P03133 (VNCS_PAVHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-capsid protein NS-1

Alternative name(s):
NCVP1
Non-structural protein NS1

Gene names

Name:

NS1

Organism

Hamster parvovirus H1 [Complete proteome]

Taxonomic identifier

10799 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Parvoviridae › Parvovirinae › Parvovirus

Virus host

Rattus norvegicus (Rat) [TaxID: 10116]
Cricetidae sp. (Hamster) [TaxID: 36483]

Protein attributes

Sequence length	672 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Seems necessary for viral DNA replication.
Sequence similarities	Belongs to the parvoviruses non-capsid protein family. Contains 1 SF3 helicase domain.

Ontologies

Keywords
Biological process	DNA replication Initiation of viral infection Viral penetration into host cytoplasm Viral penetration via permeabilization of host organellar membrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 672	672	Non-capsid protein NS-1		PRO_0000222468
Regions
	Domain	373 – 528	156	SF3 helicase
	Nucleotide binding	399 – 406	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P03133 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 12F331142F72AA6D	FASTA	672	75,993
	10 20 30 40 50 60 MAGNAYSDEV LGVTNWLKDK SSQEVFSFVF KNENVQLNGK DIGWNSYRKE LQDDELKSLQ 70 80 90 100 110 120 RGAETTWDQS EDMEWESAVD DMTKKQVFIF DSLVKKCLFE VLSTKNIAPS NVTWFVQHEW 130 140 150 160 170 180 GKDPGWHCHV LIGGKDFSQP QGKWWRRQLN VYWSRWLVTA CNVQLTPAER IKLREIAEDS 190 200 210 220 230 240 EWVTLLTYKH KHTKKDYTKC VLFGNMIAYY FLSKKKICTS PPRDGGYFLS SDSGWKTNFL 250 260 270 280 290 300 KEGERHLVSK LYTDEMKPET VETTVTTAQE AKRGRIQTRE EVSIKTTLKE LVHKRVTSPE 310 320 330 340 350 360 DWMMMQPDSY IEMMAQPGGE NLLKNTLEIC TLTLARTKTA FDLILEKAET SKLANFSMAS 370 380 390 400 410 420 TRTCRIFAEH GWNYIKVCHA ICCVLNRQGG KRNTVLFHGP ASTGKSIIAQ AIAQAVGNVG 430 440 450 460 470 480 CYNAANVNFP FNDCTNKNLI WVEEAGNFGQ QVNQFKAICS GQTIRIDQKG KGSKQIEPTP 490 500 510 520 530 540 VIMTTNENIT VVRIGCEERP EHTQPIRDRM LNIHLTRTLP GDFGLVDKHE WPLICAWLVK 550 560 570 580 590 600 NGYQSTMACY CAKWGKVPDW SEDWAEPKLD TPINSLGSMR SPSLTPRSTP LSQNYALTPL 610 620 630 640 650 660 ASDLADLALE PWSTPNTPVA GTAASQNTGE AGSTACQGAQ RSPTWSEIEA DLRACFSQEQ 670 LESDFNEELT LD

References

[1]	"Parvovirus genome: nucleotide sequence of H-1 and mapping of its genes by hybrid-arrested translation." Rhode S.L. III, Paradiso P.R. J. Virol. 45:173-184(1983) [PubMed: 6823009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X01457 Genomic DNA. Translation: CAA25689.1.
PIR	UYPVV1. A03695.
RefSeq	NP_040318.1. NC_001358.1.
3D structure databases
ProteinModelPortal	P03133.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1489601.
Family and domain databases
InterPro	IPR014015. Helicase_SF3_DNA-vir. IPR021972. Parvovirus_NS1_C. IPR001257. Parvovirus_NS1_helicase. IPR021076. Parvovirus_NS1_N. [Graphical view]
Pfam	PF12117. DUF3580. 1 hit. PF01057. Parvo_NS1. 1 hit. PF12433. PV_NSP1. 1 hit. [Graphical view]
PROSITE	PS51206. SF3_HELICASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VNCS_PAVHH

Accession

Primary (citable) accession number: P03133

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	September 21, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program