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P03526

- SIGNS_REOVD

UniProt

P03526 - SIGNS_REOVD

Protein

Protein sigma-NS

Gene

S3

Organism
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Protein that binds to ssRNA and may be involved in genome packaging.By similarity

    GO - Molecular functioni

    1. RNA-directed RNA polymerase activity Source: InterPro
    2. single-stranded RNA binding Source: InterPro

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein sigma-NS
    Short name:
    SigmaNS
    Gene namesi
    Name:S3
    OrganismiReovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
    Taxonomic identifieri10886 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
    Virus hostiMammalia [TaxID: 40674]
    ProteomesiUP000006373: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Protein sigma-NSPRO_0000222759Add
    BLAST

    Interactioni

    Subunit structurei

    Homomultimer. Interacts with protein mu-NS; in viral inclusions.By similarity

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 1111Important for ssRNA-binding and formation of complexesBy similarityAdd
    BLAST

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR002507. Reovirus_polyG_pol.
    [Graphical view]
    PfamiPF01518. PolyG_pol. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P03526-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSLRAAIS KIKRDDVGQQ VCPNYVMLRS SVTTKVVRNV VEYQIRTGGF    50
    FSCLAMLRPL QYAKRERLLG QRNLERISTR DILQTRDLHS LCMPTPDAPM 100
    SNHQASTMRE LICSYFKVDH ADGLKYIPMD ERYSPSSLAR LFTMGMAGLH 150
    ITTEPSYKRV PIMHLAADLD CMTLALPYMI TLDGDTVVPV APTLSAEQLL 200
    DDGLKGLACM DISYGCEVDA NSRPAGDQSM DSSRCINELY CEETAEAICV 250
    LKTCLVLNCM QFKLEMDDLA HNAAELDKIQ MMIPFSERVF RMASSFATID 300
    AQCFRFCVMM KDKNLKIDMR ETTRLWTRSA SDDSVATSSL SISLDRGRWV 350
    AADASDARLL VFPIRV 366
    Length:366
    Mass (Da):41,057
    Last modified:July 21, 1986 - v1
    Checksum:i201A6223C4290D7D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti260 – 2601M → T in strain: Mutant tsE320.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01627 Genomic RNA. Translation: CAA25768.1.
    AF076293 mRNA. Translation: AAG02124.1.
    EF494443 Genomic RNA. Translation: ABP48921.1.
    J02330 Genomic RNA. Translation: AAA47280.1.
    PIRiA04126. MNXRSD.
    C27401.
    RefSeqiNP_694688.1. NC_004283.1.

    Genome annotation databases

    GeneIDi956478.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01627 Genomic RNA. Translation: CAA25768.1 .
    AF076293 mRNA. Translation: AAG02124.1 .
    EF494443 Genomic RNA. Translation: ABP48921.1 .
    J02330 Genomic RNA. Translation: AAA47280.1 .
    PIRi A04126. MNXRSD.
    C27401.
    RefSeqi NP_694688.1. NC_004283.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 956478.

    Family and domain databases

    InterProi IPR002507. Reovirus_polyG_pol.
    [Graphical view ]
    Pfami PF01518. PolyG_pol. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of reovirus genome segment S3, encoding non-structural protein sigma NS."
      Richardson M.A., Furuichi Y.
      Nucleic Acids Res. 11:6399-6408(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Reovirus sigmaNS protein is required for nucleation of viral assembly complexes and formation of viral inclusions."
      Becker M.M., Goral M.I., Hazelton P.R., Baer G.S., Rodgers S.E., Brown E.G., Coombs K.M., Dermody T.S.
      J. Virol. 75:1459-1475(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: Mutant tsE320.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Infectious clone.
    4. "Sequence at both termini of the 10 genes of reovirus serotype 3 (strain Dearing)."
      Antczak J.B., Chmelo R.A., Pickup D.J., Joklik W.K.
      Virology 121:307-319(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-17.

    Entry informationi

    Entry nameiSIGNS_REOVD
    AccessioniPrimary (citable) accession number: P03526
    Secondary accession number(s): A4ZY28, Q9ENN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3