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Protein

Capsid vertex component 2

Gene

CVC2

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral genome packaging, Viral penetration into host nucleus, Virus entry into host cell, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid vertex component 2UniRule annotation
Gene namesi
Name:CVC2UniRule annotation
ORF Names:BVRF1
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007640 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Capsid vertex component 2PRO_0000116003Add
BLAST

Interactioni

Subunit structurei

Heterodimerizes with CVC1. Interacts with major capsid protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices. Interacts with the large tegument protein/LTP.UniRule annotation

Protein-protein interaction databases

MINTiMINT-6768979.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5454Interaction with major capsid protein/MCPUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the herpesviridae CVC2 protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04025. HSV_CVC2.
InterProiIPR002493. Herpes_UL25.
[Graphical view]
PfamiPF01499. Herpes_UL25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSGHVLID PARLPRDTGP ELMWAPSLRN SLRVSPEALE LAEREAERAR
60 70 80 90 100
SERWDRCAQV LKNRLLRVEL DGIMRDHLAR AEEIRQDLDA VVAFSDGLES
110 120 130 140 150
MQVRSPSTGG RSAPAPPSPS PAQPFTRLTG NAQYAVSISP TDPPLMVAGS
160 170 180 190 200
LAQTLLGNLY GNINQWVPSF GPWYRTMSAN AMQRRVFPKQ LRGNLNFTNS
210 220 230 240 250
VSLKLMTEVV AVLEGTTQDF FSDVRHLPDL QAALILSVAY LLLQGGSSHQ
260 270 280 290 300
QRPLPASREE LLELGPESLE KIIADLKAKS PGGNFMILTS GNKEARQSIA
310 320 330 340 350
PLNRQAAYPP GTFADNKIYN LFVGAGLLPT TAALNVPGAA GRDRDLVYRI
360 370 380 390 400
ANQIFGEDVP PFSSHQWNLR VGLAALEALM LVYTLCETAN LAEAATRRLH
410 420 430 440 450
LSSLLPQAMQ RRKPAMASAG MPGAYPVQTL FRHGELFRFI WAHYVRPTVA
460 470 480 490 500
ADPQASISSL FPGLVLLALE LKLMDGQAPS HYAINLTGQK FDTLFEIINQ
510 520 530 540 550
KLLFHDPAAM LAARTQLRLA FEDGVGVALG RPSPMLAARE ILERQFSASD
560 570
DYDRLYFLTL GYLASPVAPS
Length:570
Mass (Da):62,461
Last modified:July 21, 1986 - v1
Checksum:i7D8D7B9E67064BAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24800.1.
AJ507799 Genomic DNA. Translation: CAD53453.1.
PIRiA03797. QQBE2R.
RefSeqiYP_401703.1. NC_007605.1.

Genome annotation databases

GeneIDi3783732.
KEGGivg:3783732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24800.1.
AJ507799 Genomic DNA. Translation: CAD53453.1.
PIRiA03797. QQBE2R.
RefSeqiYP_401703.1. NC_007605.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-6768979.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783732.
KEGGivg:3783732.

Family and domain databases

HAMAPiMF_04025. HSV_CVC2.
InterProiIPR002493. Herpes_UL25.
[Graphical view]
PfamiPF01499. Herpes_UL25. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the 17,166 base-pair EcoRI fragment C of B95-8 Epstein-Barr virus."
    Bankier A.T., Deininger P.L., Farrell P.J., Barrell B.G.
    Mol. Biol. Med. 1:21-45(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCVC2_EBVB9
AccessioniPrimary (citable) accession number: P03233
Secondary accession number(s): Q777B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 6, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.