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Protein

Envelope glycoprotein L

Gene

gL

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL.UniRule annotation1 Publication

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein LUniRule annotation
Short name:
gLUniRule annotation
Gene namesi
Name:gLUniRule annotation
ORF Names:BKRF2
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000153037 Componenti: Genome

Subcellular locationi

  • Virion membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Extracellular side UniRule annotation
  • Host cell membrane UniRule annotationBy similarity2 Publications; Peripheral membrane protein UniRule annotation; Extracellular side UniRule annotation
  • host trans-Golgi network UniRule annotation
  • Note: gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22UniRule annotationAdd BLAST22
ChainiPRO_000003827323 – 137Envelope glycoprotein LUniRule annotationAdd BLAST115

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP03212

Interactioni

Subunit structurei

Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.UniRule annotation1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
gHP032313EBI-15897767,EBI-15815779

Protein-protein interaction databases

DIPiDIP-47676N
IntActiP03212, 1 interactor

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi47 – 50Combined sources4
Turni53 – 58Combined sources6
Beta strandi61 – 65Combined sources5
Beta strandi75 – 81Combined sources7
Helixi82 – 95Combined sources14
Helixi96 – 99Combined sources4
Helixi103 – 117Combined sources15
Beta strandi120 – 122Combined sources3
Beta strandi124 – 126Combined sources3
Turni128 – 131Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PHFX-ray3.582/4/6/B/D/F/H/J/L/N/P/R/T/V/X/Z24-131[»]
5T1DX-ray3.10B24-135[»]
5W0KX-ray3.10B/D24-137[»]
SMRiP03212
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03212

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 128Interaction with gHUniRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein L family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

KOiK19452
OrthoDBiVOG090001F9

Family and domain databases

Gene3Di1.20.120.1580, 1 hit
HAMAPiMF_04034 HSV_GL_alphagamma, 1 hit
InterProiView protein in InterPro
IPR020175 Herpes_gL_rhadinovirus
IPR038313 Herpes_gL_rhadinovirus_sf
IPR034708 HSV_GL_alphagamma
PfamiView protein in Pfam
PF11108 Phage_glycop_gL, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009419 Herpes_gL_rhadinovirus, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVGVFLAI CLVTIFVLPT WGNWAYPCCH VTQLRAQHLL ALENISDIYL
60 70 80 90 100
VSNQTCDGFS LASLNSPKNG SNQLVISRCA NGLNVVSFFI SILKRSSSAL
110 120 130
TGHLRELLTT LETLYGSFSV EDLFGANLNR YAWHRGG
Length:137
Mass (Da):15,080
Last modified:July 21, 1986 - v1
Checksum:iF0C03CDACD1893A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA Translation: CAA24817.1
AJ507799 Genomic DNA Translation: CAD53428.1
PIRiD43043 QQBE32
RefSeqiYP_401678.1, NC_007605.1

Genome annotation databases

GeneIDi3783710
KEGGivg:3783710

Similar proteinsi

Entry informationi

Entry nameiGL_EBVB9
AccessioniPrimary (citable) accession number: P03212
Secondary accession number(s): Q777E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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