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Protein

Glycoprotein

Gene

G

Organism
Rabies virus (strain ERA) (RABV)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein
Gene namesi
Name:G
OrganismiRabies virus (strain ERA) (RABV)
Taxonomic identifieri11295 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesRhabdoviridaeLyssavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Mammalia [TaxID: 40674]
Proteomesi
  • UP000008619 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 459Virion surfaceSequence analysisAdd BLAST440
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 524IntravirionSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Biotechnological usei

Primary surface antigen capable of inducing and reacting with virus-neutralizing antibodies. Almost all human and veterinary vaccines are based on the functional aspects of the G protein.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000004099320 – 524GlycoproteinAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...); by host1 Publication1
Glycosylationi266N-linked (GlcNAc...); by host1 Publication1
Glycosylationi338N-linked (GlcNAc...); by host1 Publication1
Lipidationi480S-palmitoyl cysteine; by hostBy similarity1

Post-translational modificationi

Glycosylated and palmitoylated by host. Glycosylation is crucial for glycoprotein export at the cell surface.2 Publications

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP03524.

Interactioni

Subunit structurei

Homotrimer. Interacts with matrix protein (By similarity).By similarity

Structurei

Secondary structure

1524
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi521 – 523Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NFKX-ray1.43C/D512-524[»]
ProteinModelPortaliP03524.
SMRiP03524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyssavirus glycoprotein family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR001903. Rhabd_glycop.
[Graphical view]
PfamiPF00974. Rhabdo_glycop. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPQALLFVP LLVFPLCFGK FPIYTILDKL GPWSPIDIHH LSCPNNLVVE
60 70 80 90 100
DEGCTNLSGF SYMELKVGYI LAIKMNGFTC TGVVTEAETY TNFVGYVTTT
110 120 130 140 150
FKRKHFRPTP DACRAAYNWK MAGDPRYEES LHNPYPDYRW LRTVKTTKES
160 170 180 190 200
LVIISPSVAD LDPYDRSLHS RVFPSGKCSG VAVSSTYCST NHDYTIWMPE
210 220 230 240 250
NPRLGMSCDI FTNSRGKRAS KGSETCGFVD ERGLYKSLKG ACKLKLCGVL
260 270 280 290 300
GLRLMDGTWV AMQTSNETKW CPPDQLVNLH DFRSDEIEHL VVEELVRKRE
310 320 330 340 350
ECLDALESIM TTKSVSFRRL SHLRKLVPGF GKAYTIFNKT LMEADAHYKS
360 370 380 390 400
VRTWNEILPS KGCLRVGGRC HPHVNGVFFN GIILGPDGNV LIPEMQSSLL
410 420 430 440 450
QQHMELLESS VIPLVHPLAD PSTVFKDGDE AEDFVEVHLP DVHNQVSGVD
460 470 480 490 500
LGLPNWGKYV LLSAGALTAL MLIIFLMTCC RRVNRSEPTQ HNLRGTGREV
510 520
SVTPQSGKII SSWESHKSGG ETRL
Length:524
Mass (Da):58,658
Last modified:July 21, 1986 - v1
Checksum:iBBA53981C1175880
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti27L → P in strain: ERA 2007. 1
Natural varianti55T → I in strain: CVS-11, RV194-2[F3] and RV231-22. 1
Natural varianti177K → N in strain: RV194-2[F3]. 1
Natural varianti217K → E in strain: RV231-22. 1
Natural varianti221 – 224KGSE → NGNK in strain: CVS-11, RV194-2[F3] and RV231-22. 4
Natural varianti352R → Q in strain: RV194-2[F3]. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02293 Genomic RNA. Translation: AAA47204.1. Sequence problems.
M38452 Genomic RNA. Translation: AAA47209.1.
EF206707 Genomic RNA. Translation: ABN11294.1.
K02858 Genomic RNA. Translation: AAA47191.1.
K02859 Genomic RNA. Translation: AAA47192.1.
K02860 Genomic RNA. Translation: AAA47193.1.
K02861 Genomic RNA. Translation: AAA47194.1.
K02862 Genomic RNA. Translation: AAA47195.1.
K02863 Genomic RNA. Translation: AAA47196.1.
K02864 Genomic RNA. Translation: AAA47197.1.
K02865 Genomic RNA. Translation: AAA47198.1.
K02866 Genomic RNA. Translation: AAA47205.1.
K02867 Genomic RNA. Translation: AAA47206.1.
K02868 Genomic RNA. Translation: AAA47207.1.
K02869 Genomic RNA. Translation: AAA47208.1.
PIRiA04121. VGVNG.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02293 Genomic RNA. Translation: AAA47204.1. Sequence problems.
M38452 Genomic RNA. Translation: AAA47209.1.
EF206707 Genomic RNA. Translation: ABN11294.1.
K02858 Genomic RNA. Translation: AAA47191.1.
K02859 Genomic RNA. Translation: AAA47192.1.
K02860 Genomic RNA. Translation: AAA47193.1.
K02861 Genomic RNA. Translation: AAA47194.1.
K02862 Genomic RNA. Translation: AAA47195.1.
K02863 Genomic RNA. Translation: AAA47196.1.
K02864 Genomic RNA. Translation: AAA47197.1.
K02865 Genomic RNA. Translation: AAA47198.1.
K02866 Genomic RNA. Translation: AAA47205.1.
K02867 Genomic RNA. Translation: AAA47206.1.
K02868 Genomic RNA. Translation: AAA47207.1.
K02869 Genomic RNA. Translation: AAA47208.1.
PIRiA04121. VGVNG.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NFKX-ray1.43C/D512-524[»]
ProteinModelPortaliP03524.
SMRiP03524.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP03524.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR001903. Rhabd_glycop.
[Graphical view]
PfamiPF00974. Rhabdo_glycop. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLYCO_RABVE
AccessioniPrimary (citable) accession number: P03524
Secondary accession number(s): A3F5L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Arg-352 is highly involved in rabies virus pathogenicity. Its mutation dramatically attenuates the virus.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.