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P03425

- HN_SENDH

UniProt

P03425 - HN_SENDH

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Sendai virus (strain Harris) (SeV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Protein family/group databases

    CAZyiGH83. Glycoside Hydrolase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Short name:
    HN protein
    Gene namesi
    Name:HN
    OrganismiSendai virus (strain Harris) (SeV)
    Taxonomic identifieri11196 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRespirovirus
    Virus hostiCavia cutleri (Guinea pig) [TaxID: 10144]
    Cricetidae sp. (Hamster) [TaxID: 36483]
    Mus musculus (Mouse) [TaxID: 10090]
    Rattus norvegicus (Rat) [TaxID: 10116]

    Subcellular locationi

    Virion membrane Curated; Single-pass type II membrane protein Curated. Host cell membrane Curated; Single-pass type II membrane protein Curated
    Note: Folded in the endoplasmic reticulum.By similarity

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 576576Hemagglutinin-neuraminidasePRO_0000142638Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi77 – 771N-linked (GlcNAc...); by hostBy similarity
    Disulfide bondi129 – 129InterchainSequence Analysis
    Glycosylationi499 – 4991N-linked (GlcNAc...); by hostBy similarity
    Glycosylationi511 – 5111N-linked (GlcNAc...); by hostBy similarity

    Post-translational modificationi

    N-glycosylated; glycans consist of a mixture of high mannose-type oligosaccharides and of complex-type oligosaccharides.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homotetramer; composed of disulfide-linked homodimers. Interacts with F protein trimer By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP03425.
    SMRiP03425. Positions 144-573.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737IntravirionBy similarityAdd
    BLAST
    Topological domaini59 – 576518Virion surfaceBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni10 – 145Incorporation in virionBy similarity
    Regioni59 – 14082Involved in interaction with F proteinBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P03425-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGDRGKRDS YWSTSPSGST TKLASGWERS SKVDTWLLIL SFTQWALSIA    50
    TVIICIIISA RQGYSTKEYS MTVEALNMSS REVKESLTSL IRQEVIARAV 100
    NIQSSVQTGI PVLLNKNSRD VIQMIDKSCS RQELTQLCES TIAVHHAEGI 150
    APLEPHSFWR CPVGEPYLSS DPKISLLLGP SLLSGSTTIS GCVRLPSLSI 200
    GEAIYAYSSN LITQGCADIG KSYQVLQLGY ISLNSDMFPD LNPVVSHTYD 250
    INDNRKSCSV VATGTRGYQL CSMPTVDERT DYSSDGIEDL VLDVLDLKGS 300
    TKSHRYRNSE VDLDHPFSAL YPSVGNGIAT EGSLIFLGYG GLTTPLQGDT 350
    KCRTQGCQQV SQDTCNEALK ITWLGGKQVV NVIIRVNDYL SERPKIRVTT 400
    IPITQNYLGA EGRLLKLGDR VYIYTRSSGW HSQLQIGVLD VSHPLTINWT 450
    PHEALSRPGN KECNWYNTCP KECISGVYTD AYPLSPDAAN VATVTLYANT 500
    SRVNPTIMYS NTTNIINMLR IKDVQLEVAY TTISSCITHF GKGYCFHIIE 550
    INQKSLNTLQ PMLFKTSIPK LCKAES 576
    Length:576
    Mass (Da):63,515
    Last modified:July 21, 1986 - v1
    Checksum:i01CD8067E038FC5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12397 Genomic RNA. Translation: AAA47810.1.
    PIRiA00877. HNNZS.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12397 Genomic RNA. Translation: AAA47810.1 .
    PIRi A00877. HNNZS.

    3D structure databases

    ProteinModelPortali P03425.
    SMRi P03425. Positions 144-573.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH83. Glycoside Hydrolase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence determination of the Sendai virus HN gene and its comparison to the influenza virus glycoproteins."
      Blumberg B.M., Giorgi C., Roux L., Raju R., Dowling P., Chollet A., Kolakofsky D.
      Cell 41:269-278(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiHN_SENDH
    AccessioniPrimary (citable) accession number: P03425
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3