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Protein

Trans-activator protein BZLF1

Gene

BZLF1

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1).5 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • protein dimerization activity Source: UniProtKB
  • sequence-specific DNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

G0/G1 host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF7 by virus, Inhibition of host RLR pathway by virus, Modulation of host cell cycle by virus, Transcription, Transcription regulation, Viral immunoevasion

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-activator protein BZLF1
Short name:
EB1
Alternative name(s):
Zebra
Gene namesi
ORF Names:BZLF1
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007640 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1293280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Trans-activator protein BZLF1PRO_0000076541Add
BLAST

PTM databases

iPTMnetiP03206.

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with human UBN1, CRTC2 and RACK1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CRTC2Q53ET03EBI-2621186,EBI-1181987From a different organism.
RACK1P632445EBI-2621186,EBI-296739From a different organism.

GO - Molecular functioni

  • protein dimerization activity Source: UniProtKB

Protein-protein interaction databases

IntActiP03206. 10 interactions.
MINTiMINT-6768270.

Chemistry

BindingDBiP03206.

Structurei

Secondary structure

1
245
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi57 – 593Combined sources
Helixi175 – 22147Combined sources
Helixi227 – 2304Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZSDX-ray1.70C54-64[»]
2AK4X-ray2.50C/H/M/S52-64[»]
2AXFX-ray1.80C77-86[»]
2AXGX-ray2.00C77-86[»]
2C9LX-ray2.25Y/Z175-236[»]
2C9NX-ray3.30Y/Z175-236[»]
2NX5X-ray2.70C/H/M/S54-64[»]
3KWWX-ray2.18C52-64[»]
3KXFX-ray3.10Q/R/S/T52-64[»]
3SPVX-ray1.30C190-197[»]
3VFNX-ray1.50C52-64[»]
3VFOX-ray1.70C52-64[»]
3VFPX-ray1.85C52-64[»]
3VFRX-ray1.85C52-64[»]
ProteinModelPortaliP03206.
SMRiP03206. Positions 178-236.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03206.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini170 – 22859bZIPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni178 – 19518Basic motifBy similarityAdd
BLAST
Regioni196 – 22833Leucine-zipperBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

KOiK19462.

Family and domain databases

InterProiIPR004827. bZIP.
IPR017339. Trans-activator_BZLF1_HHV-4.
[Graphical view]
PIRSFiPIRSF037966. BZLF1. 1 hit.
PROSITEiPS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDPNSTSED VKFTPDPYQV PFVQAFDQAT RVYQDLGGPS QAPLPCVLWP
60 70 80 90 100
VLPEPLPQGQ LTAYHVSTAP TGSWFSAPQP APENAYQAYA APQLFPVSDI
110 120 130 140 150
TQNQQTNQAG GEAPQPGDNS TVQTAAAVVF ACPGANQGQQ LADIGVPQPA
160 170 180 190 200
PVAAPARRTR KPQQPESLEE CDSELEIKRY KNRVASRKCR AKFKQLLQHY
210 220 230 240
REVAAAKSSE NDRLRLLLKQ MCPSLDVDSI IPRTPDVLHE DLLNF
Length:245
Mass (Da):26,860
Last modified:July 1, 1989 - v2
Checksum:i7F3D55D79F1F0196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24861.1.
AJ507799 Genomic DNA. Translation: CAD53423.1.
M17547 mRNA. Translation: AAA66529.1.
RefSeqiYP_401673.1. NC_007605.1.

Genome annotation databases

GeneIDi3783744.
KEGGivg:3783744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24861.1.
AJ507799 Genomic DNA. Translation: CAD53423.1.
M17547 mRNA. Translation: AAA66529.1.
RefSeqiYP_401673.1. NC_007605.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZSDX-ray1.70C54-64[»]
2AK4X-ray2.50C/H/M/S52-64[»]
2AXFX-ray1.80C77-86[»]
2AXGX-ray2.00C77-86[»]
2C9LX-ray2.25Y/Z175-236[»]
2C9NX-ray3.30Y/Z175-236[»]
2NX5X-ray2.70C/H/M/S54-64[»]
3KWWX-ray2.18C52-64[»]
3KXFX-ray3.10Q/R/S/T52-64[»]
3SPVX-ray1.30C190-197[»]
3VFNX-ray1.50C52-64[»]
3VFOX-ray1.70C52-64[»]
3VFPX-ray1.85C52-64[»]
3VFRX-ray1.85C52-64[»]
ProteinModelPortaliP03206.
SMRiP03206. Positions 178-236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03206. 10 interactions.
MINTiMINT-6768270.

Chemistry

BindingDBiP03206.
ChEMBLiCHEMBL1293280.

PTM databases

iPTMnetiP03206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783744.
KEGGivg:3783744.

Phylogenomic databases

KOiK19462.

Miscellaneous databases

EvolutionaryTraceiP03206.
PROiP03206.

Family and domain databases

InterProiIPR004827. bZIP.
IPR017339. Trans-activator_BZLF1_HHV-4.
[Graphical view]
PIRSFiPIRSF037966. BZLF1. 1 hit.
PROSITEiPS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBZLF1_EBVB9
AccessioniPrimary (citable) accession number: P03206
Secondary accession number(s): Q69127, Q777E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.