##gff-version 3 P03366 UniProtKB Initiator methionine 1 1 . . . Note=Removed%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Chain 2 1447 . . . ID=PRO_0000261261;Note=Gag-Pol polyprotein P03366 UniProtKB Chain 2 132 . . . ID=PRO_0000042285;Note=Matrix protein p17;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Chain 133 363 . . . ID=PRO_0000042286;Note=Capsid protein p24;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Peptide 364 377 . . . ID=PRO_0000042287;Note=Spacer peptide 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Chain 378 432 . . . ID=PRO_0000042288;Note=Nucleocapsid protein p7;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Peptide 433 440 . . . ID=PRO_0000246710;Note=Transframe peptide;Ontology_term=ECO:0000255;evidence=ECO:0000255 P03366 UniProtKB Chain 441 500 . . . ID=PRO_0000042289;Note=P6-pol;Ontology_term=ECO:0000255;evidence=ECO:0000255 P03366 UniProtKB Chain 501 599 . . . ID=PRO_0000038647;Note=Protease;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Chain 600 1159 . . . ID=PRO_0000042290;Note=Reverse transcriptase/ribonuclease H;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Chain 600 1039 . . . ID=PRO_0000042291;Note=P51 RT;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Chain 1040 1159 . . . ID=PRO_0000042292;Note=P15 P03366 UniProtKB Chain 1160 1447 . . . ID=PRO_0000042293;Note=Integrase;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Domain 520 589 . . . Note=Peptidase A2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00275 P03366 UniProtKB Domain 643 833 . . . Note=Reverse transcriptase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00405 P03366 UniProtKB Domain 1033 1156 . . . Note=RNase H type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00408 P03366 UniProtKB Domain 1213 1363 . . . Note=Integrase catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00457 P03366 UniProtKB Zinc finger 390 407 . . . Note=CCHC-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00047 P03366 UniProtKB Zinc finger 411 428 . . . Note=CCHC-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00047 P03366 UniProtKB Zinc finger 1162 1203 . . . Note=Integrase-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00450 P03366 UniProtKB DNA binding 1382 1429 . . . Note=Integrase-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00506 P03366 UniProtKB Region 7 31 . . . Note=Interaction with Gp41;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12497 P03366 UniProtKB Region 8 43 . . . Note=Interaction with host CALM1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04585 P03366 UniProtKB Region 12 19 . . . Note=Interaction with host AP3D1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12497 P03366 UniProtKB Region 14 33 . . . Note=Interaction with membrane phosphatidylinositol 4%2C5-bisphosphate and RNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12497 P03366 UniProtKB Region 73 77 . . . Note=Interaction with membrane phosphatidylinositol 4%2C5-bisphosphate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12497 P03366 UniProtKB Region 106 128 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P03366 UniProtKB Region 189 227 . . . Note=Interaction with human PPIA/CYPA and NUP153;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P12497 P03366 UniProtKB Region 277 363 . . . Note=Dimerization/Multimerization of capsid protein p24;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04585 P03366 UniProtKB Region 446 493 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P03366 UniProtKB Region 501 505 . . . Note=Dimerization of protease;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04585 P03366 UniProtKB Region 549 555 . . . Note=Dimerization of protease;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04585 P03366 UniProtKB Region 588 600 . . . Note=Dimerization of protease;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04585 P03366 UniProtKB Region 826 834 . . . Note=RT 'primer grip' P03366 UniProtKB Motif 16 22 . . . Note=Nuclear export signal;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Motif 26 32 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Motif 997 1013 . . . Note=Tryptophan repeat motif P03366 UniProtKB Active site 525 525 . . . Note=For protease activity%3B shared with dimeric partner;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU10094,ECO:0000269|PubMed:12924029;Dbxref=PMID:12924029 P03366 UniProtKB Binding site 709 709 . . . . P03366 UniProtKB Binding site 784 784 . . . . P03366 UniProtKB Binding site 785 785 . . . . P03366 UniProtKB Binding site 1042 1042 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 P03366 UniProtKB Binding site 1077 1077 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 P03366 UniProtKB Binding site 1097 1097 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 P03366 UniProtKB Binding site 1148 1148 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 P03366 UniProtKB Binding site 1171 1171 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00450 P03366 UniProtKB Binding site 1175 1175 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00450 P03366 UniProtKB Binding site 1199 1199 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00450 P03366 UniProtKB Binding site 1202 1202 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00450 P03366 UniProtKB Binding site 1223 1223 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Binding site 1275 1275 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Binding site 1311 1311 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04585 P03366 UniProtKB Site 132 133 . . . Note=Cleavage%3B by viral protease;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Site 221 222 . . . Note=Cis/trans isomerization of proline peptide bond%3B by human PPIA/CYPA;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Site 363 364 . . . Note=Cleavage%3B by viral protease;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Site 377 378 . . . Note=Cleavage%3B by viral protease;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Site 432 433 . . . Note=Cleavage%3B by viral protease;Ontology_term=ECO:0000255;evidence=ECO:0000255 P03366 UniProtKB Site 440 441 . . . Note=Cleavage%3B by viral protease P03366 UniProtKB Site 500 501 . . . Note=Cleavage%3B by viral protease P03366 UniProtKB Site 599 600 . . . Note=Cleavage%3B by viral protease;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2476069;Dbxref=PMID:2476069 P03366 UniProtKB Site 1000 1000 . . . Note=Essential for RT p66/p51 heterodimerization P03366 UniProtKB Site 1013 1013 . . . Note=Essential for RT p66/p51 heterodimerization P03366 UniProtKB Site 1039 1040 . . . Note=Cleavage%3B by viral protease%3B partial P03366 UniProtKB Site 1159 1160 . . . Note=Cleavage%3B by viral protease;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Modified residue 132 132 . . . Note=Phosphotyrosine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Modified residue 387 387 . . . Note=Asymmetric dimethylarginine%3B in Nucleocapsid protein p7%3B by host PRMT6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17415034;Dbxref=PMID:17415034 P03366 UniProtKB Modified residue 409 409 . . . Note=Asymmetric dimethylarginine%3B in Nucleocapsid protein p7%3B by host PRMT6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17415034;Dbxref=PMID:17415034 P03366 UniProtKB Lipidation 2 2 . . . Note=N-myristoyl glycine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250 P03366 UniProtKB Natural variant 297 297 . . . Note=In strain: Isolate PV22. V->L P03366 UniProtKB Natural variant 434 434 . . . Note=L->F P03366 UniProtKB Natural variant 771 771 . . . Note=In strain: Isolate PV22. K->R P03366 UniProtKB Natural variant 1050 1050 . . . Note=In strain: Isolate PV22. K->R P03366 UniProtKB Natural variant 1057 1057 . . . Note=In strain: Isolate PV22. V->L P03366 UniProtKB Natural variant 1111 1111 . . . Note=In strain: Isolate PV22. K->Q P03366 UniProtKB Natural variant 1128 1128 . . . Note=In strain: Isolate PV22. E->Q P03366 UniProtKB Mutagenesis 440 440 . . . Note=Complete loss of cleavage between NC and TF. F->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11172099;Dbxref=PMID:11172099 P03366 UniProtKB Mutagenesis 500 500 . . . Note=Complete loss of cleavage between TF and p15. F->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11172099;Dbxref=PMID:11172099 P03366 UniProtKB Mutagenesis 651 651 . . . Note=74%25 loss of polymerase activity. 86%25 loss of RNase H activity. P->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 654 654 . . . Note=64%25 loss of polymerase activity. 57%25 loss of RNase H activity. P->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 664 664 . . . Note=Strong decrease in RT binding affinity for all dNTP substrates and in catalytic efficiency. 100-fold decreased sensitivity to ddNTP inhibitors. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10794716;Dbxref=PMID:10794716 P03366 UniProtKB Mutagenesis 664 664 . . . Note=Strong decrease in RT binding affinity for all dNTP substrates and in catalytic efficiency. 100-fold decreased sensitivity to ddNTP inhibitors. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10794716;Dbxref=PMID:10794716 P03366 UniProtKB Mutagenesis 664 664 . . . Note=Strong decrease in RT binding affinity for all dNTP substrates and in catalytic efficiency. 100-fold decreased sensitivity to ddNTP inhibitors. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10794716;Dbxref=PMID:10794716 P03366 UniProtKB Mutagenesis 664 664 . . . Note=10-fold decreased sensitivity to ddATP and ddCTP inhibitors. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10794716;Dbxref=PMID:10794716 P03366 UniProtKB Mutagenesis 673 673 . . . Note=No loss of polymerase activity. No loss of RNase H activity. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 709 709 . . . Note=5- to 12-fold decrease in affinity for dTTP substrates. Strongly decreased RNA-directed and DNA-directed DNA polymerase activities. No effect on RNase H activity. Loss of pyrophosphorolysis (reverse of the polymerase reaction). D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8794733;Dbxref=PMID:8794733 P03366 UniProtKB Mutagenesis 709 709 . . . Note=5- to 12-fold decrease in affinity for dTTP substrates. Strongly decreased RNA-directed DNA polymerase activity. Slightly decreased DNA-directed DNA polymerase activity. No effect on RNase H activity. Loss of pyrophosphorolysis (reverse of the polymerase reaction). D->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8794733;Dbxref=PMID:8794733 P03366 UniProtKB Mutagenesis 752 752 . . . Note=73%25 loss of DNA-directed DNA polymerase activity. 70%25 loss of RNA-directed DNA polymerase activity. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 752 752 . . . Note=10%25 loss of DNA-directed DNA polymerase activity. 22%25 loss of RNA-directed DNA polymerase activity. W->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 752 752 . . . Note=58%25 loss of DNA-directed DNA polymerase activity. 42%25 loss of RNA-directed DNA polymerase activity. W->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 755 755 . . . Note=74%25 loss of polymerase activity. 56%25 loss of RNase H activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 755 755 . . . Note=Complete loss of polymerase activity. No loss of RNase H activity. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 755 755 . . . Note=Complete loss of polymerase activity. No loss of RNase H activity. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 756 756 . . . Note=34%25 loss of polymerase activity. No loss of RNase H activity. P->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 766 766 . . . Note=71%25 loss of DNA-directed DNA polymerase activity. 61%25 loss of RNA-directed DNA polymerase activity. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 766 766 . . . Note=16%25 loss of DNA-directed DNA polymerase activity. 24%25 loss of RNA-directed DNA polymerase activity. I->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 766 766 . . . Note=80%25 loss of DNA-directed DNA polymerase activity. 23%25 loss of RNA-directed DNA polymerase activity. I->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 766 766 . . . Note=34%25 increase of DNA-directed DNA polymerase activity. 18%25 increase of RNA-directed DNA polymerase activity. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 766 766 . . . Note=70%25 loss of DNA-directed DNA polymerase activity. 64%25 loss of RNA-directed DNA polymerase activity. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 782 782 . . . Note=Almost complete loss of polymerase activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9657675;Dbxref=PMID:9657675 P03366 UniProtKB Mutagenesis 782 782 . . . Note=70%25 loss of polymerase activity. No loss of polymerase activity%3B when associated with V-783. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9657675;Dbxref=PMID:9657675 P03366 UniProtKB Mutagenesis 783 783 . . . Note=54%25 loss of polymerase activity according to PubMed:9533880%3B increases polymerase activity according to PubMed:9657675. No loss of RNase H activity. M->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9533880,ECO:0000269|PubMed:9657675;Dbxref=PMID:9533880,PMID:9657675 P03366 UniProtKB Mutagenesis 783 783 . . . Note=90%25 loss of polymerase activity. No loss of RNase H activity. M->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9533880,ECO:0000269|PubMed:9657675;Dbxref=PMID:9533880,PMID:9657675 P03366 UniProtKB Mutagenesis 783 783 . . . Note=58%25 loss of polymerase activity. No loss of RNase H activity. M->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9533880,ECO:0000269|PubMed:9657675;Dbxref=PMID:9533880,PMID:9657675 P03366 UniProtKB Mutagenesis 784 784 . . . Note=Strongly decreased RNA-directed and DNA-directed DNA polymerase activities. No effect on RNase H activity. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8794733,ECO:0000269|PubMed:9657675;Dbxref=PMID:8794733,PMID:9657675 P03366 UniProtKB Mutagenesis 784 784 . . . Note=Strongly decreased RNA-directed and DNA-directed DNA polymerase activities. No effect on RNase H activity. D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8794733,ECO:0000269|PubMed:9657675;Dbxref=PMID:8794733,PMID:9657675 P03366 UniProtKB Mutagenesis 784 784 . . . Note=Strongly decreased RNA-directed and DNA-directed DNA polymerase activities. No effect on RNase H activity. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8794733,ECO:0000269|PubMed:9657675;Dbxref=PMID:8794733,PMID:9657675 P03366 UniProtKB Mutagenesis 785 785 . . . Note=Strongly decreased RNA-directed and DNA-directed DNA polymerase activities. Loss of pyrophosphorolysis (reverse of the polymerase reaction). No effect on RNase H activity. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8794733,ECO:0000269|PubMed:9657675;Dbxref=PMID:8794733,PMID:9657675 P03366 UniProtKB Mutagenesis 785 785 . . . Note=Drastically reduced incorporation of phosphorothioate nucleotide. Loss of pyrophosphorolysis (reverse of the polymerase reaction). No effect on RNase H activity. D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8794733,ECO:0000269|PubMed:9657675;Dbxref=PMID:8794733,PMID:9657675 P03366 UniProtKB Mutagenesis 785 785 . . . Note=Loss of pyrophosphorolysis (reverse of the polymerase reaction). No effect on RNase H activity. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8794733,ECO:0000269|PubMed:9657675;Dbxref=PMID:8794733,PMID:9657675 P03366 UniProtKB Mutagenesis 786 786 . . . Note=76%25 loss of DNA-directed DNA polymerase activity. 60%25 loss of RNA-directed DNA polymerase activity. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 786 786 . . . Note=29%25 loss of DNA-directed DNA polymerase activity. 46%25 loss of RNA-directed DNA polymerase activity. L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 786 786 . . . Note=20%25 loss of DNA-directed DNA polymerase activity. 21%25 loss of RNA-directed DNA polymerase activity. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 786 786 . . . Note=22%25 loss of DNA-directed DNA polymerase activity. No loss of RNA-directed DNA polymerase activity. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 788 788 . . . Note=37%25 increase of DNA-directed DNA polymerase activity. No loss of RNA-directed DNA polymerase activity. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 788 788 . . . Note=25%25 increase of DNA-directed DNA polymerase activity. No loss of RNA-directed DNA polymerase activity. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 788 788 . . . Note=27%25 increase of DNA-directed DNA polymerase activity. 10%25 loss of RNA-directed DNA polymerase activity. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12501197;Dbxref=PMID:12501197 P03366 UniProtKB Mutagenesis 823 823 . . . Note=No effect on RNA-dependent DNA polymerase activity. No effect on RNA 5'-end and 3'-end cleavages. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9111014;Dbxref=PMID:9111014 P03366 UniProtKB Mutagenesis 824 824 . . . Note=No effect on RNA-dependent DNA polymerase activity. No effect on RNA 5'-end and 3'-end cleavages. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9111014;Dbxref=PMID:9111014 P03366 UniProtKB Mutagenesis 825 825 . . . Note=No effect on RNA-dependent DNA polymerase activity. Complete loss of RNA 5'-end cleavage. No effect on RNA 3'-end cleavage. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9111014;Dbxref=PMID:9111014 P03366 UniProtKB Mutagenesis 826 826 . . . Note=No effect on RNA-dependent DNA polymerase activity. Complete loss of RNA 5'-end cleavage. No effect on RNA 3'-end cleavage. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9111014;Dbxref=PMID:9111014 P03366 UniProtKB Mutagenesis 827 827 . . . Note=No effect on RNA-dependent DNA polymerase activity. No effect on RNA 5'-end and 3'-end cleavages. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9111014;Dbxref=PMID:9111014 P03366 UniProtKB Mutagenesis 828 828 . . . Note=Complete loss of RNA-dependent DNA polymerase activity. No effect on RNA 5'-end and 3'-end cleavages. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9111014;Dbxref=PMID:9111014 P03366 UniProtKB Mutagenesis 829 829 . . . Note=No effect on RNA-dependent DNA polymerase activity. No effect on RNA 5'-end and 3'-end cleavages. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9111014;Dbxref=PMID:9111014 P03366 UniProtKB Mutagenesis 830 830 . . . Note=Complete loss of RNA-dependent DNA polymerase activity. Complete loss of RNA 5'-end and 3'-end cleavages. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9111014;Dbxref=PMID:9111014 P03366 UniProtKB Mutagenesis 831 831 . . . Note=Complete loss of RNA-dependent DNA polymerase activity. Complete loss of RNA 5'-end and 3'-end cleavages. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9111014;Dbxref=PMID:9111014 P03366 UniProtKB Mutagenesis 832 832 . . . Note=Complete loss of RNA-dependent DNA polymerase activity. Complete loss of RNA 5'-end and 3'-end cleavages. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9111014;Dbxref=PMID:9111014 P03366 UniProtKB Mutagenesis 834 834 . . . Note=Complete loss of RNA-dependent DNA polymerase activity. Complete loss of RNA 5'-end and 3'-end cleavages. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9111014;Dbxref=PMID:9111014 P03366 UniProtKB Mutagenesis 856 856 . . . Note=96%25 loss of polymerase activity. 45%25 loss of RNase H activity. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 861 861 . . . Note=Complete loss of polymerase activity. 25%25 loss of RNase H activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 863 863 . . . Note=17%25 loss of polymerase activity. 30%25 loss of RNase H activity. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 865 865 . . . Note=Complete loss of polymerase activity. 87%25 loss of RNase H activity. W->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 878 878 . . . Note=21%25 loss of polymerase activity. 16%25 loss of RNase H activity. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 898 898 . . . Note=68%25 loss of polymerase activity. 10%25 loss of RNase H activity. A->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 902 902 . . . Note=59%25 loss of polymerase activity. 8%25 loss of RNase H activity. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 909 909 . . . Note=31%25 loss of polymerase activity. No loss of RNase H activity. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 997 997 . . . Note=No effect on RT p66/p51 heterodimerization. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559908;Dbxref=PMID:12559908 P03366 UniProtKB Mutagenesis 1000 1000 . . . Note=Almost complete loss of RT p66/p51 heterodimerization. Complete loss of polymerase activity. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12559908,ECO:0000269|PubMed:15852304;Dbxref=PMID:12559908,PMID:15852304 P03366 UniProtKB Mutagenesis 1000 1000 . . . Note=No effect on RT p66/p51 heterodimerization. W->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12559908,ECO:0000269|PubMed:15852304;Dbxref=PMID:12559908,PMID:15852304 P03366 UniProtKB Mutagenesis 1000 1000 . . . Note=Almost complete loss of RT p66/p51 heterodimerization. Complete loss of polymerase activity. W->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12559908,ECO:0000269|PubMed:15852304;Dbxref=PMID:12559908,PMID:15852304 P03366 UniProtKB Mutagenesis 1001 1001 . . . Note=No effect on RT p66/p51 heterodimerization. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559908;Dbxref=PMID:12559908 P03366 UniProtKB Mutagenesis 1004 1004 . . . Note=No effect on RT p66/p51 heterodimerization. Y->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559908;Dbxref=PMID:12559908 P03366 UniProtKB Mutagenesis 1005 1005 . . . Note=Decreased RT p66/p51 heterodimerization. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559908;Dbxref=PMID:12559908 P03366 UniProtKB Mutagenesis 1009 1009 . . . Note=No effect on RT p66/p51 heterodimerization. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559908;Dbxref=PMID:12559908 P03366 UniProtKB Mutagenesis 1013 1013 . . . Note=Almost complete loss of RT p66/p51 heterodimerization. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12559908;Dbxref=PMID:12559908 P03366 UniProtKB Mutagenesis 1036 1036 . . . Note=Replication slightly delayed. A->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16140771;Dbxref=PMID:16140771 P03366 UniProtKB Mutagenesis 1037 1037 . . . Note=Virions contain primarily p51 RT. E->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16140771;Dbxref=PMID:16140771 P03366 UniProtKB Mutagenesis 1038 1038 . . . Note=Almost complete loss of virion production%3B when associated with G-1041. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16140771;Dbxref=PMID:16140771 P03366 UniProtKB Mutagenesis 1039 1039 . . . Note=Virions contain primarily p51 RT. F->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16140771,ECO:0000269|PubMed:2044756;Dbxref=PMID:16140771,PMID:2044756 P03366 UniProtKB Mutagenesis 1039 1039 . . . Note=Loss of cleavage between p51 RT and p15. F->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16140771,ECO:0000269|PubMed:2044756;Dbxref=PMID:16140771,PMID:2044756 P03366 UniProtKB Mutagenesis 1039 1039 . . . Note=No effect on cleavage between p51 RT and p15. F->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16140771,ECO:0000269|PubMed:2044756;Dbxref=PMID:16140771,PMID:2044756 P03366 UniProtKB Mutagenesis 1039 1039 . . . Note=Slight delays in replication. Virions contain primarily p51 RT. F->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16140771,ECO:0000269|PubMed:2044756;Dbxref=PMID:16140771,PMID:2044756 P03366 UniProtKB Mutagenesis 1039 1039 . . . Note=Slight delays in replication. Virions contain primarily p51 RT. F->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16140771,ECO:0000269|PubMed:2044756;Dbxref=PMID:16140771,PMID:2044756 P03366 UniProtKB Mutagenesis 1040 1040 . . . Note=Virions contain primarily p51 RT%3B when associated with A-1039. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16140771;Dbxref=PMID:16140771 P03366 UniProtKB Mutagenesis 1040 1040 . . . Note=Almost complete loss of virion production%3B when associated with K-1041. Y->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16140771;Dbxref=PMID:16140771 P03366 UniProtKB Mutagenesis 1040 1040 . . . Note=Virions contain primarily p51 RT%3B when associated with W-1039. Y->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16140771;Dbxref=PMID:16140771 P03366 UniProtKB Mutagenesis 1041 1041 . . . Note=Almost complete loss of virion production%3B when associated with S-1038. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16140771;Dbxref=PMID:16140771 P03366 UniProtKB Mutagenesis 1041 1041 . . . Note=Almost complete loss of virion production%3B when associated with I-1038. V->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16140771;Dbxref=PMID:16140771 P03366 UniProtKB Mutagenesis 1041 1041 . . . Note=Slight delays in replication. V->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16140771;Dbxref=PMID:16140771 P03366 UniProtKB Mutagenesis 1077 1077 . . . Note=No loss of polymerase activity. complete loss of RNase H activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9533880;Dbxref=PMID:9533880 P03366 UniProtKB Mutagenesis 1100 1100 . . . Note=Complete loss of RNAase H activity. Y->A%2CG%2CH%2CL%2CS%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11684697;Dbxref=PMID:11684697 P03366 UniProtKB Mutagenesis 1100 1100 . . . Note=Almost complete loss of RNAase H activity. Y->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11684697;Dbxref=PMID:11684697 P03366 UniProtKB Mutagenesis 1100 1100 . . . Note=Almost no effect on RNAase H activity and replication. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11684697;Dbxref=PMID:11684697 P03366 UniProtKB Mutagenesis 1100 1100 . . . Note=Almost no effect on RNAase H activity. Unable to replicate. Completely resistant to inhibition by BBNH. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11684697;Dbxref=PMID:11684697 P03366 UniProtKB Mutagenesis 1100 1100 . . . Note=Almost no effect on RNAase H activity and replication. 6-fold resistance to inhibition by BBNH. Y->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11684697;Dbxref=PMID:11684697 P03366 UniProtKB Mutagenesis 1138 1138 . . . Note=Severely reduces exonuclease activity of RNase H. Probably also reduces substrate binding affinity. Modifies cleavage preferences of RNase H. No effect on the endonuclease activity. H->D%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1714505;Dbxref=PMID:1714505 P03366 UniProtKB Mutagenesis 1138 1138 . . . Note=Severely reduced exonuclease activity of RNase H%2C but no effect on endonucleonuclease activity. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1714505;Dbxref=PMID:1714505 P03366 UniProtKB Mutagenesis 1138 1138 . . . Note=Severely reduced exonuclease activity of RNase H%2C but no effect on endonucleonuclease activity. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1714505;Dbxref=PMID:1714505 P03366 UniProtKB Mutagenesis 1159 1159 . . . Note=No effect on cleavage between reverse transcriptase/ribonuclease H and integrase. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2044756;Dbxref=PMID:2044756 P03366 UniProtKB Mutagenesis 1159 1159 . . . Note=Loss of cleavage between reverse transcriptase/ribonuclease H and integrase. L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2044756;Dbxref=PMID:2044756 P03366 UniProtKB Beta strand 134 136 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Beta strand 138 140 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Beta strand 142 144 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Helix 149 162 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Helix 168 175 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Turn 176 178 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Helix 181 189 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Helix 195 215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Helix 233 236 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Helix 243 250 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Beta strand 252 254 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Helix 258 277 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Helix 282 284 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Beta strand 289 291 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNL P03366 UniProtKB Helix 293 307 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Helix 320 324 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Helix 328 335 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Helix 343 349 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SNN P03366 UniProtKB Turn 393 395 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2EXF P03366 UniProtKB Beta strand 398 400 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2EXF P03366 UniProtKB Turn 402 404 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2EXF P03366 UniProtKB Beta strand 414 416 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2EXF P03366 UniProtKB Beta strand 419 421 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2EXF P03366 UniProtKB Turn 423 425 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2EXF P03366 UniProtKB Beta strand 426 429 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L4L P03366 UniProtKB Beta strand 502 504 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MER P03366 UniProtKB Beta strand 505 507 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3NU3 P03366 UniProtKB Beta strand 510 515 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3NU3 P03366 UniProtKB Beta strand 518 524 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3NU3 P03366 UniProtKB Beta strand 529 533 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3NU3 P03366 UniProtKB Beta strand 542 549 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3NU3 P03366 UniProtKB Beta strand 552 566 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3NU3 P03366 UniProtKB Beta strand 569 578 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3NU3 P03366 UniProtKB Beta strand 581 585 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5JG1 P03366 UniProtKB Helix 587 590 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3NU3 P03366 UniProtKB Turn 591 594 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3NU3 P03366 UniProtKB Beta strand 596 598 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3NU3 P03366 UniProtKB Beta strand 602 604 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9G P03366 UniProtKB Beta strand 611 614 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7KRF P03366 UniProtKB Helix 627 642 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 645 648 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 651 653 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9E P03366 UniProtKB Beta strand 659 663 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 665 668 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 670 674 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 677 682 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 684 687 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4PQU P03366 UniProtKB Helix 689 691 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4ICL P03366 UniProtKB Helix 696 698 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 699 701 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 703 709 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 710 712 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3ITH P03366 UniProtKB Helix 713 716 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 721 727 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 729 731 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 734 736 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 737 739 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VQV P03366 UniProtKB Beta strand 741 747 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 752 754 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IG1 P03366 UniProtKB Helix 755 773 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 774 776 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5TXL P03366 UniProtKB Beta strand 777 782 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 785 790 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 794 808 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 809 811 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 817 819 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5D3G P03366 UniProtKB Beta strand 820 822 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1R0A P03366 UniProtKB Beta strand 824 828 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 831 833 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 835 837 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 838 841 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 849 852 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2ZD1 P03366 UniProtKB Helix 853 866 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Turn 867 869 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 870 872 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6AOC P03366 UniProtKB Helix 876 879 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 880 882 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Turn 883 885 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O4G P03366 UniProtKB Beta strand 888 891 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IAJ P03366 UniProtKB Helix 896 908 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 909 911 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DUH P03366 UniProtKB Beta strand 913 915 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6AOC P03366 UniProtKB Beta strand 920 922 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2BE2 P03366 UniProtKB Beta strand 925 932 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 935 943 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 946 954 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 957 961 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 963 982 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 987 992 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 994 1003 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 1004 1006 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6AOC P03366 UniProtKB Beta strand 1012 1015 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 1017 1019 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3HVT P03366 UniProtKB Helix 1020 1022 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IAJ P03366 UniProtKB Helix 1023 1026 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 1029 1031 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1HQU P03366 UniProtKB Beta strand 1036 1045 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Turn 1047 1049 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 1052 1058 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 1059 1061 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1HQE P03366 UniProtKB Beta strand 1063 1070 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 1073 1087 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 1090 1096 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 1099 1105 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 1110 1114 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Helix 1115 1126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 1128 1134 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Beta strand 1137 1139 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2ZD1 P03366 UniProtKB Beta strand 1140 1142 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SUQ P03366 UniProtKB Helix 1144 1152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4G1Q P03366 UniProtKB Turn 1153 1155 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4QAG P03366 UniProtKB Beta strand 1219 1227 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Beta strand 1230 1237 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Turn 1238 1240 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Beta strand 1243 1250 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Helix 1253 1266 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Beta strand 1271 1273 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Helix 1277 1281 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Helix 1283 1292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Beta strand 1295 1297 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Helix 1305 1324 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Helix 1325 1327 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Helix 1331 1344 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Helix 1355 1367 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3AVI P03366 UniProtKB Beta strand 1380 1386 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QMC P03366 UniProtKB Beta strand 1395 1403 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QMC P03366 UniProtKB Beta strand 1405 1420 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QMC P03366 UniProtKB Helix 1421 1423 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QMC P03366 UniProtKB Beta strand 1424 1428 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QMC