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P03265

- DNB2_ADE05

UniProt

P03265 - DNB2_ADE05

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Protein
Early E2A DNA-binding protein
Gene
DBP
Organism
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds cooperatively single-stranded DNA in a sequence-independent manner. Involved in DNA-replication, regulation of mRNA formation, and host-range specificity. Zinc is required for DNA binding.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri273 – 28614 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA replication Source: InterPro
  2. transcription, DNA-templated Source: InterPro
  3. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early E2A DNA-binding protein
Gene namesi
Name:DBP
OrganismiHuman adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Taxonomic identifieri28285 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000004992: Genome

Subcellular locationi

Host nucleus
Note: Accumulates in infected cells.

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
  2. viral capsid Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Early E2A DNA-binding protein
PRO_0000221679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei195 – 1951Phosphotyrosine Inferred

Keywords - PTMi

Phosphoprotein

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with human SRCAP By similarity.

Protein-protein interaction databases

IntActiP03265. 5 interactions.
MINTiMINT-216016.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi180 – 19415
Helixi199 – 2046
Helixi213 – 22614
Helixi237 – 25620
Beta strandi268 – 2725
Beta strandi275 – 2784
Beta strandi287 – 2893
Beta strandi291 – 2977
Beta strandi331 – 3388
Helixi340 – 3423
Beta strandi343 – 3464
Beta strandi358 – 3603
Helixi362 – 37918
Beta strandi389 – 3946
Helixi397 – 3993
Beta strandi401 – 4033
Beta strandi415 – 4195
Turni421 – 4244
Helixi428 – 4303
Helixi434 – 4418
Beta strandi444 – 4496
Beta strandi470 – 4723
Helixi473 – 48816
Beta strandi491 – 4933
Helixi506 – 5083
Beta strandi524 – 5263

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ADUX-ray3.00A/B174-529[»]
1ADVX-ray3.20A/B174-529[»]
1ANVX-ray2.70A174-529[»]
2WAZX-ray2.30X174-529[»]
2WB0X-ray1.95X174-529[»]
DisProtiDP00003.
ProteinModelPortaliP03265.
SMRiP03265. Positions 179-529.

Miscellaneous databases

EvolutionaryTraceiP03265.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Family and domain databases

Gene3Di1.10.269.10. 1 hit.
3.90.148.10. 2 hits.
InterProiIPR005376. Adenovirus_DNA-bd_C.
IPR003176. Adenovirus_DNA-bd_N.
[Graphical view]
PfamiPF02236. Viral_DNA_bi. 1 hit.
PF03728. Viral_DNA_Zn_bi. 2 hits.
[Graphical view]
SUPFAMiSSF47724. SSF47724. 1 hit.
SSF57917. SSF57917. 2 hits.

Sequencei

Sequence statusi: Complete.

P03265-1 [UniParc]FASTAAdd to Basket

« Hide

MASREEEQRE TTPERGRGAA RRPPTMEDVS SPSPSPPPPR APPKKRMRRR    50
IESEDEEDSS QDALVPRTPS PRPSTSAADL AIAPKKKKKR PSPKPERPPS 100
PEVIVDSEEE REDVALQMVG FSNPPVLIKH GKGGKRTVRR LNEDDPVARG 150
MRTQEEEEEP SEAESEITVM NPLSVPIVSA WEKGMEAARA LMDKYHVDND 200
LKANFKLLPD QVEALAAVCK TWLNEEHRGL QLTFTSKKTF VTMMGRFLQA 250
YLQSFAEVTY KHHEPTGCAL WLHRCAEIEG ELKCLHGSIM INKEHVIEMD 300
VTSENGQRAL KEQSSKAKIV KNRWGRNVVQ ISNTDARCCV HDAACPANQF 350
SGKSCGMFFS EGAKAQVAFK QIKAFMQALY PNAQTGHGHL LMPLRCECNS 400
KPGHAPFLGR QLPKLTPFAL SNAEDLDADL ISDKSVLASV HHPALIVFQC 450
CNPVYRNSRA QGGGPNCDFK ISAPDLLNAL VMVRSLWSEN FTELPRMVVP 500
EFKWSTKHQY RNVSLPVAHS DARQNPFDF 529
Length:529
Mass (Da):59,139
Last modified:July 21, 1986 - v1
Checksum:iAC1582B80F370E23
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73260 Genomic DNA. No translation available.
X02997 Genomic DNA. Translation: CAA26755.1. Sequence problems.
PIRiA03833. W7AD25.
RefSeqiAP_000213.1. AC_000008.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73260 Genomic DNA. No translation available.
X02997 Genomic DNA. Translation: CAA26755.1 . Sequence problems.
PIRi A03833. W7AD25.
RefSeqi AP_000213.1. AC_000008.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ADU X-ray 3.00 A/B 174-529 [» ]
1ADV X-ray 3.20 A/B 174-529 [» ]
1ANV X-ray 2.70 A 174-529 [» ]
2WAZ X-ray 2.30 X 174-529 [» ]
2WB0 X-ray 1.95 X 174-529 [» ]
DisProti DP00003.
ProteinModelPortali P03265.
SMRi P03265. Positions 179-529.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P03265. 5 interactions.
MINTi MINT-216016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P03265.

Family and domain databases

Gene3Di 1.10.269.10. 1 hit.
3.90.148.10. 2 hits.
InterProi IPR005376. Adenovirus_DNA-bd_C.
IPR003176. Adenovirus_DNA-bd_N.
[Graphical view ]
Pfami PF02236. Viral_DNA_bi. 1 hit.
PF03728. Viral_DNA_Zn_bi. 2 hits.
[Graphical view ]
SUPFAMi SSF47724. SSF47724. 1 hit.
SSF57917. SSF57917. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and organization of the gene coding for the DNA binding protein of adenovirus type 5."
    Kruijer W., van Schaik F.M.A., Sussenbach J.S.
    Nucleic Acids Res. 9:4439-4457(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2."
    Chroboczek J., Bieber F., Jacrot B.
    Virology 186:280-285(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Crystal structure of the adenovirus DNA binding protein reveals a hook-on model for cooperative DNA binding."
    Tucker P.A., Tsernoglou D., Tucker A.D., Coenjaerts F.E.J., Leenders H., van der Vliet P.C.
    EMBO J. 13:2994-3002(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 176-529.

Entry informationi

Entry nameiDNB2_ADE05
AccessioniPrimary (citable) accession number: P03265
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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