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P03518

- GP_RVFV

UniProt

P03518 - GP_RVFV

Protein

Envelope glycoprotein

Gene

GP

Organism
Rift valley fever virus (RVFV)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei690 – 6912Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:GP
    OrganismiRift valley fever virus (RVFV)
    Taxonomic identifieri11588 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
    Virus hostiAedes [TaxID: 7158]
    Bos taurus (Bovine) [TaxID: 9913]
    Bos taurus x Bison bison (beefalo) [TaxID: 297284]
    Camelus bactrianus (Bactrian camel) [TaxID: 9837]
    Capra hircus (Goat) [TaxID: 9925]
    Homo sapiens (Human) [TaxID: 9606]
    Ovis aries (Sheep) [TaxID: 9940]
    Phlebotomus papatasi (Sandfly) [TaxID: 29031]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 12061190Envelope glycoproteinPRO_0000247009Add
    BLAST
    Chaini17 – 153137Non-structural protein NSmPRO_0000036847Add
    BLAST
    Chaini154 – 690537Glycoprotein G1Sequence AnalysisPRO_0000036848Add
    BLAST
    Chaini691 – 1206516Glycoprotein G2Sequence AnalysisPRO_0000036849Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi438 – 4381N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi794 – 7941N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1035 – 10351N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1077 – 10771N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP03518.

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Secondary structure

    1
    1206
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi691 – 6966
    Helixi699 – 7013
    Beta strandi702 – 7098
    Beta strandi711 – 72212
    Beta strandi728 – 7358
    Beta strandi742 – 76423
    Beta strandi767 – 77610
    Turni785 – 7906
    Helixi798 – 8036
    Beta strandi810 – 8178
    Helixi821 – 8233
    Beta strandi826 – 8294
    Beta strandi831 – 84414
    Beta strandi847 – 86418
    Beta strandi870 – 8756
    Beta strandi880 – 8834
    Beta strandi886 – 8938
    Helixi900 – 9023
    Beta strandi904 – 9085
    Turni909 – 9113
    Beta strandi912 – 9187
    Beta strandi931 – 9366
    Helixi937 – 9415
    Beta strandi947 – 9493
    Beta strandi954 – 9596
    Beta strandi962 – 9676
    Helixi972 – 9787
    Beta strandi980 – 9856
    Beta strandi988 – 9925
    Beta strandi994 – 9963
    Beta strandi999 – 10035
    Beta strandi1009 – 102113
    Beta strandi1030 – 104415
    Beta strandi1046 – 105611
    Beta strandi1058 – 10647
    Beta strandi1070 – 10756
    Beta strandi1077 – 108610
    Beta strandi1089 – 110315
    Beta strandi1106 – 11138

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HJ1X-ray1.90A/B/C/D691-1119[»]
    4HJCX-ray4.15A691-1118[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 582566LumenalSequence AnalysisAdd
    BLAST
    Topological domaini604 – 69087CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini691 – 1136446LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1158 – 120649CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei583 – 60321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1137 – 115721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016404. M_polyprot_prcur_phlebovir.
    IPR010826. Phlebovirus_G1.
    IPR009878. Phlebovirus_G2.
    IPR009879. Phlebovirus_NSM.
    [Graphical view]
    PfamiPF07243. Phlebovirus_G1. 1 hit.
    PF07245. Phlebovirus_G2. 1 hit.
    PF07246. Phlebovirus_NSM. 2 hits.
    [Graphical view]
    PIRSFiPIRSF003961. M_poly_PhleboV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P03518-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYVLLTILIS VLVCEAVIRV SLSSTREETC FGDSTNPEMI EGAWDSLREE     50
    EMPEELSCSI SGIREVKTSS QELYRALKAI IAADGLNNIT CHGKDPEDKI 100
    SLIKGPPHKK RVGIVRCERR RDAKQIGRET MAGIAMTVLP ALAVFALAPV 150
    VFAEDPHLRN RPGKGHNYID GMTQEDATCK PVTYAGACSS FDVLLEKGKF 200
    PLFQSYAHHR TLLEAVHDTI IAKADPPSCD LQSAHGNPCM KEKLVMKTHC 250
    PNDYQSAHYL NNDGKMASVK CPPKYGLTED CNFCRQMTGA SLKKGSYPLQ 300
    DLFCQSSEDD GSKLKTKMKG VCEVGVQAHK KCDGQLSTAH EVVPFAVFKN 350
    SKKVYLDKLD LKTEENLLPD SFVCFEHKGQ YKGTMDSGQT KRELKSFDIS 400
    QCPKIGGHGS KKCTGDAAFC SAYECTAQYA NAYCSHANGS GIVQIQVSGV 450
    WKKPLCVGYE RVVVKRELSA KPIQRVEPCT TCITKCEPHG LVVRSTGFKI 500
    SSAVACASGV CVTGSQSPST EITLKYPGIS QSSGGDIGVH MAHDDQSVSS 550
    KIVAHCPPQD PCLVHGCIVC AHGLINYQCH TALSAFVVVF VFSSIAIICL 600
    AVLYRVLKCL KIAPRKVLNP LMWITAFIRW IYKKMVARVA HNINQVNREI 650
    GWMEGGQLVL GNPAPIPRHA PIPRYSTYLM LLLIVSYASA CSELIQASSR 700
    ITTCSTEGVN TKCRLSGTAL IRAGSVGAEA CLMLKGVKED QTKFLKIKTV 750
    SSELSCREGQ SYWTGSISPK CLSSRRCHLV GECHVNRCLS WRDNETSAEF 800
    SFVGESTTMR ENKCFEQCGG WGCGCFNVNP SCLFVHTYLQ SVRKEALRVF 850
    NCIDWVHKLT LEITDFDGSV STIDLGASSS RFTNWGSVSL SLDAEGISGS 900
    NSFSFIESPS KGYAIVDEPF SEIPRQGFLG EIRCNSESSV LSAHESCLRA 950
    PNLISYKPMI DQLECTTNLI DPFVVFERGS LPQTRNDKTF AASKGNRGVQ 1000
    AFSKGSVQAD LTLMFDNFEV DFVGAAVSCD AAFLNLTGCY SCNAGARVCL 1050
    SITSTGTGSL SAHNKDGSLH IVLPSENGTK DQCQILHFTV PEVEEEFMYS 1100
    CDGDERPLLV KGTLIAIDPF DDRREAGGES TVVNPKSGSW NFFDWFSGLM 1150
    SWFGGPLKLY SSFACMLHYQ LGSFSSLYIL EEQASLKCGL LPLRRPHRSV 1200
    RVKVIC 1206
    Length:1,206
    Mass (Da):132,053
    Last modified:November 1, 1995 - v2
    Checksum:iD2E8017179285924
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11157 Genomic RNA. Translation: AAA47450.1.
    PIRiA04110. VGVURV.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11157 Genomic RNA. Translation: AAA47450.1 .
    PIRi A04110. VGVURV.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HJ1 X-ray 1.90 A/B/C/D 691-1119 [» ]
    4HJC X-ray 4.15 A 691-1118 [» ]
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P03518.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR016404. M_polyprot_prcur_phlebovir.
    IPR010826. Phlebovirus_G1.
    IPR009878. Phlebovirus_G2.
    IPR009879. Phlebovirus_NSM.
    [Graphical view ]
    Pfami PF07243. Phlebovirus_G1. 1 hit.
    PF07245. Phlebovirus_G2. 1 hit.
    PF07246. Phlebovirus_NSM. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF003961. M_poly_PhleboV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiGP_RVFV
    AccessioniPrimary (citable) accession number: P03518
    Secondary accession number(s): Q86494, Q86495
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3