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P03697 (EXO_LAMBD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exonuclease

EC=3.1.11.3
Gene names
Name:exo
Synonyms:red-alpha, redX
OrganismEnterobacteria phage lambda (Bacteriophage lambda) [Reference proteome]
Taxonomic identifier10710 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirus
Virus hostEscherichia coli [TaxID: 562]

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Facilitates phage DNA recombination through the double-strand break repair (DSBR) and single-strand annealing pathways. Also important for the late, rolling-circle mode of lambda DNA replication.

Catalytic activity

Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.

Cofactor

Magnesium.

Subunit structure

Trimer of three subunits that form a toroid, with a tapered channel passing through the middle.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226Exonuclease
PRO_0000077574

Sites

Metal binding1191Magnesium
Metal binding1291Magnesium

Secondary structure

......................................... 226
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P03697 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 7D93AABA17F9AE26

FASTA22625,909
        10         20         30         40         50         60 
MTPDIILQRT GIDVRAVEQG DDAWHKLRLG VITASEVHNV IAKPRSGKKW PDMKMSYFHT 

        70         80         90        100        110        120 
LLAEVCTGVA PEVNAKALAW GKQYENDART LFEFTSGVNV TESPIIYRDE SMRTACSPDG 

       130        140        150        160        170        180 
LCSDGNGLEL KCPFTSRDFM KFRLGGFEAI KSAYMAQVQY SMWVTRKNAW YFANYDPRMK 

       190        200        210        220 
REGLHYVVIE RDEKYMASFD EIVPEFIEKM DEALAEIGFV FGEQWR 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of bacteriophage lambda DNA."
Sanger F., Coulson A.R., Hong G.F., Hill D.F., Petersen G.B.
J. Mol. Biol. 162:729-773(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Toroidal structure of lambda-exonuclease."
Kovall R., Matthews B.W.
Science 277:1824-1827(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02459 Genomic DNA. Translation: AAA96569.1.
PIRNDBPXL. H94614.
RefSeqNP_040616.1. NC_001416.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AVQX-ray2.40A/B/C1-226[»]
3SLPX-ray2.30A/B/C1-226[»]
3SM4X-ray1.88A/B/C1-226[»]
ProteinModelPortalP03697.
SMRP03697. Positions 1-226.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59695N.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703469.

Enzyme and pathway databases

BRENDA3.1.11.3. 717.

Family and domain databases

Gene3D3.90.320.10. 1 hit.
InterProIPR011604. Exonuc_phg/RecB_C.
IPR011335. Restrct_endonuc-II-like.
IPR019080. YqaJ_viral_recombinase.
[Graphical view]
PfamPF09588. YqaJ. 1 hit.
[Graphical view]
SUPFAMSSF52980. SSF52980. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP03697.

Entry information

Entry nameEXO_LAMBD
AccessionPrimary (citable) accession number: P03697
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references