P03410 (TAX_HTLV2) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 61.
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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protein Tax-2 Alternative name(s): Trans-activating transcriptional regulatory protein of HTLV-2 | ||
| Gene names |
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| Organism | Human T-cell leukemia virus 2 (HTLV-2) [Reference proteome] | ||
| Taxonomic identifier | 11909 [NCBI] | ||
| Taxonomic lineage | Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Deltaretrovirus ›  | ||
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 331 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Induces T-cell transformation, although much less efficiently than HTLV-1. Required for viral replication By similarity. |
| Subunit structure | Homodimer. Interacts with host CREB1, CREBBP and EP300 By similarity. |
| Subcellular location | Host cytoplasm. Host nucleus. Note: Tax-2 is mainly found in the cytoplasm. Ref.3 |
| Domain | The 48 N-terminal residues contain a non-canonical functional nuclear localization signal (NLS) By similarity. |
| Post-translational modification | Phosphorylation at Thr-48 results in the loss of NF-kappa-B activation function. Phosphorylation at Thr-215 results in loss of CREB and NF-B responsive promoters activation. Phosphorylation at Thr-184 has no effect on these Tax functions. Phosphorylation of either Ser-300 or Ser-301 is necessary for localization to nuclear bodies. Thr-48, Thr-184 and Thr-215 are highly phosphorylated, whereas Ser-300 or Ser-301 are only rarely phosphorylated By similarity. |
| Sequence similarities | Belongs to the deltaretrovirus Tax protein family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 331 | 331 | Protein Tax-2 | PRO_0000085496 | |||||
Regions | |||||||||
| Zinc finger | 23 – 49 | 27 | Potential | ||||||
| Region | 2 – 58 | 57 | Interaction with CREB1 By similarity | ||||||
| Region | 81 – 95 | 15 | Interaction with CREBBP/P300 By similarity | ||||||
| Region | 106 – 111 | 6 | Interaction with IKBKG By similarity | ||||||
| Region | 116 – 145 | 30 | Homodimerization By similarity | ||||||
| Region | 213 – 248 | 36 | Homodimerization By similarity | ||||||
| Region | 289 – 322 | 34 | Transactivation By similarity | ||||||
| Region | 312 – 319 | 8 | Interaction with CREBBP C-terminus By similarity | ||||||
| Motif | 73 – 80 | 8 | SH3-binding Potential | ||||||
| Motif | 188 – 202 | 15 | Nuclear export signal By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 48 | 1 | Phosphothreonine; by host By similarity | ||||||
| Modified residue | 184 | 1 | Phosphothreonine; by host By similarity | ||||||
| Modified residue | 215 | 1 | Phosphothreonine; by host By similarity | ||||||
| Modified residue | 300 | 1 | Phosphoserine; by host By similarity | ||||||
| Modified residue | 301 | 1 | Phosphoserine; by host By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 5 | 1 | P → L Ref.2 | ||||||
| Sequence conflict | 22 | 1 | D → N Ref.2 | ||||||
| Sequence conflict | 204 | 1 | T → A Ref.2 | ||||||
| Sequence conflict | 261 | 1 | Y → C Ref.2 | ||||||
| Sequence conflict | 282 | 1 | E → Q Ref.2 | ||||||
Sequences
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References
| [1] | "Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene." Shimotohno K., Takahashi Y., Shimizu N., Gojobori T., Golde D.W., Chen I.S.Y., Miwa M., Sugimura T. Proc. Natl. Acad. Sci. U.S.A. 82:3101-3105(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Structure of 3' terminal region of type II human T lymphotropic virus: evidence for new coding region." Haseltine W.A., Sodroski J., Patarca R., Briggs D., Perkins D., Wong-Staal F. Science 225:419-421(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "A 10-amino acid domain within human T-cell leukemia virus type 1 and type 2 tax protein sequences is responsible for their divergent subcellular distribution." Meertens L., Chevalier S., Weil R., Gessain A., Mahieux R. J. Biol. Chem. 279:43307-43320(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M10060 Genomic DNA. Translation: AAB59888.1. K02532 Genomic RNA. No translation available. |
| PIR | TNLJH2. A04012. TNLJT2. A04013. A48751. |
| RefSeq | NP_041005.1. NC_001488.1. |
3D structure databases | |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1491946. |
Family and domain databases | |
| InterPro | IPR004120. Tax. [Graphical view] |
| Pfam | PF02959. Tax. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TAX_HTLV2 | ||||||||
| Accession | Primary (citable) accession number: P03410 Secondary accession number(s): P03411, Q85602 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Viral Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |