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Protein

Exonuclease

Gene

exo

Organism
Enterobacteria phage lambda (Bacteriophage lambda)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates phage DNA recombination through the double-strand break repair (DSBR) and single-strand annealing pathways. Also important for the late, rolling-circle mode of lambda DNA replication.

Catalytic activityi

Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi119Magnesium1
Metal bindingi129Magnesium1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.11.3. 717.

Names & Taxonomyi

Protein namesi
Recommended name:
Exonuclease (EC:3.1.11.3)
Gene namesi
Name:exo
Synonyms:red-alpha, redX
OrganismiEnterobacteria phage lambda (Bacteriophage lambda)
Taxonomic identifieri10710 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000001711 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000775741 – 226ExonucleaseAdd BLAST226

Interactioni

Subunit structurei

Trimer of three subunits that form a toroid, with a tapered channel passing through the middle.

Protein-protein interaction databases

DIPiDIP-59695N.

Structurei

Secondary structure

1226
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 10Combined sources8
Helixi14 – 16Combined sources3
Beta strandi19 – 21Combined sources3
Helixi22 – 27Combined sources6
Turni28 – 30Combined sources3
Helixi34 – 37Combined sources4
Helixi38 – 41Combined sources4
Beta strandi45 – 48Combined sources4
Helixi52 – 67Combined sources16
Helixi75 – 96Combined sources22
Beta strandi106 – 109Combined sources4
Beta strandi114 – 116Combined sources3
Beta strandi119 – 122Combined sources4
Beta strandi127 – 131Combined sources5
Helixi136 – 145Combined sources10
Helixi146 – 149Combined sources4
Helixi151 – 165Combined sources15
Beta strandi168 – 175Combined sources8
Beta strandi179 – 181Combined sources3
Beta strandi184 – 190Combined sources7
Helixi193 – 216Combined sources24
Helixi223 – 225Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AVQX-ray2.40A/B/C1-226[»]
3SLPX-ray2.30A/B/C1-226[»]
3SM4X-ray1.88A/B/C1-226[»]
4WUZX-ray2.38A/B/C1-226[»]
ProteinModelPortaliP03697.
SMRiP03697.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03697.

Family & Domainsi

Family and domain databases

Gene3Di3.90.320.10. 1 hit.
InterProiIPR011604. Exonuc_phg/RecB_C.
IPR011335. Restrct_endonuc-II-like.
IPR019080. YqaJ_viral_recombinase.
[Graphical view]
PfamiPF09588. YqaJ. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.

Sequencei

Sequence statusi: Complete.

P03697-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPDIILQRT GIDVRAVEQG DDAWHKLRLG VITASEVHNV IAKPRSGKKW
60 70 80 90 100
PDMKMSYFHT LLAEVCTGVA PEVNAKALAW GKQYENDART LFEFTSGVNV
110 120 130 140 150
TESPIIYRDE SMRTACSPDG LCSDGNGLEL KCPFTSRDFM KFRLGGFEAI
160 170 180 190 200
KSAYMAQVQY SMWVTRKNAW YFANYDPRMK REGLHYVVIE RDEKYMASFD
210 220
EIVPEFIEKM DEALAEIGFV FGEQWR
Length:226
Mass (Da):25,909
Last modified:July 21, 1986 - v1
Checksum:i7D93AABA17F9AE26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96569.1.
PIRiH94614. NDBPXL.
RefSeqiNP_040616.1. NC_001416.1.

Genome annotation databases

GeneIDi2703469.
KEGGivg:2703522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96569.1.
PIRiH94614. NDBPXL.
RefSeqiNP_040616.1. NC_001416.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AVQX-ray2.40A/B/C1-226[»]
3SLPX-ray2.30A/B/C1-226[»]
3SM4X-ray1.88A/B/C1-226[»]
4WUZX-ray2.38A/B/C1-226[»]
ProteinModelPortaliP03697.
SMRiP03697.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59695N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703469.
KEGGivg:2703522.

Enzyme and pathway databases

BRENDAi3.1.11.3. 717.

Miscellaneous databases

EvolutionaryTraceiP03697.

Family and domain databases

Gene3Di3.90.320.10. 1 hit.
InterProiIPR011604. Exonuc_phg/RecB_C.
IPR011335. Restrct_endonuc-II-like.
IPR019080. YqaJ_viral_recombinase.
[Graphical view]
PfamiPF09588. YqaJ. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEXO_LAMBD
AccessioniPrimary (citable) accession number: P03697
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.