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P03513

- NCAP_BUNSH

UniProt

P03513 - NCAP_BUNSH

Protein

Nucleoprotein

Gene

N

Organism
Bunyavirus snowshoe hare
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalization of host PABP1, thereby inhibiting host cellular translation By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. suppression by virus of host gene expression Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction

    Keywords - Ligandi

    RNA-binding, Viral nucleoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoprotein
    Alternative name(s):
    Nucleocapsid protein
    Short name:
    Protein N
    Gene namesi
    Name:N
    OrganismiBunyavirus snowshoe hare
    Taxonomic identifieri11580 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiAedes [TaxID: 7158]
    Bos taurus (Bovine) [TaxID: 9913]
    Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
    Culex [TaxID: 7174]
    Culiseta [TaxID: 174825]
    Equus caballus (Horse) [TaxID: 9796]
    Gallus gallus (Chicken) [TaxID: 9031]
    Homo sapiens (Human) [TaxID: 9606]
    Lepus americanus (Snowshoe hare) [TaxID: 48086]

    Subcellular locationi

    Virion
    Note: Internal protein of virus particle.

    GO - Cellular componenti

    1. helical viral capsid Source: UniProtKB-KW
    2. ribonucleoprotein complex Source: UniProtKB-KW
    3. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Helical capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235NucleoproteinPRO_0000221991Add
    BLAST

    Interactioni

    Subunit structurei

    Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with host PABP1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP03513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR001784. Bunya_nucleocap.
    [Graphical view]
    PfamiPF00952. Bunya_nucleocap. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
    ProDomiPD001909. Bunya_nucleocap. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform N (identifier: P03513-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDLVFYDVA STGANGFDPD AGYMAFCVKY AESVNLAAVR IFFLNAAKAK    50
    AALSRKPERK ANPKFGEWQV EVVNNHFPGN RNNPINSDDL TIHRLSGYLA 100
    RWVLEQYKEN EDESRRELIK TTIINPIAES NGVRWDSGAE IYLSFFPGTE 150
    MFLETFKFYP LTIGIYRVKQ GMMDPQYLKK ALRQRYGSLT ADKWMSQKVT 200
    AIAKSLKEVE QLKWGRGGLS DTARSFLQKF GIRLP 235
    Length:235
    Mass (Da):26,771
    Last modified:July 21, 1986 - v1
    Checksum:i687ED1D57AC097F8
    GO
    Isoform NSS (identifier: P03514-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P03514.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Produced by alternative initiation in the N gene, but encoded on another frame.

    Length:92
    Mass (Da):10,490
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02390 Genomic RNA. No translation available.
    PIRiA04103. VHVUNH.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02390 Genomic RNA. No translation available.
    PIRi A04103. VHVUNH.

    3D structure databases

    ProteinModelPortali P03513.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001784. Bunya_nucleocap.
    [Graphical view ]
    Pfami PF00952. Bunya_nucleocap. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003947. N_OrthobunV. 1 hit.
    ProDomi PD001909. Bunya_nucleocap. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence and coding content of snowshoe hare bunyavirus small (S) viral RNA species."
      Bishop D.H.L., Gould K.G., Akashi H., Clerx-Van Haaster C.M.
      Nucleic Acids Res. 10:3703-3713(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNCAP_BUNSH
    AccessioniPrimary (citable) accession number: P03513
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3