Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E1B protein, small T-antigen

Gene

E1B

Organism
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative adenovirus Bcl-2 homolog that inhibits apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis. Without E1B 19K function, virus production is compromised because of premature death of host cell. Interacts with Bax protein in cell lysates (By similarity).By similarity

GO - Molecular functioni

  • lamin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis, Host-virus interaction, Inhibition of host apoptosis by viral BCL2-like protein, Modulation of host cell apoptosis by virus

Names & Taxonomyi

Protein namesi
Recommended name:
E1B protein, small T-antigen
Alternative name(s):
E1B 19 kDa protein
Short name:
E1B-19K
E1B-175R
Gene namesi
Name:E1B
OrganismiHuman adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Taxonomic identifieri10515 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008167 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • host cell endoplasmic reticulum Source: UniProtKB
  • host cell nuclear envelope Source: UniProtKB
  • host cell nuclear lamina Source: UniProtKB-SubCell
  • host cell plasma membrane Source: UniProtKB-SubCell
  • membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Host cell membrane, Host membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002217101 – 175E1B protein, small T-antigenAdd BLAST175

Proteomic databases

PRIDEiP03247

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BNIP3LO602387EBI-849856,EBI-849893From Homo sapiens.

GO - Molecular functioni

  • lamin binding Source: UniProtKB

Protein-protein interaction databases

IntActiP03247, 5 interactors
MINTiP03247

Structurei

3D structure databases

SMRiP03247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 94Poly-Ala6
Compositional biasi133 – 136Poly-Leu4
Compositional biasi155 – 159Poly-Arg5

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG09000076

Family and domain databases

InterProiView protein in InterPro
IPR002924 Adenovir_t-Ag_E1B_19kDa
IPR002475 Bcl2-like
PfamiView protein in Pfam
PF01691 Adeno_E1B_19K, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: At least five different polypeptides are generated by alternative splicing of a common mRNA precursor.
Isoform E1B-175R (identifier: P03247-1) [UniParc]FASTAAdd to basket
Also known as: E1B-19K

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAWECLEDF SAVRNLLEQS SNSTSWFWRF LWGSSQAKLV CRIKEDYKWE
60 70 80 90 100
FEELLKSCGE LFDSLNLGHQ ALFQEKVIKT LDFSTPGRAA AAVAFLSFIK
110 120 130 140 150
DKWSEETHLS GGYLLDFLAM HLWRAVVRHK NRLLLLSSVR PAIIPTEEQQ
160 170
QEEARRRRRQ EQSPWNPRAG LDPRE
Length:175
Mass (Da):20,514
Last modified:March 1, 1992 - v2
Checksum:i2FF4279D0CC700B6
GO
Isoform E1B-495R (identifier: P03244-1) [UniParc]FASTAAdd to basket
Also known as: E1B-55K
The sequence of this isoform can be found in the external entry P03244.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:495
Mass (Da):54,909
GO
Isoform E1B-155R (identifier: P03244-2) [UniParc]FASTAAdd to basket
Also known as: E1B-18K
The sequence of this isoform can be found in the external entry P03244.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:
Mass (Da):
GO
Isoform E1B-92R (identifier: P03244-3) [UniParc]FASTAAdd to basket
Also known as: E1B-16K
The sequence of this isoform can be found in the external entry P03244.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:
Mass (Da):
GO
Isoform E1B-82R (identifier: P03244-4) [UniParc]FASTAAdd to basket
Also known as: E1B-15K
The sequence of this isoform can be found in the external entry P03244.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:
Mass (Da):
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01917 Genomic DNA Translation: AAA92200.1
PIRiB03814 Q1AD22
RefSeqiAP_000162.1, AC_000007.1 [P03247-1]
NP_040510.1, NC_001405.1

Genome annotation databases

GeneIDi2652981
KEGGivg:2652981

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiE1BS_ADE02
AccessioniPrimary (citable) accession number: P03247
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health