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Protein

Envelope glycoprotein L

Gene

gL

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL.UniRule annotation1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein LUniRule annotation
Short name:
gLUniRule annotation
Gene namesi
Name:gLUniRule annotation
ORF Names:BKRF2
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007640 Componenti: Genome

Subcellular locationi

  • Virion membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Extracellular side UniRule annotation
  • Host cell membrane UniRule annotationBy similarity2 Publications; Peripheral membrane protein UniRule annotation; Extracellular side UniRule annotation
  • Host Golgi apparatushost trans-Golgi network UniRule annotation

  • Note: gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22UniRule annotationAdd BLAST22
ChainiPRO_000003827323 – 137Envelope glycoprotein LUniRule annotationAdd BLAST115

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.UniRule annotation1 Publication

Protein-protein interaction databases

DIPiDIP-47676N.
MINTiMINT-6768171.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PHFX-ray3.582/4/6/B/D/F/H/J/L/N/P/R/T/V/X/Z24-131[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03212.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 128Interaction with gHUniRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein L family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

KOiK19452.

Family and domain databases

HAMAPiMF_04034. HSV_GL_alphagamma. 1 hit.
InterProiIPR020175. Herpes_gL_rhadinovirus.
[Graphical view]
PfamiPF11108. Phage_glycop_gL. 1 hit.
[Graphical view]
ProDomiPD009419. Herpes_gL_rhadinovirus. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVGVFLAI CLVTIFVLPT WGNWAYPCCH VTQLRAQHLL ALENISDIYL
60 70 80 90 100
VSNQTCDGFS LASLNSPKNG SNQLVISRCA NGLNVVSFFI SILKRSSSAL
110 120 130
TGHLRELLTT LETLYGSFSV EDLFGANLNR YAWHRGG
Length:137
Mass (Da):15,080
Last modified:July 21, 1986 - v1
Checksum:iF0C03CDACD1893A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24817.1.
AJ507799 Genomic DNA. Translation: CAD53428.1.
PIRiD43043. QQBE32.
RefSeqiYP_401678.1. NC_007605.1.

Genome annotation databases

GeneIDi3783710.
KEGGivg:3783710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24817.1.
AJ507799 Genomic DNA. Translation: CAD53428.1.
PIRiD43043. QQBE32.
RefSeqiYP_401678.1. NC_007605.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PHFX-ray3.582/4/6/B/D/F/H/J/L/N/P/R/T/V/X/Z24-131[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47676N.
MINTiMINT-6768171.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783710.
KEGGivg:3783710.

Phylogenomic databases

KOiK19452.

Miscellaneous databases

EvolutionaryTraceiP03212.

Family and domain databases

HAMAPiMF_04034. HSV_GL_alphagamma. 1 hit.
InterProiIPR020175. Herpes_gL_rhadinovirus.
[Graphical view]
PfamiPF11108. Phage_glycop_gL. 1 hit.
[Graphical view]
ProDomiPD009419. Herpes_gL_rhadinovirus. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiGL_EBVB9
AccessioniPrimary (citable) accession number: P03212
Secondary accession number(s): Q777E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.