P03514 (NSS_BUNSH) Reviewed, UniProtKB/Swiss-Prot
Last modified July 9, 2014. Version 44. History...
Names and origin
|Protein names||Recommended name:|
Non-structural protein NS-S
|Organism||Bunyavirus snowshoe hare|
|Taxonomic identifier||11580 [NCBI]|
|Taxonomic lineage||Viruses › ssRNA negative-strand viruses › Bunyaviridae › Orthobunyavirus ›|
|Virus host||Aedes [TaxID: 7158]|
Bos taurus (Bovine) [TaxID: 9913]
Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
Culex [TaxID: 7174]
Culiseta [TaxID: 174825]
Equus caballus (Horse) [TaxID: 9796]
Gallus gallus (Chicken) [TaxID: 9031]
Homo sapiens (Human) [TaxID: 9606]
Lepus americanus (Snowshoe hare) [TaxID: 48086]
|Sequence length||92 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1 By similarity.
Belongs to the orthobunyavirus NS-S protein family.
|Biological process||Eukaryotic host gene expression shutoff by virus|
Eukaryotic host transcription shutoff by virus
Host gene expression shutoff by virus
Inhibition of eukaryotic host transcription initiation by virus
|Coding sequence diversity||Alternative initiation|
|Gene Ontology (GO)|
|Biological_process||suppression by virus of host transcription initiation from RNA polymerase II promoter|
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
|This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]|
|Isoform NSS (identifier: P03514-1) |
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
|Note: Produced by alternative initiation in the N gene, but encoded on another frame.|
|Isoform N (identifier: P03513-1) |
The sequence of this isoform can be found in the external entry P03513.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 92||92||Non-structural protein NS-S||PRO_0000221975|
|||"The complete sequence and coding content of snowshoe hare bunyavirus small (S) viral RNA species."|
Bishop D.H.L., Gould K.G., Akashi H., Clerx-Van Haaster C.M.
Nucleic Acids Res. 10:3703-3713(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
|||"Nucleotide sequence analyses and predicted coding of bunyavirus genome RNA species."|
Clerx-Van Haaster C.M., Akashi H., Auperin D.D., Bishop D.H.L.
J. Virol. 41:119-128(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-47.
|J02390 Genomic RNA. No translation available.|
J02393 Genomic RNA. No translation available.
|PIR||MNVUSH. A04105. |
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR000797. Bunya_NSs. |
|Pfam||PF01104. Bunya_NS-S. 1 hit. |
|PIRSF||PIRSF003954. NS-S_OrthobunV. 1 hit. |
|Accession||Primary (citable) accession number: P03514|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families