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P03425

- HN_SENDH

UniProt

P03425 - HN_SENDH

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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Sendai virus (strain Harris) (SeV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Short name:
HN protein
Gene namesi
Name:HN
OrganismiSendai virus (strain Harris) (SeV)
Taxonomic identifieri11196 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRespirovirus
Virus hostiCavia cutleri (Guinea pig) [TaxID: 10144]
Cricetidae sp. (Hamster) [TaxID: 36483]
Mus musculus (Mouse) [TaxID: 10090]
Rattus norvegicus (Rat) [TaxID: 10116]

Subcellular locationi

Virion membrane Curated; Single-pass type II membrane protein Curated. Host cell membrane Curated; Single-pass type II membrane protein Curated
Note: Folded in the endoplasmic reticulum.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737IntravirionBy similarityAdd
BLAST
Transmembranei38 – 5821HelicalBy similarityAdd
BLAST
Topological domaini59 – 576518Virion surfaceBy similarityAdd
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Hemagglutinin-neuraminidasePRO_0000142638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...); by hostBy similarity
Disulfide bondi129 – 129InterchainSequence Analysis
Glycosylationi499 – 4991N-linked (GlcNAc...); by hostBy similarity
Glycosylationi511 – 5111N-linked (GlcNAc...); by hostBy similarity

Post-translational modificationi

N-glycosylated; glycans consist of a mixture of high mannose-type oligosaccharides and of complex-type oligosaccharides.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotetramer; composed of disulfide-linked homodimers. Interacts with F protein trimer (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP03425.
SMRiP03425. Positions 144-573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 145Incorporation in virionBy similarity
Regioni59 – 14082Involved in interaction with F proteinBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P03425-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGDRGKRDS YWSTSPSGST TKLASGWERS SKVDTWLLIL SFTQWALSIA
60 70 80 90 100
TVIICIIISA RQGYSTKEYS MTVEALNMSS REVKESLTSL IRQEVIARAV
110 120 130 140 150
NIQSSVQTGI PVLLNKNSRD VIQMIDKSCS RQELTQLCES TIAVHHAEGI
160 170 180 190 200
APLEPHSFWR CPVGEPYLSS DPKISLLLGP SLLSGSTTIS GCVRLPSLSI
210 220 230 240 250
GEAIYAYSSN LITQGCADIG KSYQVLQLGY ISLNSDMFPD LNPVVSHTYD
260 270 280 290 300
INDNRKSCSV VATGTRGYQL CSMPTVDERT DYSSDGIEDL VLDVLDLKGS
310 320 330 340 350
TKSHRYRNSE VDLDHPFSAL YPSVGNGIAT EGSLIFLGYG GLTTPLQGDT
360 370 380 390 400
KCRTQGCQQV SQDTCNEALK ITWLGGKQVV NVIIRVNDYL SERPKIRVTT
410 420 430 440 450
IPITQNYLGA EGRLLKLGDR VYIYTRSSGW HSQLQIGVLD VSHPLTINWT
460 470 480 490 500
PHEALSRPGN KECNWYNTCP KECISGVYTD AYPLSPDAAN VATVTLYANT
510 520 530 540 550
SRVNPTIMYS NTTNIINMLR IKDVQLEVAY TTISSCITHF GKGYCFHIIE
560 570
INQKSLNTLQ PMLFKTSIPK LCKAES
Length:576
Mass (Da):63,515
Last modified:July 21, 1986 - v1
Checksum:i01CD8067E038FC5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12397 Genomic RNA. Translation: AAA47810.1.
PIRiA00877. HNNZS.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12397 Genomic RNA. Translation: AAA47810.1 .
PIRi A00877. HNNZS.

3D structure databases

ProteinModelPortali P03425.
SMRi P03425. Positions 144-573.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence determination of the Sendai virus HN gene and its comparison to the influenza virus glycoproteins."
    Blumberg B.M., Giorgi C., Roux L., Raju R., Dowling P., Chollet A., Kolakofsky D.
    Cell 41:269-278(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiHN_SENDH
AccessioniPrimary (citable) accession number: P03425
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3