Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P03514 (NSS_BUNSH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein NS-S
Gene names
Name:N
OrganismBunyavirus snowshoe hare
Taxonomic identifier11580 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
Culex [TaxID: 7174]
Culiseta [TaxID: 174825]
Equus caballus (Horse) [TaxID: 9796]
Gallus gallus (Chicken) [TaxID: 9031]
Homo sapiens (Human) [TaxID: 9606]
Lepus americanus (Snowshoe hare) [TaxID: 48086]

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1 By similarity.

Sequence similarities

Belongs to the orthobunyavirus NS-S protein family.

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform NSS (identifier: P03514-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by alternative initiation in the N gene, but encoded on another frame.
Isoform N (identifier: P03513-1)

The sequence of this isoform can be found in the external entry P03513.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9292Non-structural protein NS-S
PRO_0000221975

Sequences

Sequence LengthMass (Da)Tools
Isoform NSS [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: B5CCF0C9FD4FA8C1

FASTA9210,490
        10         20         30         40         50         60 
MMSHQQVQMD LILMQGIWHS VLNMQNQSIL LQLGSSSSMP QRPRLLSRVS QRGRQILNLE 

        70         80         90 
SGRWRLSIII FLETGTIQLT ATILPSTDCQ DI 

« Hide

Isoform N [UniParc].

See P03513.

References

[1]"The complete sequence and coding content of snowshoe hare bunyavirus small (S) viral RNA species."
Bishop D.H.L., Gould K.G., Akashi H., Clerx-Van Haaster C.M.
Nucleic Acids Res. 10:3703-3713(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Nucleotide sequence analyses and predicted coding of bunyavirus genome RNA species."
Clerx-Van Haaster C.M., Akashi H., Auperin D.D., Bishop D.H.L.
J. Virol. 41:119-128(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-47.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02390 Genomic RNA. No translation available.
J02393 Genomic RNA. No translation available.
PIRMNVUSH. A04105.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000797. Bunya_NSs.
[Graphical view]
PfamPF01104. Bunya_NS-S. 1 hit.
[Graphical view]
PIRSFPIRSF003954. NS-S_OrthobunV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNSS_BUNSH
AccessionPrimary (citable) accession number: P03514
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families