Reviewed,
UniProtKB/Swiss-Prot P03261 (DPOL_ADE02)
Last modified
January 19, 2010.
Version 58.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: DNA polymerase EC=2.7.7.7 | ||
| Gene names |
| ||
| Organism | Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) | ||
| Taxonomic identifier | 10515 [NCBI] | ||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus | ||
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 1056 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
| Miscellaneous | This DNA polymerase requires a protein as a primer. |
| Sequence similarities | Belongs to the DNA polymerase type-B family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA replication |
| Ligand | DNA-binding |
| Molecular function | DNA-directed DNA polymerase Nucleotidyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | DNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro |
| Molecular function | 3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA bindingInferred from electronic annotation. Source: UniProtKB-KW DNA-directed DNA polymerase activityInferred from electronic annotation. Source: UniProtKB-KW nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 1056 | 1056 | DNA polymerase | PRO_0000046492 | |||
Sequences
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References
| [1] | "Nucleotide sequences from the adenovirus-2 genome." Gingeras T.R., Sciaky D., Gelinas R.E., Bing-Dong J., Yen C.E., Kelly M.M., Bullock P.A., Parsons B.L., O'Neill K.E., Roberts R.J. J. Biol. Chem. 257:13475-13491(1982) [PubMed: 7142161] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "DNA sequence analysis of the region encoding the terminal protein and the hypothetical N-gene product of adenovirus type 2." Alestroem P., Akusjaervi G., Pettersson M., Pettersson U. J. Biol. Chem. 257:13492-13498(1982) [PubMed: 7142162] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | J01917 Genomic DNA. Translation: AAA92206.1. |
| PIR | WMAD12. A92351. |
3D structure databases | |
| SMR | P03261. Positions 271-943. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.7.7.7. 291827. |
Family and domain databases | |
| InterPro | IPR006172. DNA-dir_DNA_pol_B. IPR014382. DNA-dir_DNA_pol_B_adenovir. IPR006134. DNA-dir_DNA_pol_B_cons-reg. IPR017966. DNA-dir_DNA_pol_B_cons_reg2. IPR017964. DNA-dir_DNA_pol_B_CS. IPR004868. DNA-dir_DNA_pol_B_mt/vir. IPR012337. PolynucTfrase_RNaseH_fold. [Graphical view] |
| Pfam | PF00136. DNA_pol_B. 1 hit. PF03175. DNA_pol_B_2. 1 hit. [Graphical view] |
| PIRSF | PIRSF000788. DPol_ADV. 1 hit. |
| PRINTS | PR00106. DNAPOLB. |
| SMART | SM00486. POLBc. 1 hit. [Graphical view] |
| PROSITE | PS00116. DNA_POLYMERASE_B. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DPOL_ADE02 | ||||||||
| Accession | Primary (citable) accession number: P03261 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||
