P03136 (CAPSD_PAVHH) Reviewed, UniProtKB/Swiss-Prot
Last modified May 1, 2013. Version 66. History...
Names and origin
|Protein names||Recommended name:|
Capsid protein VP1
Coat protein VP1
|Organism||Hamster parvovirus H1 [Complete proteome]|
|Taxonomic identifier||10799 [NCBI]|
|Taxonomic lineage||Viruses › ssDNA viruses › Parvoviridae › Parvovirinae › Parvovirus|
|Virus host||Cricetidae sp. (Hamster) [TaxID: 36483]|
Rattus norvegicus (Rat) [TaxID: 10116]
|Sequence length||734 AA.|
|Protein existence||Evidence at protein level|
General annotation (Comments)
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus By similarity.
The N-terminus of VP1 is sequestered within the mature capsid. It contains a phospholipase A2-like region and putative nuclear localization signals.
Belongs to the parvoviridae capsid protein family.
|This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]|
|Isoform VP1 (identifier: P03136-1) |
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
|Note: Minor splicing isoform.|
|Isoform VP2 (identifier: P03136-2) |
The sequence of this isoform differs from the canonical sequence as follows:
|Note: Major splicing isoform produced by deletion of the initiating AUG for VP1 and downstream translation of VP2.|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 734||734||Capsid protein VP1||PRO_0000039431|
|Region||19 – 64||46||Phospholipase A2-like By similarity|
|Motif||4 – 13||10||Nuclear localization signal Potential|
|Compositional bias||166 – 182||17||Gly-rich|
|Metal binding||328||1||Magnesium 1 By similarity|
|Alternative sequence||1 – 142||142||Missing in isoform VP2.||VSP_041140|
|X01457 Genomic DNA. Translation: CAB57285.1. Sequence problems.|
|PIR||VCPVV2. A03699. |
|RefSeq||NP_040319.1. NC_001358.1. |
3D structure databases
Protocols and materials databases
Genome annotation databases
Family and domain databases
|Gene3D||18.104.22.168. 1 hit. |
|InterPro||IPR016184. Capsid/spike_ssDNA_virus. |
|Pfam||PF00740. Parvo_coat. 1 hit. |
PF08398. Parvo_coat_N. 1 hit.
|SUPFAM||SSF88645. Capsid/spike_ssDNA_virus. 1 hit. |
|Accession||Primary (citable) accession number: P03136|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|