Reviewed, UniProtKB/Swiss-Prot P03360 (POL_AVIRE)

Names and origin

Protein names

Recommended name:
    Pol polyprotein
Cleaved into the following 2 chains:
    1- Recommended name:
            Reverse transcriptase/ribonuclease H
                Short name=RT
              EC=2.7.7.49
              EC=2.7.7.7
              EC=3.1.26.4
    2- Recommended name:
            Integrase
                Short name=IN

Gene names

Name:

pol

Organism

Avian reticuloendotheliosis virus

Taxonomic identifier

11636 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus

Virus host

Galliformes [TaxID: 8976]

Protein attributes

Sequence length	473 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Endonucleolytic cleavage to 5'-phosphomonoester.
Post-translational modification	Specific enzymatic cleavages in vivo yield mature proteins.
Miscellaneous	Strain A is a helper virus of the strain T.
Sequence similarities	Belongs to the retroviral Pol polyprotein family. Contains 1 integrase catalytic domain. Contains 1 RNase H domain.

Ontologies

Keywords
Biological process	DNA integration DNA recombination
Molecular function	Endonuclease Hydrolase Nuclease Nucleotidyltransferase RNA-directed DNA polymerase Transferase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological process	DNA integration Inferred from electronic annotation. Source: InterPro DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW transposition Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: EC RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW ribonuclease H activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 473	›473	Pol polyprotein		PRO_0000125480
Regions
	Domain	‹1 – 62	›62	RNase H
	Domain	184 – 360	177	Integrase catalytic
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P03360-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 89F62FA489EF51DD	FASTA	473	52,212
	10 20 30 40 50 60 KGELLTAGEK AIKNAPEILA LLTAVWLPKR VAVMHCKGHQ KDDAPTSTGN RRADEVAREV 70 80 90 100 110 120 AIRPLSTQAT ISDAPDMPDT ETPQYSHVEE ALGHRLRGTK DSAGWWHLPD GRLLLPRAVG 130 140 150 160 170 180 RKVLEQTHRA THLGESKLTE LVRKHYPICG IYRAARDITT RCVACAQVNP RAAPVEKGLN 190 200 210 220 230 240 SRIRGAAPGE HWEVDFTEMI TAKGGYKYLL VLVDTFSGWV EAYPAKRETS QVVIKHLILD 250 260 270 280 290 300 IIPRFGLPVQ IGSDNGPAFV AKVTQQLCEA LNVSWKLHCA YRPQSSGQVE RMNRTLKKAI 310 320 330 340 350 360 AKLEDRDRRG LGLPPPSGFA PGTVYPGREG LSPFEILYGL KPPVVPRVGC DKLASITNQT 370 380 390 400 410 420 LLKSLQALQA TRSLARAAAR PTAPERSSAR PYPTVPNLVT SFFVKKHDFQ QLGPRWDGPY 430 440 450 460 470 TVVLSTPTAV KAAGKTPWIH YSRLKKAPDN QEEWTVSPTS DPLRVKLTRR AKP

References

[1]	"Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel." Wilhelmsen K.C., Eggleton K., Temin H.M. J. Virol. 52:172-182(1984) [PubMed: 6090694] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X01455 Genomic RNA. Translation: CAA25685.1.
PIR	A03959.
3D structure databases
HSSP	HSSP built from PDB template 1CXQ based on UniProtKB P03354.
ModBase	Search...
Protein family/group databases
MEROPS	A02.008.
Enzyme and pathway databases
BRENDA	2.7.7.49. 96048. 3.1.26.4. 96048.
Family and domain databases
InterPro	IPR001584. Integrase_cat-core. IPR002156. RNase_H. [Graphical view]
Pfam	PF00075. RnaseH. 1 hit. PF00665. rve. 1 hit. [Graphical view]
PROSITE	PS50994. INTEGRASE. 1 hit. PS50879. RNASE_H. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

POL_AVIRE

Accession

Primary (citable) accession number: P03360

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)