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P03517 (GP_PTPV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein

Short name=GP
Alternative name(s):
M polyprotein
Gene names
Name:GP
OrganismPunta toro phlebovirus
Taxonomic identifier11587 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]

Protein attributes

Sequence length1313 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Sequence similarities

Belongs to the phlebovirus envelope glycoprotein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 13131285Envelope glycoprotein
PRO_0000247008
Chain29 – 270242Non-structural protein NSm
PRO_0000036844
Chain271 – 809539Glycoprotein G1 Potential
PRO_0000036845
Chain810 – 1313504Glycoprotein G2 Potential
PRO_0000036846

Regions

Topological domain29 – 712684Extracellular Potential
Transmembrane713 – 73321Helical; Potential
Topological domain734 – 80976Cytoplasmic Potential
Topological domain810 – 1278469Extracellular Potential
Transmembrane1279 – 129921Helical; Potential
Topological domain1300 – 131314Cytoplasmic Potential

Sites

Site809 – 8102Cleavage; by host signal peptidase By similarity

Amino acid modifications

Glycosylation761N-linked (GlcNAc...); by host Potential
Glycosylation1021N-linked (GlcNAc...); by host Potential
Glycosylation4961N-linked (GlcNAc...); by host Potential
Glycosylation11541N-linked (GlcNAc...); by host Potential
Glycosylation12431N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P03517 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 72072F27735A74A2

FASTA1,313146,375
        10         20         30         40         50         60 
MIFTILNVLT RAMLVMSMYS LTTWDSTSRN DMCFSNDSPL EGLVYYWETH SKRHDYKKQE 

        70         80         90        100        110        120 
SQRCRVGDSD KKMITNVTII SLISEIQKSI SELSLSCVND DNSTGQVLTF NGLEDTIRGD 

       130        140        150        160        170        180 
YIVDCVTGLY QSDIGVGVGL GRTHHGHQQM KNKAVVIDEK ERMISLLETQ QSENDIKMQV 

       190        200        210        220        230        240 
LMSEIEQLKN QLSKKRNERG QEKRDAEKVM SDLMARNSDL RKHNDILTAE ISQMKNKNTI 

       250        260        270        280        290        300 
QRNKNTVSTT VVPAILSVAL LSSSVAPIIA APPDSPMINP WPHAKNRVGT GMYKYDENDD 

       310        320        330        340        350        360 
SGCRPIRYGV SCIGFDFMLK MDKYPFFNAF IGHKTPLESF ADKIIEKEEE TCEIGTNKEF 

       370        380        390        400        410        420 
KCFEERAYIK GTCPTNINAV HYIDNKGKLR YVKCKENLEM TEDCAFCRKI KKKAGQSVQV 

       430        440        450        460        470        480 
QKTSVPLQDA ICQENSDTYS GPKIPFKGVC KIGLIKYKEC KFKTSSYETV SFITLKEKGK 

       490        500        510        520        530        540 
IYIEHLMLKN IEVVTNVSFV CYEHVGQDEQ EVEHRALKRV SVNDCKIVDN SKQKICTGDH 

       550        560        570        580        590        600 
VFCEKYDCST SYPDVTCIHA PGSGPLYINL MGSWIKPQCV GYERVLVDRE VKQPLLAPEQ 

       610        620        630        640        650        660 
NCDTCVSECL DEGVHIKSTG FEITSAVACS HGSCISAHQE PSTSVIVPYP GLLASVGGRI 

       670        680        690        700        710        720 
GIHLSHTSDS ASVHMVVVCP PRDSCAAHNC LLCYHGILNY QCHSTLSAIL TSFLLILFIY 

       730        740        750        760        770        780 
TVFSVTTNIL YVLRLIPKQL KSPVGWLKLF INWLLTALRI KTRNVMRRIN QRIGWVDHHD 

       790        800        810        820        830        840 
VERPRHREPM RRFKTTLLLT LIMMTGGNAC SNTVVANSKQ TRCVQEGSNT KCSITATITL 

       850        860        870        880        890        900 
RAGVIGAESC FIIKGPMENQ QKTISIKTIS SETVCREGSS FWTSLYIPSC LSSRRCHLVG 

       910        920        930        940        950        960 
DCVGNKCQSW RDDQLSREFS GVKDNHIMNE NKCFEQCGAI GCGCFNINPS CLYVHAYLKS 

       970        980        990       1000       1010       1020 
ARNEAVRVFS CSDWVHRVSF EVKGPDGETE LVTLGSPGTK FLNWGTLSLS LDAEGISGTN 

      1030       1040       1050       1060       1070       1080 
SISFLESSKG GFALYDEGYN EIPREGFLGE IRCSSESAAI SAHKSCIRAP GLIKYKPMTD 

      1090       1100       1110       1120       1130       1140 
QIECTASLVD PFAIFLKGSL PQTRNGQTFT STKDKKTVQA FTNGAIKALL SINLDDHEIV 

      1150       1160       1170       1180       1190       1200 
FINKVKNCDA TFLNVSGCYS CDYGAHVCVK VKSSESADFF AESEDKTTVL SFPIQSGTHD 

      1210       1220       1230       1240       1250       1260 
YCQVLHFQKP LVDERLSYSC GSEPKLIVIK GTLVCMGVYD FRNKTGGSST VVNPSEGAWS 

      1270       1280       1290       1300       1310 
ISNWFSGLLD WLGGPMKAIL KILGFIAIGI VCFVLFMILI RIAVNSINIK KKN 

« Hide

References

[1]"Complete sequences of the glycoproteins and M RNA of Punta Toro phlebovirus compared to those of Rift Valley fever virus."
Ihara T., Smith J., Dalrymple J.M., Bishop D.H.L.
Virology 144:246-259(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M11156 Genomic RNA. Translation: AAA47110.1.
PIRVGVUPT. A04109.

3D structure databases

ProteinModelPortalP03517.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
IPR009879. Phlebovirus_NSM.
[Graphical view]
PfamPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
PF07246. Phlebovirus_NSM. 1 hit.
[Graphical view]
PIRSFPIRSF003961. M_poly_PhleboV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGP_PTPV
AccessionPrimary (citable) accession number: P03517
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families