09588. YqaJ. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.

Sequencei

Sequence statusi: Complete.

P03697-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPDIILQRT GIDVRAVEQG DDAWHKLRLG VITASEVHNV IAKPRSGKKW
60 70 80 90 100
PDMKMSYFHT LLAEVCTGVA PEVNAKALAW GKQYENDART LFEFTSGVNV
110 120 130 140 150
TESPIIYRDE SMRTACSPDG LCSDGNGLEL KCPFTSRDFM KFRLGGFEAI
160 170 180 190 200
KSAYMAQVQY SMWVTRKNAW YFANYDPRMK REGLHYVVIE RDEKYMASFD
210 220
EIVPEFIEKM DEALAEIGFV FGEQWR
Length:226
Mass (Da):25,909
Last modified:July 21, 1986 - v1
Checksum:i7D93AABA17F9AE26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96569.1.
PIRiH94614. NDBPXL.
RefSeqiNP_040616.1. NC_001416.1.

Genome annotation databases

GeneIDi2703469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96569.1 .
PIRi H94614. NDBPXL.
RefSeqi NP_040616.1. NC_001416.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AVQ X-ray 2.40 A/B/C 1-226 [» ]
3SLP X-ray 2.30 A/B/C 1-226 [» ]
3SM4 X-ray 1.88 A/B/C 1-226 [» ]
ProteinModelPortali P03697.
SMRi P03697. Positions 1-226.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59695N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703469.

Enzyme and pathway databases

BRENDAi 3.1.11.3. 717.

Miscellaneous databases

EvolutionaryTracei P03697.

Family and domain databases

Gene3Di 3.90.320.10. 1 hit.
InterProi IPR011604. Exonuc_phg/RecB_C.
IPR011335. Restrct_endonuc-II-like.
IPR019080. YqaJ_viral_recombinase.
[Graphical view ]
Pfami PF09588. YqaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF52980. SSF52980. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Toroidal structure of lambda-exonuclease."
    Kovall R., Matthews B.W.
    Science 277:1824-1827(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

Entry informationi

Entry nameiEXO_LAMBD
AccessioniPrimary (citable) accession number: P03697
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3