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Protein

Phosphoprotein

Gene

P/V

Organism
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Viral RNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoprotein
Short name:
Protein P
Gene namesi
Name:P/V
OrganismiMeasles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri11235 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507PhosphoproteinPRO_0000142690Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NQ899333EBI-8589851,EBI-8589867From a different organism.

Protein-protein interaction databases

IntActiP03422. 1 interaction.
MINTiMINT-7009767.

Structurei

Secondary structure

1
507
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi461 – 47010Combined sources
Helixi475 – 48713Combined sources
Helixi491 – 50717Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OKSX-ray1.80A459-507[»]
2K9DNMR-A462-505[»]
DisProtiDP00133.
ProteinModelPortaliP03422.
SMRiP03422. Positions 459-506.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03422.

Family & Domainsi

Sequence similaritiesi

Belongs to the morbillivirus P protein family.Curated

Family and domain databases

InterProiIPR004897. P/V_Pprotein_paramyxoviral.
IPR028243. Paramyxo_P/V_N.
IPR016075. RNA_pol_Pprot-P_XD_paramyxovir.
[Graphical view]
PfamiPF03210. Paramyx_P_V_C. 1 hit.
PF13825. Paramyxo_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF101089. SSF101089. 1 hit.

Sequencei

Sequence statusi: Complete.

P03422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEQARHVK NGLECIRALK AEPIGSLAIE EAMAAWSEIS DNPGQERATC
60 70 80 90 100
REEKAGSSGL SKPCLSAIGS TEGGAPRIRG QGPGESDDDA ETLGIPPRNL
110 120 130 140 150
QASSTGLQCY YVYDHSGEAV KGIQDADSIM VQSGLDGDST LSGGDNESEN
160 170 180 190 200
SDVDIGEPDT EGYAITDRGS APISMGFRAS DVETAEGGEI HELLRLQSRG
210 220 230 240 250
NNFPKLGKTL NVPPPPDPGR ASTSGTPIKK GTERRLASFG TEIASLLTGG
260 270 280 290 300
ATQCARKSPS EPSGPGAPAG NVPECVSNAA LIQEWTPESG TTISPRSQNN
310 320 330 340 350
EEGGDYYDDE LFSDVQDIKT ALAKIHEDNQ KIISKLESLL LLKGEVESIK
360 370 380 390 400
KQINRQNISI STLEGHLSSI MIAIPGLGKD PNDPTADVEI NPDLKPIIGR
410 420 430 440 450
DSGRALAEVL KKPVASRQLQ GMTNGRTSSR GQLLKEFQLK PIGKKMSSAV
460 470 480 490 500
GFVPDTGPAS RSVIRSIIKS SRLEEDRKRY LMTLLDDIKG ANDLAKFHQM

LMKIIMK
Length:507
Mass (Da):54,057
Last modified:July 21, 1986 - v1
Checksum:i17F6B60CC0A78637
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti435 – 4362KE → RQ in AAA46436 (PubMed:6547185).Curated
Sequence conflicti464 – 4641I → T in AAA46436 (PubMed:6547185).Curated

RNA editingi

Edited at position 231.By similarity
Partially edited. RNA editing at this position consists of an insertion of one guanine nucleotide. The sequence displayed here is the P protein, derived from the unedited RNA. The edited RNA gives rise to the V protein (AC Q9EMA9) (By similarity).By similarity

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10456 Genomic RNA. Translation: AAA46437.1.
K02912 Genomic RNA. Translation: AAA46436.1.
PIRiA04038. RRNZM.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10456 Genomic RNA. Translation: AAA46437.1.
K02912 Genomic RNA. Translation: AAA46436.1.
PIRiA04038. RRNZM.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OKSX-ray1.80A459-507[»]
2K9DNMR-A462-505[»]
DisProtiDP00133.
ProteinModelPortaliP03422.
SMRiP03422. Positions 459-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03422. 1 interaction.
MINTiMINT-7009767.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP03422.

Family and domain databases

InterProiIPR004897. P/V_Pprotein_paramyxoviral.
IPR028243. Paramyxo_P/V_N.
IPR016075. RNA_pol_Pprot-P_XD_paramyxovir.
[Graphical view]
PfamiPF03210. Paramyx_P_V_C. 1 hit.
PF13825. Paramyxo_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF101089. SSF101089. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHOSP_MEASE
AccessioniPrimary (citable) accession number: P03422
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 14, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.