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Protein

Nucleoprotein

Gene

N

Organism
Bunyavirus snowshoe hare
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalization of host PABP1, thereby inhibiting host cellular translation (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host gene expression Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:N
OrganismiBunyavirus snowshoe hare
Taxonomic identifieri11580 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
Culex [TaxID: 7174]
Culiseta [TaxID: 174825]
Equus caballus (Horse) [TaxID: 9796]
Gallus gallus (Chicken) [TaxID: 9031]
Homo sapiens (Human) [TaxID: 9606]
Lepus americanus (Snowshoe hare) [TaxID: 48086]

Subcellular locationi

Virion
Note: Internal protein of virus particle.

GO - Cellular componenti

  1. helical viral capsid Source: UniProtKB-KW
  2. ribonucleoprotein complex Source: UniProtKB-KW
  3. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235NucleoproteinPRO_0000221991Add
BLAST

Interactioni

Subunit structurei

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with host PABP1.By similarity

Structurei

3D structure databases

ProteinModelPortaliP03513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001784. Bunya_nucleocap.
[Graphical view]
PfamiPF00952. Bunya_nucleocap. 1 hit.
[Graphical view]
PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
ProDomiPD001909. Bunya_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform N (identifier: P03513-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDLVFYDVA STGANGFDPD AGYMAFCVKY AESVNLAAVR IFFLNAAKAK
60 70 80 90 100
AALSRKPERK ANPKFGEWQV EVVNNHFPGN RNNPINSDDL TIHRLSGYLA
110 120 130 140 150
RWVLEQYKEN EDESRRELIK TTIINPIAES NGVRWDSGAE IYLSFFPGTE
160 170 180 190 200
MFLETFKFYP LTIGIYRVKQ GMMDPQYLKK ALRQRYGSLT ADKWMSQKVT
210 220 230
AIAKSLKEVE QLKWGRGGLS DTARSFLQKF GIRLP
Length:235
Mass (Da):26,771
Last modified:July 21, 1986 - v1
Checksum:i687ED1D57AC097F8
GO
Isoform NSS (identifier: P03514-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P03514.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative initiation in the N gene, but encoded on another frame.

Length:92
Mass (Da):10,490
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02390 Genomic RNA. No translation available.
PIRiA04103. VHVUNH.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02390 Genomic RNA. No translation available.
PIRiA04103. VHVUNH.

3D structure databases

ProteinModelPortaliP03513.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR001784. Bunya_nucleocap.
[Graphical view]
PfamiPF00952. Bunya_nucleocap. 1 hit.
[Graphical view]
PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
ProDomiPD001909. Bunya_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "The complete sequence and coding content of snowshoe hare bunyavirus small (S) viral RNA species."
    Bishop D.H.L., Gould K.G., Akashi H., Clerx-Van Haaster C.M.
    Nucleic Acids Res. 10:3703-3713(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNCAP_BUNSH
AccessioniPrimary (citable) accession number: P03513
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 4, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.