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P03333

- GAG_MLVAB

UniProt

P03333 - GAG_MLVAB

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Protein

Gag polyprotein

Gene
gag
Organism
Abelson murine leukemia virus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Matrix protein p15 targets Gag and gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex By similarity.
Capsid protein p30 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. viral budding via host ESCRT complex Source: UniProtKB-KW
  2. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexes, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:gag
OrganismiAbelson murine leukemia virus
Taxonomic identifieri11788 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Subcellular locationi

Chain Matrix protein p15 : Virion Reviewed prediction
Chain Capsid protein p30 : Virion Reviewed prediction

GO - Cellular componenti

  1. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed; by host By similarity
Chaini2 – 131130Matrix protein p15PRO_0000040873Add
BLAST
Chaini132 – 21584RNA-binding phosphoprotein p12PRO_0000040874Add
BLAST
Chaini216 – 23520Capsid protein p30PRO_0000040875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine; by host By similarity

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins.

Keywords - PTMi

Lipoprotein, Myristate

Structurei

3D structure databases

ProteinModelPortaliP03333.
SMRiP03333. Positions 2-98.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi162 – 1654PPPY motif Reviewed prediction
Motifi162 – 1654PPXY motif Reviewed prediction

Domaini

Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Gag-p12 contains one L domain: a PPXY motif which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase Reviewed prediction.

Family and domain databases

Gene3Di1.10.150.180. 1 hit.
InterProiIPR000840. G_retro_matrix_N.
IPR002079. Gag_p12.
IPR010999. Retrovr_matrix_N.
[Graphical view]
PfamiPF01140. Gag_MA. 1 hit.
PF01141. Gag_p12. 1 hit.
[Graphical view]
SUPFAMiSSF47836. SSF47836. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03333-1 [UniParc]FASTAAdd to Basket

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MGQTVTTPLS LTLGHWKDVE RIAHNQSVDV KKRRWVTFCS AEWPTFNVGW    50
PRDGTFNRDL ITQVKIKVFS PGPHGHPDQV PYIVTWEALA FDPPPWVKPF 100
VHPKPPPPLP PSAPSLPLEP PLSTPPRSSL YPALTPSLGA KPKPQVLSDS 150
GGPLIDLLTE DPPPYRDPRP PPSDRDGNGG EATPAGEAPD PSPMASRLRG 200
RREPPVADST TSQAFPLRTG GNGQLQYWPF SSSDL 235
Length:235
Mass (Da):25,641
Last modified:January 23, 2007 - v3
Checksum:i4D83F71D7E056C7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01541 Genomic DNA. Translation: CAA24781.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01541 Genomic DNA. Translation: CAA24781.1 .

3D structure databases

ProteinModelPortali P03333.
SMRi P03333. Positions 2-98.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.150.180. 1 hit.
InterProi IPR000840. G_retro_matrix_N.
IPR002079. Gag_p12.
IPR010999. Retrovr_matrix_N.
[Graphical view ]
Pfami PF01140. Gag_MA. 1 hit.
PF01141. Gag_p12. 1 hit.
[Graphical view ]
SUPFAMi SSF47836. SSF47836. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity."
    Reddy E.P., Smith M.J., Srinivasan A.
    Proc. Natl. Acad. Sci. U.S.A. 80:3623-3627(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGAG_MLVAB
AccessioniPrimary (citable) accession number: P03333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Abl polyprotein.

External Data

Dasty 3

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