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P03525

- SIGM2_REOVD

UniProt

P03525 - SIGM2_REOVD

Protein

Inner capsid protein sigma-2

Gene

S2

Organism
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Inner capsid (core) component.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein sigma-2
    Short name:
    Sigma2
    Gene namesi
    Name:S2
    OrganismiReovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
    Taxonomic identifieri10886 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
    Virus hostiMammalia [TaxID: 40674]
    ProteomesiUP000006373: Genome

    Subcellular locationi

    Virion Curated
    Note: Found in the inner capsid (150 copies).

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Inner capsid protein sigma-2PRO_0000222749Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with protein mu-NS; in viral inclusions.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP03525.
    SMRiP03525. Positions 2-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR004317. Sigma_1_2_reovir.
    [Graphical view]
    PfamiPF03084. Sigma_1_2. 1 hit.
    [Graphical view]
    ProDomiPD004419. Sigma_1_2_reovir. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P03525-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARAAFLFKT VGFGGLQNVP INDELSSHLL RAGNSPWQLT QFLDWISLGR    50
    GLATSALVPT AGSRYYQMSC LLSGTLQIPF RPNHRWGDIR FLRLVWSAPT 100
    LDGLVVAPPQ VLAQPALQAQ ADRVYDCDDY PFLARDPRFK HRVYQQLSAV 150
    TLLNLTGFGP ISYVRVDEDM WSGDVNQLLM NYFGHTFAEI AYTLCQASAN 200
    RPWEYDGTYA RMTQIVLSLF WLSYVGVIHQ QNTYRTFYFQ CNRRGDAAEV 250
    WILSCSLNHS AQIRPGNRSL FVMPTSPDWN MDVNLILSST LTGCLCSGSQ 300
    LPLIDNNSVP AVSRNIHGWT GRAGNQLHGF QVRRMVTEFC DRLRRDGVMT 350
    QAQQNQVEAL ADQTQQFKRD KLETWAREDD QYNQAHPNST MFRTKPFTNA 400
    QWGRGNTGAT SAAIAALI 418
    Length:418
    Mass (Da):47,161
    Last modified:August 1, 1990 - v2
    Checksum:i0E2F7824DA61D0DC
    GO

    Sequence cautioni

    The sequence J02327 differs from that shown. Reason: Frameshift at position 310.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti259 – 2591H → Y in J02327. (PubMed:6961439)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti188 – 1881A → V in strain: Mutant ts447; temperature-sensitive.
    Natural varianti323 – 3231A → V in strain: Mutant ts447; temperature-sensitive.
    Natural varianti383 – 3831N → D in strain: Mutant ts447; temperature-sensitive.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25780 Genomic DNA. Translation: AAA47279.1.
    J02327 Genomic RNA. No translation available.
    L19776 Genomic RNA. Translation: AAA47261.1.
    EF494442 Genomic RNA. Translation: ABP48920.1.
    PIRiA31475. FOXR3D.
    RefSeqiNP_694684.1. NC_004279.1.

    Genome annotation databases

    GeneIDi956473.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25780 Genomic DNA. Translation: AAA47279.1 .
    J02327 Genomic RNA. No translation available.
    L19776 Genomic RNA. Translation: AAA47261.1 .
    EF494442 Genomic RNA. Translation: ABP48920.1 .
    PIRi A31475. FOXR3D.
    RefSeqi NP_694684.1. NC_004279.1.

    3D structure databases

    ProteinModelPortali P03525.
    SMRi P03525. Positions 2-418.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 956473.

    Family and domain databases

    InterProi IPR004317. Sigma_1_2_reovir.
    [Graphical view ]
    Pfami PF03084. Sigma_1_2. 1 hit.
    [Graphical view ]
    ProDomi PD004419. Sigma_1_2_reovir. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequences of the S2 genome segments of reovirus serotype 3 and of the dsRNA-negative mutant ts447."
      Wiener J.R., McLaughlin T., Joklik W.K.
      Virology 170:340-341(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Mutant ts447.
    2. "Cloning the double-stranded RNA genes of reovirus: sequence of the cloned S2 gene."
      Cashdollar L.W., Esparza J., Hudson G.R., Chmelo R.A., Lee P.W.K., Joklik W.K.
      Proc. Natl. Acad. Sci. U.S.A. 79:7644-7648(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "The S2 gene nucleotide sequences of prototype strains of the three reovirus serotypes: characterization of reovirus core protein sigma 2."
      Dermody T.S., Schiff L.A., Nibert M.L., Coombs K.M., Fields B.N.
      J. Virol. 65:5721-5731(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Infectious clone.

    Entry informationi

    Entry nameiSIGM2_REOVD
    AccessioniPrimary (citable) accession number: P03525
    Secondary accession number(s): Q6LEC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Mutant ts447 is temperature-sensitive.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3