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Protein

E1B protein, small T-antigen

Gene

E1B

Organism
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative adenovirus Bcl-2 homolog that inhibits apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis. Without E1B 19K function, virus production is compromised because of premature death of host cell. Interacts with Bax protein in cell lysates (By similarity).By similarity

GO - Molecular functioni

  • lamin binding Source: UniProtKB

GO - Biological processi

  • negative regulation of apoptotic process Source: UniProtKB
  • suppression by virus of host apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Inhibition of host apoptosis by viral BCL2-like protein, Modulation of host cell apoptosis by virus

Names & Taxonomyi

Protein namesi
Recommended name:
E1B protein, small T-antigen
Alternative name(s):
E1B 19 kDa protein
Short name:
E1B-19K
E1B-175R
Gene namesi
Name:E1B
OrganismiHuman adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Taxonomic identifieri10515 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008167 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002217101 – 175E1B protein, small T-antigenAdd BLAST175

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BNIP3LO602387EBI-849856,EBI-849893From a different organism.

GO - Molecular functioni

  • lamin binding Source: UniProtKB

Protein-protein interaction databases

IntActiP03247. 5 interactors.
MINTiMINT-1957099.

Structurei

3D structure databases

ProteinModelPortaliP03247.
SMRiP03247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 94Poly-Ala6
Compositional biasi133 – 136Poly-Leu4
Compositional biasi155 – 159Poly-Arg5

Sequence similaritiesi

Family and domain databases

InterProiIPR002924. Adenovir_t-Ag_E1B_19kDa.
IPR002475. Bcl2-like.
[Graphical view]
PfamiPF01691. Adeno_E1B_19K. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: At least five different polypeptides are generated by alternative splicing of a common mRNA precursor.
Isoform E1B-175R (identifier: P03247-1) [UniParc]FASTAAdd to basket
Also known as: E1B-19K

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAWECLEDF SAVRNLLEQS SNSTSWFWRF LWGSSQAKLV CRIKEDYKWE
60 70 80 90 100
FEELLKSCGE LFDSLNLGHQ ALFQEKVIKT LDFSTPGRAA AAVAFLSFIK
110 120 130 140 150
DKWSEETHLS GGYLLDFLAM HLWRAVVRHK NRLLLLSSVR PAIIPTEEQQ
160 170
QEEARRRRRQ EQSPWNPRAG LDPRE
Length:175
Mass (Da):20,514
Last modified:March 1, 1992 - v2
Checksum:i2FF4279D0CC700B6
GO
Isoform E1B-495R (identifier: P03244-1) [UniParc]FASTAAdd to basket
Also known as: E1B-55K
The sequence of this isoform can be found in the external entry P03244.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:495
Mass (Da):54,909
GO
Isoform E1B-155R (identifier: P03244-2) [UniParc]FASTAAdd to basket
Also known as: E1B-18K
The sequence of this isoform can be found in the external entry P03244.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:
Mass (Da):
GO
Isoform E1B-92R (identifier: P03244-3) [UniParc]FASTAAdd to basket
Also known as: E1B-16K
The sequence of this isoform can be found in the external entry P03244.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:
Mass (Da):
GO
Isoform E1B-82R (identifier: P03244-4) [UniParc]FASTAAdd to basket
Also known as: E1B-15K
The sequence of this isoform can be found in the external entry P03244.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:
Mass (Da):
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01917 Genomic DNA. Translation: AAA92200.1.
PIRiB03814. Q1AD22.
RefSeqiAP_000162.1. AC_000007.1. [P03247-1]
NP_040510.1. NC_001405.1.

Genome annotation databases

GeneIDi2652981.
KEGGivg:2652981.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01917 Genomic DNA. Translation: AAA92200.1.
PIRiB03814. Q1AD22.
RefSeqiAP_000162.1. AC_000007.1. [P03247-1]
NP_040510.1. NC_001405.1.

3D structure databases

ProteinModelPortaliP03247.
SMRiP03247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03247. 5 interactors.
MINTiMINT-1957099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2652981.
KEGGivg:2652981.

Family and domain databases

InterProiIPR002924. Adenovir_t-Ag_E1B_19kDa.
IPR002475. Bcl2-like.
[Graphical view]
PfamiPF01691. Adeno_E1B_19K. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE1BS_ADE02
AccessioniPrimary (citable) accession number: P03247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.