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P03517

- GP_PTPV

UniProt

P03517 - GP_PTPV

Protein

Envelope glycoprotein

Gene

GP

Organism
Punta toro phlebovirus
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei809 – 8102Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:GP
    OrganismiPunta toro phlebovirus
    Taxonomic identifieri11587 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Phlebotomus papatasi (Sandfly) [TaxID: 29031]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 13131285Envelope glycoproteinPRO_0000247008Add
    BLAST
    Chaini29 – 270242Non-structural protein NSmPRO_0000036844Add
    BLAST
    Chaini271 – 809539Glycoprotein G1Sequence AnalysisPRO_0000036845Add
    BLAST
    Chaini810 – 1313504Glycoprotein G2Sequence AnalysisPRO_0000036846Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi76 – 761N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi496 – 4961N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1154 – 11541N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1243 – 12431N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP03517.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 712684ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini734 – 80976CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini810 – 1278469ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1300 – 131314CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei713 – 73321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1279 – 129921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016404. M_polyprot_prcur_phlebovir.
    IPR010826. Phlebovirus_G1.
    IPR009878. Phlebovirus_G2.
    IPR009879. Phlebovirus_NSM.
    [Graphical view]
    PfamiPF07243. Phlebovirus_G1. 1 hit.
    PF07245. Phlebovirus_G2. 1 hit.
    PF07246. Phlebovirus_NSM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003961. M_poly_PhleboV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P03517-1 [UniParc]FASTAAdd to Basket

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    MIFTILNVLT RAMLVMSMYS LTTWDSTSRN DMCFSNDSPL EGLVYYWETH     50
    SKRHDYKKQE SQRCRVGDSD KKMITNVTII SLISEIQKSI SELSLSCVND 100
    DNSTGQVLTF NGLEDTIRGD YIVDCVTGLY QSDIGVGVGL GRTHHGHQQM 150
    KNKAVVIDEK ERMISLLETQ QSENDIKMQV LMSEIEQLKN QLSKKRNERG 200
    QEKRDAEKVM SDLMARNSDL RKHNDILTAE ISQMKNKNTI QRNKNTVSTT 250
    VVPAILSVAL LSSSVAPIIA APPDSPMINP WPHAKNRVGT GMYKYDENDD 300
    SGCRPIRYGV SCIGFDFMLK MDKYPFFNAF IGHKTPLESF ADKIIEKEEE 350
    TCEIGTNKEF KCFEERAYIK GTCPTNINAV HYIDNKGKLR YVKCKENLEM 400
    TEDCAFCRKI KKKAGQSVQV QKTSVPLQDA ICQENSDTYS GPKIPFKGVC 450
    KIGLIKYKEC KFKTSSYETV SFITLKEKGK IYIEHLMLKN IEVVTNVSFV 500
    CYEHVGQDEQ EVEHRALKRV SVNDCKIVDN SKQKICTGDH VFCEKYDCST 550
    SYPDVTCIHA PGSGPLYINL MGSWIKPQCV GYERVLVDRE VKQPLLAPEQ 600
    NCDTCVSECL DEGVHIKSTG FEITSAVACS HGSCISAHQE PSTSVIVPYP 650
    GLLASVGGRI GIHLSHTSDS ASVHMVVVCP PRDSCAAHNC LLCYHGILNY 700
    QCHSTLSAIL TSFLLILFIY TVFSVTTNIL YVLRLIPKQL KSPVGWLKLF 750
    INWLLTALRI KTRNVMRRIN QRIGWVDHHD VERPRHREPM RRFKTTLLLT 800
    LIMMTGGNAC SNTVVANSKQ TRCVQEGSNT KCSITATITL RAGVIGAESC 850
    FIIKGPMENQ QKTISIKTIS SETVCREGSS FWTSLYIPSC LSSRRCHLVG 900
    DCVGNKCQSW RDDQLSREFS GVKDNHIMNE NKCFEQCGAI GCGCFNINPS 950
    CLYVHAYLKS ARNEAVRVFS CSDWVHRVSF EVKGPDGETE LVTLGSPGTK 1000
    FLNWGTLSLS LDAEGISGTN SISFLESSKG GFALYDEGYN EIPREGFLGE 1050
    IRCSSESAAI SAHKSCIRAP GLIKYKPMTD QIECTASLVD PFAIFLKGSL 1100
    PQTRNGQTFT STKDKKTVQA FTNGAIKALL SINLDDHEIV FINKVKNCDA 1150
    TFLNVSGCYS CDYGAHVCVK VKSSESADFF AESEDKTTVL SFPIQSGTHD 1200
    YCQVLHFQKP LVDERLSYSC GSEPKLIVIK GTLVCMGVYD FRNKTGGSST 1250
    VVNPSEGAWS ISNWFSGLLD WLGGPMKAIL KILGFIAIGI VCFVLFMILI 1300
    RIAVNSINIK KKN 1313
    Length:1,313
    Mass (Da):146,375
    Last modified:July 21, 1986 - v1
    Checksum:i72072F27735A74A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11156 Genomic RNA. Translation: AAA47110.1.
    PIRiA04109. VGVUPT.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11156 Genomic RNA. Translation: AAA47110.1 .
    PIRi A04109. VGVUPT.

    3D structure databases

    ProteinModelPortali P03517.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR016404. M_polyprot_prcur_phlebovir.
    IPR010826. Phlebovirus_G1.
    IPR009878. Phlebovirus_G2.
    IPR009879. Phlebovirus_NSM.
    [Graphical view ]
    Pfami PF07243. Phlebovirus_G1. 1 hit.
    PF07245. Phlebovirus_G2. 1 hit.
    PF07246. Phlebovirus_NSM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003961. M_poly_PhleboV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequences of the glycoproteins and M RNA of Punta Toro phlebovirus compared to those of Rift Valley fever virus."
      Ihara T., Smith J., Dalrymple J.M., Bishop D.H.L.
      Virology 144:246-259(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiGP_PTPV
    AccessioniPrimary (citable) accession number: P03517
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3