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P03526

- SIGNS_REOVD

UniProt

P03526 - SIGNS_REOVD

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Protein

Protein sigma-NS

Gene

S3

Organism
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Protein that binds to ssRNA and may be involved in genome packaging.By similarity

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: InterPro
  2. single-stranded RNA binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sigma-NS
Short name:
SigmaNS
Gene namesi
Name:S3
OrganismiReovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
Taxonomic identifieri10886 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006373: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Protein sigma-NSPRO_0000222759Add
BLAST

Interactioni

Subunit structurei

Homomultimer. Interacts with protein mu-NS; in viral inclusions.By similarity

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1111Important for ssRNA-binding and formation of complexesBy similarityAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR002507. Reovirus_polyG_pol.
[Graphical view]
PfamiPF01518. PolyG_pol. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03526-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MASSLRAAIS KIKRDDVGQQ VCPNYVMLRS SVTTKVVRNV VEYQIRTGGF
60 70 80 90 100
FSCLAMLRPL QYAKRERLLG QRNLERISTR DILQTRDLHS LCMPTPDAPM
110 120 130 140 150
SNHQASTMRE LICSYFKVDH ADGLKYIPMD ERYSPSSLAR LFTMGMAGLH
160 170 180 190 200
ITTEPSYKRV PIMHLAADLD CMTLALPYMI TLDGDTVVPV APTLSAEQLL
210 220 230 240 250
DDGLKGLACM DISYGCEVDA NSRPAGDQSM DSSRCINELY CEETAEAICV
260 270 280 290 300
LKTCLVLNCM QFKLEMDDLA HNAAELDKIQ MMIPFSERVF RMASSFATID
310 320 330 340 350
AQCFRFCVMM KDKNLKIDMR ETTRLWTRSA SDDSVATSSL SISLDRGRWV
360
AADASDARLL VFPIRV
Length:366
Mass (Da):41,057
Last modified:July 21, 1986 - v1
Checksum:i201A6223C4290D7D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti260 – 2601M → T in strain: Mutant tsE320.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01627 Genomic RNA. Translation: CAA25768.1.
AF076293 mRNA. Translation: AAG02124.1.
EF494443 Genomic RNA. Translation: ABP48921.1.
J02330 Genomic RNA. Translation: AAA47280.1.
PIRiA04126. MNXRSD.
C27401.
RefSeqiNP_694688.1. NC_004283.1.

Genome annotation databases

GeneIDi956478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01627 Genomic RNA. Translation: CAA25768.1 .
AF076293 mRNA. Translation: AAG02124.1 .
EF494443 Genomic RNA. Translation: ABP48921.1 .
J02330 Genomic RNA. Translation: AAA47280.1 .
PIRi A04126. MNXRSD.
C27401.
RefSeqi NP_694688.1. NC_004283.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956478.

Family and domain databases

InterProi IPR002507. Reovirus_polyG_pol.
[Graphical view ]
Pfami PF01518. PolyG_pol. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of reovirus genome segment S3, encoding non-structural protein sigma NS."
    Richardson M.A., Furuichi Y.
    Nucleic Acids Res. 11:6399-6408(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Reovirus sigmaNS protein is required for nucleation of viral assembly complexes and formation of viral inclusions."
    Becker M.M., Goral M.I., Hazelton P.R., Baer G.S., Rodgers S.E., Brown E.G., Coombs K.M., Dermody T.S.
    J. Virol. 75:1459-1475(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Mutant tsE320.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Infectious clone.
  4. "Sequence at both termini of the 10 genes of reovirus serotype 3 (strain Dearing)."
    Antczak J.B., Chmelo R.A., Pickup D.J., Joklik W.K.
    Virology 121:307-319(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-17.

Entry informationi

Entry nameiSIGNS_REOVD
AccessioniPrimary (citable) accession number: P03526
Secondary accession number(s): A4ZY28, Q9ENN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3