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Protein

Capsid vertex component 2

Gene

CVC2

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.UniRule annotation

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral genome packaging, Viral penetration into host nucleus, Viral release from host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid vertex component 2UniRule annotation
Gene namesi
Name:CVC2UniRule annotation
ORF Names:BVRF1
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000153037 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160031 – 570Capsid vertex component 2Add BLAST570

Proteomic databases

PRIDEiP03233

Interactioni

Subunit structurei

Heterodimerizes with CVC1. Interacts with major capsid protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices. Interacts with the large tegument protein/LTP.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 54Interaction with major capsid protein/MCPUniRule annotationAdd BLAST54

Sequence similaritiesi

Belongs to the herpesviridae CVC2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900005N

Family and domain databases

HAMAPiMF_04025 HSV_CVC2, 1 hit
InterProiView protein in InterPro
IPR002493 Herpes_UL25
PfamiView protein in Pfam
PF01499 Herpes_UL25, 1 hit

Sequencei

Sequence statusi: Complete.

P03233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSGHVLID PARLPRDTGP ELMWAPSLRN SLRVSPEALE LAEREAERAR
60 70 80 90 100
SERWDRCAQV LKNRLLRVEL DGIMRDHLAR AEEIRQDLDA VVAFSDGLES
110 120 130 140 150
MQVRSPSTGG RSAPAPPSPS PAQPFTRLTG NAQYAVSISP TDPPLMVAGS
160 170 180 190 200
LAQTLLGNLY GNINQWVPSF GPWYRTMSAN AMQRRVFPKQ LRGNLNFTNS
210 220 230 240 250
VSLKLMTEVV AVLEGTTQDF FSDVRHLPDL QAALILSVAY LLLQGGSSHQ
260 270 280 290 300
QRPLPASREE LLELGPESLE KIIADLKAKS PGGNFMILTS GNKEARQSIA
310 320 330 340 350
PLNRQAAYPP GTFADNKIYN LFVGAGLLPT TAALNVPGAA GRDRDLVYRI
360 370 380 390 400
ANQIFGEDVP PFSSHQWNLR VGLAALEALM LVYTLCETAN LAEAATRRLH
410 420 430 440 450
LSSLLPQAMQ RRKPAMASAG MPGAYPVQTL FRHGELFRFI WAHYVRPTVA
460 470 480 490 500
ADPQASISSL FPGLVLLALE LKLMDGQAPS HYAINLTGQK FDTLFEIINQ
510 520 530 540 550
KLLFHDPAAM LAARTQLRLA FEDGVGVALG RPSPMLAARE ILERQFSASD
560 570
DYDRLYFLTL GYLASPVAPS
Length:570
Mass (Da):62,461
Last modified:July 21, 1986 - v1
Checksum:i7D8D7B9E67064BAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA Translation: CAA24800.1
AJ507799 Genomic DNA Translation: CAD53453.1
PIRiA03797 QQBE2R
RefSeqiYP_401703.1, NC_007605.1

Genome annotation databases

GeneIDi3783732
KEGGivg:3783732

Similar proteinsi

Entry informationi

Entry nameiCVC2_EBVB9
AccessioniPrimary (citable) accession number: P03233
Secondary accession number(s): Q777B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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