P03168 (X_GSHV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein X

Alternative name(s):
HBx
Peptide X
pX

Gene names

Name:

X

Organism

Ground squirrel hepatitis virus (strain 27) (GSHV) [Complete proteome]

Taxonomic identifier

10406 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Hepadnaviridae › Orthohepadnavirus

Virus host

Spermophilus [TaxID: 9996]

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. Effect on apoptosis is controversial depending on the cell types in which the studies have been conducted By similarity.
Subunit structure	May form homodimer By similarity.
Subcellular location	Host cytoplasm. Host nucleus. Host mitochondrion By similarity.
Sequence similarities	Belongs to the orthohepadnavirus protein X family.

Ontologies

Keywords
Biological process	Activation of host NF-kappa-B by virus Apoptosis Host G2/M cell cycle arrest by virus Host-virus interaction Modulation of host cell cycle by virus Transcription Transcription regulation
Cellular component	Host cytoplasm Host mitochondrion Host nucleus
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Cellular component	host cell mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	Protein X		PRO_0000222358
Regions
	Region	68 – 113	46	Mitochondrial targeting sequence By similarity

Sequences

	Sequence		Length	Mass (Da)
	P03168 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: CD7D1E75A9550893	FASTA	138	15,057
	10 20 30 40 50 60 MAARLCCQLD SSRDVLLLRP LRGQPSGPSV SGTSAGSPSS AASAFSSGHQ ADIPVGRLPA 70 80 90 100 110 120 CFYSSAGPCC LGFTCADLRT MDSTVNFVPW HAKRQLGMMQ KDFWTAYIRD QLLTLWEEGI 130 IDPRLKLFVL GGCRHKYM

References

[1]	"Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus." Seeger C., Ganem D., Varmus H.E. J. Virol. 51:367-375(1984) [PubMed: 6086950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	K02715 Genomic DNA. Translation: AAA46758.1.
PIR	QQVLS. A03721.
RefSeq	NP_040996.1. NC_001484.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1488457.
Family and domain databases
InterPro	IPR000236. Transactivation_prot_X. [Graphical view]
Pfam	PF00739. X. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

X_GSHV

Accession

Primary (citable) accession number: P03168

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 31, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program