P03226 (MCP_EBVB9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major capsid protein
Short name=MCP

Gene names

ORF Names:

BcLF1

Organism

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) [Reference proteome]

Taxonomic identifier

10377 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Lymphocryptovirus › Epstein-Barr virus (strain GD1)

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	1381 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Self-assembles to form an icosahedral capsid with a T=16 symmetry and a diameter of 140 nm. The capsid is composed of pentamers and hexamers of BcLF1, which are linked together by heterotrimers called triplex. These triplex are formed by a single molecule of triplex protein BORF1 and two copies of triplex protein BDLF1, which bridge major capsid protein BcLF1 multimers together. Triplexes occupy the local treefold positions between hexons and between hexamers and pentamers. Ref.3
Subunit structure	Homohexamer or homopentamer. Interacts with BVRF1, and triplex proteins BDLF1 and BORF1 By similarity.
Subcellular location	Virion. Host nucleus By similarity Ref.2.
Sequence similarities	Belongs to the herpesviridae major capsid protein family.

Ontologies

Keywords
Cellular component	Host nucleus Virion
Developmental stage	Late protein
Molecular function	Capsid protein T=16 icosahedral capsid protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	T=16 icosahedral viral capsid Inferred from electronic annotation. Source: UniProtKB-KW host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1381	1381	Major capsid protein		PRO_0000115710

Sequences

	Sequence		Length	Mass (Da)
	P03226 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 04DCBC7A506DA11A	FASTA	1,381	153,917
	10 20 30 40 50 60 MASNEGVENR PFPYLTVDAD LLSNLRQSAA EGLFHSFDLL VGKDAREAGI KFEVLLGVYT 70 80 90 100 110 120 NAIQYVRFLE TALAVSCVNT EFKDLSRMTD GKIQFRISVP TIAHGDGRRP SKQRTFIVVK 130 140 150 160 170 180 NCHKHHISTE MELSMLDLEI LHSIPETPVE YAEYVGAVKT VASALQFGVD ALERGLINTV 190 200 210 220 230 240 LSVKLRHAPP MFILQTLADP TFTERGFSKT VKSDLIAMFK RHLLEHSFFL DRAENMGSGF 250 260 270 280 290 300 SQYVRSRLSE MVAAVSGESV LKGVSTYTTA KGGEPVGGVF IVTDNVLRQL LTFLGEEADN 310 320 330 340 350 360 QIMGPSSYAS FVVRGENLVT AVSYGRVMRT FEHFMARIVD SPEKAGSTKS DLPAVAAGVE 370 380 390 400 410 420 DQPRVPISAA VIKLGNHAVA VESLQKMYND TQSPYPLNRR MQYSYYFPVG LFMPNPKYTT 430 440 450 460 470 480 SAAIKMLDNP TQQLPVEAWI VNKNNLLLAF NLQNALKVLC HPRLHTPAHT LNSLNAAPAP 490 500 510 520 530 540 RDRRETYSLQ HRRPNHMNVL VIVDEFYDNK YAAPVTDIAL KCGLPTEDFL HPSNYDLLRL 550 560 570 580 590 600 ELHPLYDIYI GRDAGERARH RAVHRLMVGN LPTPLAPAAF QEARGQQFET ATSLAHVVDQ 610 620 630 640 650 660 AVIETVQDTA YDTAYPAFFY VVEAMIHGFE EKFVMNVPLV SLCINTYWER SGRLAFVNSF 670 680 690 700 710 720 SMIKFICRHL GNNAISKEAY SMYRKIYGEL IALEQALMRL AGSDVVGDES VGQYVCALLD 730 740 750 760 770 780 PNLLPPVAYT DIFTHLLTVS DRAPQIIIGN EVYADTLAAP QFIERVGNMD EMAAQFVALY 790 800 810 820 830 840 GYRVNGDHDH DFRLHLGPYV DEGHADVLEK IFYYVFLPTC TNAHMCGLGV DFQHVAQTLA 850 860 870 880 890 900 YNGPAFSHHF TRDEDILDNL ENGTLRDLLE ISDLRPTVGM IRDLSASFMT CPTFTRAVRV 910 920 930 940 950 960 SVDNDVTQQL APNPADKRTE QTVLVNGLVA FAFSERTRAV TQCLFHAIPF HMFYGDPRVA 970 980 990 1000 1010 1020 ATMHQDVATF VMRNPQQRAV EAFNRPEQLF AEYREWHRSP MGKYAAECLP SLVSISGMTA 1030 1040 1050 1060 1070 1080 MHIKMSPMAY IAQAKLKIHP GVAMTVVRTD EILSENILFS SRASTSMFIG TPNVSRREAR 1090 1100 1110 1120 1130 1140 VDAVTFEVHH EMASIDTGLS YSSTMTPARV AAITTDMGIH TQDFFSVFPA EAFGNQQVND 1150 1160 1170 1180 1190 1200 YIKAKVGAQR NGTLLRDPRT YLAGMTNVNG APGLCHGQQA TCEIIVTPVT ADVAYFQKSN 1210 1220 1230 1240 1250 1260 SPRGRAACVV SCENYNQEVA EGLIYDHSRP DAAYEYRSTV NPWASQLGSL GDIMYNSSYR 1270 1280 1290 1300 1310 1320 QTAVPGLYSP CRAFFNKEEL LRNNRGLYNM VNEYSQRLGG HPATSNTEVQ FVVIAGTDVF 1330 1340 1350 1360 1370 1380 LEQPCSFLQE AFPALSASSR ALIDEFMSVK QTHAPIHYGH YIIEEVAPVR RILKFGNKVV F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and expression of the B95-8 Epstein-Barr virus genome." Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J., Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C., Tuffnell P.S., Barrell B.G. Nature 310:207-211(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Proteins of purified Epstein-Barr virus." Johannsen E., Luftig M., Chase M.R., Weicksel S., Cahir-McFarland E., Illanes D., Sarracino D., Kieff E. Proc. Natl. Acad. Sci. U.S.A. 101:16286-16291(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[3]	"Self-assembly of Epstein-Barr virus capsids." Henson B.W., Perkins E.M., Cothran J.E., Desai P. J. Virol. 83:3877-3890(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V01555 Genomic DNA. Translation: CAA24794.1. AJ507799 Genomic DNA. Translation: CAD53447.1.
PIR	QQBE45. H43044.
RefSeq	YP_401697.1. NC_007605.1.
3D structure databases
ProteinModelPortal	P03226.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6768237.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3783688.
Phylogenomic databases
ProtClustDB	CLSP2509619.
Family and domain databases
InterPro	IPR000912. Herpes_MCP. IPR023233. Herpes_MCP_upper. [Graphical view]
Pfam	PF03122. Herpes_MCP. 1 hit. [Graphical view]
PRINTS	PR00235. HSVCAPSIDMCP.
SUPFAM	SSF103417. Herpes_MCP_upper. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCP_EBVB9

Accession

Primary (citable) accession number: P03226
Secondary accession number(s): Q777C2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program