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P03525

- SIGM2_REOVD

UniProt

P03525 - SIGM2_REOVD

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Protein
Inner capsid protein sigma-2
Gene
S2
Organism
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Inner capsid (core) component.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein sigma-2
Short name:
Sigma2
Gene namesi
Name:S2
OrganismiReovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
Taxonomic identifieri10886 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006373: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Found in the inner capsid (150 copies).

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Inner capsid protein sigma-2
PRO_0000222749Add
BLAST

Interactioni

Subunit structurei

Interacts with protein mu-NS; in viral inclusions By similarity.

Structurei

3D structure databases

ProteinModelPortaliP03525.
SMRiP03525. Positions 2-418.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR004317. Sigma_1_2_reovir.
[Graphical view]
PfamiPF03084. Sigma_1_2. 1 hit.
[Graphical view]
ProDomiPD004419. Sigma_1_2_reovir. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P03525-1 [UniParc]FASTAAdd to Basket

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MARAAFLFKT VGFGGLQNVP INDELSSHLL RAGNSPWQLT QFLDWISLGR    50
GLATSALVPT AGSRYYQMSC LLSGTLQIPF RPNHRWGDIR FLRLVWSAPT 100
LDGLVVAPPQ VLAQPALQAQ ADRVYDCDDY PFLARDPRFK HRVYQQLSAV 150
TLLNLTGFGP ISYVRVDEDM WSGDVNQLLM NYFGHTFAEI AYTLCQASAN 200
RPWEYDGTYA RMTQIVLSLF WLSYVGVIHQ QNTYRTFYFQ CNRRGDAAEV 250
WILSCSLNHS AQIRPGNRSL FVMPTSPDWN MDVNLILSST LTGCLCSGSQ 300
LPLIDNNSVP AVSRNIHGWT GRAGNQLHGF QVRRMVTEFC DRLRRDGVMT 350
QAQQNQVEAL ADQTQQFKRD KLETWAREDD QYNQAHPNST MFRTKPFTNA 400
QWGRGNTGAT SAAIAALI 418
Length:418
Mass (Da):47,161
Last modified:August 1, 1990 - v2
Checksum:i0E2F7824DA61D0DC
GO

Sequence cautioni

The sequence J02327 differs from that shown. Reason: Frameshift at position 310.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti188 – 1881A → V in strain: Mutant ts447; temperature-sensitive.
Natural varianti323 – 3231A → V in strain: Mutant ts447; temperature-sensitive.
Natural varianti383 – 3831N → D in strain: Mutant ts447; temperature-sensitive.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti259 – 2591H → Y in J02327. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25780 Genomic DNA. Translation: AAA47279.1.
J02327 Genomic RNA. No translation available.
L19776 Genomic RNA. Translation: AAA47261.1.
EF494442 Genomic RNA. Translation: ABP48920.1.
PIRiA31475. FOXR3D.
RefSeqiNP_694684.1. NC_004279.1.

Genome annotation databases

GeneIDi956473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25780 Genomic DNA. Translation: AAA47279.1 .
J02327 Genomic RNA. No translation available.
L19776 Genomic RNA. Translation: AAA47261.1 .
EF494442 Genomic RNA. Translation: ABP48920.1 .
PIRi A31475. FOXR3D.
RefSeqi NP_694684.1. NC_004279.1.

3D structure databases

ProteinModelPortali P03525.
SMRi P03525. Positions 2-418.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956473.

Family and domain databases

InterProi IPR004317. Sigma_1_2_reovir.
[Graphical view ]
Pfami PF03084. Sigma_1_2. 1 hit.
[Graphical view ]
ProDomi PD004419. Sigma_1_2_reovir. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "The sequences of the S2 genome segments of reovirus serotype 3 and of the dsRNA-negative mutant ts447."
    Wiener J.R., McLaughlin T., Joklik W.K.
    Virology 170:340-341(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Mutant ts447.
  2. "Cloning the double-stranded RNA genes of reovirus: sequence of the cloned S2 gene."
    Cashdollar L.W., Esparza J., Hudson G.R., Chmelo R.A., Lee P.W.K., Joklik W.K.
    Proc. Natl. Acad. Sci. U.S.A. 79:7644-7648(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "The S2 gene nucleotide sequences of prototype strains of the three reovirus serotypes: characterization of reovirus core protein sigma 2."
    Dermody T.S., Schiff L.A., Nibert M.L., Coombs K.M., Fields B.N.
    J. Virol. 65:5721-5731(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Infectious clone.

Entry informationi

Entry nameiSIGM2_REOVD
AccessioniPrimary (citable) accession number: P03525
Secondary accession number(s): Q6LEC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: July 9, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Mutant ts447 is temperature-sensitive.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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