SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P03517

- GP_PTPV

UniProt

P03517 - GP_PTPV

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Envelope glycoprotein
Gene
GP
Organism
Punta toro phlebovirus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei809 – 8102Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiPunta toro phlebovirus
Taxonomic identifieri11587 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 712684Extracellular Reviewed prediction
Add
BLAST
Transmembranei713 – 73321Helical; Reviewed prediction
Add
BLAST
Topological domaini734 – 80976Cytoplasmic Reviewed prediction
Add
BLAST
Topological domaini810 – 1278469Extracellular Reviewed prediction
Add
BLAST
Transmembranei1279 – 129921Helical; Reviewed prediction
Add
BLAST
Topological domaini1300 – 131314Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 13131285Envelope glycoprotein
PRO_0000247008Add
BLAST
Chaini29 – 270242Non-structural protein NSm
PRO_0000036844Add
BLAST
Chaini271 – 809539Glycoprotein G1 Reviewed prediction
PRO_0000036845Add
BLAST
Chaini810 – 1313504Glycoprotein G2 Reviewed prediction
PRO_0000036846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi76 – 761N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi102 – 1021N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi496 – 4961N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1154 – 11541N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1243 – 12431N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Structurei

3D structure databases

ProteinModelPortaliP03517.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
IPR009879. Phlebovirus_NSM.
[Graphical view]
PfamiPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
PF07246. Phlebovirus_NSM. 1 hit.
[Graphical view]
PIRSFiPIRSF003961. M_poly_PhleboV. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03517-1 [UniParc]FASTAAdd to Basket

« Hide

MIFTILNVLT RAMLVMSMYS LTTWDSTSRN DMCFSNDSPL EGLVYYWETH     50
SKRHDYKKQE SQRCRVGDSD KKMITNVTII SLISEIQKSI SELSLSCVND 100
DNSTGQVLTF NGLEDTIRGD YIVDCVTGLY QSDIGVGVGL GRTHHGHQQM 150
KNKAVVIDEK ERMISLLETQ QSENDIKMQV LMSEIEQLKN QLSKKRNERG 200
QEKRDAEKVM SDLMARNSDL RKHNDILTAE ISQMKNKNTI QRNKNTVSTT 250
VVPAILSVAL LSSSVAPIIA APPDSPMINP WPHAKNRVGT GMYKYDENDD 300
SGCRPIRYGV SCIGFDFMLK MDKYPFFNAF IGHKTPLESF ADKIIEKEEE 350
TCEIGTNKEF KCFEERAYIK GTCPTNINAV HYIDNKGKLR YVKCKENLEM 400
TEDCAFCRKI KKKAGQSVQV QKTSVPLQDA ICQENSDTYS GPKIPFKGVC 450
KIGLIKYKEC KFKTSSYETV SFITLKEKGK IYIEHLMLKN IEVVTNVSFV 500
CYEHVGQDEQ EVEHRALKRV SVNDCKIVDN SKQKICTGDH VFCEKYDCST 550
SYPDVTCIHA PGSGPLYINL MGSWIKPQCV GYERVLVDRE VKQPLLAPEQ 600
NCDTCVSECL DEGVHIKSTG FEITSAVACS HGSCISAHQE PSTSVIVPYP 650
GLLASVGGRI GIHLSHTSDS ASVHMVVVCP PRDSCAAHNC LLCYHGILNY 700
QCHSTLSAIL TSFLLILFIY TVFSVTTNIL YVLRLIPKQL KSPVGWLKLF 750
INWLLTALRI KTRNVMRRIN QRIGWVDHHD VERPRHREPM RRFKTTLLLT 800
LIMMTGGNAC SNTVVANSKQ TRCVQEGSNT KCSITATITL RAGVIGAESC 850
FIIKGPMENQ QKTISIKTIS SETVCREGSS FWTSLYIPSC LSSRRCHLVG 900
DCVGNKCQSW RDDQLSREFS GVKDNHIMNE NKCFEQCGAI GCGCFNINPS 950
CLYVHAYLKS ARNEAVRVFS CSDWVHRVSF EVKGPDGETE LVTLGSPGTK 1000
FLNWGTLSLS LDAEGISGTN SISFLESSKG GFALYDEGYN EIPREGFLGE 1050
IRCSSESAAI SAHKSCIRAP GLIKYKPMTD QIECTASLVD PFAIFLKGSL 1100
PQTRNGQTFT STKDKKTVQA FTNGAIKALL SINLDDHEIV FINKVKNCDA 1150
TFLNVSGCYS CDYGAHVCVK VKSSESADFF AESEDKTTVL SFPIQSGTHD 1200
YCQVLHFQKP LVDERLSYSC GSEPKLIVIK GTLVCMGVYD FRNKTGGSST 1250
VVNPSEGAWS ISNWFSGLLD WLGGPMKAIL KILGFIAIGI VCFVLFMILI 1300
RIAVNSINIK KKN 1313
Length:1,313
Mass (Da):146,375
Last modified:July 21, 1986 - v1
Checksum:i72072F27735A74A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11156 Genomic RNA. Translation: AAA47110.1.
PIRiA04109. VGVUPT.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11156 Genomic RNA. Translation: AAA47110.1 .
PIRi A04109. VGVUPT.

3D structure databases

ProteinModelPortali P03517.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
IPR009879. Phlebovirus_NSM.
[Graphical view ]
Pfami PF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
PF07246. Phlebovirus_NSM. 1 hit.
[Graphical view ]
PIRSFi PIRSF003961. M_poly_PhleboV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequences of the glycoproteins and M RNA of Punta Toro phlebovirus compared to those of Rift Valley fever virus."
    Ihara T., Smith J., Dalrymple J.M., Bishop D.H.L.
    Virology 144:246-259(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_PTPV
AccessioniPrimary (citable) accession number: P03517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi