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P03517

- GP_PTPV

UniProt

P03517 - GP_PTPV

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Protein

Envelope glycoprotein

Gene

GP

Organism
Punta toro phlebovirus
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei809 – 8102Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiPunta toro phlebovirus
Taxonomic identifieri11587 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 13131285Envelope glycoproteinPRO_0000247008Add
BLAST
Chaini29 – 270242Non-structural protein NSmPRO_0000036844Add
BLAST
Chaini271 – 809539Glycoprotein G1Sequence AnalysisPRO_0000036845Add
BLAST
Chaini810 – 1313504Glycoprotein G2Sequence AnalysisPRO_0000036846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi76 – 761N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi496 – 4961N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi1154 – 11541N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi1243 – 12431N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Structurei

3D structure databases

ProteinModelPortaliP03517.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 712684ExtracellularSequence AnalysisAdd
BLAST
Topological domaini734 – 80976CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini810 – 1278469ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1300 – 131314CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei713 – 73321HelicalSequence AnalysisAdd
BLAST
Transmembranei1279 – 129921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
IPR009879. Phlebovirus_NSM.
[Graphical view]
PfamiPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
PF07246. Phlebovirus_NSM. 1 hit.
[Graphical view]
PIRSFiPIRSF003961. M_poly_PhleboV. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03517-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIFTILNVLT RAMLVMSMYS LTTWDSTSRN DMCFSNDSPL EGLVYYWETH
60 70 80 90 100
SKRHDYKKQE SQRCRVGDSD KKMITNVTII SLISEIQKSI SELSLSCVND
110 120 130 140 150
DNSTGQVLTF NGLEDTIRGD YIVDCVTGLY QSDIGVGVGL GRTHHGHQQM
160 170 180 190 200
KNKAVVIDEK ERMISLLETQ QSENDIKMQV LMSEIEQLKN QLSKKRNERG
210 220 230 240 250
QEKRDAEKVM SDLMARNSDL RKHNDILTAE ISQMKNKNTI QRNKNTVSTT
260 270 280 290 300
VVPAILSVAL LSSSVAPIIA APPDSPMINP WPHAKNRVGT GMYKYDENDD
310 320 330 340 350
SGCRPIRYGV SCIGFDFMLK MDKYPFFNAF IGHKTPLESF ADKIIEKEEE
360 370 380 390 400
TCEIGTNKEF KCFEERAYIK GTCPTNINAV HYIDNKGKLR YVKCKENLEM
410 420 430 440 450
TEDCAFCRKI KKKAGQSVQV QKTSVPLQDA ICQENSDTYS GPKIPFKGVC
460 470 480 490 500
KIGLIKYKEC KFKTSSYETV SFITLKEKGK IYIEHLMLKN IEVVTNVSFV
510 520 530 540 550
CYEHVGQDEQ EVEHRALKRV SVNDCKIVDN SKQKICTGDH VFCEKYDCST
560 570 580 590 600
SYPDVTCIHA PGSGPLYINL MGSWIKPQCV GYERVLVDRE VKQPLLAPEQ
610 620 630 640 650
NCDTCVSECL DEGVHIKSTG FEITSAVACS HGSCISAHQE PSTSVIVPYP
660 670 680 690 700
GLLASVGGRI GIHLSHTSDS ASVHMVVVCP PRDSCAAHNC LLCYHGILNY
710 720 730 740 750
QCHSTLSAIL TSFLLILFIY TVFSVTTNIL YVLRLIPKQL KSPVGWLKLF
760 770 780 790 800
INWLLTALRI KTRNVMRRIN QRIGWVDHHD VERPRHREPM RRFKTTLLLT
810 820 830 840 850
LIMMTGGNAC SNTVVANSKQ TRCVQEGSNT KCSITATITL RAGVIGAESC
860 870 880 890 900
FIIKGPMENQ QKTISIKTIS SETVCREGSS FWTSLYIPSC LSSRRCHLVG
910 920 930 940 950
DCVGNKCQSW RDDQLSREFS GVKDNHIMNE NKCFEQCGAI GCGCFNINPS
960 970 980 990 1000
CLYVHAYLKS ARNEAVRVFS CSDWVHRVSF EVKGPDGETE LVTLGSPGTK
1010 1020 1030 1040 1050
FLNWGTLSLS LDAEGISGTN SISFLESSKG GFALYDEGYN EIPREGFLGE
1060 1070 1080 1090 1100
IRCSSESAAI SAHKSCIRAP GLIKYKPMTD QIECTASLVD PFAIFLKGSL
1110 1120 1130 1140 1150
PQTRNGQTFT STKDKKTVQA FTNGAIKALL SINLDDHEIV FINKVKNCDA
1160 1170 1180 1190 1200
TFLNVSGCYS CDYGAHVCVK VKSSESADFF AESEDKTTVL SFPIQSGTHD
1210 1220 1230 1240 1250
YCQVLHFQKP LVDERLSYSC GSEPKLIVIK GTLVCMGVYD FRNKTGGSST
1260 1270 1280 1290 1300
VVNPSEGAWS ISNWFSGLLD WLGGPMKAIL KILGFIAIGI VCFVLFMILI
1310
RIAVNSINIK KKN
Length:1,313
Mass (Da):146,375
Last modified:July 21, 1986 - v1
Checksum:i72072F27735A74A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11156 Genomic RNA. Translation: AAA47110.1.
PIRiA04109. VGVUPT.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11156 Genomic RNA. Translation: AAA47110.1 .
PIRi A04109. VGVUPT.

3D structure databases

ProteinModelPortali P03517.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
IPR009879. Phlebovirus_NSM.
[Graphical view ]
Pfami PF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
PF07246. Phlebovirus_NSM. 1 hit.
[Graphical view ]
PIRSFi PIRSF003961. M_poly_PhleboV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequences of the glycoproteins and M RNA of Punta Toro phlebovirus compared to those of Rift Valley fever virus."
    Ihara T., Smith J., Dalrymple J.M., Bishop D.H.L.
    Virology 144:246-259(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_PTPV
AccessioniPrimary (citable) accession number: P03517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3