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P03518

- GP_RVFV

UniProt

P03518 - GP_RVFV

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Protein
Envelope glycoprotein
Gene
GP
Organism
Rift valley fever virus (RVFV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei690 – 6912Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiRift valley fever virus (RVFV)
Taxonomic identifieri11588 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Bos taurus x Bison bison (beefalo) [TaxID: 297284]
Camelus bactrianus (Bactrian camel) [TaxID: 9837]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 582566Lumenal Reviewed prediction
Add
BLAST
Transmembranei583 – 60321Helical; Reviewed prediction
Add
BLAST
Topological domaini604 – 69087Cytoplasmic Reviewed prediction
Add
BLAST
Topological domaini691 – 1136446Lumenal Reviewed prediction
Add
BLAST
Transmembranei1137 – 115721Helical; Reviewed prediction
Add
BLAST
Topological domaini1158 – 120649Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 12061190Envelope glycoprotein
PRO_0000247009Add
BLAST
Chaini17 – 153137Non-structural protein NSm
PRO_0000036847Add
BLAST
Chaini154 – 690537Glycoprotein G1 Reviewed prediction
PRO_0000036848Add
BLAST
Chaini691 – 1206516Glycoprotein G2 Reviewed prediction
PRO_0000036849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi88 – 881N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi438 – 4381N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi794 – 7941N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1035 – 10351N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1077 – 10771N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP03518.

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi691 – 6966
Helixi699 – 7013
Beta strandi702 – 7098
Beta strandi711 – 72212
Beta strandi728 – 7358
Beta strandi742 – 76423
Beta strandi767 – 77610
Turni785 – 7906
Helixi798 – 8036
Beta strandi810 – 8178
Helixi821 – 8233
Beta strandi826 – 8294
Beta strandi831 – 84414
Beta strandi847 – 86418
Beta strandi870 – 8756
Beta strandi880 – 8834
Beta strandi886 – 8938
Helixi900 – 9023
Beta strandi904 – 9085
Turni909 – 9113
Beta strandi912 – 9187
Beta strandi931 – 9366
Helixi937 – 9415
Beta strandi947 – 9493
Beta strandi954 – 9596
Beta strandi962 – 9676
Helixi972 – 9787
Beta strandi980 – 9856
Beta strandi988 – 9925
Beta strandi994 – 9963
Beta strandi999 – 10035
Beta strandi1009 – 102113
Beta strandi1030 – 104415
Beta strandi1046 – 105611
Beta strandi1058 – 10647
Beta strandi1070 – 10756
Beta strandi1077 – 108610
Beta strandi1089 – 110315
Beta strandi1106 – 11138

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HJ1X-ray1.90A/B/C/D691-1119[»]
4HJCX-ray4.15A691-1118[»]

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
IPR009879. Phlebovirus_NSM.
[Graphical view]
PfamiPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
PF07246. Phlebovirus_NSM. 2 hits.
[Graphical view]
PIRSFiPIRSF003961. M_poly_PhleboV. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03518-1 [UniParc]FASTAAdd to Basket

« Hide

MYVLLTILIS VLVCEAVIRV SLSSTREETC FGDSTNPEMI EGAWDSLREE     50
EMPEELSCSI SGIREVKTSS QELYRALKAI IAADGLNNIT CHGKDPEDKI 100
SLIKGPPHKK RVGIVRCERR RDAKQIGRET MAGIAMTVLP ALAVFALAPV 150
VFAEDPHLRN RPGKGHNYID GMTQEDATCK PVTYAGACSS FDVLLEKGKF 200
PLFQSYAHHR TLLEAVHDTI IAKADPPSCD LQSAHGNPCM KEKLVMKTHC 250
PNDYQSAHYL NNDGKMASVK CPPKYGLTED CNFCRQMTGA SLKKGSYPLQ 300
DLFCQSSEDD GSKLKTKMKG VCEVGVQAHK KCDGQLSTAH EVVPFAVFKN 350
SKKVYLDKLD LKTEENLLPD SFVCFEHKGQ YKGTMDSGQT KRELKSFDIS 400
QCPKIGGHGS KKCTGDAAFC SAYECTAQYA NAYCSHANGS GIVQIQVSGV 450
WKKPLCVGYE RVVVKRELSA KPIQRVEPCT TCITKCEPHG LVVRSTGFKI 500
SSAVACASGV CVTGSQSPST EITLKYPGIS QSSGGDIGVH MAHDDQSVSS 550
KIVAHCPPQD PCLVHGCIVC AHGLINYQCH TALSAFVVVF VFSSIAIICL 600
AVLYRVLKCL KIAPRKVLNP LMWITAFIRW IYKKMVARVA HNINQVNREI 650
GWMEGGQLVL GNPAPIPRHA PIPRYSTYLM LLLIVSYASA CSELIQASSR 700
ITTCSTEGVN TKCRLSGTAL IRAGSVGAEA CLMLKGVKED QTKFLKIKTV 750
SSELSCREGQ SYWTGSISPK CLSSRRCHLV GECHVNRCLS WRDNETSAEF 800
SFVGESTTMR ENKCFEQCGG WGCGCFNVNP SCLFVHTYLQ SVRKEALRVF 850
NCIDWVHKLT LEITDFDGSV STIDLGASSS RFTNWGSVSL SLDAEGISGS 900
NSFSFIESPS KGYAIVDEPF SEIPRQGFLG EIRCNSESSV LSAHESCLRA 950
PNLISYKPMI DQLECTTNLI DPFVVFERGS LPQTRNDKTF AASKGNRGVQ 1000
AFSKGSVQAD LTLMFDNFEV DFVGAAVSCD AAFLNLTGCY SCNAGARVCL 1050
SITSTGTGSL SAHNKDGSLH IVLPSENGTK DQCQILHFTV PEVEEEFMYS 1100
CDGDERPLLV KGTLIAIDPF DDRREAGGES TVVNPKSGSW NFFDWFSGLM 1150
SWFGGPLKLY SSFACMLHYQ LGSFSSLYIL EEQASLKCGL LPLRRPHRSV 1200
RVKVIC 1206
Length:1,206
Mass (Da):132,053
Last modified:November 1, 1995 - v2
Checksum:iD2E8017179285924
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11157 Genomic RNA. Translation: AAA47450.1.
PIRiA04110. VGVURV.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11157 Genomic RNA. Translation: AAA47450.1 .
PIRi A04110. VGVURV.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HJ1 X-ray 1.90 A/B/C/D 691-1119 [» ]
4HJC X-ray 4.15 A 691-1118 [» ]
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P03518.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
IPR009879. Phlebovirus_NSM.
[Graphical view ]
Pfami PF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
PF07246. Phlebovirus_NSM. 2 hits.
[Graphical view ]
PIRSFi PIRSF003961. M_poly_PhleboV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_RVFV
AccessioniPrimary (citable) accession number: P03518
Secondary accession number(s): Q86494, Q86495
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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