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Protein

Glycoprotein 55

Gene

env

Organism
Rauscher spleen focus-forming virus (RSFFV)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Envelope-like membrane glycoprotein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein 55
Short name:
gp55
Gene namesi
Name:env
OrganismiRauscher spleen focus-forming virus (RSFFV)
Taxonomic identifieri11821 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 385Virion surfaceSequence analysisAdd BLAST353
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 408IntravirionSequence analysis2

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host endoplasmic reticulum, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000004079533 – 408Glycoprotein 55Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi58N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi297N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi329N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi378N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP03389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili335 – 371Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi230 – 279Pro-richAdd BLAST50

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.90.310.10. 1 hit.
InterProiIPR008981. FMuLV_rcpt-bd.
IPR018154. TLV/ENV_coat_polyprotein.
[Graphical view]
PANTHERiPTHR10424. PTHR10424. 1 hit.
PfamiPF00429. TLV_coat. 2 hits.
[Graphical view]
SUPFAMiSSF49830. SSF49830. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPAFSKPL KDKINPWGPL IILGILIRAG VSVQHDSPHQ VFNVTWRVTN
60 70 80 90 100
LMTGQTANAT SLLGTMTDAF PKLYFDLCDL IGDDWDETGL GCRTPGGRKR
110 120 130 140 150
ARTFDFYVCP GHTVPTGCGG PREGYCGKWG CETTGQAYWK PSSSWDLISL
160 170 180 190 200
KRGNTPRNQG PCYDSSAVSS DIKGATPGGR CNPLVLEFTD AGKKASWDGP
210 220 230 240 250
KVWGLRLYRS TGTDPVTRFS LTRQVLNIGP RVPIGPNPVI TDQLPPSRPV
260 270 280 290 300
QIMLPRPPQP PPPGAASIVP ETAPPSQQPG TGDRLLNLVD GAYQALNLTN
310 320 330 340 350
PDKTQDCWLC LVSGPPYYEG VAVLGTYYNH TSALKEECCF YADHTGLVRD
360 370 380 390 400
SMAKLRERLT QRQKLFESSQ GWFEELFNRS TWFTTLIFTI IGPLIILLLI

LLFWTLHS
Length:408
Mass (Da):44,940
Last modified:July 21, 1986 - v1
Checksum:i66383F99BCE9514A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02375 Genomic RNA. Translation: AAA46505.1.
PIRiA03988. VCMVSR.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02375 Genomic RNA. Translation: AAA46505.1.
PIRiA03988. VCMVSR.

3D structure databases

ProteinModelPortaliP03389.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.90.310.10. 1 hit.
InterProiIPR008981. FMuLV_rcpt-bd.
IPR018154. TLV/ENV_coat_polyprotein.
[Graphical view]
PANTHERiPTHR10424. PTHR10424. 1 hit.
PfamiPF00429. TLV_coat. 2 hits.
[Graphical view]
SUPFAMiSSF49830. SSF49830. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiENV_RSFFV
AccessioniPrimary (citable) accession number: P03389
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 5, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Compared to other gammaretroviruses which possess 2 envelope proteins (gp70 and p15E), RSFFV gp55 corresponds to a gp70-p15E fusion protein with a deletion of a portion of p15E. It is encoded by the defective env gene of the virus.
The Rauscher murine leukemia virus complex induces a rapid and fatal erythroleukemia in adult mice. It is the replication-defective spleen focus-forming virus (SFFV) contained in this complex that causes foci of proliferating erythroid cells in spleens of infected mice. The second component is a replication competent Rauscher murine leukemia virus (R-MuLV) that serves as a helper virus for SFFV. Spleens of infected mice also contain a third component, the Rauscher mink cell focus-inducing (R-MCF) virus.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.