Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Envelope glycoprotein L

Gene

gL

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. May also be required for virus attachment to epithelial cells (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein L
Alternative name(s):
Glycoprotein 25
Short name:
gp25
Gene namesi
Name:gL
ORF Names:BKRF2
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007640 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 137115Envelope glycoprotein LPRO_0000038273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi53 – 531N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi69 – 691N-linked (GlcNAc...); by hostSequence analysis

Keywords - PTMi

Glycoprotein

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Forms a heterodimer with gH, and a complex with gH and gp42; these complexes are differentially used for invasion of host epithelial cells or B-lymphocytes.By similarity

Protein-protein interaction databases

DIPiDIP-47676N.
MINTiMINT-6768171.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PHFX-ray3.582/4/6/B/D/F/H/J/L/N/P/R/T/V/X/Z24-131[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03212.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

KOiK19452.

Family and domain databases

InterProiIPR020175. Herpes_gL_rhadinovirus.
[Graphical view]
PfamiPF11108. Phage_glycop_gL. 1 hit.
[Graphical view]
ProDomiPD009419. Herpes_gL_rhadinovirus. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVGVFLAI CLVTIFVLPT WGNWAYPCCH VTQLRAQHLL ALENISDIYL
60 70 80 90 100
VSNQTCDGFS LASLNSPKNG SNQLVISRCA NGLNVVSFFI SILKRSSSAL
110 120 130
TGHLRELLTT LETLYGSFSV EDLFGANLNR YAWHRGG
Length:137
Mass (Da):15,080
Last modified:July 21, 1986 - v1
Checksum:iF0C03CDACD1893A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24817.1.
AJ507799 Genomic DNA. Translation: CAD53428.1.
PIRiD43043. QQBE32.
RefSeqiYP_401678.1. NC_007605.1.

Genome annotation databases

GeneIDi3783710.
KEGGivg:3783710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24817.1.
AJ507799 Genomic DNA. Translation: CAD53428.1.
PIRiD43043. QQBE32.
RefSeqiYP_401678.1. NC_007605.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PHFX-ray3.582/4/6/B/D/F/H/J/L/N/P/R/T/V/X/Z24-131[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47676N.
MINTiMINT-6768171.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783710.
KEGGivg:3783710.

Phylogenomic databases

KOiK19452.

Miscellaneous databases

EvolutionaryTraceiP03212.

Family and domain databases

InterProiIPR020175. Herpes_gL_rhadinovirus.
[Graphical view]
PfamiPF11108. Phage_glycop_gL. 1 hit.
[Graphical view]
ProDomiPD009419. Herpes_gL_rhadinovirus. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiGL_EBVB9
AccessioniPrimary (citable) accession number: P03212
Secondary accession number(s): Q777E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: December 9, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.