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Protein

Replication and transcription activator

Gene

BRLF1

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Immediate-early transcription factor that controls the initiation of viral lytic gene expression and lytic reactivation from latency. Triggers lytic replication, and initiates a cellular senescence program in epithelial cells. Upregulates human DCR3/TNFRSF6B by directly binding to its receptor.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Replication and transcription activator
Short name:
Rta
Alternative name(s):
Immediate-early protein Rta
Gene namesi
ORF Names:BRLF1
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007640 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Replication and transcription activatorPRO_0000116201Add
BLAST

PTM databases

iPTMnetiP03209.

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with human ATF7IP protein, leading to promote and regulate host genes in virus-infected cells.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LF2Q3KSP52EBI-2621080,EBI-2621084From a different organism.

Protein-protein interaction databases

BioGridi971769. 4 interactions.
IntActiP03209. 3 interactions.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi327 – 3348Poly-Ser
Compositional biasi445 – 49955Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the herpesviridae Rta family.Curated

Family and domain databases

InterProiIPR004998. Herpes_TAF50.
[Graphical view]
PfamiPF03326. Herpes_TAF50. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPKKDGLED FLRLTPEIKK QLGSLVSDYC NVLNKEFTAG SVEITLRSYK
60 70 80 90 100
ICKAFINEAK AHGREWGGLM ATLNICNFWA ILRNNRVRRR AENAGNDACS
110 120 130 140 150
IACPIVMRYV LDHLIVVTDR FFIQAPSNRV MIPATIGTAM YKLLKHSRVR
160 170 180 190 200
AYTYSKVLGV DRAAIMASGK QVVEHLNRME KEGLLSSKFK AFCKWVFTYP
210 220 230 240 250
VLEEMFQTMV SSKTGHLTDD VKDVRALIKT LPRASYSSHA GQRSYVSGVL
260 270 280 290 300
PACLLSTKSK AVETPILVSG ADRMDEELMG NDGGASHTEA RYSESGQFHA
310 320 330 340 350
FTDELESLPS PTMPLKPGAQ SADCGDSSSS SSDSGNSDTE QSEREEARAE
360 370 380 390 400
APRLRAPKSR RTSRPNRGQT PCPSNAAEPE QPWIAAVHQE SDERPIFPHP
410 420 430 440 450
SKPTFLPPVK RKKGLRDSRE GMFLPKPEAG SAISDVFEGR EVCQPKRIRP
460 470 480 490 500
FHPPGSPWAN RPLPASLAPT PTGPVHEPVG SLTPAPVPQP LDPAPAVTPE
510 520 530 540 550
ASHLLEDPDE ETSQAVKALR EMADTVIPQK EEAAICGQMD LSHPPPRGHL
560 570 580 590 600
DELTTTLESM TEDLNLDSPL TPELNEILDT FLNDECLLHA MHISTGLSIF

DTSLF
Length:605
Mass (Da):66,595
Last modified:July 21, 1986 - v1
Checksum:iB5B7DF0593FADB08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24814.1.
AJ507799 Genomic DNA. Translation: CAD53424.1.
PIRiA43043. QQBE29.
RefSeqiYP_401674.1. NC_007605.1.

Genome annotation databases

GeneIDi3783727.
KEGGivg:3783727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24814.1.
AJ507799 Genomic DNA. Translation: CAD53424.1.
PIRiA43043. QQBE29.
RefSeqiYP_401674.1. NC_007605.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971769. 4 interactions.
IntActiP03209. 3 interactions.

PTM databases

iPTMnetiP03209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783727.
KEGGivg:3783727.

Family and domain databases

InterProiIPR004998. Herpes_TAF50.
[Graphical view]
PfamiPF03326. Herpes_TAF50. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1."
    Chang L.-K., Chung J.-Y., Hong Y.-R., Ichimura T., Nakao M., Liu S.-T.
    Nucleic Acids Res. 33:6528-6539(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HUMAN ATF7IP.
  3. "The Epstein-Barr virus replication and transcription activator, Rta/BRLF1, induces cellular senescence in epithelial cells."
    Chen Y.L., Chen Y.J., Tsai W.H., Ko Y.C., Chen J.Y., Lin S.F.
    Cell Cycle 8:58-65(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Epstein-Barr virus transcription activator Rta upregulates decoy receptor 3 expression by binding to its promoter."
    Ho C.H., Hsu C.F., Fong P.F., Tai S.K., Hsieh S.L., Chen C.J.
    J. Virol. 81:4837-4847(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "The Rta/Orf50 transactivator proteins of the gamma-herpesviridae."
    Staudt M.R., Dittmer D.P.
    Curr. Top. Microbiol. Immunol. 312:71-100(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiRTA_EBVB9
AccessioniPrimary (citable) accession number: P03209
Secondary accession number(s): Q777E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 16, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.