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Protein

Protein sigma-1-small

Gene

S1

Organism
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  1. suppression by virus of G2/M transition of host mitotic cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host G2/M cell cycle arrest by virus, Host-virus interaction, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sigma-1-small
Short name:
Sigma1s
Alternative name(s):
Sigma-s
Sigma1NS
Sigma1bNS
p14
Gene namesi
Name:S1
OrganismiReovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
Taxonomic identifieri10886 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 120120Protein sigma-1-smallPRO_0000222755Add
BLAST

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003478. Capsid_sigma_1s.
[Graphical view]
PfamiPF02454. Sigma_1s. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03529-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYHCQKGLN QGSRRSRRRL KYTLILSSGS PRDSMMQTNE SSLLSKVGMT
60 70 80 90 100
WLHQSVMLNL QSPDWKALSE PSKQLSMDLI RVLPSWVLEW DNLRQDLQSY
110 120
ALITTISLRE WILQNVTLDH
Length:120
Mass (Da):14,017
Last modified:July 21, 1986 - v1
Checksum:iAC152A19E80E47E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31Y → H in CAA25606 (PubMed:6095208).Curated
Sequence conflicti99 – 991S → T in CAA25606 (PubMed:6095208).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01161 Genomic RNA. Translation: CAA25606.1.
PIRiA04128. QQXRS3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01161 Genomic RNA. Translation: CAA25606.1.
PIRiA04128. QQXRS3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR003478. Capsid_sigma_1s.
[Graphical view]
PfamiPF02454. Sigma_1s. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of reovirus haemagglutinin predicts a coiled-coil structure."
    Bassel-Duby R., Jayasuriya A.K., Chatterjee D., Sonenberg N., Maizel J.V. Jr., Fields B.N.
    Nature 315:421-423(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Molecular cloning and sequencing of the reovirus (serotype 3) S1 gene which encodes the viral cell attachment protein sigma 1."
    Nagata L., Masri S.A., Mah D.C.W., Lee P.W.K.
    Nucleic Acids Res. 12:8699-8710(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiSIG1S_REOVD
AccessioniPrimary (citable) accession number: P03529
Secondary accession number(s): Q85669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.