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Protein

Inner capsid protein sigma-2

Gene

S2

Organism
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Inner capsid (core) component.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein sigma-2
Short name:
Sigma2
Gene namesi
Name:S2
OrganismiReovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
Taxonomic identifieri10886 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006373: Genome

Subcellular locationi

Virion Curated
Note: Found in the inner capsid (150 copies).

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Inner capsid protein sigma-2PRO_0000222749Add
BLAST

Interactioni

Subunit structurei

Interacts with protein mu-NS; in viral inclusions.By similarity

Structurei

3D structure databases

ProteinModelPortaliP03525.
SMRiP03525. Positions 2-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR004317. Sigma_1_2_reovir.
[Graphical view]
PfamiPF03084. Sigma_1_2. 1 hit.
[Graphical view]
ProDomiPD004419. Sigma_1_2_reovir. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P03525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAAFLFKT VGFGGLQNVP INDELSSHLL RAGNSPWQLT QFLDWISLGR
60 70 80 90 100
GLATSALVPT AGSRYYQMSC LLSGTLQIPF RPNHRWGDIR FLRLVWSAPT
110 120 130 140 150
LDGLVVAPPQ VLAQPALQAQ ADRVYDCDDY PFLARDPRFK HRVYQQLSAV
160 170 180 190 200
TLLNLTGFGP ISYVRVDEDM WSGDVNQLLM NYFGHTFAEI AYTLCQASAN
210 220 230 240 250
RPWEYDGTYA RMTQIVLSLF WLSYVGVIHQ QNTYRTFYFQ CNRRGDAAEV
260 270 280 290 300
WILSCSLNHS AQIRPGNRSL FVMPTSPDWN MDVNLILSST LTGCLCSGSQ
310 320 330 340 350
LPLIDNNSVP AVSRNIHGWT GRAGNQLHGF QVRRMVTEFC DRLRRDGVMT
360 370 380 390 400
QAQQNQVEAL ADQTQQFKRD KLETWAREDD QYNQAHPNST MFRTKPFTNA
410
QWGRGNTGAT SAAIAALI
Length:418
Mass (Da):47,161
Last modified:August 1, 1990 - v2
Checksum:i0E2F7824DA61D0DC
GO

Sequence cautioni

The sequence J02327 differs from that shown. Reason: Frameshift at position 310. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti259 – 2591H → Y in J02327 (PubMed:6961439).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti188 – 1881A → V in strain: Mutant ts447; temperature-sensitive.
Natural varianti323 – 3231A → V in strain: Mutant ts447; temperature-sensitive.
Natural varianti383 – 3831N → D in strain: Mutant ts447; temperature-sensitive.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25780 Genomic DNA. Translation: AAA47279.1.
J02327 Genomic RNA. No translation available.
L19776 Genomic RNA. Translation: AAA47261.1.
EF494442 Genomic RNA. Translation: ABP48920.1.
PIRiA31475. FOXR3D.
RefSeqiNP_694684.1. NC_004279.1.

Genome annotation databases

GeneIDi956473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25780 Genomic DNA. Translation: AAA47279.1.
J02327 Genomic RNA. No translation available.
L19776 Genomic RNA. Translation: AAA47261.1.
EF494442 Genomic RNA. Translation: ABP48920.1.
PIRiA31475. FOXR3D.
RefSeqiNP_694684.1. NC_004279.1.

3D structure databases

ProteinModelPortaliP03525.
SMRiP03525. Positions 2-418.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi956473.

Family and domain databases

InterProiIPR004317. Sigma_1_2_reovir.
[Graphical view]
PfamiPF03084. Sigma_1_2. 1 hit.
[Graphical view]
ProDomiPD004419. Sigma_1_2_reovir. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "The sequences of the S2 genome segments of reovirus serotype 3 and of the dsRNA-negative mutant ts447."
    Wiener J.R., McLaughlin T., Joklik W.K.
    Virology 170:340-341(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Mutant ts447.
  2. "Cloning the double-stranded RNA genes of reovirus: sequence of the cloned S2 gene."
    Cashdollar L.W., Esparza J., Hudson G.R., Chmelo R.A., Lee P.W.K., Joklik W.K.
    Proc. Natl. Acad. Sci. U.S.A. 79:7644-7648(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "The S2 gene nucleotide sequences of prototype strains of the three reovirus serotypes: characterization of reovirus core protein sigma 2."
    Dermody T.S., Schiff L.A., Nibert M.L., Coombs K.M., Fields B.N.
    J. Virol. 65:5721-5731(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Infectious clone.

Entry informationi

Entry nameiSIGM2_REOVD
AccessioniPrimary (citable) accession number: P03525
Secondary accession number(s): Q6LEC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: January 7, 2015
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Mutant ts447 is temperature-sensitive.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.