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P03526 (SIGNS_REOVD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein sigma-NS

Short name=SigmaNS
Gene names
Name:S3
OrganismReovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3) [Complete proteome]
Taxonomic identifier10886 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostMammalia [TaxID: 40674]

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein that binds to ssRNA and may be involved in genome packaging By similarity. Ref.2

Subunit structure

Homomultimer By similarity. Interacts with protein mu-NS; in viral inclusions By similarity.

Sequence similarities

Belongs to the orthoreovirus sigma-NS protein family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Protein sigma-NS
PRO_0000222759

Regions

Region1 – 1111Important for ssRNA-binding and formation of complexes By similarity

Natural variations

Natural variant2601M → T in strain: Mutant tsE320.

Sequences

Sequence LengthMass (Da)Tools
P03526 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 201A6223C4290D7D

FASTA36641,057
        10         20         30         40         50         60 
MASSLRAAIS KIKRDDVGQQ VCPNYVMLRS SVTTKVVRNV VEYQIRTGGF FSCLAMLRPL 

        70         80         90        100        110        120 
QYAKRERLLG QRNLERISTR DILQTRDLHS LCMPTPDAPM SNHQASTMRE LICSYFKVDH 

       130        140        150        160        170        180 
ADGLKYIPMD ERYSPSSLAR LFTMGMAGLH ITTEPSYKRV PIMHLAADLD CMTLALPYMI 

       190        200        210        220        230        240 
TLDGDTVVPV APTLSAEQLL DDGLKGLACM DISYGCEVDA NSRPAGDQSM DSSRCINELY 

       250        260        270        280        290        300 
CEETAEAICV LKTCLVLNCM QFKLEMDDLA HNAAELDKIQ MMIPFSERVF RMASSFATID 

       310        320        330        340        350        360 
AQCFRFCVMM KDKNLKIDMR ETTRLWTRSA SDDSVATSSL SISLDRGRWV AADASDARLL 


VFPIRV 

« Hide

References

[1]"Nucleotide sequence of reovirus genome segment S3, encoding non-structural protein sigma NS."
Richardson M.A., Furuichi Y.
Nucleic Acids Res. 11:6399-6408(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Reovirus sigmaNS protein is required for nucleation of viral assembly complexes and formation of viral inclusions."
Becker M.M., Goral M.I., Hazelton P.R., Baer G.S., Rodgers S.E., Brown E.G., Coombs K.M., Dermody T.S.
J. Virol. 75:1459-1475(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: Mutant tsE320.
[3]"A plasmid-based reverse genetics system for animal double-stranded RNA viruses."
Kobayashi T., Antar A.A., Boehme K.W., Danthi P., Eby E.A., Guglielmi K.M., Holm G.H., Johnson E.M., Maginnis M.S., Naik S., Skelton W.B., Wetzel J.D., Wilson G.J., Chappell J.D., Dermody T.S.
Cell Host Microbe 1:147-157(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Infectious clone.
[4]"Sequence at both termini of the 10 genes of reovirus serotype 3 (strain Dearing)."
Antczak J.B., Chmelo R.A., Pickup D.J., Joklik W.K.
Virology 121:307-319(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-17.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01627 Genomic RNA. Translation: CAA25768.1.
AF076293 mRNA. Translation: AAG02124.1.
EF494443 Genomic RNA. Translation: ABP48921.1.
J02330 Genomic RNA. Translation: AAA47280.1.
PIRMNXRSD. A04126.
C27401.
RefSeqNP_694688.1. NC_004283.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID956478.

Family and domain databases

InterProIPR002507. Reovirus_polyG_pol.
[Graphical view]
PfamPF01518. PolyG_pol. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSIGNS_REOVD
AccessionPrimary (citable) accession number: P03526
Secondary accession number(s): A4ZY28, Q9ENN1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families