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Reviewed, UniProtKB/Swiss-Prot P03264 (DNB2_ADE02)

Last modified January 19, 2010. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesRecommended name:
    Early E2A DNA-binding protein
Gene names
Name: DBP
OrganismHuman adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Taxonomic identifier10515 [NCBI]
Taxonomic lineageViruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

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Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds cooperatively single-stranded DNA in a sequence-independent manner. Involved in DNA-replication, regulation of mRNA formation, and host-range specificity. Zinc is required for DNA binding.

Subunit structure

Interacts with human SRCAP. Ref.4

Subcellular location

Host nucleus. Note: Accumulates in infected cells.

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Ontologies

Keywords
   Biological processHost-virus interaction
   Cellular componentHost nucleus
   Developmental stageEarly protein
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological processDNA replication

Inferred from electronic annotation. Source: InterPro

interspecies interaction between organisms

Inferred from electronic annotation. Source: UniProtKB-KW

transcription

Inferred from electronic annotation. Source: InterPro

   Cellular componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Early E2A DNA-binding protein
PRO_0000221677

Regions

Zinc finger273 – 28614 Potential

Amino acid modifications

Modified residue1951Phosphotyrosine Probable

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Sequences

Sequence LengthMass (Da)Tools
P03264-1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 114F8F02A77B28F1

FASTA52959,086
        10         20         30         40         50         60 
MASREEEQRE TTPERGRGAA RRPPTMEDVS SPSPSPPPPR APPKKRLRRR LESEDEEDSS 

        70         80         90        100        110        120 
QDALVPRTPS PRPSTSTADL AIASKKKKKR PSPKPERPPS PEVIVDSEEE REDVALQMVG 

       130        140        150        160        170        180 
FSNPPVLIKH GKGGKRTVRR LNEDDPVARG MRTQEEKEES SEAESESTVI NPLSLPIVSA 

       190        200        210        220        230        240 
WEKGMEAARA LMDKYHVDND LKANFKLLPD QVEALAAVCK TWLNEEHRGL QLTFTSNKTF 

       250        260        270        280        290        300 
VTMMGRFLQA YLQSFAEVTY KHHEPTGCAL WLHRCAEIEG ELKCLHGSIM INKEHVIEMD 

       310        320        330        340        350        360 
VTSENGQRAL KEQSSKAKIV KNRWGRNVVQ ISNTDARCCV HDAACPANQF SGKSCGMFFS 

       370        380        390        400        410        420 
EGAKAQVAFK QIKAFMQALY PNAQTGHGHL LMPLRCECNS KPGHAPFLGR QLPKLTPFAL 

       430        440        450        460        470        480 
SNAEDLDADL ISDKSVLASV HHPALIVFQC CNPVYRNSRA QGGGPNCDFK ISAPDLLNAL 

       490        500        510        520 
VMVRSLWSEN FTELPRMVVP EFKWSTKHQY RNVSLPVAHS DARQNPFDF

« Hide

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References

[1]"Nucleotide sequence of the gene encoding adenovirus type 2 DNA binding protein."
Kruijer W., van Schaik F.M.A., Sussenbach J.S.
Nucleic Acids Res. 10:4493-4500(1982) [PubMed: 6985485] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The sequence of the 3' non-coding region of the hexon mRNA discloses a novel adenovirus gene."
Akusjaervi G., Zabielski J., Perricaudet M., Pettersson U.
Nucleic Acids Res. 9:1-17(1981) [PubMed: 6259616] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 438-529.
[3]"Phosphorylation of adenovirus DNA-binding protein."
Russell W.C., Webster A., Leith I.R., Kemp G.D.
J. Gen. Virol. 70:3249-3259(1989) [PubMed: 2607338] [Abstract]
Cited for: PHOSPHORYLATION.
[4]"Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription."
Xu X., Chackalaparampil I., Monroy M.A., Cannella M.T., Pesek E., Chrivia J., Yaciuk P.
J. Virol. 75:10033-10040(2001) [PubMed: 11581372] [Abstract]
Cited for: INTERACTION WITH SRCAP.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J01917 Genomic DNA. Translation: AAA92217.1.
PIRW7AD22. B03833.
RefSeqAP_000177.1.
NP_040527.1.

3D structure databases

SMRP03264. Positions 179-529.
ModBaseSearch...

Genome annotation databases

GeneID5739977.

Family and domain databases

InterProIPR005376. Early_E2A_DNA/Zn-bd.
IPR003176. Vir_DNA_bd.
[Graphical view]
Gene3DG3DSA:3.90.148.10. E2A_DNA_Zn_bd. 1 hit.
PfamPF02236. Viral_DNA_bi. 1 hit.
PF03728. Viral_DNA_Zn_bi. 2 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDNB2_ADE02
AccessionPrimary (citable) accession number: P03264
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 19, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information