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Protein

Viral interleukin-10 homolog

Gene

BCRF1

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in masking infected cells for immune recognition by cytotoxic T-lymphocytes. Down-regulates the expression of the host TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. Inhibits IFN-gamma synthesis.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Evasion of host immunity by viral interleukin-like protein, Host-virus interaction, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Viral interleukin-10 homolog
Short name:
vIL-10
Alternative name(s):
20 kDa protein
Protein BCRF1
Gene namesi
ORF Names:BCRF1
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007640 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001537524 – 170Viral interleukin-10 homologAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 119
Disulfide bondi73 ↔ 125
Glycosylationi127N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IL10RAQ136512EBI-1042167,EBI-1031656From a different organism.

Protein-protein interaction databases

DIPiDIP-35519N.
IntActiP03180. 1 interactor.
MINTiMINT-6597721.

Structurei

Secondary structure

1170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni30 – 33Combined sources4
Helixi34 – 45Combined sources12
Turni46 – 48Combined sources3
Turni49 – 51Combined sources3
Helixi61 – 68Combined sources8
Helixi72 – 85Combined sources14
Helixi87 – 94Combined sources8
Turni96 – 98Combined sources3
Helixi99 – 118Combined sources20
Turni120 – 122Combined sources3
Helixi124 – 126Combined sources3
Helixi130 – 141Combined sources12
Helixi143 – 152Combined sources10
Helixi154 – 166Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VLKX-ray1.90A26-170[»]
1Y6MX-ray2.80L26-170[»]
1Y6NX-ray2.70L26-170[»]
ProteinModelPortaliP03180.
SMRiP03180.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03180.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili97 – 145Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

KOiK05443.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRLVVTLQ CLVLLYLAPE CGGTDQCDNF PQMLRDLRDA FSRVKTFFQT
60 70 80 90 100
KDEVDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPEAKD
110 120 130 140 150
HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQIKNAFN KLQEKGIYKA
160 170
MSEFDIFINY IEAYMTIKAR
Length:170
Mass (Da):19,914
Last modified:July 21, 1986 - v1
Checksum:iAE20AE65D358F0CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24863.1.
M11924 Genomic DNA. Translation: AAA45900.1.
AJ507799 Genomic DNA. Translation: CAD53385.1.
PIRiA03741. QQBE2.
RefSeqiYP_401634.1. NC_007605.1.

Genome annotation databases

GeneIDi3783689.
KEGGivg:3783689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24863.1.
M11924 Genomic DNA. Translation: AAA45900.1.
AJ507799 Genomic DNA. Translation: CAD53385.1.
PIRiA03741. QQBE2.
RefSeqiYP_401634.1. NC_007605.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VLKX-ray1.90A26-170[»]
1Y6MX-ray2.80L26-170[»]
1Y6NX-ray2.70L26-170[»]
ProteinModelPortaliP03180.
SMRiP03180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35519N.
IntActiP03180. 1 interactor.
MINTiMINT-6597721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783689.
KEGGivg:3783689.

Phylogenomic databases

KOiK05443.

Miscellaneous databases

EvolutionaryTraceiP03180.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL10H_EBVB9
AccessioniPrimary (citable) accession number: P03180
Secondary accession number(s): Q777H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Be careful of the possible confusion between BCRF1 with BcRF1.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.