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Protein

Epstein-Barr nuclear antigen 4

Gene

EBNA4

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation of both viral and cellular genes by interacting with the host DNA-binding protein RBPJ.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Epstein-Barr nuclear antigen 4
Short name:
EBNA-4
Short name:
EBV nuclear antigen 4
Alternative name(s):
Epstein-Barr nuclear antigen 3B
Short name:
EBNA-3B
Short name:
EBV nuclear antigen 3B
Gene namesi
Name:EBNA4
ORF Names:BERF2A-BERF2B
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007640 Componenti: Genome

Subcellular locationi

  • Host nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 938938Epstein-Barr nuclear antigen 4PRO_0000116178Add
BLAST

Interactioni

Subunit structurei

Interacts (via N-terminus) with host RBPJ.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPJQ063304EBI-9346250,EBI-632552From a different organism.

Protein-protein interaction databases

BioGridi971805. 5 interactions.
DIPiDIP-573N.
IntActiP03203. 7 interactions.
MINTiMINT-1517084.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi526 – 753228Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the herpesviridae EBNA-4 family.Curated

Family and domain databases

InterProiIPR007706. EBNA-3.
[Graphical view]
PfamiPF05009. EBV-NA3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKAWLSRAQ QADAGGASGS EDPPDYGDQG NVTQVGSEPI SPEIGPFELS
60 70 80 90 100
AASEDDPQSG PVEENLDAAA REEEEPHEQE HNGGDDPLDV HTRQPRFVDV
110 120 130 140 150
NPTQAPVIQL VHAVYDSMLQ SDLRPLGSLF LEQNLNIEEF IWMCMTVRHR
160 170 180 190 200
CQAIRKKPLP IVKQRRWKLL SSCRSWRMGY RTHNLKVNSF ESGGDNVHPV
210 220 230 240 250
LVTATLGCDE GTRHATTYSA GIVQIPRISD QNQKIETAFL MARRARSLSA
260 270 280 290 300
ERYTLFFDLV SSGNTLYAIW IGLGTKNRVS FIEFVGWLCK KDHTHIREWF
310 320 330 340 350
RQCTGRPKAA KPWLRAHPVA IPYDDPLTNE EIDLAYARGQ AMNIEAPRLP
360 370 380 390 400
DDPIIVEDDD ESEEIEAESD EEEDKSGMES LKNIPQTLPY NPTVYGRPAV
410 420 430 440 450
FDRKSDAKST KKCRAIVTDF SVIKAIEEEH RKKKAARTEQ PRATPESQAP
460 470 480 490 500
TVVLQRPPTQ QEPGPVGPLS VQARLEPWQP LPGPQVTAVL LHEESMQGVQ
510 520 530 540 550
VHGSMLDLLE KDDEVMEQRV MATLLPPVPQ QPRAGRRGPC VFTGDLGIES
560 570 580 590 600
DEPASTEPVH DQLLPAPGPD PLEIQPLTSP TTSQLSSSAP SCAQTPWPVV
610 620 630 640 650
QPSQTPDDPT KQSRPPETAA PRQWPMPLRP IPMRPLRMQP IPFNHPVGPT
660 670 680 690 700
PHQTPQVEIT PYKPTWAQIG HIPYQPTPTG PATMLLRQWA PATMQTPPRA
710 720 730 740 750
PTPMSPPEVP PVPRQRPRGA PTPTPPPQVP PVPRQRPRGA PTPTPPPQVL
760 770 780 790 800
PTPMQLALRA PAGQQGPTKQ ILRQLLTGGV KKGRPSLKLQ AALERQAAAG
810 820 830 840 850
WQPSPGSGTS DKIVQAPIFY PPVLQPIQVM GQGGSPTAMA ASAVTQAPTE
860 870 880 890 900
YTRERRGVGP MPPTDIPPSK RAKIEAYTEP EMPHGGASHS PVVILENVGQ
910 920 930
GQQQTLECGG TAKQERDMLG LGDIAVSSPS SSETSNDE
Length:938
Mass (Da):102,860
Last modified:August 1, 1990 - v3
Checksum:i98A513AAFC0676FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24858.1.
AJ507799 Genomic DNA. Translation: CAD53420.1.
PIRiS33012. QQBE24.
RefSeqiYP_401670.1. NC_007605.1.

Genome annotation databases

GeneIDi3783763.
KEGGivg:3783763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24858.1.
AJ507799 Genomic DNA. Translation: CAD53420.1.
PIRiS33012. QQBE24.
RefSeqiYP_401670.1. NC_007605.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971805. 5 interactions.
DIPiDIP-573N.
IntActiP03203. 7 interactions.
MINTiMINT-1517084.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783763.
KEGGivg:3783763.

Family and domain databases

InterProiIPR007706. EBNA-3.
[Graphical view]
PfamiPF05009. EBV-NA3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEBNA4_EBVB9
AccessioniPrimary (citable) accession number: P03203
Secondary accession number(s): Q777E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: September 7, 2016
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.