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P03518 (GP_RVFV) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein
Short name=GP
Alternative name(s):
M polyprotein

Cleaved into the following 3 chains:

  1. Non-structural protein NSm
  2. Glycoprotein G1
  3. Glycoprotein G2
Gene names
Name:GP
OrganismRift valley fever virus (RVFV)
Taxonomic identifier11588 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Bunyaviridae › Phlebovirus
Virus hostAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Bos taurus x Bison bison (beefalo) [TaxID: 297284]
Camelus bactrianus (Bactrian camel) [TaxID: 9837]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]

Protein attributes

Sequence length1206 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Sequence similarities

Belongs to the phlebovirus envelope glycoprotein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 12061190Envelope glycoprotein
PRO_0000247009
Chain17 – 153137Non-structural protein NSm
PRO_0000036847
Chain154 – 690537Glycoprotein G1 Potential
PRO_0000036848
Chain691 – 1206516Glycoprotein G2 Potential
PRO_0000036849

Regions

Topological domain17 – 582566Lumenal Potential
Transmembrane583 – 60321Helical; Potential
Topological domain604 – 69087Cytoplasmic Potential
Topological domain691 – 1136446Lumenal Potential
Transmembrane1137 – 115721Helical; Potential
Topological domain1158 – 120649Cytoplasmic Potential

Sites

Site690 – 6912Cleavage; by host signal peptidase By similarity

Amino acid modifications

Glycosylation881N-linked (GlcNAc...); by host Potential
Glycosylation4381N-linked (GlcNAc...); by host Potential
Glycosylation7941N-linked (GlcNAc...); by host Potential
Glycosylation10351N-linked (GlcNAc...); by host Potential
Glycosylation10771N-linked (GlcNAc...); by host Potential

Secondary structure

1 ........................................................................... 1206
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P03518 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: D2E8017179285924

FASTA1,206132,053
        10         20         30         40         50         60 
MYVLLTILIS VLVCEAVIRV SLSSTREETC FGDSTNPEMI EGAWDSLREE EMPEELSCSI 

        70         80         90        100        110        120 
SGIREVKTSS QELYRALKAI IAADGLNNIT CHGKDPEDKI SLIKGPPHKK RVGIVRCERR 

       130        140        150        160        170        180 
RDAKQIGRET MAGIAMTVLP ALAVFALAPV VFAEDPHLRN RPGKGHNYID GMTQEDATCK 

       190        200        210        220        230        240 
PVTYAGACSS FDVLLEKGKF PLFQSYAHHR TLLEAVHDTI IAKADPPSCD LQSAHGNPCM 

       250        260        270        280        290        300 
KEKLVMKTHC PNDYQSAHYL NNDGKMASVK CPPKYGLTED CNFCRQMTGA SLKKGSYPLQ 

       310        320        330        340        350        360 
DLFCQSSEDD GSKLKTKMKG VCEVGVQAHK KCDGQLSTAH EVVPFAVFKN SKKVYLDKLD 

       370        380        390        400        410        420 
LKTEENLLPD SFVCFEHKGQ YKGTMDSGQT KRELKSFDIS QCPKIGGHGS KKCTGDAAFC 

       430        440        450        460        470        480 
SAYECTAQYA NAYCSHANGS GIVQIQVSGV WKKPLCVGYE RVVVKRELSA KPIQRVEPCT 

       490        500        510        520        530        540 
TCITKCEPHG LVVRSTGFKI SSAVACASGV CVTGSQSPST EITLKYPGIS QSSGGDIGVH 

       550        560        570        580        590        600 
MAHDDQSVSS KIVAHCPPQD PCLVHGCIVC AHGLINYQCH TALSAFVVVF VFSSIAIICL 

       610        620        630        640        650        660 
AVLYRVLKCL KIAPRKVLNP LMWITAFIRW IYKKMVARVA HNINQVNREI GWMEGGQLVL 

       670        680        690        700        710        720 
GNPAPIPRHA PIPRYSTYLM LLLIVSYASA CSELIQASSR ITTCSTEGVN TKCRLSGTAL 

       730        740        750        760        770        780 
IRAGSVGAEA CLMLKGVKED QTKFLKIKTV SSELSCREGQ SYWTGSISPK CLSSRRCHLV 

       790        800        810        820        830        840 
GECHVNRCLS WRDNETSAEF SFVGESTTMR ENKCFEQCGG WGCGCFNVNP SCLFVHTYLQ 

       850        860        870        880        890        900 
SVRKEALRVF NCIDWVHKLT LEITDFDGSV STIDLGASSS RFTNWGSVSL SLDAEGISGS 

       910        920        930        940        950        960 
NSFSFIESPS KGYAIVDEPF SEIPRQGFLG EIRCNSESSV LSAHESCLRA PNLISYKPMI 

       970        980        990       1000       1010       1020 
DQLECTTNLI DPFVVFERGS LPQTRNDKTF AASKGNRGVQ AFSKGSVQAD LTLMFDNFEV 

      1030       1040       1050       1060       1070       1080 
DFVGAAVSCD AAFLNLTGCY SCNAGARVCL SITSTGTGSL SAHNKDGSLH IVLPSENGTK 

      1090       1100       1110       1120       1130       1140 
DQCQILHFTV PEVEEEFMYS CDGDERPLLV KGTLIAIDPF DDRREAGGES TVVNPKSGSW 

      1150       1160       1170       1180       1190       1200 
NFFDWFSGLM SWFGGPLKLY SSFACMLHYQ LGSFSSLYIL EEQASLKCGL LPLRRPHRSV 


RVKVIC

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References

[1]"Complete nucleotide sequence of the M RNA segment of Rift Valley fever virus."
Collett M.S., Purchio A.F., Keegan K., Frazier S., Hays W., Anderson D.K., Parker M.D., Schmaljohn C.S., Schmidt J., Dalrymple J.M.
Virology 144:228-245(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M11157 Genomic RNA. Translation: AAA47450.1.
PIRVGVURV. A04110.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HJ1X-ray1.90A/B/C/D691-1119[»]
4HJCX-ray4.15A691-1118[»]
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
IPR009879. Phlebovirus_NSM.
[Graphical view]
PfamPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
PF07246. Phlebovirus_NSM. 2 hits.
[Graphical view]
PIRSFPIRSF003961. M_poly_PhleboV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGP_RVFV
AccessionPrimary (citable) accession number: P03518
Secondary accession number(s): Q86494, Q86495
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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