P03529 (SIG1S_REOVD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein sigma-1-small
Short name=Sigma1s

Alternative name(s):
Sigma-s
Sigma1NS
Sigma1bNS
p14

Gene names

Name:

S1

Organism

Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

Taxonomic identifier

10886 [NCBI]

Taxonomic lineage

Viruses › dsRNA viruses › Reoviridae › Spinareovirinae › Orthoreovirus › Mammalian orthoreovirus › Mammalian orthoreovirus 3

Virus host

Mammalia [TaxID: 40674]

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the orthoreovirus sigma-1s protein family.

Ontologies

Keywords
Biological process	Host G2/M cell cycle arrest by virus Host-virus interaction Modulation of host cell cycle by virus
Gene Ontology (GO)
Biological_process	suppression by virus of G2/M transition of host mitotic cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 120	120	Protein sigma-1-small		PRO_0000222755
Experimental info
	Sequence conflict	3	1	Y → H in CAA25606. Ref.2
	Sequence conflict	99	1	S → T in CAA25606. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P03529 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: AC152A19E80E47E4	FASTA	120	14,017
	10 20 30 40 50 60 MEYHCQKGLN QGSRRSRRRL KYTLILSSGS PRDSMMQTNE SSLLSKVGMT WLHQSVMLNL 70 80 90 100 110 120 QSPDWKALSE PSKQLSMDLI RVLPSWVLEW DNLRQDLQSY ALITTISLRE WILQNVTLDH

References

[1]	"Sequence of reovirus haemagglutinin predicts a coiled-coil structure." Bassel-Duby R., Jayasuriya A.K., Chatterjee D., Sonenberg N., Maizel J.V. Jr., Fields B.N. Nature 315:421-423(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Molecular cloning and sequencing of the reovirus (serotype 3) S1 gene which encodes the viral cell attachment protein sigma 1." Nagata L., Masri S.A., Mah D.C.W., Lee P.W.K. Nucleic Acids Res. 12:8699-8710(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X01161 Genomic RNA. Translation: CAA25606.1.
PIR	QQXRS3. A04128.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003478. Capsid_sigma_1s. [Graphical view]
Pfam	PF02454. Sigma_1s. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIG1S_REOVD

Accession

Primary (citable) accession number: P03529
Secondary accession number(s): Q85669

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program