Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Major capsid protein

Gene

MCP

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
Gene namesi
Name:MCPUniRule annotation
ORF Names:BcLF1
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000153037 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157101 – 1381Major capsid proteinAdd BLAST1381

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.UniRule annotation

Protein-protein interaction databases

MINTiMINT-6768237.

Structurei

3D structure databases

ProteinModelPortaliP03226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900000D.

Family and domain databases

HAMAPiMF_04016. HSV_MCP. 1 hit.
InterProiView protein in InterPro
IPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
PfamiView protein in Pfam
PF03122. Herpes_MCP. 1 hit.
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

P03226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNEGVENR PFPYLTVDAD LLSNLRQSAA EGLFHSFDLL VGKDAREAGI
60 70 80 90 100
KFEVLLGVYT NAIQYVRFLE TALAVSCVNT EFKDLSRMTD GKIQFRISVP
110 120 130 140 150
TIAHGDGRRP SKQRTFIVVK NCHKHHISTE MELSMLDLEI LHSIPETPVE
160 170 180 190 200
YAEYVGAVKT VASALQFGVD ALERGLINTV LSVKLRHAPP MFILQTLADP
210 220 230 240 250
TFTERGFSKT VKSDLIAMFK RHLLEHSFFL DRAENMGSGF SQYVRSRLSE
260 270 280 290 300
MVAAVSGESV LKGVSTYTTA KGGEPVGGVF IVTDNVLRQL LTFLGEEADN
310 320 330 340 350
QIMGPSSYAS FVVRGENLVT AVSYGRVMRT FEHFMARIVD SPEKAGSTKS
360 370 380 390 400
DLPAVAAGVE DQPRVPISAA VIKLGNHAVA VESLQKMYND TQSPYPLNRR
410 420 430 440 450
MQYSYYFPVG LFMPNPKYTT SAAIKMLDNP TQQLPVEAWI VNKNNLLLAF
460 470 480 490 500
NLQNALKVLC HPRLHTPAHT LNSLNAAPAP RDRRETYSLQ HRRPNHMNVL
510 520 530 540 550
VIVDEFYDNK YAAPVTDIAL KCGLPTEDFL HPSNYDLLRL ELHPLYDIYI
560 570 580 590 600
GRDAGERARH RAVHRLMVGN LPTPLAPAAF QEARGQQFET ATSLAHVVDQ
610 620 630 640 650
AVIETVQDTA YDTAYPAFFY VVEAMIHGFE EKFVMNVPLV SLCINTYWER
660 670 680 690 700
SGRLAFVNSF SMIKFICRHL GNNAISKEAY SMYRKIYGEL IALEQALMRL
710 720 730 740 750
AGSDVVGDES VGQYVCALLD PNLLPPVAYT DIFTHLLTVS DRAPQIIIGN
760 770 780 790 800
EVYADTLAAP QFIERVGNMD EMAAQFVALY GYRVNGDHDH DFRLHLGPYV
810 820 830 840 850
DEGHADVLEK IFYYVFLPTC TNAHMCGLGV DFQHVAQTLA YNGPAFSHHF
860 870 880 890 900
TRDEDILDNL ENGTLRDLLE ISDLRPTVGM IRDLSASFMT CPTFTRAVRV
910 920 930 940 950
SVDNDVTQQL APNPADKRTE QTVLVNGLVA FAFSERTRAV TQCLFHAIPF
960 970 980 990 1000
HMFYGDPRVA ATMHQDVATF VMRNPQQRAV EAFNRPEQLF AEYREWHRSP
1010 1020 1030 1040 1050
MGKYAAECLP SLVSISGMTA MHIKMSPMAY IAQAKLKIHP GVAMTVVRTD
1060 1070 1080 1090 1100
EILSENILFS SRASTSMFIG TPNVSRREAR VDAVTFEVHH EMASIDTGLS
1110 1120 1130 1140 1150
YSSTMTPARV AAITTDMGIH TQDFFSVFPA EAFGNQQVND YIKAKVGAQR
1160 1170 1180 1190 1200
NGTLLRDPRT YLAGMTNVNG APGLCHGQQA TCEIIVTPVT ADVAYFQKSN
1210 1220 1230 1240 1250
SPRGRAACVV SCENYNQEVA EGLIYDHSRP DAAYEYRSTV NPWASQLGSL
1260 1270 1280 1290 1300
GDIMYNSSYR QTAVPGLYSP CRAFFNKEEL LRNNRGLYNM VNEYSQRLGG
1310 1320 1330 1340 1350
HPATSNTEVQ FVVIAGTDVF LEQPCSFLQE AFPALSASSR ALIDEFMSVK
1360 1370 1380
QTHAPIHYGH YIIEEVAPVR RILKFGNKVV F
Length:1,381
Mass (Da):153,917
Last modified:July 21, 1986 - v1
Checksum:i04DCBC7A506DA11A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24794.1.
AJ507799 Genomic DNA. Translation: CAD53447.1.
PIRiH43044. QQBE45.
RefSeqiYP_401697.1. NC_007605.1.

Genome annotation databases

GeneIDi3783688.
KEGGivg:3783688.

Similar proteinsi

Entry informationi

Entry nameiMCP_EBVB9
AccessioniPrimary (citable) accession number: P03226
Secondary accession number(s): Q777C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 15, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families