P03153 (HBEAG_GSHV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
External core antigen

Alternative name(s):
HBeAg
Precore protein

Gene names

Name:

C

Organism

Ground squirrel hepatitis virus (strain 27) (GSHV) [Complete proteome]

Taxonomic identifier

10406 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Hepadnaviridae › Orthohepadnavirus

Virus host

Spermophilus [TaxID: 9996]

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May regulate immune response to the intracellular capsid in acting as a T cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T cells By similarity.
Subunit structure	Homodimerizes By similarity.
Subcellular location	Secreted By similarity.
Post-translational modification	Phosphorylated By similarity. Cleaved by host furin By similarity.
Sequence similarities	Belongs to the orthohepadnavirus precore antigen family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral immunoevasion
Cellular component	Secreted
Coding sequence diversity	Alternative initiation
Domain	Repeat Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	evasion by virus of host immune response Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Isoform External core antigen (identifier: P03153-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Capsid protein (identifier: P0C6J1-1)

The sequence of this isoform can be found in the external entry P0C6J1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 188	169	External core antigen		PRO_0000222306
	Propeptide	189 – 217	29	By similarity		PRO_0000324689
Regions
	Repeat	189 – 195	7	1; half-length
	Repeat	196 – 203	8	2
	Repeat	204 – 211	8	3
	Region	189 – 211	23	3 X 8 AA repeats of S-P-R-R-R-R-S-Q
Sites
	Site	188 – 189	2	Cleavage; by host By similarity
Amino acid modifications
	Disulfide bond	78		Interchain By similarity
	Disulfide bond	91		Interchain By similarity

Sequences

	Sequence		Length	Mass (Da)
	Isoform External core antigen [UniParc]. Last modified July 21, 1986. Version 1. Checksum: DF489467355EC11A	FASTA	217	25,189
	10 20 30 40 50 60 MYLFHLCLVF ACVPCPTVQA SKLCLGWLWD MDIDPYKEFG SSYQLLNFLP LDFFPDLNAL 70 80 90 100 110 120 VDTAAALYEE ELTGREHCSP HHTAIRQALV CWEELTRLIT WMSENTTEEV RRIIVDHVNN 130 140 150 160 170 180 TWGLKVRQTL WFHLSCLTFG QHTVQEFLVS FGVWIRTPAP YRPPNAPILS TLPEHTVIRR 190 200 210 RGGSRAARSP RRRTPSPRRR RSQSPRRRRS QSPASNC
	Isoform Capsid protein [UniParc]. See P0C6J1.		–	–

References

[1]	"Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus." Seeger C., Ganem D., Varmus H.E. J. Virol. 51:367-375(1984) [PubMed: 6086950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	K02715 Genomic DNA. Translation: AAA46755.1.
PIR	NKVLS. A03715.
RefSeq	NP_040993.1. NC_001484.1.
3D structure databases
ProteinModelPortal	P03153.
SMR	P03153. Positions 31-172.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1488460.
Family and domain databases
InterPro	IPR013195. Hepatitis_B_virus_capsid_N. IPR002006. Viral_capsid_core_Hepatitis. [Graphical view]
Pfam	PF08290. Hep_core_N. 1 hit. PF00906. Hepatitis_core. 1 hit. [Graphical view]
ProDom	PD000874. Vir_capsid_Znf-put_N_Hepatitis. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47852. Viral_capsid_core_Hepatitis. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HBEAG_GSHV

Accession

Primary (citable) accession number: P03153

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	September 21, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program